检索结果-南通市图书馆

刺玫根多糖对环磷酰胺诱导的免疫抑制小鼠的免疫调节作用

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

天然产物研究与开发 2024年第2期36卷 196-205,292页

作者：查苏娜苏日娜齐和日玛彭斯格热希萨仁高娃内蒙古医科大学呼和浩特010110

采用水提醇沉法提取刺玫根粗多糖,以Sevage法和TCA法脱蛋白,进一步分级醇沉法分离纯化得到较纯的60%醇沉物(RDRP)进行结构鉴定和活性评价。苯酚浓硫酸法测定出刺玫根多糖RDRP总糖含量为94.1%;高效凝胶渗透色谱法测定表明主要含有重均分... 详细信息

采用水提醇沉法提取刺玫根粗多糖,以Sevage法和TCA法脱蛋白,进一步分级醇沉法分离纯化得到较纯的60%醇沉物(RDRP)进行结构鉴定和活性评价。苯酚浓硫酸法测定出刺玫根多糖RDRP总糖含量为94.1%;高效凝胶渗透色谱法测定表明主要含有重均分子量为13.1 kDa,相对分散度为1.2的多糖;通过高效离子色谱法和红外光谱测定,鉴定刺玫根多糖为由葡萄糖、阿拉伯糖、半乳糖、甘露糖、木糖等5种单糖组成的含有α-构型的中性吡喃多糖。环磷酰胺诱导的免疫抑制小鼠模型实验结果表明,与模型组相比,刺玫根多糖各剂量组小鼠的脾脏和胸腺指数明显升高(P<0.05,P<0.01);血细胞分析仪检测发现白细胞数、红细胞数、血小板显著升高(P<0.05);ELISA法检测血清中免疫相关蛋白IgG、IgM、IgA以及细胞因子TNF-α、IFN-γ、IL-6与IL-2的分泌水平,结果显示,与模型组比较,刺玫根多糖组显著上调小鼠血清中免疫球蛋白IgA、IgG、IgM浓度水平(P<0.01)及IL-2、IFN-γ、TNF-α、IL-6的含量(P<0.01);Western blot法测定各组TLR4、MyD88、TRAF-6和NF-κB p65蛋白的表达水平,发现刺玫根多糖各剂量组脾脏中TLR4、TRAF-6蛋白极显著上升(P<0.01),高剂量组的MyD88蛋白极显著上升(P<0.01),其他组呈现上升趋势;刺玫根多糖各剂量组NF-κB p65蛋白均有上升趋势,因此其免疫调节作用机制可能与TLR/NF-κB通道有关。本研究初步阐明刺玫根多糖的基本结构特征和其免疫调节作用及其机制,为刺玫根多糖的开发应用提供一定价值的实验依据。

关键词：刺玫根多糖结构鉴定免疫调节 TLR/NF-κB

Pancreatic ductal system obstruction and acute recurrent pancreatitis

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2008年第7期14卷 1027-1033页

作者： M Delhaye C Matos M Arvanitakis J Devière Department of Gastroenterology and Hepatopancreatology Erasme University HospitalBrusselsBelgium

Acute recurrent pancreatitis is a clinical entity largely associated with pancreatic ductal obstruction. This latter includes congenital variants, of which pancreas divisum is the most frequent but also controversial, chronic pancreatitis, tumors of the pancreaticobiliary junction and sphincter of Oddi dysfunction. This review summarizes current knowledge about diagnostic work-up and therapy of these conditions.

关键词： Pancreatitis Congenital variants Sphincter of Oddi dysfunction Pancreatic tumors Magnetic resonance cholangiopancreatography Endoscopic retrograde cholangiopancreatography

Combinatorial Method with Static Analysis for Source Code Security in Web Applications

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Computer Modeling in Engineering & Sciences 2021年第11期129卷 541-565页

作者： Juan Ramon Bermejo Higuera Javier Bermejo Higuera Juan Antonio Sicilia Montalvo Tomas Sureda riera Christopher I.Argyros A.Alberto Magrenan Escuela Superior de Ingenierıa y Tecnologıa Universidad Internacional de La RiojaLogronoLa Rioja26006Spain Computer Science Department University of AlcalaMadrid28801Spain Department of Computing and Technology Cameron UniversityLawton73505OklahomaUSA Universidad de la Rioja LogronoLa Rioja26006Spain

Security weaknesses in web applications deployed in cloud architectures can seriously affect its data confidentiality and *** construction of the procedure utilized in the static analysis tools of source code security differs and therefore each tool finds a different number of each weakness type for which it is *** utilize the possible synergies different static analysis tools may process,this work uses a new method to combine several source codes aiming to investigate how to increase the performance of security weakness detection while reducing the number of false ***,five static analysis tools will be combined with the designed method to study their behavior using an updated benchmark for OWASP Top Ten Security Weaknesses(OWASP TTSW).The method selects specific metrics to rank the tools for different criticality levels of web applications considering different weights in the *** findings show that simply including more tools in a combination is not synonymous with better results;it depends on the specific tools included in the combination due to their different designs and techniques.

关键词： Weakness benchmark security testing analysis comparative methodology tools combination web application

Corrosion behaviour and cytocompatibility of selected binary magnesium-rare earth alloys

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Magnesium and Alloys 2021年第2期9卷 581-591页

作者： Hiba Azzeddine Abdelkader Hanna Achour Dakhouche Bérengère Luthringer-Feyerabend Department of Physics Faculty of SciencesUniversity of Mohamed BoudiafM’silaAlgeria Inorganic Materials Laboratory Department of ChemistryFaculty of SciencesUniversity of Mohamed BoudiafM’silaAlgeria Metallic Biomaterials Institute of Material ResearchHelmholtz-Zentrum Geesthacht21502 GeesthachtGermany

The corrosion behaviour of as-cast binary Mg–0.3 Ce,Mg–1.44 Nd,Mg–0.63 Gd and Mg–0.41 Dy(wt%)alloys was investigated in DMEM+10%FBS solution using electrochemical and weight loss *** results revealed that the alloys with heavy re elements(Gd and Dy)exhibited the lowest corrosion rate compared to the alloys with light re elements(Ce and Nd).The cytocompatibility of the Mg–re alloys was assessed via live/dead straining after 3 and 7 *** results show that Mg–0.63 Gd alloy is a suitable candidate for biomedical applications.

关键词： Corrosion Cytotoxicity Magnesium alloys Rare earth element Weight loss test

Fully digital intensity modulated LIDAR

在线全文

学校读者我要写书评

暂无评论

Defence Technology（防务技术） 2016年第4期12卷 290-296页

作者： Fabio POLLASTRONE Gian Carlo CARDARILLI Roberto PIZZOFERRATO Marco re Department FSN FUSTEC–IEE-ENEA Frascati Department of Electronics Engineering University of Rome "Tor Vergata" Department of Industrial Engineering University of Rome "Tor Vergata"

In several applications, such as collision avoidance, it is necessary to have a system able to rapidly detect the simultaneous presence of different obstacles. In general, these applications do not require high resolution performance, but it is necessary to assure high system reliability also within critical scenarios, as in the case of partially transparent atmosphere or environment in presence of multiple objects(implying multiple echoes having different delay times.) This paper describes the algorithm, the architecture and the implementation of a digital Light Detection and Ranging(LIDAR) system based on a chirped optical carrier. This technique provides some advantages compared to the pulsed approach, primarily the reduction of the peak power of the laser. In the proposed architecture all the algorithms for signal processing are implemented using digital hardware. In this way, some specific advantages are obtained: improved detection performance(larger dynamics, range and resolution), capability of detecting multiple obstacles having different echoes amplitude, reduction of the noise effects, reduction of the costs, size and weight of the resulting equipment. The improvement provided by this fully digital solution is potentially useful in different applications such as: collision avoidance systems, 3D mapping of environments and, in general, remote sensing systems which need wide distance and dynamics.

关键词： CW-IM LIDAR Chirp Laser Obstacle Avoidance

Earthquake distribution and lithospheric rheology beneath the Northwestern Andes, Colombia

在线全文

学校读者我要写书评

暂无评论

Geodesy and Geodynamics 2021年第1期12卷 1-10页

作者： Carla Lagardère Carlos A.Vargas Department of Geosciences Universidad Nacional de ColombiaBogotaColombia Ecole nationale superieure en environnement georessources et ingenierie du developpement durable(ENSEGID)BordeauxFrance

The rheological behavior of the lithosphere beneath the Northwestern(NW)Andes(Colombian)remains uncertain under a complex geological ***,we analyze the earthquake distribution and the stress drop on the western and the eastern of the transition area between the Upper Magdalena Valley(UMV)and the Middle Magdalena Valley(MMV),a zone related to a plate tectonic transition from steeper to flatter subduction style slabs(Nazca and Caribbean plates).Our results consistently explain the tectonic and geodynamic context of the study area supported in two rheological profiles,which reveal the brittle/ductile transition of the lithospheric crust and mantle and allow to constrain the lithospheric rheological *** subduction phenomenon of the Nazca Plate under the South American Plate is observed in the western *** the eastern region,we find a remarkable aseismic zone under the Eastern Cordillera below 20-km-deep,which made more difficultan accurate estimation of the crust/mantle *** seismic particularity leads us to support the hypothesis of a delamination process due to the tectonic overload generated by the Eastern Cordillera,and that promotes thermal *** results also suggest that the earthquake dataset correlated with rheological estimations may offer a consistent interpretation of the mechanical behavior of the lithosphere.

关键词： Lithosphere rheology Seismicity Northwestern Andes Delamination process

Systematic Approach for Web Protection Runtime Tools’Effectiveness Analysis

在线全文

学校读者我要写书评

暂无评论

Computer Modeling in Engineering & Sciences 2022年第12期133卷 579-599页

作者： Tomás Sureda riera Juan Ramón Bermejo Higuera Javier Bermejo Higuera Juan Antonio Sicilia Montalvo José Javier Martínez Herráiz Computer Science Department University of AlcaláMadrid28801Spain Escuela Superior de Ingeniería y Tecnología Universidad Internacional de La RiojaLogrono26006Spain

Web applications represent one of the principal vehicles by which attackers gain access to an organization’s network or ***,different approaches to protect web applications have been proposed to *** them,the two major approaches are Web Application Firewalls(WAF)and Runtime Application Self Protection(RASP).It is,thus,essential to understand the differences and relative effectiveness of both these approaches for effective decisionmaking regarding the security of web *** we present a comparative study between WAF and RASP simulated settings,with the aim to compare their effectiveness and efficiency against different categories of *** this,we used computation of different metrics and sorted their results using F-Score *** found that RASP tools scored better than WAF *** this study,we also developed a new experimental methodology for the objective evaluation ofweb protection tools since,to the best of our knowledge,nomethod specifically evaluates web protection tools.

关键词： Web Application Firewall(WAF) Runtime Application Self Protection(RASP) F-Score web attacks experimental methodology

Exosomes from adipose tissue-derived stem/stromal cells:A key to future regenerative medicine

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

BIOCELL 2022年第12期46卷 2701-2704页

作者： JÉRÔME LALOZE ALEXIS DESMOULIÈre University of Limoges Neuropathies and Therapeutic Innovations(UR 20218)Faculties of Medicine and PharmacyLimogesF-87000France Department of Maxillo-Facial and reconstructive Surgery and Stomatology University Hospital DupuytrenLimogesF-87000France

Advances in regenerative medicine correlate strongly with progress in the use of adipose tissue-derived mesenchymal stem/stromal *** range of therapeutic indications has also expanded over recent *** recent studies have highlighted the primary importance of paracrine secretion by these *** it is interesting to compare the different types of such secretions,we believe that exosomes(extra-cellular vesicles possessing the same properties as their source cells)will likely be the main key in tomorrow’s cell *** also have many advantages compared to the direct use of cells,making these particles amajor target in fundamental and translational research.

关键词： Adipose-derived mesenchymal stem/stromal cell Exosome regenerative medicine Secretome

Corrosion rate determination of rare-earth Mg alloys in a Na_(2)SO_(4)solution by electrochemical measurements and inductive coupled plasma-optical emission spectroscopy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Magnesium and Alloys 2019年第1期7卷 47-57页

作者： Samuel Leleu Bertrand Rives Nicolas Causse Nadine Pébère CIRIMAT Universitéde ToulouseCNRSINPTUPSENSIACET4 allée Emile Monso BP4436231030 Toulouse cedex 4 France IRT Saint Exupéry 118 route de Narbonne-CS 4424831432 ToulouseFrance

The corrosion resistance of three Mg alloys containing rare-earth elements(WE43,EV31 and ZE41)was studied and compared to that of two Mg-Al alloys(AZ31 and AZ91)and of pure Mg(99.95 wt.%).Current-voltage curves and electrochemical impedance measurements were performed with rotating disk electrodes in an aerated 0.1 M Na_(2)SO_(4)*** all the alloys,it was confirmed that the intermetallic particles acted as local cathodes and that more protective films were formed on the alloys surface by comparison with the pure *** rates were determined from inductive coupled plasma-optical emission spectroscopy measurements and from the electrochemical *** corrosion rates were observed for the rare-earth Mg alloys compared to the AZ series *** data allowed the corrosion mechanisms to be discussed.

关键词： Magnesium alloys Rare-earth elements EIS ICP-OES Interface