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Quantification of Steroid Receptors Gene Expression in Breast Cancer Patients: Possible Correlation with Serum Level of Adipocytokines

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Journal of Cancer Therapy 2011年第5期2卷 659-665页

作者： Rana Jahanban Esfahlan Nosratollah Zarghami Μohammad Rahmati-Yamchi Amir Monfaredan Samira Valiyari Ali Jahanban Esfahlan raziallah jafari jozani Morteza Gojazadeh Fereidoun Mamaghani Majid Mobasseri 不详

Background: While the role of adipocyte-derived hormones in breast cancer pathogenesis well studied, it is speculated that there is a crosstalk between adipocytokines and Esterogen receptor(ER) signaling. To test this hypothesis we evaluate the possible correlation between serum levels of adipocytokins with steroid hormone receptors gene expression in breast cancer patients. Methods: In this case-control study, 70 women with breast cancer participated with different grades of obesity (36 none obese, BMI 0.05). In case of leptin, we observed a positive correlation between leptin and ERα and PR mRNA. (r = 0.553, n = 64, p < 0.001, r = 0.359, n = 64, p = 0.002 and a reverse significant correlation between leptin and ERβ (r= –0.506, n = 64 and p < 0.001). We also observed a significant correlation between TNFα and IL6 with steroid receptors gene expression in samples (P < 0.05). Conclusion: As the presence of steroid receptors are used as the most common prognostic markers in breast cancer patients, so targeting adipocytokines as potential regulators of steroid receptorsgene expression can be a new approach in treatment of obese breast cancer subjects.

关键词： Obesity Breast Cancer Steroid Receptors Adipocytokines

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Support effects on the chemical property and catalytic activity of Co-Mo HDS catalyst in sulfur recovery

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Journal of Natural Gas Chemistry 2010年第1期19卷 91-95页

作者： Ali Nakhaei Pour Ali Morad Rashidi Kherolah jafari jozani Ali Mohajeri Payman Khorami Research Institute of Petroleum Industry of National Iranian Oil Company P. O. Box 114665-137 Tehran Iran

Effects of carbon nanotubes （CNT） and alumina （γ-Al2O3） supports on the catalytic activities of hydrodesulfurization （HDS） process over Co- Mo catalyst have been studied. XRD results indicated that the main active phases in CNT and γ-Al2O3 supported Co-Mo catalysts are MoO2 and MOO3, respectively. The TPR results reveal that the reduction peak temperatures of the active species on CNT supported Co-Mo catalyst is lower than those on alumina supported Co-Mo catalyst, indicating that the CNT supports favor the reduction of active species. Catalytic evaluation results displayed that the sulfur content in the reaction products on the CNT supported Co-Mo catalyst is lower than that on the alumina supported Co-Mo catalyst if the HDS reaction was carried out at a temperature above 583 K.

关键词： sulfur recovery Co-Mo catalyst carbon nanotubes HDS process

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