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Systematic review of anorectal leiomyosarcoma: Current challenges and recent advances

World Journal of Gastrointestinal Surgery 2019年第8期11卷 334-341页

作者： Mohammed O Nassif razan a habib Luai Z Almarzouki Nora H Trabulsi Department of Surgery King Abdulaziz University

BACKGROUND The anorectal leiomyosarcoma (LMS) is an aggressive malignant neoplasm. Owing to the rarity of LMSs, an optimal treatment modality has yet to be determined. AIM To collect all published data on anorectal LMS characteristics, explore current treatment options, and review recent cases of postradiation LMS. METHODS A literature search of the PubMed electronic database was conducted using the MeSH terms "rectal neoplasms","anus neoplasms" and "gastrointestinal neoplasms" combined with "leiomyosarcoma". The search was limited to English language and human studies. All available case reports and case series of anal or rectal LMSs that were published from the beginning of January 1996 to May 2017 were included if the diagnosis of LMS had been confirmed by histopathologic examination. Data were analyzed using simple statistics (mean, median, and standard deviation). Independent sample t-test was used to compare means for continuous variables. RESULTS A total of 27 articles reporting on 51 cases of anorectal LMS were identified. Among these cases, 11.7% had undergone previous pelvic radiotherapy (developing LMS at 13-35 years afterwards). Anorectal LMS affected the rectum in 92.2% of the cases, and no sex-based predominance was observed. Surgical resection with negative margins remains the mainstay of treatment, which can be accomplished with wide local excision or radical resection. The local recurrence rate was higher among cases who received wide local excision (30%), as compared to radical resection (20%);however, the overall rate of metastasis was 51.61% regardless of the treatment approach. The use of neoadjuvant radiation lowers the risk of local recurrence compared to adjuvant radiotherapy, and facilitates R0 resection of the tumor. Cases treated with adjuvant chemotherapy showed better rates of distant recurrence and overall survival. Nonetheless, multidisciplinary team discussion is necessary to determine the optimal management plan whilst considering pa

关键词： Leiomyosarcoma Rectal neoplasms Anal neoplasms Gastrointestinal neoplasms Soft tissue neoplasms

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Controlled growth and composition of multivariate metal-organic frameworks-199 via a reaction-diffusion process

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Nano Research 2021年第2期14卷 423-431页

作者： razan lssa Fayrouz Abou Ibrahim Mazen Al-Ghoul Mohamad Hmadeh Department of Chemistry American University of BeirutP.O.Box 11-0236RiadEl-Solh 11072020BeirutLebanon Department of Chemistry McGill University801 Sherbrooke Street WestMontreal H2A 0B8Canada

In this paper,we exploit our prior successful synthesis of MOF-199 single crystals using the reaction-diffusion framework(RDF),to synthesize multivariate metal-organic frameworks(MTV-MOFs)version with enhanced *** MTV-MOFs are synthesized by creating defects within the MOF-199 crystal structure by integrating organic linkers entailing different functional ***,5-aminoisophthalic acid(NH_(2)-BDC)and 5-hydroxyisophthalic acid(OH-BDC)are separately mixed with 1,3,5-benzenetricarboxylic acid(BTC)in three different starting ratios of X-BDC:BTC(1:3,1:1)and(3:1).The effects of this linker on the morphology of the synthesized MTV-MOFs,their thermal stability,and their surface area are *** extent of the incorporation of the linkers in the framework is elucidated via^(1)H-NMR spectroscopy and it is shown that the incorporation varies as a function of the location along the tubular reactor,a characteristic of *** enhanced properties of the synthesized MTV-MOFs are further demonstrated by measuring its adsorptive capability for methylene blue(MB)and rhodamine B(Rh B)in aqueous solution,and compared with that of the as-synthesized *** kinetic and thermodynamic studies reveal that MTV-MOFs with the ratio of X-BDC:BTC(1:1)exhibit the best uptakes of MB(263 mg/g)for X=OH and Rh B(156 mg/g)for X=NH_(2).The adsorbents are also easily regenerated for three consecutive cycles without losing their *** finally demonstrate that MTV-MOFs can be designed to tune the dye removal selectivity and enhance the removal capacity of both MB and RhB in a binary aqueous solution of these dyes.

关键词： reaction-diffusion framework(RDF) multivariate metal-organic frameworks(MTV-MOFs) adsorption methylene blue(MB) rhodamine B(Rh B)

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Adequacy of Logistic models for describing the dynamics of COVID-19 pandemic

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Infectious Disease Modelling 2020年第1期5卷 536-542页

作者： Abdallah Abusam razan Abusam Bader Al-Anzi Water Research Center Kuwait Institute for Scientific ResearchP.O.Box 24885Safat13109Kuwait Chemical Engineering Department University of the West of ScotlandUK Department of Environment Technologies and Management Kuwait UniversityKuwait

Logistic models have been widely used for modelling the ongoing COVID-19 *** study used the data for Kuwait to assess the adequacy of the two most commonly used logistic models(Verhulst and Richards models)for describing the dynamics ***,the study assessed the predictive performance of these two models and the practical identifiability of their *** model calibration approaches were *** the first approach,all the data was used to fit the models as per the heuristic model fitting *** the second approach,only the first half of the data was used for calibrating the models,while the other half was left for validating the *** of the obtained calibration and validation results have indicated that parameters of the two models cannot be identified with high certainty from COVID-19 ***,the models shown to have structural problems as they could not predict reasonably the validation ***,they should not be used for long-term predictions of *** have been made for improving the performances of the models.

关键词： Infectious disease modeling Logistic growth models Parameter identification Model performance COVID-19 in Kuwait

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Inner Ear Disorders in the Elderly with Carotid Artery Disease Requiring Revascularization:Prevalence,Characteristics,and Association

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Journal of Geriatric Medicine 2020年第3期2卷 6-11页

作者： razan Alfakir Department of Otolaryngology and Division of Audiology Mayo ClinicJacksonvilleFloridaUnited States Department of Communication Disorders Auburn UniversityAlabamaUnited States

Background:Aging is almost assocaited with inner ear disorders(InEarDs)by means of age-related hearing impairment(ARHI)or vertigo-anddizziness as well as the carotid artery disease requiring revascularization(CAD-R).Objective:The present study aimed to study the prevalence and characteristics of InEarDs in older adults diagnosed with *** other aim was to determine if InEarDs in CAD-R patients is age-related or might be explained by a concomitant ***:A retrospective,case-control study was conducted at the Mayo Clinic,*** study cohort includes 919 patients who had *** control group consisted of 244 age-and gender-matched patients presenting with cardiac or peripheral artery *** InEarDs were assessed based on the diagnosis upon presentation to the Audiology Clinic and ***:Of the 919,348 had ARHI that includes significant peripheral signs and central symptoms(24.9%),vertigo-and-dizziness events that are recurrent and persistent with normal objective vestibular testing(12.9%),or a combination of both(11.0%).These percentages were significantly higher in the study group relative to the control *** adjustment for the vascular risk factors,the study group had significantly higher odds of ARHI(OR=1.94;95%CI:1.09-3.44;P<0.05).Conclusion:CAD-R patients had significantly higher InEarDs than the control ***-R is more likely to be associated with ARHI rather than the vertigo-and-dizziness even after adjusting for the vascular risk factors.

关键词： Carotid Atherosclerosis Age-related hearing impairment Vertigo-and-dizziness

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Explainable Classification Model for Android Malware Analysis Using API and Permission-Based Features

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Computers, Materials & Continua 2023年第9期76卷 3167-3188页

作者： Nida Aslam Irfan Ullah Khan Salma Abdulrahman Bader Aisha Alansari Lama Abdullah Alaqeel razan Mohammed Khormy Zahra Abdultawab AlKubaish Tariq Hussain SAUDI ARAMCO Cybersecurity Chair Department of Computer ScienceCollege of Computer Science and Information TechnologyImam Abdulrahman Bin Faisal UniversityP.O.Box 1982Dammam31441Saudi Arabia Department of Computer Science College of Computer Science and Information TechnologyImam Abdulrahman Bin Faisal UniversityP.O.Box 1982Dammam31441Saudi Arabia Computer Engineering Department College of Computer Science and Information TechnologyImam Abdulrahman Bin Faisal UniversityP.O.Box 1982Dammam31441Saudi Arabia School of Computer Science and Technology Zhejiang Gongshang UniversityHangzhouChina

One of the most widely used smartphone operating systems,Android,is vulnerable to cutting-edge malware that employs sophisticated *** malware attacks could lead to the execution of unauthorized acts on the victims’devices,stealing personal information and causing hardware *** previous studies,machine learning(ML)has shown its efficacy in detecting malware events and classifying their ***,attackers are continuously developing more sophisticated methods to bypass ***,up-to-date datasets must be utilized to implement proactive models for detecting malware events in Android mobile ***,this study employed ML algorithms to classify Android applications into malware or goodware using permission and application programming interface(API)-based features from a recent *** overcome the dataset imbalance issue,RandomOverSampler,synthetic minority oversampling with tomek links(SMOTETomek),and RandomUnderSampler were applied to the Dataset in different *** results indicated that the extra tree(ET)classifier achieved the highest accuracy of 99.53%within an elapsed time of 0.0198 s in the experiment that utilized the RandomOverSampler ***,the explainable Artificial Intelligence(EAI)technique has been applied to add transparency to the high-performance ET *** global explanation using the Shapely values indicated that the top three features contributing to the goodware class are:Ljava/net/URL;->openConnection,Landroid/location/LocationManager;->getLastKgoodwarewnLocation,and *** the other hand,the top three features contributing to themalware class are Receive_Boot_Completed,Get_Tasks,and Kill_Background_*** is believed that the proposedmodel can contribute to proactively detectingmalware events in Android devices to reduce the number of victims and increase users’trust.

关键词： Android malware machine learning malware detection explainable artificial intelligence cyber security

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Ensemble-Based Approach for Efficient Intrusion Detection in Network Traffic

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Intelligent Automation & Soft Computing 2023年第8期37卷 2499-2517页

作者： Ammar Almomani Iman Akour Ahmed M.Manasrah Omar Almomani Mohammad Alauthman Esra’a Abdullah Amaal Al Shwait razan Al Sharaa School of Computing Skyline University CollegeUniversity City of SharjahP.O.Box 1797SharjahUnited Arab Emirates IT-Department-Al-Huson University College Al-Balqa Applied UniversityP.O.Box 50IrbidJordan Information Systems Department College of Computing&InformaticsUniversity of SharjahUnited Arab Emirates Comp.Info Sciences(CIS)Division Higher Colleges of TechnologySharjahUnited Arab Emirates Computer Sciences Department Yarmouk UniversityIrbidJordan Computer Network and Information Systems Department The World Islamic Sciences and Education UniversityAmman11947Jordan Department of Information Security Faculty of Information TechnologyUniversity of PetraAmmanJordan

The exponential growth of Internet and network usage has neces-sitated heightened security measures to protect against data and network ***,executed through network packets,pose a significant challenge for firewalls to detect and prevent due to the similarity between legit-imate and intrusion *** vast network traffic volume also complicates most network monitoring systems and *** intrusion detection methods have been proposed,with machine learning techniques regarded as promising for dealing with these *** study presents an Intrusion Detection System Based on Stacking Ensemble Learning base(Random For-est,Decision Tree,and k-Nearest-Neighbors).The proposed system employs pre-processing techniques to enhance classification efficiency and integrates seven machine learning *** stacking ensemble technique increases performance by incorporating three base models(Random Forest,Decision Tree,and k-Nearest-Neighbors)and a meta-model represented by the Logistic Regression *** using the UNSW-NB15 dataset,the pro-posed IDS gained an accuracy of 96.16%in the training phase and 97.95%in the testing phase,with precision of 97.78%,and 98.40%for taring and testing,*** obtained results demonstrate improvements in other measurement criteria.

关键词： Intrusion detection system(IDS) machine learning techniques stacking ensemble random forest decision tree k-nearest-neighbor

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A Deep Learning Approach to Industrial Corrosion Detection

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Computers, Materials & Continua 2024年第11期81卷 2587-2605页

作者： Mehwash Farooqui Atta Rahman Latifa Alsuliman Zainab Alsaif Fatimah Albaik Cadi Alshammari razan Sharaf Sunday Olatunji Sara Waslallah Althubaiti Hina Gull Department of Computer Engineering(CE) College of Computer Science and Information Technology(CCSIT)Imam Abdulrahman Bin Faisal UniversityDammam31441Saudi Arabia Department of Computer Science(CS) College of Computer Science and Information Technology(CCSIT)Imam Abdulrahman Bin Faisal UniversityDammam31441Saudi Arabia Department of Computer Information Systems(CIS) College of Computer Science and Information Technology(CCSIT)Imam Abdulrahman Bin Faisal UniversityDammam31441Saudi Arabia

The proposed study focuses on the critical issue of corrosion,which leads to significant economic losses and safety risks worldwide.A key area of emphasis is the accuracy of corrosion detection *** recent studies have made progress,a common challenge is the low accuracy of existing detection *** models often struggle to reliably identify corrosion tendencies,which are crucial for minimizing industrial risks and optimizing resource *** proposed study introduces an innovative approach that significantly improves the accuracy of corrosion detection using a convolutional neural network(CNN),as well as two pretrained models,namely YOLOv8 and *** leveraging advanced technologies and methodologies,we have achieved high accuracies in identifying and managing the hazards associated with corrosion across various industrial *** advancement not only supports the overarching goals of enhancing safety and efficiency,but also sets a new benchmark for future research in the *** results demonstrate a significant improvement in the ability to detect and mitigate corrosion-related concerns,providing a more accurate and comprehensive solution for industries facing these *** CNN and EfficientNetB0 exhibited 100%accuracy,precision,recall,and F1-score,followed by YOLOv8 with respective metrics of 95%,100%,90%,and 94.74%.Our approach outperformed state-of-the-art with similar datasets and methodologies.

关键词： Deep learning YOLOv8 EfficientNetB0 CNN corrosion detection Industry 4.0 sustainability

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The scaffold protein menin is essential for activating the MYC locus and MYC-mediated androgen receptor transcription in androgen receptor-dependent prostate cancer cells

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Cancer Communications 2021年第12期41卷 1427-1430页

作者： Yakun Luo Virginie Vlaeminck-Guillem Romain Teinturier razan Abou Ziki Philippe Bertolino Muriel Le Romancer Chang Xian Zhang Department of Tumor Escape Resistance and ImmunityUniversitéLyonUniversitéClaude Bernard Lyon 1INSERM 1052CNRS 5286Centre Léon BérardCentre de Recherche en Cancérologie de LyonLyon 69008France Centre de Biologie Sud Hôpital Lyon SudHospices Civils de LyonPierre-Bénite 69310France

Dear Editor,The proto-oncogene MYC has a well-documented role in driving androgen receptor(AR)oncogenic functions in prostate cancer(PCa cells)[1]and was recently reported as a key activator in the regulation of AR transcription[2].Dissecting the mechanisms underlying MYC-mediated AR regulation may be crucial for better understanding PCa development and improving its *** recently demonstrated that menin,encoded by the MEN1 gene,plays an oncosuppressive role in the generation of ARlow/CD44+microinvasive prostate adenocarcinoma in mice but exerts oncogenic effects specifically in ARdependent human PCa cells,both likely by modulating AR transcription and AR targets[3].We herein wondered whether this oncogenic function of menin would occur through its interaction with other factors known to play a crucial role forAR transcription in PCa,in particular,MYC.

关键词： cancer likely MYC

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MEN1基因突变小鼠模型的研究进展:探究MEN1失活在肿瘤发展过程中的分子机制

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中华消化杂志 2019年第8期39卷 528-532页

作者：张昌贤 Ziki razan Abou 罗亚坤法国国家健康与医学研究院 1052 法国里昂癌症研究中心 F-69008

多发性内分泌肿瘤1型(MEN1)基因突变会影响多种内分泌和非内分泌细胞,从而使患者具有了对MEN1的易感性。使用基因打靶方法建立动物模型有助于观察MEN1失活后发生的细胞和分子水平的变化,由此揭示该疾病发展的具体机制。本文重点关注通过... 详细信息

多发性内分泌肿瘤1型(MEN1)基因突变会影响多种内分泌和非内分泌细胞,从而使患者具有了对MEN1的易感性。使用基因打靶方法建立动物模型有助于观察MEN1失活后发生的细胞和分子水平的变化,由此揭示该疾病发展的具体机制。本文重点关注通过MEN1突变小鼠模型的研究所揭示的MEN1基因分子功能。

关键词：基因突变小鼠模型分子机制肿瘤发展失活多发性内分泌肿瘤内分泌细胞分子水平

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Use of porcine small intestinal submucosa for pediatric endoscopic tympanic membrane repair

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2017年第3期3卷 142-147页

作者： razan A.Basonbul Michael S.Cohen Department of Otolaryngology Massachusetts Eye and Ear Infirmary BostonMA USA Department of Otolaryngology Harvard Medical School BostonMA USA Department of Otolaryngology Head and Neck Surgery Faculty of Medicine in Rabigh King Abdulaziz University Jeddah Saudi Arabia

Tympanic membrane perforationsoccur frequently in children,and can result in hearing loss,otorrhea,pain,and *** to the narrower ear canal in children,a postauricular incision is often needed to access the tympanic membrane for surgical *** approaches are increasingly being used for tympanic membrane repair,reducing the need for postauricular *** the need for a postauricular incision decreases,the demand for non-autologous grafting material has *** porcine small intestinal submucosa (SIS) has been described in the literature as an alternative to commonly used autologous grafts,and is well suited for use with transcanal endoscopic ear surgery as a minimally invasive *** paper describes techniques for use of SIS in endoscopic tympanic membrane repair in children.

关键词： Pediatric Endoscopic ear surgery Tympanoplasty Acellular matrix Porcine small intestinal submucosa

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