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Personalized nutrition for people with diabetes and at risk of diabetes has begun

Journal of Future Foods 2022年第3期2卷 193-202页

作者： raymond chen Guoxun chen Department of Biochemistry University of Texas at AustinAustin 78705USA Department of Nutrition University of Tennessee at KnoxvilleKnoxville 37996USA

Food and nutrition are essential parts for the management of blood glucose of patients with diabetes and other metabolic *** results of recent human clinical studies have shown that the blood glucose levels change differently in different people in response to the same standardized *** phenomenon shows the challenges to find a one-size-fits-all approach to combat *** the development of technologies,personalized nutrition/precision nutrition has gradually become more practical in order to treat individual *** aim of this review article is to summarize personalized nutrition’s progress and potential in treating the diabetes *** have searched PubMed to identify relevant articles and found that personalized nutrition on multiple factors associated with an individual has started to draw attention to scientifi c *** seminal studies have shown that healthy adults show differential responses of postprandial blood glucose levels to the same standardized *** clinical trials have started to integrate sensor technologies such as continuous glucose monitoring and personal data such as genomic sequences and microbiome to provide personalized nutrition advice,and shown promises in intervention and management of type 2 *** appears that the interplays of diets and genomes,gut microbiome,gut transit time,insulin sensitivity,cultural,social,and economic factors should all be considered to create a personalized treatment for an individual’s chronic metabolic *** probably can be achieved through the integration of personalized nutrition and personalized food intervention with the development of technologies and advances in food and nutrition *** research should be anticipated soon.

关键词： Blood glucose Type 2 diabetes Insulin Microbiome Precision nutrition Personaliz

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Laparoscopic Orchidopexy after 4 Weeks of Testicular Traction with Preservation of Blood Supply: A New Concept for the Treatment of Intra-Abdominal Cryptorchidism: Original Article

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Open Journal of Pediatrics 2024年第2期14卷 205-217页

作者： Ntsobe Tobie Eric Haijin Liu Nyanit Bob Dorcas Wei Peng Feng chen Ndikontar raymond Kouna Tsala Irene Nadine Qian Liu Surgery Department Garoua General Hospital Garoua Cameroon Paediatric Surgery Department First Affiliated Hospital of Gannan Medical College Ganzhou China Paediatric Surgery Department China Medical University Shenyang China Faculty of Medicine and Biomedical Sciences University of Yaounde I Yaounde Cameroon Paediatric Surgery Department Yaounde Central Hospital Yaounde Cameroon China Traditional Medicine University Nanchang China

Background: Testicular atrophy is recurrent after orchidopexy for intra-abdominal cryptorchidism due to damage to vessels. Fowlers-Stephens and Shehata methods proposed staged orchidopexy, but are still associated to a rate of atrophy greater than 10%. Purpose: We set out to present a new technique that preserves testicular vessels. Our study is aimed at investigating testicular vitality after surgery. Patients and Method: We reviewed files of boys who underwent orchidopexy for 2 years in our department. Those who have been operated for intra-abdominal cryptorchidism with the new technique and aged between 6 months and 14 years old were included in our study. We excluded boys who have been operated before 6 months and after 14 years old and those who did not respect their follow-up plane. Ultrasound (US) outcomes were used to measure testicular volumes and blood flow at each postoperative visit. The Sample population was divided into group A and group B representing testes that were followed respectively for 12 and 24 months. Results: 22 boys with 25 testes were included in our study;11 testes in group A and 14 testes in group B. In each group, we noted a significant difference of UDT volumes from the third month after surgery with respective P-values 0.05. There was no statistical difference between UDT and contra lateral testes volumes 12 months after surgery in group A and 24 months in group B with respective P-values of 0.07 and 0.72. All volume differential indexes were Conclusion: This method offers a new perspective in performing safe orchidopexy for intra abdominal undescended testes.

关键词： Laparoscopy Staged-Orchidopexy Testicar Traction Testicular Atrophy

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Endovascular treatment of ruptured lobulated anterior communicating artery aneurysms:A retrospective study of 24 patients

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World Journal of Clinical Cases 2024年第15期12卷 2529-2541页

作者： Sheng-Xuan Huang Xun-Ping Ai Ze-Hui Kang Zhi-Yong chen Ren-Man Li Zu-Chao Wu Feng Zhu Department of Neurosurgery Sanming First Hospital Affiliated to Fujian Medical UniversitySanming 365000Fujian ProvinceChina

BACKGROUND Lobulated intracranial aneurysm is a special type of aneurysm with at least one additional cyst in the neck or body of the *** intracranial aneurysm is a complex aneurysm with complex morphology and structure and weak tumor wall,which is an independent risk factor for rupture and *** aneurysms located in the anterior communicating artery complex account for 36.9%of all intracranial lobular *** to its special anatomical structure,both craniotomy and endovascular treatment are more *** with single-capsule aneurysms,craniotomy for lobular intracranial aneurysms has a higher risk and complication *** To investigate the efficacy and safety of endovascular treatment for ruptured lobulated anterior communicating artery aneurysm(ACoAA).METHODS Patients with ruptured lobulated ACoAA received endovascular treatment in Sanming First Hospital Affiliated to Fujian Medical University from June 2020 to June 2022 were retrospectively *** demographic,clinical and imaging characteristics,endovascular treatment methods and follow-up results were *** A total of 24 patients with ruptured lobulated ACoAA were included,including 9 males(37.5%)and 15 females(62.5%).Their age was 56.2±8.9 years old(range 39-74).The time from rupture to endovascular treatment was 10.9±12.5 *** maximum diameter of the aneurysms was 5.1±1.0 mm and neck width were 3.0±0.7 *** patients(79.2%)were double-lobed and 5(20.8%)were ***'s grade:Grade 2 in 16 cases(66.7%),grade 3 in 6 cases(25%),and grade 4 in 2 cases(8.3%).Hunt-Hess grade:Grade 0-2 in 5 cases(20.8%),grade 3-5 in 19 cases(79.2%).Glasgow Coma Scale score:9-12 in 14 cases(58.3%),13-15 in 10 cases(41.7%).Immediately postprocedural raymond-Roy grade:grade 1 in 23 cases(95.8%),grade 2 in 1 case(4.2%).raymond-Roy grade in imaging follow-up for 2 wk to 3 months:grade 1 in 23 cases(95.8%),grade 2 in 1 case(4.2%).Followup for 2 to 12 months sho

关键词： Intracranial aneurysm Anterior cerebral artery Endovascular surgery Embolism Treatment outcome

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Impacts of acupressure treatment on depression:A systematic review and meta-analysis

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World Journal of Psychiatry 2022年第1期12卷 169-186页

作者： Jingxia Lin Tianhao chen Jiali He raymond CK Chung Haixia Ma HWH Tsang Department of Rehabilitation Sciences The Hong Kong Polytechnic UniversityHong Kong 00852China Mental Health Research Centre The Hong Kong Polytechnic UniversityHong Kong 00852China

BACKGROUND Depression is recognized as a major public health problem with a substantial impact on individuals and *** therapies such as acupressure may be considered a safe and cost-effective treatment for people with *** increasing body of research has been undertaken to assess the effectiveness of acupressure in various populations with depression,but the evidence thus far is *** To examine the efficacy of acupressure on *** A systematic literature search was performed on PubMed,PsycINFO,Scopus,Embase,MEDLINE,and China National Knowledge(CNKI).Randomized clinical trials(RCTs)or single-group trials in which acupressure was compared with control methods or baseline in people with depression were *** were synthesized using a random-effects or a fixed-effects model to analyze the impacts of acupressure treatment on depression and anxiety in people with *** primary outcome measures were set for depression *** were created,and meta-regression analyses were performed to explore which factors are relevant to the greater or lesser effects of treating *** A total of 14 RCTs(1439 participants)were *** of the betweengroup showed that acupressure was effective in reducing depression[Standardized mean differences(SMDs)=-0.58,95%CI:-0.85 to-0.32,P<0.0001]and anxiety(SMD=-0.67,95%Cl:-0.99 to-0.36,P<0.0001)in participants with mildto-moderate primary and secondary *** analyses suggested that acupressure significantly reduced depressive symptoms compared with different controlled conditions and in participants with different ages,clinical conditions,and duration of *** events,including hypotension,dizziness,palpitation,and headache,were reported in one *** The evidence of acupressure for mild-to-moderate depressive symptoms was ***,the findings should be interpreted with caution due to study limita

关键词： Acupressure Depression Mild-to-moderate depressive symptoms Systematic review Meta-analysis

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Use of biological and chemical molecules in regulating embryo implantation and endometrial receptivity

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Reproductive and Developmental Medicine 2022年第4期6卷 234-242页

作者： Xian chen Shu-Ya Sun Ernest Hung-Yu Ng raymond Hang-Wun Li William Shu-Biu Yeung Kai-Fai Lee Department of Obstetrics and Gynaecology LKS Faculty of Medicinethe University of Hong KongHong Kong SARChina Shenzhen Key Laboratory of Fertility Regulation the University of Hong Kong-Shenzhen HospitalShenzhen 518053China

This review summarizes the drugs and chemicals that may modulate embryo ***-hormonal molecules,including aspirin,improved endometrial blood flow,while low molecular weight heparin,vitamin E,sildenafil,and atosiban modulated the expression of endometrial *** factors,including human chorionic gonadotropin and growth hormones,can regulate the expression of endometrial receptivity *** immunomodulatory molecules,including granulocyte colony-stimulating factor,peripheral blood mononuclear cells,autologous platelet-rich plasma,and intralipid and intravenous immunoglobulins,may improve implantation rate by modulating endometrial immune *** extracts of the Chinese herbs Paeonia lactiflora and Perilla frutescens increased the expression of leukemia inhibitory factors in endometrial epithelial ***,the use of the commercially available Library of Pharmacologically Active Compounds with a high-throughput screening method has provided an approach to screen for compounds that may potentially enhance or suppress embryo *** these biomedical findings translate into clinical effects that enhance or suppress embryo implantation requires further investigation.

关键词： Embryo implantation Endometrial receptivity fertilization Repeated implantation failure Birth control Emergency contraception

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[^(18)F]MAGL-4-11 positron emission tomography molecular imaging of monoacylglycerol lipase changes in preclinical liver fibrosis models

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Acta Pharmaceutica Sinica B 2022年第1期12卷 308-315页

作者： Tuo Shao Zhen chen Jian Rong Vasily Belov Jiahui chen Andre Jeyarajan Xiaoyun Deng Hualong Fu Qingzhen Yu Steve H.Rwema Wenyu Lin Mikhail Papisov Lee Josephson raymond T.Chung Steven H.Liang Division of Nuclear Medicine and Molecular Imaging Department of RadiologyMassachusetts General Hospital and Harvard Medical SchoolBostonmA 02114USA Liver Center and Gastrointestinal Division Department of MedicineMassachusetts General HospitalHarvard Medical SchoolBostonA 02114USA Shriners Hospitals for Children-Boston Boston BostonMA 02114USA

Monoacylglycerol lipase(MAGL) is a pivotal enzyme in the endocannabinoid system, which metabolizes 2-arachidonoylglycerol(2-AG) into the proinflammatory eicosanoid precursor arachidonic acid(AA). MAGL and other endogenous cannabinoid(EC) degrading enzymes are involved in the fibrogenic signaling pathways that induce hepatic stellate cell(HSC) activation and ECM accumulation during chronic liver disease. Our group recently developed an;F-labeled MAGL inhibitor([18F]MAGL-4-11)for PET imaging and demonstrated highly specific binding in vitro and in vivo. In this study, we determined [18F]MAGL-4-11 PET enabled imaging MAGL levels in the bile duct ligation(BDL) and carbon tetrachloride(CCl_(4)) models of liver cirrhosis;we also assessed the hepatic gene expression of the enzymes involved with EC system including MAGL, NAPE-PLD, FAAH and DAGL that as a function of disease severity in these models;[18F]MAGL-4-11 autoradiography was performed to assess tracer binding in frozen liver sections both in animal and human. [18F]MAGL-4-11 demonstrated reduced PET signals in early stages of fibrosis and further significantly decreased with disease progression compared with control mice. We confirmed MAGL and FAAH expression decreases with fibrosisseverity, while its levels in normal liver tissue are high;in contrast, the EC synthetic enzymes NAPE-PLD and DAGL are enhanced in these different fibrosis models. In vitro autoradiography further supported that[18F]MAGL-4-11 bound specifically to MAGL in both animal and human fibrotic liver tissues. Our PET ligand [18F]MAGL-4-11 shows excellent sensitivity and specificity for MAGL visualization in vivo and accurately reflects the histological stages of liver fibrosis in preclinical models and human liver tissues.

关键词： [18F]MAGL-4-11 PET imaging Liver fibrosis MAGL

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An efficient method for privacy preserving location queries

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Frontiers of Computer Science 2012年第4期6卷 409-420页

作者： Yubao LIU Xiuwei chen Zhan LI Zhijie LI raymond Chi-Wing WONG Department of Computer Science Sun Yat-Sen UniversityGuangzhou 510006China Department of Computer Science Jinan UniversityGuangzhou 510632China Department of Computer Science and Engineering The Hong Kong University of Science and TechnologyHong KongChina

Recently, the issue of privacy preserving loca- tion queries has attracted much research. However, there are few works focusing on the tradeoff between location privacy preservation and location query information collection. To tackle this kind of tradeoff, we propose the privacy persevering location query （PLQ）, an efficient privacy pre-serving location query processing framework. This frame- work can enable the location-based query without revealing user location information. The framework can also facilitate location-based service providers to collect some information about the location based query, which is useful in practice. PLQ consists of three key components, namely, the location anonymizer at the client side, the privacy query processor at the server side, and an additional trusted third party connect- ing the client and server. The location anonymizer blurs the user location into a cloaked area based on a map-hierarchy. The map-hierarchy contains accurate regions that are parti- tioned according to real landforms. The privacy query pro- cessor deals with the requested nearest-neighbor （NN） loca- tion based query. A new convex hull of polygon （CHP） algo- rithm is proposed for nearest-neighbor queries using a poly- gon cloaked area. The experimental results show that our al- gorithms can efficiently process location based queries.

关键词： location based service (LBS) privacy preserva- tion nearest-neighbor (NN) location query

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Numerical investigation of wave propagation in the Liverpool Bay,NW England

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Acta Oceanologica Sinica 2011年第5期30卷 1-13页

作者： LI Ming raymond Ip WOLF Judith chen Xueen BURROWS Richard School of Engineering University of Liverpool Liverpool L69 3GQ UK National Oceanography Centre Joseph Proudman Building Liverpool L3 5DA UK College of Physical and Environmental Oceanography Ocean University of China Qingdao 266100 China

The computer model for near shore wave propagation,SWAN,was used to study wave climates in Liverpool Bay,northwest England with various input parameters,including bottom friction factor,white capping,wind drag formulation and effects of tidal *** were compared with in-situ measurements and reveal the impacts from these inputs on the predictions of wave height and propagation *** particular,the model results were found very sensitive to different input formulations,and tend to underestimate the wave parameters under storm conditions in comparison with the *** is therefore important to further validate the model against detailed field measurements,particularly under large storms that are often of the primary concern.

关键词： coastal engineering flooding wave model near shore tide

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Optimal location query based on k nearest neighbours

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Frontiers of Computer Science 2021年第2期15卷 105-117页

作者： Yubao LIU Zitong chen Ada Wai-Chee FU raymond Chi-Wing WONG Genan DAI School of Data and Computer Science Sun Yat-Sen UniversityGuangzhou510006China Guangdong Key Laboratory of Big Data Analysis and Processing Guangzhou510006China Department of Computer Science and Engineering Chinese University of Hong KongHong Kong999077China Department of Computer Science and Engineering The Hong Kong University of Science and TechnologyHong Kong999077China

Optimal location query in road networks is a basic operation in the location intelligence *** a set of clients and servers on a road network,the purpose of optimal location query is to obtain a location for a new server,so that a certain objective function calculated based on the locations of clients and servers is *** works assume no labels for servers and that a client only visits the nearest *** assumptions are not realistic and it renders the existing work not useful in many *** this paper,we relax these assumptions and consider the k nearest neighbours(KNN)of *** introduce the problem of KNN-based optimal location query(KOLQ)which considers the k nearest servers of clients and labeled *** also introduce a variant problem called relocation KOLQ(RKOLQ)which aims at relocating an existing server to an optimal *** main analysis algorithms are proposed for these *** experiments on the real road networks illustrate the efficiency of our proposed solutions.

关键词： optimal location query k nearest neighbours road network

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