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中学生数学建模能力培养途径研究

中学生数学建模能力培养途径研究

作者：唐晓明（raymond tang）湖南科技大学

学位级别：硕士

最近几十年,随着各种科学技术尤其是计算机技术的发展,数学迅速渗透到各个领域,它的功效显著,其解决问题的卓越能力已渗透到如社会学、生态、历史等各个领域,数学作为一种“技术”越来越受重视。在科学技术日益发展的大环境下,数学教育... 详细信息

最近几十年,随着各种科学技术尤其是计算机技术的发展,数学迅速渗透到各个领域,它的功效显著,其解决问题的卓越能力已渗透到如社会学、生态、历史等各个领域,数学作为一种“技术”越来越受重视。在科学技术日益发展的大环境下,数学教育也不断改革,为了使学生能更好的解决各种实际问题,数学教育的目的也随之转变,除了要求学生掌握扎实的数学理论知识外,还要求他们要学会用数学知识去解决实际问题,注重实践,培养他们的动手能力,数学建模作为数学学科中最注重实践的环节日益受到重视。2003年教育部颁发了新的课程标准,新课标中要求数学课程把数学建模渗透到各个知识板块中,课程标准对数学建模也有具体要求,其中指出数学建模过程包括运用数学思想和方法解决实际问题,中学数学教育改革逐渐拉开帷幕,中学数学建模教学成为了许多数学教育工作者进行研究的新天地,中学生数学建模能力的培养也成为了众多学者重点研究的课题。通过查阅资料和实际调查,结合新课标对数学建模活动的具体要求,本文对中学生建模能力的培养方法进行了较为详细的分析和总结,旨在提出一套较为完整的中学生建模能力的培养方案,为中学数学建模教学提供参考和建议。论文分为五个部分,第一部分介绍研究背景、研究内容及意义;第二部分是对当前中学数学建模教学现状的调查分析;第三部是对中学生建模能力培养的探讨;第四部分是基于新课标的中学数学建模教学设计;第五部分是结语,对本研究进行总结。

关键词：数学建模中学数学建模数学建模能力培养

The Hong Kong consensus recommendations on the diagnosis and management of pancreatic cystic lesions

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Hepatobiliary Surgery and Nutrition 2023年第5期12卷 715-735,I0019-I0020页

作者： Tan-To Cheung Yuk Tong Lee raymond Shing-Yan tang Wong Hoi She Kai Chi Cheng Chin Cheung Cheung Keith Wan Hang Chiu Kenneth Siu Ho Chok Wing Sun Chow Tak Wing Lai Wai-Kay Seto Thomas Yau Department of Surgery Queen Mary HospitalThe University of Hong KongHong KongChina Gastroenterologist in private practice Hong KongChina Department of Medicine and Therapeutics The Chinese University of Hong KongHong KongChina Department of Surgery Kwong Wah HospitalHong KongChina Department of Surgery Tuen Mun HospitalHong KongChina Department of Radiology&Imaging Queen Elizabeth HospitalHong KongChina Department of Medicine The University of Hong KongHong KongChina Department of Surgery Princess Margaret HospitalHong KongChina Department of Medicine School of Clinical MedicineThe University of Hong KongHong KongChina State Key Laboratory of Liver Research The University of Hong KongHong KongChina

Background:The finding of pancreatic cystic lesions(PCL)on incidental imaging is becoming increasingly *** studies report a prevalence of 2.2-44.7%depending on the population,imaging modality and indication for imaging,and the prevalence increases with *** with PCL are at risk of developing pancreatic cancer,a disease with a poor *** publication summarizes recommendations for the diagnosis and management of PCL and post-operative pancreatic exocrine insufficiency(PEI)from a group of local ***:Clinical evidence was consolidated from narrative reviews and consensus statements formulated during two online meetings in March *** expert panel included gastroenterologists,hepatobiliary surgeons,oncologists,radiologists,and ***:Patients with PCL require careful investigation and follow-up due to the risk of malignant transformation of these *** should undergo clinical investigation and pancreas-specific imaging to classify lesions and understand the risk profile of the *** indicated,patients should undergo pancreatectomy to excise *** pancreatectomy,patients are at risk of PEI,leading to gastrointestinal dysfunction and ***,such patients should be monitored for symptoms of PEI,and promptly treated with pancreatic enzyme replacement therapy(PERT).Patients with poor response to PERT may require increases in dose,addition of a proton pump inhibitor,and/or further investigation,including tests for pancreatic *** are also at risk of new-onset diabetes mellitus after pancreatectomy;they should be screened and treated with insulin if ***:These statements are an accurate summary of our approach to the diagnosis and management of patients with PCL and will be of assistance to clinicians treating these patients in a similar clinical landscape.

关键词： Pancreatic cystic lesions pancreatic endocrine insufficiency pancreatic enzyme replacement therapy

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爱搽

现代装饰 2018年第11期 74-79页

作者： Edward Tan Kyan Foo raymond tang Ed Chan Simon Liu Spacemen

在第三个店铺的设计前期,业主考察团队曾进到一个＂画中＂的茶园,并深深地沉浸在茶园的＂宁静＂氛围中。他们想要把这种＂氛围＂作为店铺的特色体验。SPACEMEN从大自然中汲取灵感,通过一系列黄铜色调的＂波浪链面＂,抽象化地在餐厅空间... 详细信息

在第三个店铺的设计前期,业主考察团队曾进到一个＂画中＂的茶园,并深深地沉浸在茶园的＂宁静＂氛围中。他们想要把这种＂氛围＂作为店铺的特色体验。SPACEMEN从大自然中汲取灵感,通过一系列黄铜色调的＂波浪链面＂,抽象化地在餐厅空间设计中表达了茶园的标志性地形。餐厅位于上海新开发的露天购物中心＂丰盛里＂,本餐厅将成为该品牌的新旗舰店。

关键词：空间设计购物中心茶园考察团大自然标志性餐厅抽象化

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克尔先生访问记

科技导报 1980年第1期 91-92页

作者：汤乃文柏克莱加州大学东方图书馆

克拉克·克尔博士(Dr. Clark Kerr)曾任柏克莱加州大学校长。在他任职期间,柏克莱成为美国最好的大学之一。克尔博士现任卡乃基高等教育政策研究委员会(Carnegie Commission on Higher Education)主席,其见解在美国高教界颇受尊重。曾于... 详细信息

克拉克·克尔博士(Dr. Clark Kerr)曾任柏克莱加州大学校长。在他任职期间,柏克莱成为美国最好的大学之一。克尔博士现任卡乃基高等教育政策研究委员会(Carnegie Commission on Higher Education)主席,其见解在美国高教界颇受尊重。曾于1978年率美国高教代表团访华。他欣然接受本刊访问,并答应为本刊写稿。下面

关键词：人类学校研究生中华人民共和国学堂人力计划人力资源计划柏克莱加州大学克尔先生

城市绽放——BRAUN BUFFEL旗舰店

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现代装饰 2022年第6期 68-71页

作者： Edward Tan Edward Chan raymond tang Phyllis Zhang Kuma Ni Alvin Zhou 舒禹(编译) David Yeow Photograph(摄影) 不详

项目是Spacemen为Braun Buffel设计的最新旗舰店,是一系列名为“城市绽放”的概念空间中的第一个项目。设计案例对立在森林中的一棵活树进行抽象诠释,通过一个具有视觉冲击力的概念来吸引人们进入零售店。项目的设计避开了传统的奢华概... 详细信息

项目是Spacemen为Braun Buffel设计的最新旗舰店,是一系列名为“城市绽放”的概念空间中的第一个项目。设计案例对立在森林中的一棵活树进行抽象诠释,通过一个具有视觉冲击力的概念来吸引人们进入零售店。项目的设计避开了传统的奢华概念,转而采用极简主义方法,空间的核心是对一棵树从地板发芽到天花板的过程演绎,就像在科幻实验室中生长一样,覆盖着苔藓的装置与商店的开放式布局形成对比,旨在将建筑与装置融为一体,赋予空间独特的个性。

关键词：极简主义概念空间实验室旗舰店设计案例天花板视觉冲击力

Evolutionary Optimization: Pitfalls and Booby Traps

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Journal of Computer Science & Technology 2012年第5期27卷 907-936页

作者： Thomas Weise raymond Chiong Ke tang Nature Inspired Computation and Applications Laboratory School of Computer Science and Technology University of Science and Technology of China Hefei 230027 China Faculty of Higher Education Swinburne University of Technology 50 Melba Avenue Lilydale Victoria 3140 Australia

Evolutionary computation （EC）, a collective name rithms, is one of the fastest-growing areas in computer science. for a range of metaheuristic black-box optimization algo- Many manuals and ＂how-to＇s on the use of different EC methods as well as a variety of free or commercial software libraries are widely available nowadays. However, when one of these methods is applied to a real-world task, there can be many pitfalls and booby traps lurking certain aspects of the optimization problem that may lead to unsatisfactory results even if the algorithm appears to be correctly implemented and executed, These include the convergence issues, ruggedness, deceptiveness, and neutrality in the fitness landscape, epistasis, non-separability, noise leading to the need for robustness, as well as dimensionality and scalability issues, among others. In this article, we systematically discuss these related hindrances and present some possible remedies. The goal is to equip practitioners and researchers alike with a clear picture and understanding of what kind of problems can render EC applications unsuccessful and how to avoid them from the start.

关键词： evolutionary computing problem difficulty optimization meta-heuristics

Low-temperature caproate production,microbial diversity,and metabolic pathway in xylose anaerobic fermentation

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Frontiers of Environmental Science & Engineering 2023年第3期17卷 121-130页

作者： Qingting Wang Kun Dai Jie tang Sidi Hong Sijie Zheng Ting Sun raymond Jianxiong Zeng Fang Zhang Center of Wastewater Resource Recovery College of Resources and EnvironmentFujian Agriculture and Forestry UniversityFuzhou 350002China

Mixed culture fermentation(MCF)is challenged by the unqualified activity of enriched bacteria and unwanted methane dissolution under low *** this work,caproate production from xylose was investigated by MCF at a low temperature(20°C).The results showed that a 9 d long hydraulic retention time(HRT)in a continuously stirred tank reactor was necessary for caproate production(~0.3 g/L,equal to 0.6 g COD/L)from xylose(10 g/L).The caproate concentration in the batch mode was further increased to 1.6 g/***,changing the substrate to ethanol did not promote caproate production,resulting in~1.0 g/L after 45 d of *** genera,Bifidobacterium,Caproiciproducens,Actinomyces,and Clostridium_sensu_stricto_12,were identified as the enriched caproate-producing *** enzymes in the fatty acid biosynthesis(FAB)pathway for caproate production were identified via metagenomic *** enzymes for the conversion of(C_(n+2))-2,3-Dehydroxyacyl-CoA to(C_(n+2))-Acyl-CoA(i.e.,EC 1.***.1.8 and EC 1.***.1.38)in the reverseβ-oxidation(RBO)pathway were not *** results could extend the understanding of low-temperature caproate production.

关键词： Xylose fermentation Caproate Low temperature Bifidobacterium FAB pathway RBO pathway

MR-seq:measuring a single cell's transcriptome repeatedly by RNA-seq

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Science Bulletin 2017年第6期62卷 391-398页

作者： Lu Yang Zhaochun Ma Chen Cao Yuhao Zhang Xinglong Wu raymond Lee Boqiang Hu Lu Wen Hao Ge Yanyi Huang Kaiqin Lao Fuchou tang Biodynamic Optical Imaging Center School of Life Sciences Peking University Beijing 100871 China Thermo Fisher Scientific.South San Francisco CA 94080 USA Peking-Tsinghua Center for Life Sdences Beijing 100084 China Beijing International Center for Mathematical Research (BICMR) Peking University Beijing 100871 China College of Engineering Peking University Beijing 100871 China China Center for Molecular and Translationai Medicine (CMTM) Beijing 100101 China Beijing Advanced Innovation Center for Cenomics (ICG) Peking University Beijing 100871 China

We described a novel single-cell RNA-seq technique called MR-seq （measure a single-cell transcriptome repeatedly）, which permits statistically assessing the technical variation and identifying the differentially expressed genes between just two single ceils by measuring each single cell twice. We demonstrated that MR-seq gave sensitivity and reproducibility similar to the standard single-cell RNA-seq and increased the positive predicate value, Application of MR-seq to early mouse embryos identified hundreds of candidate intra-embryonic heterogeneous genes among mouse 2-, 4- and 8-cell stage embryos. MR-seq should be useful for detecting differentially exnre^ed ~enes ~rnnn~ ~ ~m^ll nHmhpr nf c^ll~

关键词： Single-cell RNA-seqDifferentially expressed geneslntra-embryonic heterogeneity Mouse early preimplantation embryos

IN VIVO NEAR-INFRAREDFLUORESCENCEIMAGING OF HUMANCOLONADENOCARCINOMABY SPECIFIC IMMUNOTARGETINGOFA TUMOR-ASSOCIATEDMUCIN

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Journal of Innovative Optical Health Sciences 2009年第4期2卷 407-422页

作者： RALPH S.DACOSTA YING tang TUULA KALLIOMAKI raymond M.REILLY ROBERT WEERSINK ALISHA R.ELFORD NORMAN E.MARCON BRIAN C.WILSON Division of Biophysics and Bioimaging Ontario Cancer Institute 610 University of TorontoTorontoOntarioM5G 2M9Canada Department of Medical Biophysics University of Toronto Princess Margaret Hospital/Ontario Cancer Institute University Health NetworkTorontoOntarioCanada NIH/NCI Radiation Oncology Branch BethesdaMDUSA Division of Clinical Investigation and Human Physiology Toronto General Hospital Research Institute and University of Toronto Leslie Dan Faculty of Pharmacy TorontoOntarioCanada Laboratory for Applied Biophotonics University Health Network TorontoOntarioCanada Campbell Family Institute for Breast Cancer Research University Health Network/Ontario Cancer Institute Department of Medical Biophysics and Immunology Toronto OntarioCanada St.Michael’s Hospital Center for Therapeutic Endoscopy and Endoscopic Oncology Toronto OntarioCanada

Background and Aims: Accurate endoscopic detection of premalignant lesions and earlycancers in the colon is essential for cure, since prognosis is closely related to lesion size andstage. Although it has great clinical potential, autofluorescence endoscopy has limited tumorto-normal tissue image contrast for detecting small preneoplastic lesions. We have developed amolecularly specific, near-infrared fluorescent monoclonal antibody (CC49) bioconjugate whichtargets tumor-associated glycoprotein 72 (TAG72), as a contrast agent to improve fluorescencebased endoscopy of colon cancer. Methods: The fluorescent anti-TAG72 conjugate was evaluated in vitro and in vivo in athymic nude mice bearing human colon adenocarcinoma (LS174T)subcutaneous tumors. Autofluorescence, a fluorescent but irrelevant antibody and the free fluorescent dye served as controls. Fluorescent agents were injected intravenously, and in vivowhole body fluorescence imaging was performed at various time points to determine pharmacokinetics, followed by ex vivo tissue analysis by confocal fluorescence microscopy and histology Results: Fluorescence microscopy and histology confirmed specific LS174T cell membrane targeting of labeled CC49 in vitro and ex vivo. In vivo fluorescence imaging demonstrated significant tumor-to-normal tissue contrast enhancement with labeled-CC49 at three hours postinjection, with maximum contrast after 48 h. Accumulation of tumor fluorescence demonstratedthat modification of CC49 antibodies did not alter their specific tumor-localizing properties, andwas antibody-dependent since controls did not produce detectable tumor fluorescence. Conclusions: These results show proof-of-principle that our near-infrared fluorescent-antibody probetargeting a tumor-associated mucin detects colonic tumors at the molecular level in real time,and offer a basis for future improvement of image contrast during clinical fluorescence endoscopy.

关键词： Autofluorescence imaging endoscopy colon adenocarcinoma TAG72 CC49 mucin monoclonal antibody conjugate confocal fluorescence microscopy.