检索结果-南通市图书馆

Health Impacts and Mechanisms of Per- and Polyfluoroalkyl Substances (PFAS) from Epidemiological to Toxicological

Journal of Biosciences and Medicines 2023年第12期11卷 218-240页

作者： Godspower Oghenemaroh Sebe Ebuka Victor Anyaogu Adeyemo David Adebowale raymond chidozie ntomchukwu Supreme O. Oghenerhoro Ogbole E. Jonathan Department of Chemical Chemistry and Biomedical Engineering University of New Haven West Haven USA Department of Cell and Molecular Biology University of New Haven West Haven USA Department of Chemistry and Biochemistry University of Toledo Toledo USA Department of Chemical Engineering Chukwuemeka Odumegwu Ojukwu University Uli Nigeria

This research provides a comprehensive analysis of the health impacts of Per- and Polyfluoroalkyl Substances (PFAS) through an integration of epidemiological and toxicological studies. The study identifies significant correlations between PFAS exposure and adverse health outcomes, including thyroid dysfunction, elevated cholesterol levels, and increased risk of specific cancers. Utilizing a mixed-methods approach, the research combines a systematic review and meta-analysis of recent literature with in vitro and in vivo toxicological experiments. The epidemiological analysis reveals increased risks of thyroid dysfunction, cholesterol elevation, and certain cancers among PFAS-exposed individuals. Toxicological findings further corroborate these results, showing dose-dependent cytotoxic effects in human cell lines and endocrine disruption in rodent models. The study emphasizes the importance of regulatory measures to mitigate PFAS exposure and the urgent need for more comprehensive research into their long-term effects. The integration of epidemiological and toxicological data underscores the significant health risks posed by PFAS, highlighting the necessity of immediate action to limit exposure and develop safer alternatives.

关键词： PFAS Public Health Epidemiology Toxicology Endocrine Disruption Carcinogenicity Environmental Policy Chemical

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Enhancing Accumulation and Penetration Efficiency of Next-Generation Antibiotics to Mitigate Antibiotic Resistance in Pseudomonas aeruginosa PAO1

引用

Journal of Biomedical Science and Engineering 2023年第8期16卷 107-120页

作者： Godspower Oghenemaroh Sebe Supreme O. Oghenerhoro Ogbole E. Jonathan Ebuka Victor Anyaogu Adeyemo David Adebowale raymond chidozie ntomchukwu Department of Chemical Chemistry and Biomedical Engineering University of New Haven West Haven USA Chemistry and Biochemistry University of Toledo Toledo USA Department of Cell and Molecular Biology University of New Haven West Haven USA Chukwuemeka Odumegwu Ojukwu University Uli Nigeria

This study explores the efficacy of advanced antibiotic compounds against P. aeruginosa, focusing on Antibiotic B, an enhanced derivative of Ceftriaxone. The study measured the intracellular uptake of Antibiotic B and introduced a novel adjuvant, Influximax, which augmented its antibacterial activity. Results showed a diminished potential for resistance emergence with Antibiotic B, particularly when used in combination with Influximax. The study suggests that optimizing antibiotic delivery into bacterial cells and leveraging syner-gistic adjuvant combinations can enhance drug resistance combat. .

关键词： Pseudomonas aeruginosa PAO1 Antibiotic Resistance Next-Generation Antibiotics Adjuvant Synergy Intracellular Accumulation Penetration Rates Minimum Inhibitory Concentration (MIC) Resistance Tra-jectory Fluorescence Quantification

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：