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Journal of Sport and Health Science 2023年第1期12卷 36-44页

作者： Kate M.Sales rayl.ne a.reimer Faculty of Kinesiology University of CalgaryCalgaryAB T2N 1N4Canada Department of Biochemistry&Molecular Biology Cumming School of MedicineUniversity of CalgaryCalgaryAB T2N 4N1Canada

The gut microbiota refers to the collection of trillions of intestinal microorganisms that modulate central aspects of health and disease through influential effects on host ***,a connection has been made between the gut microbiota and *** investigations demonstrated the beneficial effects of exercise on the gut microbiota,with cross-sectional studies revealing positive correlations between exerciseassociated states,and healthy gut microbiota and exercise interventions showed post-intervention increases in the abundance of beneficial bacterial *** recent investigations have focused on exploring the reverse relationship:the influence of the gut microbiota on exercise *** investigations have revealed that certain bacterial taxa may enhance endurance exercise performance by augmenting various aspects of lactate ***,short-chain fatty acids—which modulate metabolism at various organ sites,including within skeletal muscle—have been shown to enhance endurance exercise capacity in *** review highlights what is currently known about the connection between the gut microbiota and exercise,with a particular focus on the ergogenic potential of the gut microbiota and how it may be leveraged to enhance endurance exercise performance.

关键词： Exercise performance Gut microbiota Short-chain fatty acids

Gut microbiota and obesity:Impact of antibiotics and prebiotics and potential for musculoskeletal health

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Journal of Sport and Health Science 2020年第2期9卷 110-118页

作者： Teja Klancic rayl.ne a.reimer Faculty of Kinesiology University of CalgaryCalgaryAB T2N1N4Canada Department of Biochemistry&Molecular Biology Cumming School of MedicineUniversity of CalgaryCalgaryAB T2N 4N1Canada

Obesity is a complex disease with multiple contributing *** of the most intensely studied factors during the past decade has been the gut microbiota,which is the community of all microbes in the intestinal *** gut microbiota,via energy extraction,inflammation,and other actions,is now recognized as an important player in the pathogenesis of ***,or an imbalance in the microbial community,can initiate a cascade of metabolic disturbances in the *** life is a particularly important period for the development of the gut microbiota,and perturbations such as with antibiotic exposure can have long-lasting consequences for host *** early life and throughout the life span,diet is one of the most important factors that shape the gut *** diets high in fat and sugar have been shown to contribute to dysbiosis and disease,dietary fiber is recognized as an important fermentative fuel for the gut microbiota and results in the production of short-chain fatty acids that can act as signaling molecules in the *** particular type of fiber,prebiotic fiber,contributes to changes in the gut microbiota,the most notable of which is an increase in the abundance of *** review highlights our current understanding of the role of gut microbiota in obesity development and the ways in which manipulating the microbiota through dietary means,specifically prebiotics,could contribute to improved health in the host,including musculo skeletal health.

关键词： Gut microbiota Musculoskeletal health Obesity Prebiotics

Impact of age on host responses to diet-induced obesity:Development of joint damage and metabolic set points

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Journal of Sport and Health Science 2020年第2期9卷 132-139页

作者： Kelsey H.Collins Graham Z.MacDonald David A.Hart Ruth A.Seerattan Jaqueline L.Rios rayl.ne a.reimer Walter Herzog Human Performance Laboratory University of CalgaryCalgaryAB T2N IN 4Canada McCaig Institute for Bone and Joint Health University of CalgaryAB T2N1N4Canada Department of Orthopaedic Surgery Washington UniversitySt.LouisMO 63108USA Bone&Joint Health Strategic Clinical network Alberta Health ServicesEdmontonAB T5E 4E3Canada Department of Biochemistry and Molecular Biology Cumming School of MedicineUniversity of CalgaryAB T2N IN4Canada

Background:Osteoarthritis is one of the leading causes of pain and disability worldwide,and a large percentage of patients with osteoarthritis are individuals who are also *** recent years,a series of animal models have demonstrated that obesity-inducing diets can result in synovial joint damage(both with and without the superimposition of trauma),which may be related to changes in percentage of body fat and a series of low-level systemic inflammatory *** note,there is a disparity between whether the dietary challenges commence at weaning,representing a weanling onset,or at skeletal maturity,representing an adult onset of *** wished to evaluate the effect ofthe dietary exposure time and the age at which animals are exposed to a high-fat and high-sucrose(HFS) diet to determine whether these factors may result in disparate outcomes,as there is evidence suggesting that these factors result in differential metabolic *** on dietary exposure time,we hypothesized that rats fed an HFS diet for 14 weeks from weaning(HFS Weanling) would demonstrate an increase in knee joint damage scores,whereas rats exposed to the HFS diet for 4 weeks,starting at 12 weeks of age(HFS Adult) and rats exposed to a standard chow diet(Chow)would not display an increase in knee joint damage ***:Male Sprague-Dawley rats were fed either an HFS diet for 14 weeks from weaning(HFS Weanling) or an HFS diet for 4 weeks,starting at 12 weeks of age(HFS Adult).At sacrifice,joints were scored using the modified Mankin Criteria,and serum was analyzed for a defined subset of inflammatory markers(Interleukin-6,leptin,monocyte chemoattractant protein-1,and tumor necrosis factorα).Results:When the HFS Weanling and HFS Adult groups were compared,both groups had a similar percent of body fat,although the HFS Weanling group had a significantly greater body mass than the HFS Adult *** HFS Weanling and HFS Adult animals had a significant increase in body mass and pe

关键词： Adult exposure High-fat high-sucrose diet Rat obesity model Serum biomarkers Weanling exposure

ZONAL SPHERICAL POLYNOMIALS WITH MINIMAL L_1-NORM

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Analysis in Theory and Applications 1995年第3期11卷 22-35页

作者： M. reimer Universitat Dortmund Germany

Radial functions have become a useful tool in numerical mathematics. On the sphere they have to be identified with the zonal functions. We investigate zonal polynomials with mass concentration at the pole, in the sense of their L1-norm is attaining the minimum value. Such polynomials satisfy a complicated system of nonlinear e-quations (algebraic if the space dimension is odd, only) and also a singular differential equation of third order. The exact order of decay of the minimum value with respect to the polynomial degree is determined. By our results we can prove that some nodal systems on the sphere, which are defined by a minimum-property, are providing fundamental matrices which are diagonal-dominant or bounded with respect to the ∞-norm, at least, as the polynomial degree tends to infinity.

关键词： ZONAL SPHERICAL POLYNOMIALS WITH MINIMAL L1-NORM

Uptake and transformation of arsenic during the reproductive life stage of Agaricus bisporus and Agaricus campestris

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Journal of Environmental Sciences 2016年第11期28卷 140-149页

作者： Michelle M.nearing Iris Koch Kenneth J.reimer Environmental Sciences Group Royal Military College of Canada

Fruiting bodies from the Agaricus genus have been found to contain non-toxic arsenobetaine（AB） as a major compound. It is unknown whether AB is formed during the vegetative or reproductive life stages of the fungus, or by the surrounding microbial community, but AB＇s structural similarity to glycine betaine has led to the hypothesis that AB may be adventitiously accumulated as an osmolyte. To investigate the potential formation of AB during the reproductive life stage of Agaricus species, growth substrate and fungi were collected during the commercial growth of Agaricus bisporus and analyzed for arsenic speciation using HPLC-ICP-MS. AB was found to be the major arsenic compound in the fungus at the earliest growth stage of fruiting（the primordium）. The growth substrate mainly contained arsenate（As（V））. The distribution of arsenic in an A. bisporus primordium grown on As（V） treated substrate, and in a mature Agaricus campestris fruiting body collected from arsenic contaminated mine tailings, was mapped using two dimensional XAS imaging. The primordium and stalk of the mature fruiting body were both found to be growing around pockets of substrate material containing higher As concentrations, and AB was found exclusively in the fungal tissues. In the mature A. campestris the highest proportion of AB was found in the cap, supporting the AB as an osmolyte hypothesis. The results have allowed us to pinpoint the fungus life stage at which AB formation takes place,namely reproduction, which provides a direction for further research.

关键词： Arsenobetaine Arsenic Agaricus Fungi HPLC-ICP-MS XAS imaging

Topical treatment with propranolol gel as a supplement to the existing treatment of hemangiomas

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World Journal of Pediatrics 2014年第4期10卷 313-317页

作者： Markus Schneider Andreas reimer Hansjoerg Cremer Peter Ruef Children's Hospital Heilbronn Hospital Heilbronn 74074 HeilbronnGermany

Background:Systemic treatment with propranolol is proven to be effective for patients with hemangiomas with less *** used a propranolol gel for topical use on ***:In this retrospective study,we analyzed 148 patients who had been treated topically with propranolol gel for 12 *** analyzed the data of patients and clinically gave each hemangioma a"hemangioma score"to determine the treatment ***:In 147 of the 148 patients,strong signs of resolution under treatment included lightening,paling,and less *** hemangioma score showed a signifi cant decrease during the *** serum levels of propranolol were not *** effects were rare and not related to ***:Topical treatment with propranolol gel is suitable for specific hemangiomas in addition to cryotherapy and systemic treatment with propranolol.

关键词： hemangioma hemangioma score propranolol propranolol gel topical treatment

Successful management of therapy-refractory pseudoachalasia after Ivor Lewis esophagectomy by bypassing colonic pull-up:A case report

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World Journal of Clinical Cases 2021年第16期9卷 3971-3978页

作者： Sven Flemming Johan F Lock Mohammed Hankir Stanislaus reimer Bernhard Petritsch Christoph-ThomasGermer Florian Seyfried Department of General VisceralTransplantationVascular and Pediatric SurgeryUniversity Hospital of WuerzburgWürzburg 97080Germany Department of Internal Medicine II Section of GastroenterologyUniversity Hospital of WuerzburgWürzburg 97080Germany Department of Diagnostic and Interventional Radiology University Hospital of WuerzburgWürzburg 97080Germany

BACKGROUND Gastric pull-up after esophagectomy is still a demanding surgical procedure and associated with considerable morbidity such as anastomotic leaks,fistulas or *** complications are usually managed by endoscopy,but in extreme cases multidisciplinary management including reoperations may be ***,we report managing therapy-refractory pseudoachalasia after Ivor Lewis esophagectomy by bypassing colonic *** SUMMARY A 70-year-old male with dysphagia and regurgitation after esophagectomy with gastric pull-up reconstruction was transferred to our tertiary *** endoscopic approaches including balloon dilatation and stenting failed,retrosternal colonic pull-up with Roux-en-Y reconstruction was performed with no subsequent adverse *** Secondary colonic pull-up is a demanding but successful surgical procedure in patients suffering from therapy-refractory complaints after esophagectomy with gastric pull-up reconstruction.

关键词： Pseudoachalasia Ivor Lewis esophagectomy Dysphagia Colonic pull-up Esophageal stenting Case report

Managing esophagocutaneous fistula after secondary gastric pullup:A case report

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World Journal of Gastroenterology 2021年第16期27卷 1841-1846页

作者： Johan F Lock Stanislaus reimer Sebastian Pietryga Rafael Jakubietz Sven Flemming Alexander Meining Christoph-Thomas Germer Florian Seyfried Department of General VisceralTransplantationVascular and Pediatric SurgeryUniversity Hospital WürzburgWürzburg 97080Germany Department of Gastroenterology University Hospital WürzburgWürzburg 97080Germany Department of Trauma- Hand-Plastic-and Reconstructive SurgeryUniversity Hospital WürzburgWürzburg 97080Germany

BACKGROUND Gastric pull-up(GPU)procedures may be complicated by leaks,fistulas,or *** complications are usually managed by endoscopy,but in extreme cases multidisciplinary management including reoperation may be ***,we report a combined endoscopic and surgical approach to manage a failed secondary GPU *** SUMMARY A 70-year-old male with treatment-refractory cervical esophagocutaneous fistula with stenotic remnant esophagus after secondary GPU was transferred to our tertiary *** and systemic infection originating from the infected fistula was resolved by ***,elective esophageal reconstruction with freejejunal interposition was performed with no subsequent adverse *** A multidisciplinary approach involving interventional endoscopists and surgeons successfully managed severe complications arising from a cervical esophagocutaneous fistula after *** treatment may have lowered the perioperative risk to promote primary wound healing after free-jejunal graft interposition.

关键词： Esophageal fistula Gastric fistula Esophageal stenosis Esophageal perforation Endoscopic vacuum therapy Free-jejunal graft Autogenous jejunum transplantation Case report

Aerobic bacteria associated with chronic suppurative otitis media in Angola

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Infectious Diseases of Poverty 2018年第1期7卷 404-413页

作者： Fabian Udden Matuba Filipe Ake reimer Maria Paul Erika Matuschek John Thegerstrom Sven Hammerschmidt Tuula Pelkonen Kristian Riesbeck Clinical Microbiology Department of Translational MedicineFaculty of MedicineLund UniversityMalmoSweden ORL-department Hospital Josina Machel Faculty of MedicineAgostinho Neto UniversityLuandaAngola Nashalsan Höllviken AB HollvikenSweden EUCAST Development Laboratory c/o Clinical MicrobiologyCentral HospitalVaxjoSweden Department of Molecular Genetics and Infection Biology University of GreifswaldGreifswaldGermany Children’s Hospital Helsinki University HospitalHelsinkiFinland and University of HelsinkiHelsinkiFinland

Background:Chronic suppurative otitis media(CSOM)is an important cause of hearing loss in children and constitutes a serious health problem globally with a strong association to resource-limited living *** antibiotics combined with aural toilet is the first-hand treatment for CSOM but antimicrobial resistance and limited availability to antibiotics are obstacles in some *** goal of this study was to define aerobic pathogens associated with CSOM in Angola with the overall aim to provide a background for local treatment ***:Samples from ear discharge and the nasopharynx were collected and cultured from 152 patients with ear discharge and perforation of the tympanic *** of bacterial species was performed with matrix-assisted laser desorption/ionization-time of flight mass spectrometry and pneumococci were serotyped using multiplex polymerase chain *** susceptibility testing was done according to ***:One hundred eighty-four samples from ear discharge and 151 nasopharyngeal swabs were collected and yielded 534 and 289 individual isolates,*** all patients,correspondence rate of isolates from 2 ears in patients with bilateral disease was 27.3%and 9.3%comparing isolates from the nasopharynx and ear discharge,*** spp.(14.7%),Pseudomonas aeruginosa(13.2%)and Enterococcus spp.(8.8%)were dominating pathogens isolated from ear discharge.A large part of the remaining species belonged to Enterobacteriaceae(23.5%).Pneumococci and Staphylococcus aureus were detected in approximately 10%of nasopharyngeal *** rates to quinolones exceeded 10%among Enterobacteriaceae and was 30.8%in ***,whereas 6.3%of *** were ***:The infection of the middle ear in CSOM is highly polymicrobial,and isolates found in nasopharynx do not correspond well with those found in ear *** associated with CSOM in Angola are dominated b

关键词： Chronic suppurative otitis media Enterobacteria Infection Otitis media Proteus Pseudomonas aeruginosa

Population Bursts of Parvalbumin-Positive Interneurons Inhibit Spiking Pyramidal Cells in Spontaneously Active Cortical in Vitro networks

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Journal of Chemistry and Chemical Engineering 2012年第11期6卷 1033-1042页

作者： Tom reimer Werner Baumann Jan Gimsa Department of Biophysics University of Rostock Rostock 18057 Germany

Author present the interplay between different neuron types in the spontaneous electrical activity of low density cortical in vitro networks grown on MEA （multielectrode arrays） of glass neurochips. In 10% of the networks, the continuously spiking activity of some neurons was inhibited by synchronous bursts or superbursts of the majority of the other neurons. Immunohistochemical staining subsequent to MEA recordings suggest that the synchronously bursting neurons are parvalbumin-positive interneurons with abundant axonal ramifications. Blocking chemical synaptic transmission by Ca2＋-free medium revealed that the curbed spiking neurons are intrinsically active. It is assumed that these neurons are pyramidal cells which may be inhibited by groups of synchronously bursting interneurons. It is propose that the observed burst-induced inhibition is an important principle in the temporal organization of neuronal activity as well as in the restriction of excitation, and thus essential for information processing in the cerebral cortex.

关键词： neurochip MEA cerebral cortex cortical networks spontaneous activity inhibitory interaction parvalbumin interneurons.