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Montanide ISA-720 and Naloxone in HBsAg Vaccine Formulation:Cytokine Profiling and Monitoring of Long-Lasting Humoral Immune Responses

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Biomedical and Environmental Sciences 2022年第9期35卷 792-803页

作者： Mina mirzaee Setareh Haghighat Bahareh Golkaran Fatemeh Asgarhalvaei rayhaneh mirzaee Morteza Taghizadeh Mohammad Ali Savoji Behzad Esfandiari Mehdi Mahdavi Department of Microbiology Faculty of Advanced Sciences&TechnologyTehran Medical SciencesIslamic Azad University(IAUPS)TehranIran Department of Biotechnology Faculty of Advanced Sciences&TechnologyPharmaceutical Sciences BranchIslamic Azad UniversityTehran-Iran(IAUPS) Department of Medical vaccine Razi Vaccine and Serum Research InstituteAgricultural ResearchEducation and Extension Organization(AREEO)KarajIran Department of Epidemiology and Biostatistics Pasteur Institute of IranTehranIran Department of Laboratory Animal Science Pasteur Institute of IranKarajIran Advanced Therapy Medicinal Product(ATMP)Department Breast Cancer Research CenterMotamed Cancer InstituteAcademic Center for EducationCulture and Research(ACECR)TehranIran Recombinant Vaccine Research Center Tehran University of Medical SciencesTehranIran Department of Immunology Pasteur Institute of IranTehranIran Immunotherapy Group The Institute of Pharmaceutical Sciences(TIPS)Tehran University of Medical SciencesTehranIran

Objective This study aimed to investigate the effects of Montanide ISA-720 and Naloxone(NLX)in Hepatitis B surface antigen(HBsAg)vaccine formulation on cytokine and long-lasting antibody *** First,the HBsAg was formulated in Montanide ISA-720 adjuvant and Naloxone at 5 and 10mg/*** experimental mice were immunized three times at a 2-week interval,and then IL-4,IL-2,TNF-α,and IFN-γcytokines;long-lasting IgG antibody responses 220 days after the last shot;and IgG1/IgG2a isotypes were assessed by *** The HBsAg-Alum group exhibited the highest IL-4 cytokine response among the experimental groups,whereas NLX in HBsAg-MON720 vaccine formulation did not affect cytokine *** addition,NLX in Alum-based vaccine suppressed IL-4 cytokine response and increased the IL-2/IL-4 cytokine ***,HBsAg-MON720 was more potent than HBsAg-Alum in the induction of antibody responses,and NLX in Alum-and MON720-based vaccines induced long-lasting antibody *** NLX in Alum-based vaccine decreased IL-4 cytokine response,increased IL-2/IL-4 cytokine ratio,and improved long-lasting humoral immune responses in both vaccine ***,the adjuvant activity of NLX in the vaccine formulation depends on the type of adjuvant and the nature of the antigen in the vaccine formulation.

关键词： HBsAg Vaccine Naloxone Montanide ISA-720 Long-lasting humoral response

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Effects of Acupressure and Ibuprofen on the Severity of Primary Dysmenorrhea

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Journal of Traditional Chinese Medicine 2002年第3期22卷 205-210页

作者： Zahra Pouresmail rayhaneh Ibrahimzadeh Faculty Member of Shaheed Beheshti University of Medical Sciences and Health Services Tehran-Iran MA in Midwifery

　　The present study aims at comparing the effects of acupressure using new combination of acupoints, and Ibuprofen on the severity of primary dysmenorrhea (PD). 216 female high school students, aged between 14 to 18 years, were randomly selected and divided into three groups. Each group underwent different treatment techniques: acupressure, Ibuprofen and sham acupressure as a placebo. The results indicated that the three therapeutic techniques were significantly effective in reducing the pain. However the therapeutic efficacies of acupressure and Ibuprofenwere similar with no significant difference, and were significantly better thanthe placebo. Thus acupressure, with no complications, is recommended as an alternative and also a better choice in the decrease of the severity of PD.　　……

关键词： Effects of Acupressure and Ibuprofen on the Severity of Primary Dysmenorrhea

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