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Earthquake Engineering and Engineering Vibration 2013年第2期12卷 319-332页

作者： ray kai leung su Chien-Liang Lee Department of Civil Engineering The University of Hong Kong

This study presents a seismic fragility analysis and ultimate spectral displacement assessment of regular low-rise masonry infilled （MI） reinforced concrete （RC） buildings using a coefficient-based method. The coefficient-based method does not require a complicated finite element analysis; instead, it is a simplifed procedure for assessing the spectral acceleration and displacement of buildings subjected to earthquakes. A regression analysis was first performed to obtain the best-fitting equations for the inter-story drift ratio （IDR） and period shift factor of low-rise MI RC buildings in response to the peak ground acceleration of earthquakes using published results obtained from shaking table tests. Both spectral acceleration- and spectral displacement-based fragility curves under various damage states （in terms of IDR） were then constructed using the coefficient-based method. Finally, the spectral displacements of low-rise MI RC buildings at the ultimate （or near- collapse） state obtained from this paper and the literature were compared. The simulation results indicate that the fragility curves obtained from this study and other previous work correspond well. Furthermore, most of the spectral displacements of low-rise MI RC buildings at the ultimate state from the literature fall within the bounded spectral displacements predicted by the coefficient-based method.

关键词： seismic fragility analysis masonry spectral displacement

Genomics-driven derivatization of the bioactive fungal sesterterpenoid variecolin:Creation of an unnatural analogue with improved anticancer properties

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Acta Pharmaceutica Sinica B 2024年第1期14卷 421-432页

作者： Dexiu Yan Jemma Arakelyan Teng Wan Ritvik Raina Tsz Ki Chan Dohyun Ahn Vladimir Kushnarev Tsz Kiu Cheung Ho Ching Chan Inseo Choi Pui Yi Ho Feijun Hu Yujeong Kim Hill Lam Lau Ying Lo Law Chi Seng leung Chun Yin Tong kai Kap Wong Wing Lam Yim Nikolay S.Karnaukhov Richard Y.C.Kong Maria V.Babak Yudai Matsuda Department of Chemistry City University of Hong KongHong Kong SARChina iGEM Team“VarieCure” City University of Hong KongHong Kong SARChina Department of Biomedical Engineering City University of Hong KongHong Kong SARChina Moscow Clinical Research Center Named After A.S.Loginov Moscow 111123Russian Federation

A biosynthetic gene cluster for the bioactive fungal sesterterpenoids variecolin(1)and variecolactone(2)was identified in Aspergillus aculeatus ATCC *** production of 1 and 2 was achieved in Aspergillus oryzae by expressing the sesterterpene synthase VrcA and the cytochrome P450 ***,the replacement of VrcB with homologous P450s from other fungal terpenoid pathways yielded three new variecolin analogues(5-7).Analysis of the compounds’anticancer activity in vitro and in vivo revealed that although 5 and 1 had comparable activities,5 was associated with significantly reduced toxic side effects in cancer-bearing mice,indicating its potentially broader therapeutic *** study describes the first tests of variecolin and its analogues in animals and demonstrates the utility of synthetic biology for creating molecules with improved biological activities.

关键词： Animal studies Anticancer properties Biosynthesis Natural products Sesterterpenoids Synthetic biology Terpene synthases Variecolin

Self-supervised image quality assessment for X-ray tomographic images of Li-ion battery

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npj Computational Materials 2022年第1期8卷 1848-1856页

作者： kai Zhang Tuan-Tu Nguyen Zeliang su Arnaud Demortière Laboratoire de Réactivitéet Chimie des Solides(LRCS) CNRS UMR 7314UPJVHub de l’Energie15 rue Baudelocque80039Amiens CedexFrance ENSTA Paris 91120PalaiseauFrance Renault Technocentre 78084GuyancourtFrance Réseau sur le Stockage Electrochimique de l’Energie(RS2E) CNRS FR 3459Hub de l’EnergieRue Baudelocque80039Amiens CedexFrance ALISTORE-European Research Institute CNRS FR 3104Hub de l’EnergieRue Baudelocque80039Amiens CedexFrance

Image perception plays a fundamental role in the tomography-based approaches for microstructure characterization and has a deep impact on all subsequent stages of image processing,such as segmentation and 3D *** enhancement of image perception,however,frequently involves observer-dependence,which reflects user-to-user dispersion and uncertainties in the calculated *** work presents an objective quantitative method,which uses convolutional neural networks (CNN) for the quality assessment of the X-ray tomographic *** only dozens of annotations,our method allows to evaluate directly and precisely the quality of tomographic *** metrics were employed to evaluate the correlation between our predicted scores and subjective human *** evaluation results demonstrate that our method can be a direct tool to guide the enhancement process in order to produce reliable segmentation *** processing of the tomographic image can thus evolve into a robust observer-independent procedure and advance towards the development of an efficient self-supervised approach.

关键词： image networks battery

高功率密度外延的单晶金刚石制备高性能辐射探测器

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Science China Materials 2024年第7期67卷 2329-2334页

作者：丁森川张金风苏凯任泽阳陈军飞杨智清张进成郝跃 State Key Laboratory of Wide-Bandgap Semiconductor Devices and Integrated Technology School of MicroelectronicsXidian UniversityXi’an 710071China Xidian-Wuhu Research Institute Wuhu 241002China

辐射探测器是用来研究超宽禁带半导体金刚石中载流子动力学的重要表征工具.本文采用微波等离子体化学气相沉积(MPCVD)方法在高温高压(HTHP)金刚石衬底上制备了高质量的单晶金刚石.我们通过压缩等离子体球来提高微波功率密度,优化了等离... 详细信息

辐射探测器是用来研究超宽禁带半导体金刚石中载流子动力学的重要表征工具.本文采用微波等离子体化学气相沉积(MPCVD)方法在高温高压(HTHP)金刚石衬底上制备了高质量的单晶金刚石.我们通过压缩等离子体球来提高微波功率密度,优化了等离子体中的碳氢(C/H)比,并显著降低了金刚石外延层中的杂质和位错含量.(004)面X射线衍射摇摆曲线的半高宽(FWHM)仅为15弧秒,在室温下的光致发光光谱中没有检测到杂质发光带.使用制备的200μm厚的外延金刚石膜制成的辐射探测器可对α-粒子响应,其电子的电荷收集效率为97.03%,能量分辨率为2.1%,空穴的电荷收集效率和能量分辨率为97.86%和1.5%.此外,电子和空穴的迁移率和寿命的乘积分别达到8×10^(−5)和4.1×10^(−4) cm^(2) V^(−1).此方法有望满足商用金刚石辐射探测器对性能和成本控制的严苛要求.

关键词： single-crystal diamond radiation detectors high-power-density epitaxy charge collection efficiency

Spectral computed tomography-guided photothermal therapy of osteosarcoma by bismuth sulfide nanorods

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Nano Research 2023年第7期16卷 9885-9893页

作者： Yuhan Li Xiaoxue Tan Han Wang Xiuru Ji Zi Fu kai Zhang Weijie su Jian Zhang Dalong Ni School of Medicine Shanghai UniversityNo.99 Shangda RdShanghai 200444China Shanghai University Shanghai Universal Medical Imaging Diagnostic CenterBldg 8No.406 Guilin RdShanghai 200233China Department of Orthopaedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint DiseasesShanghai Institute of Traumatology and OrthopaedicsRuijin HospitalShanghai Jiao Tong University School of MedicineNo.197Ruijin 2nd RdShanghai 200025China Department of Plastic and Reconstructive surgery Shanghai Ninth People’s HospitalShanghai JiaoTong University School of MedicineNo.639Zhizaoju Rd.Shanghai 200011China

Osteosarcoma(OS)is the most normally primary malignant bone cancer in *** to their analogous X-ray attenuation properties,healthy bones and malignancies with iodine enhancement cannot be distinguished by conventional computed tomography(CT).As one kind of spectral CT,dual-energy CT(DECT)offers multiple functions for material separation and cancer ***,bismuth sulfide(Bi_(2)S_(3))nanorods(NRs)were synthesized as special contrast agents(CAs)for DECT,which have superior imaging properties than clinical iodine *** the same time,the high photothermal conversion rates of Bi_(2)S_(3)NRs can be used for DECT-guided photothermal therapy(PTT)to destroy OS and inhibit tumor growth under the guidance of DECT ***,DECT imaging real-timely monitored that PTT could accelerate the diffusion of Bi2S3 NRs in the tumor,obtaining detailed information on the internal distribution of nanomaterials in tumors around the bone to avoid injury to normal tissues by ***,the proposed strategy of DECT imaging-guided PTT appears enormous promise for bone disease treatment.

关键词： dual-energy computed tomography nanomedicine bismuth sulfide photothermal therapy osteosarcoma

Optimal gamma-ray selections for monochromatic line searches with DAMPE

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Frontiers of physics 2022年第3期17卷 1-6页

作者： Zun-Lei Xu kai-kai Duan Wei Jiang Shi-Jun Lei Xiang Li Zhao-Qiang Shen Tao Ma Meng su Qiang Yuan Chuan Yue Yi-Zhong Fan Jin Chang Key Laboratory of Dark Matter and Space Astronomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing 210023China School of Astronomy and Space Science University of Science and Technology of ChinaHefei 230026China

The DArk Matter Particle Explorer (DAMPE) is a space high-energy cosmic-ray detector covering a wide energy band with a high energy resolution. One of the key scientific goals of DAMPE is to carry out indirect detection of dark matter by searching for high-energy gamma-ray line structure. To promote the sensitivity of gamma-ray line search with DAMPE, it is crucial to improve the acceptance and energy resolution of gamma-ray photons. In this paper, we quantitatively proved that the photon sample with the largest ratio of acceptance to energy resolution is optimal for line search. We therefore developed a line-search sample specifically optimized for the line-search. Meanwhile, in order to increase the statistics, we also selected the so-called BGO-only photons that convert into e^(+)e^(-) pairs only in the BGO calorimeter. The standard, the line-search, and the BGO-only photon samples are then tested for line-search individually and collectively. The results show that a significantly improved limit could be obtained from an appropriate combination of the date sets, and the increase is about 20% for the highest case compared with using the standard sample only.

关键词： DArk Matter Particle Explorer(DAMPE) gamma-ray line-search

便携式X射线荧光光谱仪对粉丝中KAl(SO_(4))_(2)的快速检测技术研究

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光谱学与光谱分析 2024年第4期44卷 1067-1072页

作者：苏莹周陶鸿刘杰黄徽柳迪王晶晶谢云飞湖北省食品质量安全监督检验研究院湖北武汉430075 国家市场监管重点实验室(动物源性食品中重点化学危害物检测技术) 湖北武汉430075 湖北省食品质量安全检测工程技术研究中心湖北武汉430075 苏州佳谱科技有限公司江苏苏州215000 江南大学食品学院江苏无锡214000

硫酸铝钾[KAl(SO_(4))_(2)]又称明矾,常被加入到粉丝的制作工艺中为了改善粉丝韧劲差、易断裂的缺点,也能在一定程度上提升粉丝的口感。硫酸铝钾中的铝元素具有神经毒性,长期摄入过量的铝对人身体健康具有极大危害。常规测定粉丝中硫酸... 详细信息

硫酸铝钾[KAl(SO_(4))_(2)]又称明矾,常被加入到粉丝的制作工艺中为了改善粉丝韧劲差、易断裂的缺点,也能在一定程度上提升粉丝的口感。硫酸铝钾中的铝元素具有神经毒性,长期摄入过量的铝对人身体健康具有极大危害。常规测定粉丝中硫酸铝钾时,样品需要消解,处理方法繁琐且费时。而便携式X射线荧光光谱仪(XRF)具有体积小、操作简便、检测速度快和灵敏度高等优点还能同时测定多种金属元素。以粉丝为研究对象,以电感耦合等离子体质谱法(ICP-MS)为参比,建立了XRF对粉丝中的KAl(SO_(4))_(2)的快速检测与鉴别新方法,并将XRF技术用于鉴别粉丝中是否添加KAl(SO_(4))_(2)。首先使用方程对仪器进行基体效应修正,建立了峰面积和浓度的线性曲线,校正的工作曲线拟合R^(2)>0.99,可用于粉丝样品的测定。对仪器的检测条件进行优化。将样品直接上机测定时,XRF测试结果相对误差在0.65%~24.33%范围内。针对KAl(SO_(4))_(2)中铝含量小于100 mg·kg^(-1)的粉丝样品可采用快速碳化处理,将粉丝中低含量的铝富集后再测定,XRF测试结果相对误差为1.36%~15.39%,碳化处理极大缩短了样品直接测定的相对误差。研究发现添加了硫酸铝钾的粉丝标样Al、S和K元素成相关性,三种元素的比例在1∶3∶1~1∶4∶1范围内,而未添加硫酸铝钾的粉丝并不满足这个比例。便携式XRF能高效完成大批量样品分析,单次测试仅需5 min,方法快速、简便、经济、精密度高,同时可快速鉴别粉丝中是否添加KAl(SO_(4))_(2),及时发现食品质量安全隐患,为粉丝的质量控制提供了新思路,具有广泛的实际推广意义。

关键词：能量色散X射线荧光粉丝硫酸铝钾碳化

Pharmacological efficacy of the traditional Chinese medicinal formula Kun-Tai-1A in the treatment of letrozole-induced polycystic ovary syndrome

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Traditional Medicine Research 2022年第3期7卷 44-54页

作者： Leanne Lee leung Jing Xie Ya-Cun Chen Kar-Ho Lam Hei Wan su-Lan Yu Tzi-Bun Ng George Pak-Heng leung Jin Yu Ren-Min Yao Shu-Jia sun Sydney Chi-Wai Tang Hai-Yong Chen Jia Zhao Zhang-Jin Zhang Calvin kai-Fai Lee Kalin Yan-Bo Zhang Li-Xing Lao Yun Feng Xiang Lin Wei Meng School of Chinese Medicine Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong 999077China School of Biomedical Sciences Faculty of MedicineThe Chinese University of Hong KongHong Kong 999077China Department of Pharmacology and Pharmacy Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong 999077China Workstation for Training and Research(Hong Kong Branch) Distinguished Professor Yu Jin Gynaecology of Chinese Medicine&Integrative MedicineHong Kong 999077China Shanghai Taikuntang Chinese Medicine Hospital Shanghai 200023China Department of Medicine Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong 999077China Department of Obstetrics and Gynaecology Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong 999077China Virginia University of Integrative Medicine Virginia 22031USA Department of Ophthalmology Peking University Third HospitalBeijing 100191China Workstation of Zhu Nansun National Master of Chinese MedicineHong Kong Branch of Zhu’s School of Gynaecology of Chinese Medicine from ShanghaiHong Kong 999077China

Background:Polycystic ovary syndrome(PCOS)is an endocrine disorder that occurs in women of child-bearing ***,PCOS patients have decreased pregnancy rates and clomiphene citrate *** traditional Chinese medicine formula Kun-Tai-1S(KT1S),consisting of the seahorse species hippocampus,has been reported to elicit therapeutic effects in patients with ***,given the limited resources and global demand for wild hippocampus,whether KT1S with or without hippocampus can elicit similar therapeutic effects has not been ***:KT1S and Kun-Tai-1A(KT1A,KT1S without dry hippocampus)were used to treat a letrozole-induced rat model of PCOS with an established *** serum levels of testosterone,luteinizing hormone,anti-Müllerian hormone,and estradiol were determined,the luteinizing hormone/follicle-stimulating hormone ratio was determined,and the ovarian pathology was ***:Similar to the therapeutic effects of cyproterone acetate,both the KT1S and KT1A treatments reduced the body weight and ovarian and uterine indices in the rats with *** serum levels of testosterone,anti-Müllerian hormone,and luteinizing hormone and the luteinizing hormone/follicle-stimulating hormone ratio were significantly lower in the KT1S and KT1A treatment groups compared to the model group(Psults suggested that both the KT1S and KT1A treatments significantly ameliorated the PCOS pathology in the rats with an established disease,with a reduced number of cystic and atretic follicles and an increased number of corpora lutea being observed in the ***,there was no obvious difference in the disease outcomes between the KT1S and KT1A-treated *** pharmacology analysis revealed that 4’,7-dihydroxyflavanone,sinpemine A,quercetin,8-isopentenyl-kaempferol,and luteolin in KT1A may promote estrogen signaling;furthermore,the nitric oxide regulation pathway is also cl

关键词： polycystic ovary syndrome traditional Chinese medicine ovulation Kun-Tai-1A seahorse endocrine disease

Validation of quantitative computed tomography-derived areal bone mineral density with dual energy X-ray absorptiometry in an elderly Chinese population

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Chinese Medical Journal 2014年第8期127卷 1445-1449页

作者： Cheng Xiaoguang Wang Ling Wang Qianqian Ma Yimin su Yongbin Li kai Department of Radiology Department of Epidemiology (Wang QQ) Beijing Jishuitan Hospital Beijing 100035 China Department of Epidemiology Beijing Jishuitan Hospital Beijing 100035 China

Background The performance of computed tomography X-ray absorptiometry （CTXA） against the dual energy X-ray absorptiometry （DXA） as standard has not been studied in Chinese population. The aim of this study was to evaluate the precision of this measurement and validate the value of quantitative computed tomography （QCT） by comparing CTXA results with DXA results in an elderly Chinese population. Methods One hundred and three females of 46 to 76 years old and 49 males of 52 to 76 years old were recruited from the Prospective Urban Rural Epidemiology study. All subjects underwent hip scans by both QCT and DXA on the same day. For precision determination, 30 subjects had duplicate DXA hip scans. The hip QCT data of a subset of 27 subjects were separately analyzed by two observers and reanalyzed by one observer at a different time. The inter- and intra-observer variations of CTXA measurement were assessed, and the difference and correlation between CTXA and DXA results were analyzed. Results The inter- and intra-observer variations of CTXA were 0.070 and 0.024 g/cm^2 in the femoral neck （FN）, and 0.030 and 0.012 g/cm2 in the total hip （TH）, which were comparable to the DXA inter-scan variations （0.013 g/cm2 for FN and 0.014 g/cm2 for TH）. The results of CTXA bone mineral density （BMD） were highly correlated with those of DXA （R2 = 0.810 for FN and R2 = 0.878 for TH）. The BMD values of CTXA in FN and TH were lower than those of DXA by 21.0% and 17.8% （P〈0.05）, respectively. However, after appropriate transformation, the difference was eliminated and a comparable T score could be obtained. Conclusions CTXA shows good agreement with DXA for the measurement of BMD in the proximal femur, which makes QCT suitable for the quantification of bone mineral content in the hip and helpful for the diagnosis of osteoporosis.

关键词： bone mineral density osteoporosis quantitative computed tomography dual energy X-ray absorptiometry

Research on the On-orbit Background of the Hard X-ray Imager Onboard ASO-S

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Research in Astronomy and Astrophysics 2022年第9期22卷 116-131页

作者： Wei Liu Deng-Yi Chen Xian-kai Jiang Jian Wu Zhe Zhang Yi-Ming Hu Yang su Wei Chen Tao Ma Key Laboratory of Dark Matter and Space Astronomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing 210023China School of Astronomy and Space Science University of Science and Technology of ChinaHefei 230026China

The space environment background of various particle fluxes of the Hard X-ray Imager(HXI), one of the payloads of the Advanced Space-based Solar Observatory(ASO-S) spacecraft, is investigated and presented. Different approaches are used to obtain the input information on various space environment particles(protons, alpha particles, electrons, positrons, neutrons, and photons). Some special regions(SAA and radiation belt) are also taken into account. The findings indicate that electrons are the primary background source in the radiation belt. Due to the large background flux generated by electrons, HXI cannot effectively observe solar flares in the radiation *** the radiation belt, primary protons and albedo photons are the main sources of background at low and high magnetic latitudes respectively. The statistical analysis of the flare and background spectra shows that the errors of the flare energy spectrum observation are mainly concentrated in the high energy band, and the detector still has a certain spectrum observation capability for flares of C-class and below in the low energy band of the non-radiation belt. The imaging observation of flares of C-class and below is significantly affected by the accuracy of background subtraction. The energy band with the best signal-to-noise ratio is from 10 to 50 ke V, which can be used to monitor the formation and class of flares.

关键词： instrumentation:detectors sun:X-rays gamma-rays X-rays:diffuse background (cosmology:)cosmic background radiation