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Radiation-based immunogenic vaccine combined with a macrophage“checkpoint inhibitor”for boosting innate and adaptive immunity against metastatic colon cancers

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Acta Pharmaceutica Sinica B 2024年第5期14卷 2247-2262页

作者： Hongbo Xu Xianya Qin Yuanyuan guo Siyu Zhao Xingxing Feng Runzan Zhang Tianyi Tian Li Kong Conglian Yang Zhiping Zhang Tongji School of Pharmacy Huazhong University of Science and TechnologyWuhan 430030China Hubei Engineering Research Center for Novel Drug Delivery System Wuhan 430030China Wuhan Liyuan Hospital of Tongji School of Pharmacy Huazhong University of Science and TechnologyWuhan 430077China

Immunogenic dying tumor cells hold promising prospects as cancer vaccines to activate systemic immunity against both primary and metastatic ***,X-ray-induced dying tumor cells are rich in highly immunogenic tumor-associated antigens and self-generated dsDNA as potent ***,we found that the X-ray induction process can result in the excessive exposure of phosphatidylserine in cancer vaccines,which can specifically bind with the MerTK receptor on macrophages,acting as a“checkpoint”to facilitate immune silence in the tumor ***,we developed a novel strategy combining X-ray-induced cancer vaccines with UNC2250,a macrophage MerTK“checkpoint inhibitor,”for treating peritoneal carcinomatosis in colon *** incorporating UNC2250 into the treatment regimen,immunosuppressive efferocytosis of macrophages,which relies on MerTK-directed recognition of phosphatidylserine on vaccines,was effectively ***,the immune analysis revealed that this combination strategy promoted the maturation of dendritic cells and M1-like repolarization of macrophages,thereby simultaneously eliciting robust adaptive and innate *** innovative approach utilizing X-ray-induced vaccines combined with a checkpoint inhibitor may provide valuable insights for developing effective cancer vaccines and immunotherapies targeting colon cancer.

关键词： Immunogenic cell death Cancer vaccine X-ray Efferocytosis Macrophage STING Adaptive immunity Innate immunity

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Analysis of the joint detection capability of the SMILE satellite and EISCAT-3D radar

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Earth and Planetary Physics 2024年第1期8卷 299-306页

作者： JiaoJiao Zhang TianRan Sun XiZheng Yu DaLin Li Hang Li JiaQi guo ZongHua Ding Tao Chen Jian Wu Chi Wang State Key Laboratory of Space Weather National Space Science CenterChinese Academy of SciencesBeijing 100190China Key Laboratory of Solar Activity and Space Weather National Space Science CenterChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 101408China Key Laboratory of Electronics and Information Technology for Space Systems Chinese Academy of SciencesBeijing 100190China China Research Institute of Radio-wave Propagation Qingdao 266075China

The Solar wind Magnetosphere Ionosphere Link Explorer(SMILE)satellite is a small magnetosphere–ionosphere link explorer developed cooperatively between China and *** pioneers the use of X-ray imaging technology to perform large-scale imaging of the Earth’s magnetosheath and polar cusp *** uses a high-precision ultraviolet imager to image the overall configuration of the aurora and monitor changes in the source of solar wind in real time,using in situ detection instruments to improve human understanding of the relationship between solar activity and changes in the Earth’s magnetic *** SMILE satellite is scheduled to launch in *** European Incoherent Scatter Sciences Association(EISCAT)-3D radar is a new generation of European incoherent scatter radar constructed by EISCAT and is the most advanced ground-based ionospheric experimental device in the high-latitude polar *** has multibeam and multidirectional quasi-real-time three-dimensional(3D)imaging capabilities,continuous monitoring and operation capabilities,and multiple-baseline interferometry *** detection by the SMILE satellite and the EISCAT-3D radar is of great significance for revealing the coupling process of the solar wind–magnetosphere–***,we performed an analysis of the joint detection capability of the SMILE satellite and EISCAT-3D,analyzed the period during which the two can perform joint detection,and defined the key scientific problems that can be solved by joint *** addition,we developed Web-based software to search for and visualize the joint detection period of the SMILE satellite and EISCAT-3D radar,which lays the foundation for subsequent joint detection experiments and scientific research.

关键词： Solar wind Magnetosphere Ionosphere Link Explorer(SMILE)satellite European Incoherent Scatter Sciences Association(EISCAT)-3D radar joint detection

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Impact of computed tomography/magnetic resonance imaging registration on rehabilitation after percutaneous endoscopic decompression for lumbar stenosis: Retrospective study

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World Journal of Orthopedics 2024年第10期15卷 939-949页

作者： Xiao-Bo guo Jin-Wei Chen Jun-Yang Liu Jiang-Tao Jin Department of Orthopedics Jincheng General HospitalJincheng 048006Shanxi ProvinceChina

BACKGROUND Percutaneous endoscopic lumbar decompression(PELD)shows promise for lumbar spinal stenosis(LSS)treatment,but its use is limited by the disease's complexity and procedural *** In this study,the effects of preoperative planning and intraoperative guidance with computed tomography(CT)/magnetic resonance imaging(MRI)registration techniques on PELD for LSS and postoperative rehabilitation outcomes were *** This retrospective study was conducted with data from patients who underwent PELD for LSS between January 2021 and December *** were assigned to preoperative CT/MRI registration and control *** collected included the operative time,length of hospital stay,visual analog scale(VAS)scores for low back and leg pain,and the Japanese Orthopaedic Association(JOA)lumbar spine *** between groups were assessed using Student’s t *** Data from 135 patients(71 in the CT/MRI registration group,64 in the control group)were *** operative time was significantly shorter in the CT/MRI registration group(P=0.007).At 2 months postoperatively,both groups showed significant reductions in VAS leg and low back pain scores(all P<0.001)and improvements in the JOA score(both P<0.001).No complication or death ***,pain and JOA scores were similar between groups(P=0.830,P=0.470,and P=0.287,respectively).At 2 months postoperatively,patients in the CT/MRI registration group reported lower leg and low back pain levels(P<0.001 and P=0.001,respectively)and had higher JOA scores(P=0.004)than did patients in the control *** Preoperative CT/MRI registration for PELD for LSS reduced the operative time and VAS pain scores at 2 months and improved JOA scores,demonstrating enhanced effectiveness and safety.

关键词： Endoscopy Spinal stenosis Lumbar vertebrae Tomography X-ray computed Magnetic resonance imaging

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Physical and mechanical properties and microstructures of submarine soils in the Yellow Sea

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Deep Underground Science and Engineering 2024年第2期3卷 197-206页

作者： Zhuangcai Tian Yihua Chang Sichao Chen Gengchen Wang Yanhong Hu Chuan guo Lei Jia Lei Song Jianhua Yue State Key Laboratory for Geomechanics and Deep Underground Engineering China University of Mining and TechnologyXuzhouChina School of Mechanics and Civil Engineering China University of Mining and TechnologyXuzhouChina Research Center for Deep Ocean Science and Underwater Engineering China University of Mining and TechnologyXuzhouChina School of Resources and Geosciences China University of Mining and TechnologyXuzhouChina

In recent years,the exploration of seabed has been intensified,but the submarine soils of silt and sand in the Yellow Sea area have not been well investigated so *** this study,the physical and mechanical properties of silt and sand from the Yellow Sea were measured using a direct shear apparatus and their microstructures were observed using a scanning electron *** test results suggest that the shear strength of silt and sand increases linearly with the increase of normal *** on the direct shear test,the scanning electron microscope was used to observe the section surface of *** is observed that the section surface becomes rough,with many“V”‐shaped *** particles appear on the surface of the silt structure and tend to be *** X‐ray diffraction experiment reveals that the sand and silt have different *** shear strength of sand is slightly greater than that of silt under high stress,which is related to the shape of soil particles and the mineral *** results can be a reference for further study of other soils in the Yellow Sea;meanwhile,they can serve as soil parameters for the stability and durability analyses of offshore infrastructure construction.

关键词： direct shear test microscope physical properties submarine soil Yellow Sea

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黄色系硅化造礁石珊瑚的结构特征及颜色成因研究

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岩石矿物学杂志 2024年第3期43卷 663-672页

作者：郭逸琳郭颖中国地质大学(北京)珠宝学院北京100083

近些年,黄色系硅化造礁石珊瑚以其独特的花纹和美丽的颜色受到了人们的关注和喜爱。为充分认识硅化造礁石珊瑚的结构特征及颜色成因,本文采用X射线粉末衍射仪、偏光显微镜、热场发射扫描电子显微镜、紫外-可见光分光光度计和拉曼光谱仪... 详细信息

近些年,黄色系硅化造礁石珊瑚以其独特的花纹和美丽的颜色受到了人们的关注和喜爱。为充分认识硅化造礁石珊瑚的结构特征及颜色成因,本文采用X射线粉末衍射仪、偏光显微镜、热场发射扫描电子显微镜、紫外-可见光分光光度计和拉曼光谱仪对3块天然黄色系硅化造礁石珊瑚进行了研究。结果表明:所研究的硅化造礁石珊瑚空腔区与隔片区石英颗粒的形态、种类及分布特征不同。当隔片和体壁所围成的空腔或是共骨之间的空腔足够大时,沿空腔内壁到中心,石英颗粒的种类和形态从不规则的细粒→他形的中粒→他形-半自形粗粒;当空腔受到挤压时,石英颗粒主要为他形或似纤维状的细粒石英。隔片区的石英颗粒主要为细粒石英。在偏光显微镜下观察到的黄色-褐红色的矿物经证实为针铁矿和赤铁矿,其中赤铁矿是黄色系硅化造礁石珊瑚的主要致色矿物。受造礁石珊瑚骨骼结构的影响,微观上针铁矿和赤铁矿总是以色素点的方式存在于极细粒或细粒石英颗粒的间隙,宏观上富集于隔片区和空腔边缘。

关键词：硅化造礁石珊瑚石英质玉二氧化硅结构特征颜色成因

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Heterostructural NiFeW disulfide and hydroxide dual‐trimetallic core‐shell nanosheets for synergistically effective water oxidatio

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Carbon Energy 2024年第8期6卷 192-204页

作者： Peng‐Fei guo Yang Yang Bing Zhu Qian‐Nan Yang Yan Jia Wei‐Tao Wang Zhao‐Tie Liu Shi‐Qiang Zhao Xun Cui Key Laboratory of Chemical Additives for China National Light Industry College of Chemistry and Chemical EngineeringShaanxi University of Science and TechnologyXi'anChina School of Chemistry and Chemical Engineering Shaanxi Normal UniversityXi'anChina Key Laboratory of Carbon Materials of Zhejiang Province Wenzhou Key Lab of Advanced Energy Storage and ConversionZhejiang Province Key Lab of Leather EngineeringCollege of Chemistry and Materials EngineeringWenzhou UniversityWenzhouChina State Key Laboratory of New Textile Materials and Advanced Processing Technologies Wuhan Textile UniversityWuhanChina

A stable and highly active core‐shell heterostructure electrocatalyst is essential for catalyzing oxygen evolution reaction(OER).Here,a dual‐trimetallic core‐shell heterostructure OER electrocatalyst that consists of a NiFeWS_(2)inner core and an amorphous NiFeW(OH)_(z)outer shell is designed and synthesized using in situ electrochemical *** electrochemical measurements of different as‐synthesized catalysts with a similar mass loading suggest that the core‐shell Ni_(0.66)Fe_(0.17)W_(0.17)S_(2)@amorphous NiFeW(OH)_(z)nanosheets exhibit the highest overall performance compared with that of other bimetallic reference catalysts for the ***,the nanosheet arrays were in situ grown on hydrophilic‐treated carbon paper to fabricate an integrated three‐dimensional electrode that affords a current density of 10 mA cm^(−2)at a small overpotential of 182 mV and a low Tafel slope of 35 mV decade^(−1)in basic *** Faradaic efficiency of core‐shell Ni_(0.66)Fe_(0.17)W_(0.17)S_(2)@amorphous NiFeW(OH)_(z)is as high as 99.5%for *** scanning electron microscope,transmission electron microscope,and X‐ray photoelectron spectroscopy analyses confirm that this electrode has excellent stability in morphology and elementary composition after long‐term electrochemical ***,density functional theory calculations further indicate that the core‐shell heterojunction increased the conductivity of the catalyst,optimized the adsorption energy of the OER intermediates,and improved the OER *** study provides a universal strategy for designing more active core‐shell structure electrocatalysts based on the rule of coordinated regulation between electronic transport and active sites.

关键词： amorphous NiFeW hydroxide core‐shell heterojunction in situ electrochemical tuning NiFeW disulfide oxygen evolution reaction

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Dinitrophenyl-oxadiazole compounds:Design strategy,synthesis,and properties of a series of new melt-cast explosives

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Defence Technology（防务技术） 2024年第5期35卷 100-107页

作者： Bao-long Kuang Ting-wei Wang Cong Li Mou Sun Qamar-un-Nisa Tariq Chao Zhang Zhi-ming Xie Zu-jia Lu Jian-guo Zhang State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing100081China China Wuzhou Engineering Group CO. LTD.Beijing 100053China

Melt-cast explosives are the most widely used energetic materials in military composite explosives,researchers have been unremittingly exploring high-energy and insensitive melt-cast *** this work,a series of dinitrophenyl-oxadiazole compounds were designed and *** compounds have an ideal low melting point(80-97℃),good detonation performance(detonation velocity D=6455-6971 m/s,detonation pressure P=18-19 GPa)and extreme insensitive nature(impact sensitivity≥60 J,friction sensitivity>360 N).All these compounds were well characterized by nuclear magnetic resonance,fourier transform infrared spectroscopy,elemental *** 2,3 were unambiguously confirmed by X-ray single crystal diffraction *** a result,their overall properties are superior to traditional melt-cast explosives trinitrotoluene(TNT)and dinitroanisole(DNAN)which may have excellent potential applications in insensitive melt-cast explosives.

关键词： Dinitrophenyl-oxadiazole Melt-cast explosive Low sensitivity

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Deformations at Earth’s dayside magnetopause during quasi-radial IMF conditions:Global kinetic simulations and Soft X-ray Imaging

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Earth and Planetary Physics 2024年第1期8卷 59-69页

作者： ZhongWei Yang RiKu Jarvinen XiaoCheng guo TianRan Sun Dimitra Koutroumpa George K.Parks Can Huang BinBin Tang QuanMing Lu Chi Wang State Key Laboratory of Space Weather National Space Science CenterChinese Academy of SciencesBeijing 100190China Finnish Meteorological Institute FI-00101 HelsinkiFinland LATMOS/IPSL CNRSUVSQ UniversitéParis-SaclaySorbonne UniversitéGuyancourt78280France Space Sciences Laboratory University of CaliforniaBerkeleyCalifornia 94720USA CAS Engineering Laboratory for Deep Resources Equipment and Technology Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029 China Deep Space Exploration Laboratory/School of Earth and Space Sciences University of Science and Technology of ChinaHefei 230026China

The Solar wind Magnetosphere Ionosphere Link Explorer(SMILE)is a joint mission of the European Space Agency(ESA)and the Chinese Academy of Sciences(CAS).Primary goals are investigating the dynamic response of the Earth's magnetosphere to the solar wind(SW)impact via simultaneous in situ magnetosheath plasma and magnetic field measurements,X-ray images of the magnetosheath and magnetic cusps,and UV images of global auroral *** deformations associated with magnetosheath high speed jets(HSJs)under a quasi-parallel interplanetary magnetic field condition are studied using a threedimensional(3-D)global hybrid *** X-ray intensity calculated based on both physical quantities of solar wind proton and oxygen ions is *** obtain key findings concerning deformations at the magnetopause:(1)Magnetopause deformations are highly coherent with the magnetosheath HSJs generated at the quasi-parallel region of the bow shock,(2)X-ray intensities estimated using solar wind h+and self-consistentO7+ions are consistent with each other,(3)Visual spacecraft are employed to check the discrimination ability for capturing magnetopause deformations on Lunar and polar orbits,*** SMILE spacecraft on the polar orbit could be expected to provide opportunities for capturing the global geometry of the magnetopause in the equatorial plane.A striking point is that SMILE has the potential to capture small-scale magnetopause deformations and magnetosheath transients,such as HSJs,at medium altitudes on its *** results also demonstrate that a lunar based imager(e.g.,Lunar Environment heliospheric X-ray Imager,LEXI)is expected to observe a localized brightening of the magnetosheath during HSJ events in the meridian *** preliminary results might contribute to the pre-studies for the SMILE and LEXI missions by providing qualitative and quantitative soft X-ray estimates of dayside kinetic processes.

关键词： collisionless shock SMILE mission foreshock

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The hard X-ray nanoprobe beamline at the SSRF

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Nuclear Science and Techniques 2024年第7期35卷 79-88页

作者： Yan He Hui Jiang Dong-Xu Liang Zhi-Sen Jiang Huai-Na Yu Hua Wang Cheng-Wen Mao Jia-Nan Xie Ai-guo Li Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai201210China

The hard X-ray nanoprobe beamline BL13U is a phase-Ⅱ beamline project at the Shanghai Synchrotron Radiation *** beamline aims to enable comprehensive experiments at high spatial resolutions ranging from 50 to 10 nm. The X-ray energy range of the beamline, 5–25 keV, can detect most elements in the periodic table. Two operating modes were designed to accommodate the experimental requirements of high-energy resolution or high photon flux, respectively. X-ray nanofluorescence, nanodiffraction, and coherent diffraction imaging are developed as the main experimental techniques for BL13U. This paper describes the beamline optics, end station configurations, experimental methods under development, and preliminary test results. This comprehensive overview aims to provide a clear understanding of the beamline capabilities and potential applications.

关键词： Shanghai synchrotron radiation facility Hard X-ray nanoprobe X-ray nanofocusing

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Dynamic tracking of exsolved PdPt alloy/perovskite catalyst for efficient lean methane oxidation

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Chinese Chemical Letters 2024年第4期35卷 170-175页

作者： Yanling Yang Zhenfa Ding Huimin Wang Jianhui Li Yanping Zheng Hongquan guo Li Zhang Bing Yang Qingqing Gu Haifeng Xiong Yifei Sun College of Energy Xiamen UniversityXiamen 361005China School of Environment and Civil Engineering Dongguan University of TechnologyDongguan 523808China Department of Chemistry College of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China State Key Laboratory of Physical Chemistry of Solid Surfaces College of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China CAS Key Laboratory of Science and Technology on Applied Catalysis Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province(IKKEM) Xiamen 361102China

Supported Pd based catalysts are considered as the efficient candidates for low-carbon alkane oxidation for their outstanding capability to break C-H bond. Whereas, the irreversible deactivation of Pd based catalysts was still frequently observed. Herein, we reinforced the extruded Pd nanoparticles with quantitive Pt to assemble the evenly distributed Pd Pt nanoalloy onto ferrite perovskite(Pd Pt-LCF) matrix with strengthened robustness of metal/oxide support interface. We further co-achieved the enhanced performance, anti-overoxidation as well as resistance of vapor-poisoning in durability measurement. The operando X-ray photoelectron spectroscopy(O-XPS) combined with various morphology characterizations confirms that the accumulation of surface deep-oxidation species of Pd^(4+) is the culprit for fast activity loss in exsolved Pd system, especially at high temperature of 400 ℃. Conversely, it could be completely suppressed by in-situ alloying Pd with equal amount of Pt, which helps maintain the metastable Pd^(2+)/Pd shell and metallic solid-solution core structure. The density function theory(DFT) calculations further buttress that the dissociation of C–H was facilitated on alloy/perovskite interface which is, on the contrary, resistant toward O–H bond cleavage, as compared to Pd/perovskite. Our work suggests that the modification of exsolved metal/oxide catalytic interface could further enrich the toolkit of heterogeneous catalyst design.

关键词： Exsolution PdPt alloy Operando characterization Methane conversion Deep-oxidation

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