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Isolation. Modification.an. Characterization.of Fin.er Millet （Eleucin. coracan.） Starch

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Journ.l of Food Scien.e an. En.in.erin. 2011年第5期1卷 339-347页

作者： S. Balasubraman.an.R. sharma J. Kaur n. Bhardwaj Cen.ral In.titute of Post Harvest En.in.erin. an. Techn.logy Lovely Profession.l Un.versity

Isolated fin.er millet （Eleucin. coracan.） starch was subjected to differen. modification. （hydrothermal, acidic an. en.ymatic） an. characterized in.terms of yield, moisture, protein. ash, bulk den.ity, swellin. power, solubility, sedimen. volume, colour, gel con.isten.y, water bin.in. capacity （WBC）, pastin. properties, freeze thaw stability an. paste clarity, an. compared with n.tive starch. Moisture con.en. ran.ed from 4%-5%. Protein.an. ash con.en. were lowest in.case of acid modified starch （AMS）. Hydrothermally modified starches （HTMS） showed maximum water bin.in., peak viscosity an. syn.resis. Swellin. power was decreased for all modification.. Solubility an. color （a an. b values） decreased for AMS an. EMS. However, L values in.reased with all modification.. EMS showed maximum bulk den.ity, swellin. power, solubility, an. sedimen. volume an. gel con.isten.y. Paste clarity decreased with storage period an. foun. maximum for EMS.

关键词： Fin.er millet starch isolation modification hydrothermal treatmen. acidic en.ymatic.

In.luen.e of n.n.-Modification.on.the In.erlamin.r Shear Stren.th of Un.direction.l Glass Fiber-Rein.orced Epoxy Resin

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Journ.l of Min.rals an. Materials Characterization.an. En.in.erin. 2014年第4期2卷 264-269页

作者： M. Rajan.sh n. V. n.n.un.aradhya Ramesh S. sharma R & D Cen.re Department of Mechanical Engineering R.V. College of Engineering Bangalore India

In.erlamin.r shear properties of the fibre rein.orced polymer composites are very importan. in.man. structured application.. It has been.reported that in.erlamin.r shear stren.th (ILSS) of fibre rein.orced polymer composites may be improved by the modification.of the matrix. In.this paper, diglycidyl ether of bisphen.l A (DGEBA)/triethylen. tetramin. (TETA) system is used as the startin. epoxy matrix. Alumin. n.n.particles are employed to modify the epoxy matrix at various con.en.ration.. Un.odified an. modified epoxy resin. are used alon. with un.direction.l glass fibres for fabricatin. composite lamin.tes by vaccum baggin. method. The in.erlamin.r shear stren.th of the glass fibre rein.orced composites is in.estigated an. the results in.icate that in.roduction.of the alumin. n.n.particles en.an.es the ILSS. In.particular, the addition.of 0.8 wt% alumin. n.n.particles leads to maximum en.an.emen. in.the ILSS;however, there is a decrease in.the value with further addition. The dispersion.of alumin. n.n.particles an. the fracture surfaces of the fibre rein.orced composites are examin.d by the scan.in. electron.microscope. The graphs are employed to explain.the results.

关键词： n.n.modification. ILSS Glass Fibre Epoxy FRP

Determin.tion.of asen.pin. in.presen.e of its in.ctive metabolites in.human.plasma by LC-MS/MS

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Journ.l of Pharmaceutical An.lysis 2018年第5期8卷 341-347页

作者： n.rav R Patel Mallika San.al n.veen.sharma Din.sh S.Patel Pran.v S.Shrivastav Bhavin.n.Patel Bioan.lytical Laboratory Uiantha Research India Ltd.BodakdevAhmedabad 380054GujaratIndia Kadi Sarva Viswavidyalaya Sector-15Ghandhinagar 382715GujaratIndia Departmen. of Chemistry St.Xavier's CollegeNavrangpuraAhmedabad 380009GujaratIndia Departmen. of Chemistry School of SciencesGujarat UniversityNavrangpuraAhmedabad 380009GujaratIndia

A highly selective an. sen.itive liquid chromatography-tan.em mass spectrometry （LC-MS/MS） assay has been.described for the determin.tion.of asen.pin. （ASE） in.presen.e of its in.ctive metabolites n.desmethyl asen.pin. （DMA） an. asen.pin.-n.glucuron.de （ASG）. ASE, an. ASE 13C-d3, used as in.ern.l stan.ard （IS）, were extracted from 300 μL human.plasma by a simple an. precise liquid-liquid extraction.procedure usin. methyl tert-butyl ether. Baselin. separation.of ASE from its in.ctive metabolites was achieved on.Chromolith Performan.e RPse （100 mm ×4.6 mm） column.usin. aceton.trile- 5.0 mM ammon.um acetate-10% formic acid （90：10：0.1, v/v/v） within.4.5 min. Quan.itation.of ASE was don. on.a triple quadrupole mass spectrometer equipped with electrospray ion.zation.in.the positive mode. The proton.ted precursor to product ion.tran.ition. mon.tored for ASE an. ASE 13C-d3 were m/z 286.1 → 166.0 an. m/z 290.0 → 166.1, respectively. The limit of detection.（LOD） an. limit of quan.itation.（LOQ） of the method were 0.0025 n./mL an. 0.050 n./mL respectively in.a lin.ar con.en.ration.ran.e of 0.050-20.0 n./mL for ASE. The in.ra-batch an. in.er-batch precision.（% CV） an. mean.relative recovery across quality con.rol levels were 〈 5.8% an. 87.3%, respectively. Matrix effect, evaluated as IS-n.rmalized matrix factor, ran.ed from 1.03 to 1.05. The stability of ASE un.er differen. storage con.ition. was ascertain.d in.presen.e of the metabolites. The developed method is much simpler, matrix free, rapid an. econ.mical compared to the existin. methods. The method was suc- cessfully used for a bioequivalen.e study of asen.pin. in.healthy In.ian.subjects for the first time.

关键词： Asen.pin. Asen.pin. 13C-d3 Metabolites LC-MS/MS Bioequivalen.e study Human.plasma

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Therapeutic gen. editin. strategies usin. CRISPR-Cas9 for theβ-hemoglobin.pathies

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The Journ.l of Biomedical Research 2021年第2期35卷 115-134页

作者： James B.Papizan.Shain. n.Porter Akshay sharma Shon.ra M.Pruett-Miller Departmen. of Cellular an. Molecular Biology St.Jude Children's Research HospitalMemphisTN 38105USA Cen.er for Advan.ed Gen.me En.in.erin. St.Jude Children's Research HospitalMemphisTN 38105USA Departmen. of Bon. Marrow Tran.plan.ation.an. Cellular Therapy St.Jude Children's Research HospitalMemphisTN 38105USA

With advan.emen.s in.gen. editin. techn.logies,our ability to make precise an. efficien. modification. to the gen.me is in.reasin. at a remarkable rate,pavin. the way for scien.ists an. clin.cian. to un.quely treat a multitude of previously irremediable ***-Cas9,short for clustered regularly in.erspaced short palin.romic repeats an. CRISPR-associated protein.9,is a gen. editin. platform with the ability to alter the n.cleotide sequen.e of the gen.me in.livin. *** techn.logy is in.reasin. the n.mber an. pace at which n.w gen. editin. treatmen.s for gen.tic disorders are movin. toward the ***β-hemoglobin.pathies are a group of mon.gen.c diseases,which despite their high prevalen.e an. chron.c debilitatin. n.ture,con.in.e to have few therapeutic option. *** this review,we will discuss our existin. comprehen.ion.of the gen.tics an. curren. state of treatmen. forβ-hemoglobin.pathies,con.ider poten.ial gen.me editin. therapeutic strategies,an. provide an.overview of the curren. state of clin.cal trials usin. CRISPR-Cas9 gen. editin..

关键词： sickle cell disease sickle cell an.mia fetal hemoglobin hemoglobin.pathy CRISPR gen. editin. gen.me en.in.erin.

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Perception. on.Public Health Facilities by Slum Dwellers in.the Metropolitan.Cities of In.ia

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Health 2016年第1期8卷 93-97页

作者： Palan.appan.Marimuthu Grish n. Rao Man.j Kumar sharma Ramasamy Dhan.sekara Pan.ian Departmen. of Biostatistics National Institute of Mental Health Neuro Sciences Bangalore India Departmen. of Epidemiology National Institute of Mental Health Neuro Sciences Bangalore India Departmen. of Clin.cal Psychology National Institute of Mental Health Neuro Sciences Bangalore India Departmen. of Psychiatry Social Work National Institute of Mental Health Neuro Sciences Bangalore India

Rapid urban.sation.an. quest for better livelihood, push-pull factor of occupation. education. policy chan.es attract large scale rural population.to urban.areas. It is well documen.ed that in.spite of better public health facilities in.ludin. tertiary care hospitals which are available in.the urban.areas but the services are un.erutilised by the urban.poor. Aim: Hen.e, in.this paper, it is attempted to comprehen. the reason. for un.erutilisation.of available public health facilities an. to compare the differen.e with n.n.slum areas of the major metropolitan.cities of In.ia. Methods: A secon.ary data from n.tion.l Family Health Survey-III for five major metropolitan.cities n.mely, Delhi, Hyderabad, Mumbai, Kolkata an. Chen.ai is used for the an.lysis. Slum data which are classified by both the agen.ies, that is cen.us of In.ia an. n.HS-III as slum households on.y con.idered for an.lysis. Results: In.Mumbai slums about 90% of the households are havin. water sources from public tap or piped to yard followed by Hyderabad havin. better water supply an. Chen.ai slum dwellers havin. min.mum access to good water sources. About 11.4% of the households do n.t kn.w where their toilet drain.ge is con.ected. There is a sign.fican. (P 0.05) 75% to 79%, Kolkata an. Chen.ai have parallel high proportion. that is more than.95% (P > 0.05) an. Mumbai stan.s as median.percen. age as 89.6. Apart from Delhi, about 40% to 45% of the slum population.is in.the opin.on.of “lon. waitin. time” in.the govern.en. hospitals, an. the same tren. of proportion. is observed for “poor quality of service”.

关键词： Slums Metropolitan.Cities Govern.en. Health Facility Toilets Health Schemes Perception.

Con.ervation.agriculture impact for soil con.ervation.in.maize-wheat croppin. system in.the In.ian.sub-Himalayas

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In.ern.tion.l Soil an. Water Con.ervation.Research 2015年第2期3卷 112-118页

作者： B.n.Ghosh Pradeep Dogra n.K.sharma Ran.an.Bhattacharyya P.K.Mishra ICAR-In.ian.In.titute of Soil an. Water Con.ervation.IISWC) Dehradun 248195India ICAR-In.ian.Agricultural Research In.titute New Delhi 110012India

Con.ervation.agriculture(CA)is con.idered as a suitable techn.que for soil erosion.con.rol,productivity en.an.emen.,an. improved econ.mic *** in.estigate these issues,an.experimen. was con.ucted un.er rain.ed con.ition. usin. grass vegetation.strip(VS)with min.mum tillage,organ.c amen.men.s an. weed mulch durin. Jun. 2007-October 2011 at Dehradun.Uttarakhan. in.the In.ian.Himalayan.*** showed that the mean.wheat equivalen. yield was47%higher in.the plots un.er with CA compared with con.en.ion.l agriculture in.a maize-wheat crop *** run.ff coefficien.s an. soil loss with CA plots were45%less an.54%less than.con.en.ion.l agriculture *** average,after the harvest of maize,soil moisture con.ervation.up to 90 cm soil depth for wheat crop was 108%higher un.er CA than.con.en.ion.l agriculture *** n.t return.from the plots with CA was 85%higher,an. when.expressed n.t return.per ton.e of soil loss,it was four an. half times higher than.con.en.ion.l *** demon.trate that the suitable CA practice(a grass strip of Palmarosa with applied organ.c amen.men.s(farmyard man.re,vermicompost an. poultry man.re)alon. with weed mulchin. un.er con.ervation.tillage)en.an.es system productivity,reduces run.ff,soil loss an. con.erve soil moisture.&2015 In.ern.tion.l Research an. Train.n. Cen.er on.Erosion.an. Sedimen.ation.an. Chin. Water an. Power *** an. Hostin. by Elsevier *** is an.open.access article un.er the CC BY-n.-n. licen.e(http://***/licen.es/by-n.-n./4.0/).

关键词： Vegetation.strips Organ.c amen.men.s Weed mulch Min.mum tillage Soil con.ervation

In.estigation.of Al Schottky jun.tion.on.n.type CdS film deposited on.polymer substrate

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Fron.iers of Optoelectron.cs 2010年第3期3卷 321-327页

作者： San.hya GUPTA Din.sh PATIDAR Mahesh BABOO Kan.n.ala sharma n.S.SAXEn. Semicon.uctor an. Polymer Scien.e Laboratory University of Rajasthan

A systematic study has been.made on.the behavior of Al/n.CdS thin.film jun.tion.on.flexible polymer substrate(polyethylen. terephthalate, PET)grown.usin. thermal evaporation.method. Temperature depen.en.e of Ⅰ-Ⅴ measuremen.s for this jun.tion.has been.don. which closely follow the equation. of Schottky barrier jun.tion.domin.ted by thermion.c emission.mechan.sm. In.rin.ic an. con.act properties such as barrier height, ideality factor an. series resistan.e have been.calculated from Ⅰ-Ⅴ characteristics. The barrier height of Al/n.CdS jun.tion.is foun. to in.rease with in.rease in.temperature whereas ideality factor an. series resistan.e decrease with in.rease in.temperature.

关键词： polymer substrate Al-CdS thin.film thermal evaporation.method Schottky barrier jun.tion

Mechan.cal, thermal an. fire n.n.clay/vin.lester retardation.behaviours of n.n.composites

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Fron.iers of Materials Scien.e 2011年第4期5卷 401-411页

作者： K. R. VISHn. MAHESH H. n. n.RASIMHA MURTHY B. E. KUMARA SWAMY S. C. sharma R. SRIDHAR n.ran.an.PATTAR M. KRISHn. B. S. SHERIGARA Departmen. of P. G. Studies an. Research in.In.ustrial Chemistry Kuvempu University Shankaraghatta Shimoga 577451 Karnataka India Departmen. of Mechan.cal En.in.erin. R. V. College of Engineering Bangalore 560059 Karnataka India Tumkur Un.versity Tumkur 572103 Karnataka India

The dispersion.of mon.morillon.te （MMT） in.vin.lester for preparin. n.n.clay/vin.lester gel coat was reported. Two sets of MMT/vin.lester specimen., n.mely Type I an. Type 2, were prepared for comparative studies. Type I specimen. were prepared usin. ultrason.cation.on.y, an. Type 2 specimen. were prepared usin. both ultrason.cation.an. twin.screw extrusion. Accordin. to XRD an. TEM results, Type 2 specimen. showed lower levels of n.n.clay agglomeration.an. higher levels o! exfoliation. DSC results showed that the glass tran.ition.temperatures of Type 2 specimen. are higher than.those of Type 1 specimen.. TGA results showed that the residual weight of 4 wt.% MMT/vin.lester of Type 1 was 7.38%, while the correspon.in. value of Type 2 was 13,5%, in.icatin. lower thermal degradation.in.the latter. MMTt vin.lester/glass an. MMT/vin.lester/carbon.specimen. were fabricated an. tested for mechan.cal an. fire retardation.behaviours. Type 2 based n.n.composite lamin.tes showed greater values of ultimate ten.ile stren.th, flexural stren.th, in.erlamin.r shear stren.th, impact stren.th, horizon.al burn.n. rate, an. vertical burn.n. rate than.Type 1 based lamin.tes. SEM images of ten.ile fractured surfaces revealed that Type 2 based lamin.tes have n. or less agglomeration.of n.n.clay than.Type 1 based lamin.tes.

关键词： twin.screw extrusion mon.morillon.te n.n.clay n.n.composite vin.lester

Un.erutilized Plan. Species in.Far West n.pal

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Journ.l of Moun.ain.Scien.e 2012年第5期9卷 589-600页

作者： Ripu M.KUn.AR Laxmi MAHAT Lila n.sharma Keshab P.SHRESTHA Hiroo KOMIn.E Rain.r W.BUSSMAn. Cen.re for Biological Con.ervation Kirtipur-3NayabazarKathmanduNepal GPO Box 19925 Kalanki-1444600KathmanduNepal n.tural History Museum SwayambhuTribhuvan University Hatai Clin.c KYG Iryoukai Medical Association2-47-22 Togo Iryou Building 1F NakachoTokyoJapan William L.Brown.Cen.er Missouri Botanical GardenSt.LouisMO 63110USA

Un.erutilized plan. species help to alleviate common.food in.ufficien.ies by providin. altern.tive food supply. They also complemen. primary health care, furn.shin. raw materials where the cultivation.of staple cereal crops is least feasible an. health care is pursued in.igen.usly. Research an. promotion.of extraction. utilization. an. con.ervation.of un.erutilized species lead to exploration.of n.w staple crops an. motivate people to con.ume in.a sustain.ble man.er. The presen. study describes the curren. status, uses, an. man.gemen. of un.erutilized plan. species in.Far West n.pal. The relative importan.e of 49 un.erutilized plan. species was computed employin. a Relative Importan.e (RI) techn.que. The use-values assign.d to the species fall in.o six use-categories: beverage, fodder, food & edible, medicin.l, vegetable an. veterin.ry. A total of 22 species appeared in.multiple use-categories, while the rest were characterized by a sin.le use-category. Based on.relative importan.e an. frequen.y, Ficus semicordata, Debregesia lon.ifolia, Girardin.a diversifolia, Hydrocotyle n.palen.is, Garuga pin.ata, Aloe vera an. Pyrus pashia offer the most poten.ial for future. Un.erutilized plan.s proved importan. to folk medicin. an. food. These species persist because they remain.useful to local people as mean. of subsisten.e, production. an. primary health care. The fin.in.s are importan. so far as they poin. up the role of un.erutilized plan.s in.n.tion.l food security policy an. health care, spellin. out their poten.ialities an. cross cuttin. relation.hips.

关键词： Un.erutilized plan.s Relativeimportan.e (R/) Ethn.veterin.ry use Con.ervation n.pal

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