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EGFR signaling augments TLR4 cell surface expression and function in macrophages via regulation of Rab5a activation

Protein & Cell 2020年第8期11卷 144-149页

作者： Jing Tang Bowei Zhou Melanie JScott Linsong Chen Dengming Lai Erica kFan Yuehua Li Qiang Wu Timothy RBilliar mark AWilson Ping Wang Jie Fan The Department of Anesthesiology Affiliated hospital of Guangdong Medical UniversityZhanjiang 524000China Department of Surgery University of Pittsburgh School of MedicinePittsburghPA 15213USA Research and Development Veterans Affairs Pittsburgh Healthcare SystemPittsburghPA 15240USA Department of Anesthesiology Nanfang HospitalSouthern Medical UniversityGuangzhou 510515China Department of Thoracic Surgery Shanghai Pulmonary HospitalTongji University School of MedicineShanghai 200433China Department of Cardiovascular Surgery The Children's Hospital of Zhejiang University School of MedicineHangzhou 310052China University of Pittsburgh The Graduate School of Public Health PittsburghPA 15213USA Laboratory of Tropical Biomedicine and Biotechnology School of Tropical Medicine and Laboratory MedicineHainan Medical UniversityHaikou 571199China The Feinstein Institute for Medical Research ManhassetNY 11030USA McGowan Institute for Regenerative Medicine University of PittsburghPittsburghPA 15219USA key Laboratory of Organ Injury/Protection and Translational Medicine of Zhanjiang Zhanjiang 524000China

Dear Editor,oll-like receptor 4(TLR4)is a key receptor sensing bacterial lipopolysaccharide(LPS),and is the most investigated member of the Tol-like receptor family(kawai and Akira,2007;kayagaki et al,2013;klein et al.,2015).Cell surface TLR4 expression is determined by the balance between receptor trafficking from the Golgi apparatus to the cell membrane,and internalization of the cell surface receptor into endosomal compartments(Saltoh,2009).In bone mar-row-derived macrophages(BMDM),we observed LPS-in-duced EGFR phosphorylation on the surface of BMDM,and this was inhibited by pretreatment with PD168393 or TAPI-1(Fig.S1).Next,we measured dynamic changes in cell sur-face TLR4 expression after LPS ***6,12,and 24 h after LPS treatment,TLR4 expression on the surface of BMDM was increased^2-,~6-,and^9-fold,respectively,as compared with controls.

关键词： PD1 TLR4 inhibited

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Fungal diversity notes 1512–1610: taxonomic and phylogenetic contributions on genera and species of fungal taxa

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Fungal Diversity 2022年第6期117卷 1-272页

作者： Ruvishika S.Jayawardena kevin D.Hyde Song Wang Ya‑Ru Sun Nakarin Suwannarach Phongeun Sysouphanthong Mohamed A.Abdel‑Wahab Faten A.Abdel‑Aziz Pranami D.Abeywickrama Vanessa P.Abreu Alireza Armand AndréAptroot Dan‑Feng Bao Dominik Begerow Jean‑Michel Bellanger Jadson D.P.Bezerra Digvijayini Bundhun mark S.Calabon Ting Cao Taimy Cantillo João LVRCarvalho Napalai Chaiwan Che‑Chih Chen Régis Courtecuisse Bao‑kai Cui Ulrike Damm Cvetomir M.Denchev Teodor T.Denchev Chun Y.Deng Bandarupalli Devadatha Nimali Ide Silva Lidiane Ados Santos Nawal k.Dubey Sylvain Dumez Himashi SFerdinandez André L.Firmino Yusufon Gaforov Achala J.Gajanayake Deecksha Gomdola Sugantha Gunaseelan Shucheng‑He Zin H.Htet Malarvizhi kaliyaperumal martin kemler kezhocuyi kezo Nuwan Dkularathnage marco Leonardi Ji‑Peng Li Chunfang Liao Shun Liu Michael Loizides Thatsanee Luangharn Jian Ma Hugo Madrid S.Mahadevak.mar Sajeewa S.N.Maharachchikumbura Dimuthu S.Manamgoda maría P.martín Niranjan Mekala Pierre‑Arthur Moreau Yan‑Hong Mu Pasouvang Pahoua Dhandevi Pem Olinto L.Pereira Wiphawanee Phonrob Chayanard Phukhamsakda Mubashar Raza Guang‑Cong Ren Andrea C.Rinaldi Walter Rossi Binu C.Samarakoon Milan CSamarakoon Vemuri V.Sarma Indunil C.Senanayake Archana Singh maria F.Souza Cristina M.Souza‑Motta Adriano A.Spielmann Wenxin Su Xia Tang XingGuo Tian kasun M.Thambugala Naritsada Thongklang Danushka S.Tennakoon Nopparat Wannathes DingPeng Wei Stéphane Welti Subodini N.Wijesinghe Hongde Yang Yunhui Yang Hai‑Sheng Yuan Huang Zhang Jingyi Zhang Abhaya Balasuriya Chitrabhanu SBhunjun Timur S.Bulgakov Lei Cai Erio Camporesi Putarak Chomnunti Y.S.Deepika Mingkwan Doilom Wei‑Jun Duan Shi‑Ling Han Naruemon Huanraluek EBGareth Jones NLakshmidevi Yu Li Saisamorn Lumyong Zong‑Long Luo Surapong khuna Jaturong kumla Ishara S.Manawasinghe Ausana Mapook Wilawan Punyaboon Saowaluck Tibpromma Yong‑Zhong Lu JiYe Yan Yong Wang Center of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand Innovative Institute for Plant Health Zhongkai University of Agriculture and EngineeringGuangzhou 510225P.R.China Department of Plant Pathology College of AgricultureGuizhou UniversityGuiyang 550025GuizhouChina Research Center of Microbial Diversity and Sustainable Utilization Chiang Mai UniversityChiang Mai 50200Thailand Department of Biology Faculty of ScienceChiang Mai UniversityChiang Mai 50200Thailand Biotechnology and Ecology Institute Ministry of Agriculture and ForestryP.O.Box:811Vientiane CapitalLao PDR Department of Botany and Microbiology Faculty of ScienceSohag UniversitySohag 82524Egypt Beijing key Laboratory of Environment-Friendly Management on Fruit Diseases and Pests in North China Institute of Plant ProtectionBeijing Academy of Agriculture and Forestry SciencesBeijing 100097China Departamento de Fitopatologia Universidade Federal de ViçosaViçosaMinas GeraisBrazil Laboratório de Botânica/Liquenologia Instituto de BiociênciasUniversidade Federal de Mato Grosso do SulAvenida Costa e Silva S/NBairro UniversitárioCampo GrandeMato Grosso do Sul CEP 79070-900Brazil College of Agriculture and Biological Sciences Dali UniversityDali 671003YunnanChina Department of Entomology and Plant Pathology Faculty of AgricultureChiang Mai UniversityChiang Mai 50200Thailand Institute of Plant Science and Microbiology Universität HamburgOrganismic Botany and MycologyOhnhorststr.1822609 HamburgGermany CEFE CNRSUniv.MontpellierEPHEIRDINSERM1919Route de Mende34293 Montpellier Cedex 5France Setor de Micologia Departamento de Biociências e TecnologiaInstituto de Patologia Tropical e Saúde PúblicaUniversidade Federal de GoiásRua 235S/NSetor UniversitárioGoiâniaGO CEP:74605-050Brazil Division of Biological Sciences College of Arts and SciencesUniversity of the Philippines Visayas5023 MiagaoIloiloPhilippines CA

This article is the 14th in the Fungal Diversity Notes series,wherein we report 98 taxa distributed in two phyla,seven classes,26 orders and 50 families which are described and *** in this study were collected from Australia,Brazil,Burkina Faso,Chile,China,Cyprus,Egypt,France,French Guiana,India,Indonesia,Italy,Laos,Mexico,Russia,Sri Lanka,Thailand,and *** are 59 new taxa,39 new hosts and new geographical distributions with one new *** 59 new species comprise Angustimassarina kunmingense,Asterina lopi,Asterina brigadeirensis,Bartalinia bidenticola,Bartalinia caryotae,Buellia pruinocalcarea,Coltricia insularis,Colletotrichum fexuosum,Colletotrichum thasutense,Coniochaeta caraganae,Coniothyrium yuccicola,Dematipyriforma aquatic,Dematipyriforma globispora,Dematipyriforma nilotica,Distoseptispora bambusicola,Fulvifomes jawadhuvensis,Fulvifomes malaiyanurensis,Fulvifomes thiruvannamalaiensis,Fusarium purpurea,Gerronema atrovirens,Gerronema favum,Gerronema keralense,Gerronema kuruvense,Grammothele taiwanensis,Hongkongmyces changchunensis,Hypoxylon inaequale,kirschsteiniothelia acutisporum,kirschsteiniothelia crustaceum,kirschsteiniothelia extensum,kirschsteiniothelia septemseptatum,kirschsteiniothelia spatiosum,Lecanora immersocalcarea,Lepiota subthailandica,Lindgomyces guizhouensis,marthe asmius pallidoaurantiacus,marasmius tangerinus,Neovaginatispora mangiferae,Pararamichloridium aquisubtropicum,Pestalotiopsis piraubensis,Phacidium chinaum,Phaeoisaria goiasensis,Phaeoseptum thailandicum,Pleurothecium aquisubtropicum,Pseudocercospora vernoniae,Pyrenophora verruculosa,Rhachomyces cruralis,Rhachomyces hyperommae,Rhachomyces magrinii,Rhachomyces platyprosophi,Rhizomarasmius cunninghamietorum,Skeletocutis cangshanensis,Skeletocutis subchrysella,Sporisorium anadelphiae-leptocomae,Tetraploa dashaoensis,Tomentella exiguelata,Tomentella fuscoaraneosa,Tricholomopsis lechatii,Vaginatispora favispora and Wetmoreana *** new combin

关键词： 59 New taxa 39 New records Ascomycota Basidiomycota Dothideomycetes Lecanoromycetes Leotiomycetes Sordariomycetes Ustilaginomycotina

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中国产紫菜属藻胆蛋白的研究

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海洋与湖沼 1985年第5期 417-420页

作者：潘忠正曾呈奎中国科学院海洋研究所中国科学院海洋研究所青岛

本研究以羟基磷灰石(Hydroxyla patite)为吸附剂的柱层析法分离和纯化了中国产紫菜属(Porphyra)6种紫菜——条斑紫菜(***)、少精紫菜(***)、华北半叶紫菜(*** ***)、甘紫菜(***)、坛紫菜(***)和边紫菜(***)——中的藻胆蛋白。吸收光谱... 详细信息

本研究以羟基磷灰石(Hydroxyla patite)为吸附剂的柱层析法分离和纯化了中国产紫菜属(Porphyra)6种紫菜——条斑紫菜(***)、少精紫菜(***)、华北半叶紫菜(*** ***)、甘紫菜(***)、坛紫菜(***)和边紫菜(***)——中的藻胆蛋白。吸收光谱测定的结果显示,R-藻红蛋白(R-phycoerythrin)和变藻蓝蛋白(Allophycocyanin)存在于所研究的6种紫菜中,而C-藻蓝蛋白(C-phycocyanin)只出现于甘紫菜、条斑紫菜、少精紫菜和华北半叶紫菜中,而R-藻蓝蛋白(R-phycocyanin)则只出现于坛紫菜和边紫菜中。

关键词：紫菜属藻红蛋白藻类色素条斑紫菜藻胆朊边紫菜种紫菜

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低剂量CT平扫显示正常阑尾:使用滑动板平均技术

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国际医学放射学杂志 2009年第4期32卷 393-393页

作者： S.M. Joo k.H. Lee Y.H. kim S.Y. kim k. kim k.J. kim 孙东辉（译）万业达（校） Department of Radiology Seoul National University Bundang Hospital Republic of Korea. 不详

目的回顾性对16或64层低剂量CT平扫影像采用滑动板平均技术,确定正常阑尾的显示率。方法本研究获机构伦理审查委员会批准,并免除知情同意。共有259例病人进行了16或64层CT低剂量平扫（平均有效剂量为1．7mSv）以评估泌尿系绞痛,其中37例... 详细信息

目的回顾性对16或64层低剂量CT平扫影像采用滑动板平均技术,确定正常阑尾的显示率。方法本研究获机构伦理审查委员会批准,并免除知情同意。共有259例病人进行了16或64层CT低剂量平扫（平均有效剂量为1．7mSv）以评估泌尿系绞痛,其中37例（143.3％）有阑尾切除史。3位阅片者使用滑动板平均技术回顾性复习薄层（层厚为O．67或2．00mm）影像并进行分级,分为阑尾不显示、不确切或部分显示、清晰及全部显示。以加权,c统计方法评估阅片者间的一致性。采用McNemar试验比较阅片者之间的敏感度。

关键词：阑尾切除 CT平扫低剂量伦理审查委员会 64层CT mar试验有效剂量统计方法

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结肠癌手术中主要营养血管的最佳结扎水平和肠切缘距肿瘤的距离:主要营养血管位置的影响

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世界核心医学期刊文摘（胃肠病学分册） 2006年第4期2卷 17-17页

作者： Hida J.-I Okuno k Yasutomi M. 尹勇 Department of Surgery Kinki University School of Medicine 377-2 Ohno-Higashi Osaka-Sayama Osaka 589-8511 Japan

PURPOSE: In colon cancer surgery, it is recommended that en bloc resection involving extended lymphadenectomy, characterized as a hemicolectomy, be performed by ligating the primary feeding artery at a high position and resecting proximal and distal with 5-cm to 10-cm bowel margins. However, there is little evidenc e to unequivocally support such extensive lymphovascular resection. METHODS: The distribution of nodal metastases was obtained by the clearing method in 164 pat ients with colon cancer. RESULTS: For pericolic spread, for pT1 tumors, the dist ance from the primary tumor to a diseased node was 2.5 cm; for pT2, the distance was less than 5 cm; for 97.0 percent of pT3 tumors and 93.3 percent of pT4 tumo rs with nodes involved, the distance was less than 7 cm. For central spread, for pT1 tumors, the rate of spread to central nodes was 0 percent; for pT2, the rat e of spread was 20.0 percent to intermediate nodes (for tumors more than 5 cm fr om the feeding artery, the rate for central nodes was 0 percent); for pT3, the r ate was 30.6 percent to intermediate nodes and 15.3 percent to main nodes; for p T4, the rate was 44.4 percent to intermediate nodes and 22.2 percent to main nod es. For curative resection cases with pT3 tumors more than 7 cm from the feeding artery, the rate to central nodes was 0 percent. CONCLUSIONS: In T1 tumors, cen tral node dissection is not required, but resection with proximal and distal 3cm margins are required; in T2, central node dissection that includes the intermed iate node should be performed in addition to resection with proximal and distal 5-cm margins. In T3 and T4, central node dissection that includes the main node should be performed in addition to resection with proximal and distal 7-cm mar gins. However, for T2 more than 5 cm from the primary feeding artery, and for T3 more than 7 cm from the primary feeding artery, proximal and distal resection a lone may be adequate.

关键词：结肠癌手术营养血管切缘中央淋巴结结肠切除术结肠癌患者淋巴结转移淋巴血管淋巴结清扫清

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P450cam突变体蛋白表达、纯化与结晶的改进及其四突变体(F87L/Y96F/L244A/V247A)晶体结构

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生物化学与生物物理进展 2004年第7期31卷 611-615页

作者：刘斌斌孙蕾徐峰娄智勇庞海 L.L.WONG 刘一苇清华大学结构生物学实验室 Department of Chemistry Inorganic Chemistry Laboratory University of Oxford U.K.

在P4 5 0cam突变体蛋白纯化过程中使用 2 80nm/ 392nm双波长比值检测蛋白质纯度 ,采用 β 巯基乙醇对蛋白质进行还原性保护 ,有效地缩短了纯化进程 ,纯化效率相应提高 .以PEG 80 0 0为沉淀剂经悬滴汽相扩散法筛选得到适合衍射的P4 5 0ca... 详细信息

在P4 5 0cam突变体蛋白纯化过程中使用 2 80nm/ 392nm双波长比值检测蛋白质纯度 ,采用 β 巯基乙醇对蛋白质进行还原性保护 ,有效地缩短了纯化进程 ,纯化效率相应提高 .以PEG 80 0 0为沉淀剂经悬滴汽相扩散法筛选得到适合衍射的P4 5 0cam四突变体 (F87L/Y96F/L2 4 4A/V2 4 7A)晶体 ,在mar Research面探测器系统上收集了0 2 2nm分辨率的X射线衍射数据 .采用同晶差值傅立叶法解析结构 ,最后的晶体学R因子和Rfree分别为 0 197和 0 2 4 7,键长偏差为 0 0 0 177nm ,键角偏差为 1 96°.结构测定显示P4 5 0cam四突变体 (F87L/Y96F/L2 4 4A/V2 4 7A)和P4 5 0cam野生型的整体构象无重大变化 ,突变后活性口袋变大而疏水性增加 ,这与突变设计预期目标一致 .

关键词： P450cam 四突变体纯化双波长检测晶体结构

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