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The path forward in prostate cancer therapeutics

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Asian Journal of Andrology 2018年第3期20卷 213-214页

作者： Jeanny B Aragon-Ching ravi a.madan Department of Genitourinary Medical Oncology Inova Schar Cancer Institute Fairfax VA 22031USA Genitourinary Malignancies Branch Center for Cancer Research National CancerInstitute National Institutes of Health BethesdaMD. USA

The last decade has seen remarkable advances in the treatment of prostatecancer. Until 2010, only docetaxel had demonstrated the ability to improve the survival in metastatic castration-resistant prostate cancer （mC...

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Perspectives on the clinical development of mmunotherapy in prostate cancer

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Asian Journal of Andrology 2018年第3期20卷 253-259页

作者： Lisa M Cordes James L Gulley ravi a.madan Clinical Center National Institutes of Health Bethesda MD 20892 USA Genitourinary Malignancies Branch Center for Cancer Research National Cancer Institute National Institutes of Health Bethesda MD 20892 USA

Despite impressive survival benefits with immunotherapy in patients with various solid tumors, the full potential of these agents in prostate cancer has yet to be realized. SipuleuceI-T demonstrated a survival benefit in this population, indicating that prostate cancer is an immunoresponsive disease; however, these results have not been matched by other agents. A large trial with ipilimumab in prostate cancer failed to meet its primary objective, and small trials with PD-1/PD-L1 inhibitors did not yield a significant improvement in overall response. However, several late-stage clinical trials are underway with other vaccines in prostate cancer. Reports of clinical benefit with immunotherapies, particularly when used in combination or a select population, have provided the framework to develop sound clinical trials. Understanding immunogenic modulation, antigen spread, biomarkers, and DNA-repair defects will also help mold future strategies. Through rational patient selection and evidence-based combination approaches, patients with prostate cancer may soon derive durable survival benefits with immunotherapies.

关键词： checkpoint inhibitor immunotherapy prostate cancer therapeutic vaccine

Repair and Restoration of the Historical Wellesley Bridge at Srirangapatna:A Case Study

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Journal of Smart Buildings and Construction Technology 2022年第1期4卷 28-39页

作者： madan Kumar L Pruthviraj S R ravi Kumar C M Department of Civil Engineering Department The National Institute of EngineeringMysoreKarnatakaIndia Department of Studies in Civil Engineering University B.D.T College of EngineeringDavangereIndia

The Historical Wellesley Bridge,built by the Krishnaraja Wadiyar under the supervision of Dewan Purnaih across river Cauvery at *** of bridge is got when heavy rainfall followed by heavy inflow from Cauvery Catchment area in Kodagu *** present,the Government of Karnataka has taken measures to do the restoration works using the same previously used materials with slight ***,in the present investigation the authors are doing a case study on the above structure by testing the ingredients of the materials used for it and also by conducting Non-Destructive Test on the structure to know its strength before and after *** on the test results obtained,the authors will give a conclusion with respect to durability *** addition to the above,the authors will test for few alternative materials i.e.,lime mortar with Cement(***2 Grade Masonary mortar).Finally,from the obtained test results here the authors can suggest suitable material for the structures.

关键词： Repair and restoration Scanning electron microscope(SEM)

Forestry Interventions and Groundwater Recharge, Sediment Control and Carbon Sequestration in the Krishna River Basin

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Open Journal of Forestry 2023年第4期13卷 368-395页

作者： Humachadakatte Ramachandra swamy Prabuddha.madan Prasad Singh Prathima Purushotham Baragur Neelappa Divakara Tattekere Nanjappa Manohara Basavarajaiah Shivamma Chandrashekar Namasivayam ravi Nimmala Mohan Reddy Ombir Singh Institute of Wood Science and Technology Bengaluru India AgriCapita Innotech Private Limited Bhopal India Forest Research Institute Dehradun India

It is a known fact that human activities have a significant impact on global rivers, making the task of rehabilitating them to their former natural state or a more semi-natural state quite challenging. The ongoing initiative called “Rejuvenation of Krishna River through Forestry Interventions” aims to contribute to the overall river rejuvenation program in the country. In this context, the effects of forestry interventions on the Krishna River will be evaluated based on water quantity, water quality, and the potential for carbon sequestration through plantation efforts. To assess the outcomes of this study, various methodologies such as Soil Conservation Service Curve Number (SCS-CN), Central Ground Water Board (CGWB) and Intergovernmental Panel on Climate Change (IPCC) have been utilized to estimate water savings, reduction in sedimentation, and carbon sequestration potential within the Krishna basin. The projected results indicate that the implementation of forestry plantations and soil and moisture conservation measures in the Krishna River rejuvenation program could lead to significant improvements. Specifically, the interventions are expected to enhance water recharge by 400.49 million cubic meters per year, reduce sedimentation load by 869.22 cubic meters per year, and increase carbon sequestration by 3.91 lakh metric tonnes per year or 14.34 lakh metric tonnes of CO2 equivalent. By incorporating forestry interventions into the Krishna riverscape, it is anticipated that the quality and quantity of water flowing through the river will be positively impacted. These interventions will enhance water infiltration, mitigate soil erosion, and contribute to an improved vegetation cover, thereby conserving biodiversity. Moreover, they offer additional intangible benefits such as addressing climate change concerns through enhanced carbon sequestration potential along the entire stretch of riverine areas.

关键词： Forestry Interventions Krishna River Basin Sediment Control Water Recharge Carbon Sequestration