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Bioengineering breakthroughs:The impact of stem cell models on advanced therapy medicinal product development

World Journal of Stem Cells 2024年第10期16卷 860-872页

作者： José Mauro Granjeiro Priscila Grion de miranda Borchio Icaro Paschoal Brito Ribeiro Katiucia Batista Silva Paiva Division of Biological Metrology The National Institute of MetrologyQualityand TechnologyDuque de Caxias 25250020Rio de JaneiroBrazil Laboratory of Regenerative Medicine Arthur SáEarp Neto UniversityPetropolis 25680120Rio de JaneiroBrazil Laboratory of Extracellular Matrix Biology and Cellular Interaction Department of AnatomyInstitute of Biomedical SciencesUniversity of São PauloSão Paulo 05508000São PauloBrazil

The burgeoning field of bioengineering has witnessed significant strides due to the advent of stem cell models,particularly in their application in advanced therapy medicinal products(ATMPs).In this review,we examine the multifaceted impact of these developments,emphasizing the potential of stem cell models to enhance the sophistication of ATMPs and to offer alternatives to animal *** cell-derived tissues are particularly promising because they can reshape the preclinical landscape by providing more physiologically relevant and ethically sound platforms for drug screening and disease *** also discuss the critical challenges of reproducibility and accuracy in measurements to ensure the integrity and utility of stem cell models in research and ***,this review highlights the imperative of stem cell models to align with regulatory standards,ensuring using stem cells in ATMPs translates into safe and effective clinical *** regulatory approval serving as a gateway to clinical adoption,the collaborative efforts between scientists and regulators are vital for the progression of stem cell applications from bench to *** advocate for a balanced approach that nurtures innovation within the framework of rigorous validation and regulatory compliance,ensuring that stem cell-base solutions are maximized to promote public trust and patient health in ATMPs.

关键词： Stem cells Advanced therapy medicinal products Tissue-engineered products Health Three-dimensional cell culture

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Role of the Americans with Disabilities Act in Parental Rights Court Cases

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Cultural and Religious Studies 2014年第1期2卷 1-10页

作者： miranda Sue terry Stephen F. Austin State University Naeogdoehes U.S.A

In this paper, media provides a means of thinking critically about the role of ADA regulations should play in parental fights for individuals with mental disabilities, specifically mental illness, developmental disabilities, and brain injuries. Congress passed the Americans with Disabilities Act more than 20 years ago to ensure the rights of individuals with disabilities, including parental rights. Title II of the ADA applies to decisions made in the courtroom and other governmental agencies, which include child custody cases and termination of parental rights. ＂Reasonable Accommodations＂ is one requirement of the ADA to make society more inclusive for individuals with disabilities, even in the realm of parenting. Under Title II, such modifications would include parenting classes, homecare assistance, support groups, community resources, and counseling. Through a critical examination of experiences as depicted through media and court case analyses of parents with mental disabilities, this paper argues that challenging the idea that individuals with disabilities cannot or should not be parents must start in the courtroom, by changing the attitudes and perceptions of judges presiding over child custody cases and termination of parental rights cases involving parents with mental disabilities.

关键词： Americans with Disabilities Act parental rights court cases people with disabilities

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Endoscopic ultrasonography guided drainage:Summary of consortium meeting,May 21,2012,San Diego,California

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World Journal of Gastroenterology 2015年第3期21卷 726-741页

作者： Michel Kahaleh Everson LA Artifon Manuel Perez-miranda Monica Gaidhane Carlos Rondon Takao Itoi Marc Giovannini Division of Gastroenterology and Hepatology Department of MedicineWeill Cornell Medical CenterNew YorkNY 10021United States Department of Surgery University of Sao Paulo Medical SchoolSao Paulo 05403-000Brazil Endoscopy Unit Hospital Universitario Rio Hortega47012 ValladolidSpain Department of Gastroenterology and Hematology Tokyo Medical UniversityTokyo 160-0023Japan Department of Gastroenterology PaoliCalmettes Institute13273 MarseilleFrance

Endoscopic retrograde cholangiopancreatography(ERCP) is the preferred procedure for biliary and pancreatic *** ERCP is successful in about 95% of cases,a small subset of cases are unsuccessful due to altered anatomy,peri-ampullary pathology,or malignant *** ultrasound-guided drainage is a promising technique for biliary,pancreatic and recently gallbladder decompression,which provides multiple advantages over percutaneous or surgical biliary *** retrospective and some prospective studies have shown endoscopic ultrasoundguided drainage to be safe and *** on the currently reported literature,regardless of the approach,the cumulative success rate is 84%-93% with an overall complication rate of 16%-35%.endoscopic ultrasoundguided drainage seems a viable therapeutic modality for failed conventional drainage when performed by highly skilled advanced endoscopists at tertiary centers with expertise in both echo-endoscopy and therapeutic

关键词： Endoscopic ultrasound Endoscopic ultrasoundguided

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Nutritional supplementation on wound healing in diabetic foot:What is known and what is new?

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World Journal of Diabetes 2022年第11期13卷 940-948页

作者： Andrea Da Porto Cesare miranda Gabriele Brosolo Giorgio Zanette Andrea Michelli Roberto Da Ros Department of Internal Medicine Clinic of Endocrinology and Metabolism Diseases Azienda Sanitaria Friuli OccidentalePordenone 33170Italy Department of Internal Medicine SC Diabete e Centro Trattamento Piede DiabeticoMonfalcone 34074GoriziaItaly

Non-healing diabetic foot ulcers(DFU)are the most notable and striking complications of diabetes *** than 25% of nonhealing DFU can ultimately lead to amputation of the lower extremity within 6-18 mo after the first manifestation of the *** wound healing is complex,nutritional status is crucial in soft tissue *** is highly prevalent and overlooked in patients with diabetes and chronic ***,to date,we do not have clear recommendations or evidence about the use of nutritional supplements for improving wound healing in patients with *** this article the authors briefly analyzed the current evidence on the use of nutritional supplements of proteins or amino acids,fatty acids,probiotics,vitamins,and trace elements in the wound healing process in patients with DFU.

关键词： Malnutrition Supplements Diabetic foot Diabetes Wound healing Nutritional therapy

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Host-parasite interactions in perpetual darkness:Macroparasite diversity in the cavefish Astyanax mexicanus

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Zoological Research 2023年第4期44卷 782-792页

作者： Ana Santacruz David Hernández-Mena Ramses miranda-Gamboa Gerardo Pérez-Ponce De León Claudia Patricia Ornelas-García Departamento de Zoología Instituto de BiologíaUniversidad Nacional Autónoma de MéxicoMéxico City CP 04510México Departamento de Sistemas y Procesos Naturales Escuela Nacional de Estudios Superiores Unidad MéridaUcúYucatán CP 97357México Instituto de Energías Renovables Universidad Nacional Autónoma de MéxicoTemixcoMorelos CP 62580México Colección Nacional de Peces Departamento de ZoologíaInstituto de BiologíaUniversidad Nacional Autónoma de MéxicoMéxico City CP 04510México Stowers Institute for Medical Research Kansas CityMO 64110USA

Astyanax mexicanus has repeatedly colonized cave environments,displaying evolutionary parallelisms in many troglobitic *** being a model system for the study of adaptation to life in perpetual darkness,the parasites that infect cavefish are practically *** this study,we investigated the macroparasite communities in 18 cavefish populations from independent lineages and compared them with the parasite diversity found in their sister surface fish populations,with the aim of better understanding the role that parasites play in the colonization of new *** the cavefish populations,we identified 13 parasite taxa,including a subset of 10 of the 27 parasite taxa known for the surface *** infecting the cavefish belong to five taxonomic groups,including trematodes,monogeneans,nematodes,copepods,and *** are the most dominant group,found in 14 *** macroparasites include species with direct life cycles and trophic transmission,including invasive ***,paired comparisons indicate higher parasite richness in the cavefish than in the surface *** variation in parasite composition across the caves suggests historical and geographical contingencies in the host-parasite colonization process and potential evolution of local *** base-line data on parasite diversity in cavefish populations of *** provides a foundation to explore the role of divergent parasite infections under contrasting ecological pressures(cave *** environments)in the evolution of cave adaptive traits.

关键词： Adaptation Metazoan parasites Niche change Parasite assemblage Prevalence

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Myenteric neurons and intestinal mucosa of diabetic rats after ascorbic acid supplementation

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World Journal of Gastroenterology 2008年第42期14卷 6518-6524页

作者： Priscila de Freitas Maria Raquel Maral Natali Renata Virginia Fernandes Pereira Marcilio Hubner miranda Neto Jacqueline Nelisis Zanoni Department of Morphophysiological Sciences Enteric Neurons LaboratoryState University of Maringá Avenida Colombo 5790 Maringá87020-900 Paraná Brazil

AIM: To investigate the effect of ascorbic acid (AA) dietary supplementation on myenteric neurons and epithelial cell proliferation of the jejunum of adult rats with chronic diabetes mellitus. METHODS: Thirty rats at 90 d of age were divided into three groups: Non-diabetic, diabetic and diabetic treated with AA (DA) (1 g/L). After 120 d of treatment with AA the animals were killed. The myenteric neurons were stained for myosin-V and analyzed quantitatively in an area of 11.2 mm2/animal. We further measured the cellular area of 500 neurons per group. We also determined the metaphasic index (MI) of the jejunum mucosa layer of about 2500 cells in the intestinal crypts, as well as the dimensions of 30 villi and 30 crypts/animal. The data area was analyzed using the Olympus BX40 microscope. RESULTS: There was an increase of 14% in the neuronal density (792.6 ± 46.52 vs 680.6 ± 30.27) and 4.4% in the cellular area (303.4 ± 5.19 vs 291.1 ± 6.0) respectively of the diabetic group treated with AA when compared to control diabetic animals. There were no signifi cant differences in MI parameters, villi height or crypt depths among the ***: Supplementation with AA in the diabetic animal promoted moderate neuroprotection. There was no observation of alteration of the cellular proliferation of the jejunum mucosa layer of rats with chronic diabetes mellitus with or without supplementation with AA.

关键词： Ascorbic acid Diabetes mellitus Intestinalmucosa layer Myenteric neurons Myosin-V

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Preliminary study of gravimetric anomalies in the Magallanes-Fagnano fault system,South America

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Geodesy and Geodynamics 2018年第1期9卷 42-49页

作者： Juan Manuel Alcacer María Romina Onorato Laura P.Perucca Silvia miranda CONICET-Av.lgnacio de La Roza(oeste)590 J5402DCSSan JuanArgentina Departmento Geofisica Universidad Nacional de San JuanAv.Ignacio de ga Roza(oeste)590J5402DC5San JuanArgentina CIGEOBIO-CONICET Gabinete de Neotect6nica y Geomorfologfa(INGEO)Facultad de Ciencias ExactasFfsicas y NaturalesUniversidad Nacional de San JuanAv.lgnacio de La Roza(oeste)590J5402DCSSan JuanArgentina

The main objective of this research is to recognize several geological structures associated with the shear zones of the MFFS（Magallanes-Fagnano fault system） by the analysis and interpretation of gravimetric anomalies. Besides, to compare the gravimetrical response of the cortical blocks that integrate the region under study, which is related to the different morphotectonic domains recognized in the region. This research was developed employing data obtained from World Gravity 1.0, which includes earth and satellite gravity data derived from the EGM2008 model. The study and interpretation of the MFFS from the analysis and processing of the gravimetric data, allowed appreciation of a noticeable correlation with the most superficial cortical structure.

关键词： Gravimetry Isostatic anomaly Magallanes-Fagnano fault system Argentina

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The Periaqueductal Gray and Its Extended Participation in Drug Addiction Phenomena

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Neuroscience Bulletin 2021年第10期37卷 1493-1509页

作者： Priscila Vazquez-Leon Abraham miranda-Paez Jesus Chavez-Reyes Gonzalo Allende Paulino Barragan-Iglesias Bruno A.Marichal-Cancino Departamento de Fisiologia y Farmacologia Centro de Ciencias BasicasUniversidad Autonoma de AguascalientesCiudad Universitaria20131 AguascalientesAgs.Mexico Departamento de Fisiologia Escuela Nacional de Ciencias BiologicasInstituto Politecnico NacionalWilfrido Massieu esq.Manuel Stampa s/n Col.Nueva Industrial Vallejo07738 Gustavo A.MaderoMexico CityMexico

The periaqueductal gray(PAG)is a complex mesencephalic structure involved in the integration and execution of active and passive self-protective behaviors against imminent threats,such as immobility or flight from a *** activity is also associated with the integration of responses against physical discomfort(e.g.,anxiety,fear,pain,and disgust)which occurs prior an imminent attack,but also during withdrawal from drugs such as morphine and *** PAG sends and receives projections to and from other well-documented nuclei linked to the phenomenon of drug addiction including:(i)the ventral tegmental area;(ii)extended amygdala;(iii)medial prefrontal cortex;(iv)pontine nucleus;(v)bed nucleus of the stria terminalis;and(vi)*** models have suggested that the PAG contributes to the modulation of anxiety,fear,and nociception(all of which may produce physical discomfort)linked with chronic exposure to drugs of *** produced by the major pharmacological classes of drugs of abuse is mediated through actions that include participation of the *** support of this,there is evidence of functional,pharmacological,***/or genetic alterations in the PAG during the impulsive/compulsive intake or withdrawal from a *** to its small size,it is difficult to assess the anatomical participation of the PAG when using classical neuroimaging techniques,so its phys-iopathology in drug addiction has been underestimated and poorly *** this theoretical review,we discuss the involvement of the PAG in drug addiction mainly via its role as an integrator of responses to the physical discomfort associated with drug withdrawal.

关键词： Periaqueductal gray Reward circuit Antireward circuit Alcohol Caffeine Cannabis Opioids Stimulants

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Efficient metallization of magnetite concentrate by reduction with agave bagasse as a source of reducing agents

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International Journal of Minerals,Metallurgy and Materials 2021年第4期28卷 603-611页

作者： Diana Cholico-González NoemíOrtiz Lara Mario Alberto Sánchez miranda Ricardo Morales Estrella Ramiro Escudero García Carlos ALeón Patiño CONACYT-Metallurgy and Materials Research Institute Michoacana University of San Nicolás de HidalgoMorelia CP 58030Mexico Metallurgy and Materials Research Institute Michoacana University of San Nicolás de HidalgoMorelia CP 58030Mexico

The reduction behavior and metallization degree of magnetite concentrate with agave bagasse were investigated in an inert *** effects of temperature,biomass content,and residence time on reduction experiments and metallization degree were investigated by X-ray diffraction and scanning electron *** with other types of biomass,agave bagasse had lower contents of nitrogen,sulfur,and ash.X-ray diffraction analysis showed that the metallization degree improved with increasing temperature and biomass *** metallization was achieved at 1100℃ for 30 min with 65:35 and 50:50 ratios of the magnetite concentrate to the agave *** results demonstrate that agave bagasse promotes the efficient metallization of magnetite concentrate without the external addition of a reducing ***,this biomass is a technical suitable alternative to replace fossil fuels in steelmaking.

关键词： magnetite concentrate agave bagasse biomass reduction metallization degree

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Creed vs. Greed- The Philosophy of Management

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Chinese Business Review 2011年第9期10卷 783-789页

作者： Melville miranda Shruti Mahajan Australian Education Academy Pry Ltd. Melbourne Australia

Creed is ＂a system of Christian or other religious belief; a faith There is no doubt that business is about making financial profit, and that is the way it should be. However, it is also important to understand that a person＇s creed-their principles and beliefs-has a tremendous influence on the way in which they will practice business. In recent decades, for example, the fraudulent business practices of major corporations such as Adelphia, Enron, Dynergy, Global Crossing, Merrill Lynch, Qwest, Tyco, and WorldCom, became international news. One after one, major world businesses, which were widely trusted and respected, toppled, leaving in their quake millions of ruined lives. Seemingly respectable and successful business practices were guilty of behaving with criminal intentions; consequently appearing, in the opinion of many observers, little more than common thieves As such, the philosophy of management, especially in relation to Creed vs. Greed, has become increasingly important within today＇s business world.

关键词： profit religion management business corporate social responsibility

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