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Dissecting role of regulatory factors in NF-κB pathway with siRNA

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Acta Pharmacologica Sinica 2005年第7期26卷 780-788页

作者： Carlos R becerra Dallas Division of Hematology-Oncology Department of Medicine Harold Simmons Cancer Center Texas 75390 USA University of Texas Southwestern Medical Center

NF-κB,a family of related transcription factors,has been a focus of intense scien-tific research during the past *** stimuli,both extracellular andintracellular,lead to its *** NF-κB pathway regulates expression of adiverse array of genes involved in different biological *** patho-logical states are characterized by the dysregulated NF-κB ***,NF-κB activation has been connected with multiple aspects of oncogenesis andserves as an important mechanism to regulate cell survival in response to chemo-therapy by activating different genes that inhibit *** methods ofinhibiting NF-κB activation,such as antisense oligonucleotides,proteosome in-hibitors and RNA interference(RNAi)are currently under *** a powerful tool to better define the role of specific genes in differentsignal transduction pathways and has recently been used to define the functionof genes that regulate the NF-κB *** review discusses the emergingrole of RNAi to dissect the function of regulatory factors in the NF-κB pathwayand its potential use as a targeted therapy.

关键词： NF-κB pathway small interfering RNA RNA interference

On the generalized Hermite-based lattice Boltzmann construction, lattice sets, weights,moments, distribution functions and high-order models

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Frontiers of physics 2014年第4期9卷 490-510页

作者： raul Machado Faculty of Engineering and the Environment University of Southampton Southarapton XO171BJ UK

The influence of the use of the generalized Hermite polynomial on the Hermite-based lattice Bofiz- mann （LB） construction approach, lattice sets, the thermal weights, moments and the equilibrium distribution function （EDF） are addressed. A new moment system is proposed. The theoretical possibility to obtain a unique high-order Hermite-based singel relaxation time LB model capable to exactly inatch some first hydrodynamic inoments thermally i） on-Cartesian lattice, ii） with thermal weights in the EDF, iii） whilst the highest possible hydrodynamic moments that are exactly reatched are obtained with the shortest on-Cartesian lattiee sets with some fixed real-valued temperatures, is also analyzed.

关键词： lattice Boltzmann fluid dynamics kinetic theory distribution function

Day-ahead industrial load forecasting for electric RTG cranes

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Journal of Modern Power Systems and Clean Energy 2018年第2期6卷 223-234页

作者： Feras ALASALI Stephen HABEN Victor becerra William HOLDERBAUM School of Systems Engineering University of Reading Mathematical Institute University of Oxford School of Engineering University of Portsmouth School of Engineering Metropolitan Manchester University

Given the increase in international trading and the significant energy and environmental challenges in ports around the world, there is a need for a greater understanding of the energy demand behaviour at *** move towards electrified rubber-tyred gantry(RTG)cranes is expected to reduce gas emissions and increase energy savings compared to diesel RTG cranes but it will increase electrical energy demand. Electrical load forecasting is a key tool for understanding the energy demand which is usually applied to data with strong regularities and seasonal patterns. However, the highly volatile and stochastic behaviour of the RTG crane demand creates a substantial prediction challenge. This paper is one of the first extensive investigations into short term load forecastsfor electrified RTG crane demand. Options for model inputs are investigated depending on extensive data and correlation analysis. The effect of estimation accuracy of exogenous variables on the forecast accuracy is investigated as well. The models are tested on two different RTG crane data sets that were collected from the Port of Felixstowe in the UK. The results reveal the effectiveness of the forecast models when the estimation of the number of crane moves and container gross weight are accurate.

关键词： Rubber-tyred gantry(RTG) cranes Correlation analysis Exogenous variables estimation Artificial neural networks Time series forecast modelling

The Hsp90-binding immunophilin FKBP52 enhances neurodifferentiation and neuroregeneration in murine models

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Neural Regeneration Research 2022年第3期17卷 555-556页

作者： Cristina Daneri-becerra Mario D.Galigniana Instituto de Biología y Medicina Experimental/CONICET&Departamento de Química Biológica Facultad de Ciencias Exactas y Naturales Universidad de Buenos AiresBuenos AiresArgentina

The term immunophilin involves a family of proteins whose domain shows peptidylprolyl-(cis/trans)-isomerase (PPIase)enzymatic activity,i.e., the reversible cis/trans interconversion of Xaa-Pro bonds (Annett et al.,2020).The PPlase domain of these proteins usually binds to immunosuppressive drugs,such as the macrolide FK506 (referred to as the FKBP subfamily) or the cyclic undecapeptide cyclosporine A (called CyP subfamily).

关键词： bonds reversible enzymatic

Science Letters:Effects of polyurethane matrices on fungal tannase and gallic acid production under solid state culture

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2007年第10期8卷 771-776页

作者： TREVI■O Lucia CONTRERAS-ESQUIVEL Juan C. RODRíGUEZ-herrera raul AGUILAR Cristóbal Noé Department of Food Research Autonomous University of Coahuila Saltillo Coahuila 25000 Mexico

The influence of the physical structure of polyurethane matrix as a support in a solid state culture in tannase production and gallic acid accumulation by Aspergillus niger Aa-20 was evaluated. Three different polyurethane matrices were used as the support: continuous, semi-discontinuous and discontinuous. The highest tannase production at 2479.59 U/L during the first 12 h of culture was obtained using the discontinuous matrix. The gallic acid was accumulated at 7.64 g/L at the discontinuous matrix. The results show that the discontinuous matrix of polyurethane is better for tannase production and gallic acid accumulation in a solid state culture bioprocess than the continuous and semi-discontinuous matrices.

关键词： Tannase Gallic acid Polyurethane matrix support Solid state culture Aspergillus niger Aa-20

Comment on "Vortex of Fluid Field as Viewed from Curvature" [Commun. Theor. Phys. 43 (2005) 604]

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Communications in Theoretical Physics 2010年第1期53卷 43-44页

作者： Blas herrera Gerard Fortuny Departament d'Enginyeria Informàtica i Matemàtiques Universitat Rovira i Virgili

Here, we make comments to the conclusions of the paper： LIU Shi-Da, Sill Shao-Ying, LIU Shi-Kuo, et al., ＂Vortex of Fluid Field as Viewed from Curvature＂ [Commun. Theor. Phys. 43 （2005） 604].

关键词： curvature vortex

Mapping frequent spatio-temporal wind profile patterns using multi-dimensional sequential pattern mining

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International Journal of Digital Earth 2017年第3期10卷 238-256页

作者： Norhakim Yusof raul Zurita-Milla Department of Geo-Information Processing Faculty of Geo-Information Science and Earth Observation(ITC)University of TwenteEnschedeThe Netherlands Department of Geoinformation Faculty of Geoinformation and Real EstateUniversiti Teknologi MalaysiaUTMJohor BahruMalaysia

Holistic understanding of wind behaviour over space,time and height is essential for harvesting wind energy *** study presents a novel approach for mapping frequent wind profile patterns using multidimensional sequential pattern mining(MDSPM).This study is illustrated with a time series of 24 years of European Centre for Medium-Range Weather Forecasts European Reanalysis-Interim gridded(0.125°×0.125°)wind data for the Netherlands every 6 h and at six height *** wind data were first transformed into two spatio-temporal sequence databases(for speed and direction,respectively).Then,the Linear time Closed Itemset Miner Sequence algorithm was used to extract the multidimensional sequential patterns,which were then visualized using a 3D wind rose,a circular histogram and a geographical *** patterns were further analysed to determine their wind shear coefficients and turbulence intensities as well as their spatial overlap with current areas with wind *** analysis identified four frequent wind profile *** of them highly suitable to harvest wind energy at a height of 128 m and 68.97%of the geographical area covered by this pattern already contains wind *** study shows that the proposed approach is capable of efficiently extracting meaningful patterns from complex spatio-temporal datasets.

关键词： Spatio-temporal data mining multi-dimensional sequential pattern mining wind shear coefficient turbulence intensity wind energy

Premigratory fat metabolism in hummingbirds： A Rumsfeldian approach

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Current Zoology 2013年第3期59卷 371-380页

作者： raul K. SUAREZ Department of Ecology Evolution and Marine Biology University of California Santa Barbara California 93106 USA

Hummingbird migration is a remarkable feat, given the small body sizes of migratory species, their high metabolic rates during flight and the long distances traveled using fat to fuel the effort. Equally remarkable is the ability of premigratory hummingbirds in the wild to accumulate fat, synthesized from sugar, at rates as high as 10% of body mass per day. This paper summarizes, using Rumsfeldian terminology, ＂known knowns＂ concerning the energetics of hummingbird migration and premi- gratory fattening. Energy metabolism during hover-feeding on floral nectar is fueled directly by dietary sugar through the path- way recently named the ＂sugar oxidation cascade＂. However, flight without feeding for more than a few minutes requires shifting to fat as a fuel. It is proposed that behavior and metabolic fuel choice are coadapted to maximize the rate of fat deposition during premigratory fattening. The hummingbird liver appears to possess extraordinarily high capacities for fatty acid synthesis. The analysis of ＂known knowns＂ leads to identification of ＂known unknowns＂, e.g., the fates of dietary glucose and fructose, the regulation of fat metabolism and metabolic interactions between liver and adipose tissue. The history of science behooves recog- nition of ＂tmknown unknowns＂ that, when discovered serendipitously, might shed new light on fundamental mechanisms as well as human pathological conditions .

关键词： Lipid synthesis Metabolic rate Metabolic regulation Muscle energy metabolism Sugar oxidation

TWO NOVEL GRADIENT METHODS WITH OPTIMAL STEP SIZES

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Journal of Computational Mathematics 2021年第3期39卷 375-391页

作者： Harry Oviedo Oscar Dalmau Rafael herrera Centro de Investigacion en Matematicas CIMAT A.C.GuanajuatoGto.Mexico

In this work we introduce two new Barzilai and Borwein-like steps sizes for the classical gradient method for strictly convex quadratic optimization *** proposed step sizes employ second-order information in order to obtain faster gradient-type *** step sizes are derived from two unconstrained optimization models that involve approximate information of the Hessian of the objective function.A convergence analysis of the proposed algorithm is *** numerical experiments are performed in order to compare the efficiency and effectiveness of the proposed methods with similar methods in the ***,it is observed that our proposals accelerate the gradient method at nearly no extra computational cost,which makes our proposal a good alternative to solve large-scale problems.

关键词： Gradient methods Convex quadratic optimization Hessian spectral properties Steplength selection