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Impact of obesity and Ala16Val MnSOD polymorphism interaction on lipid, inflammatory and oxidative blood biomarkers

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Open Journal of Genetics 2012年第4期2卷 202-209页

作者： Maria Fernanda Manica-Cattani Francine Carla Cadoná raul de Oliveira Tális da Silva Alencar Kolinski Machado Fernanda Barbisan Marta Maria Medeiros Frescura Duarte Ivana Beatrice Manica da cruz Biogenomic Laboratory Center of Science of Health Federal University of Santa Maria Santa Maria Brazil Post-Graduate Program in Pharmacology Federal University of Santa Maria Santa Maria Brazil Post-Graduate Program in Toxicology Biochemistry Federal University of Santa Maria Santa Maria Brazil

Previous investigations suggest association between obesity and Ala16Val MnSOD gene polymorphism. The V allele produces enzyme which not catalyze the superoxide anion efficiently as occurs with A allele. As obesity is related to development of other metabolic disorders we performed a study that analyzed the effect of interaction between Ala16Val MnSOD polymorphism and obesity on lipid, oxidative and inflammatory biomarkers of adult subjects. The study enrolled 161 volunteers as categorized in six groups with different genotypes: Obeses with different genotypes (AAO, VVO and AVO) and nonobese (AANO, VVNO and AVNO). In general the group AANO presented lower values whereas VVO presented higher values of biomarkers analyzed. These results suggest that oxidative metabolism influenced by genetic status could to minimize or maximize the obesity effects on lipid, oxidative and inflammatory biomarkers that are also implicated in the genesis of important dysfunctions and diseases as atherosclerosis, diabetes 2 and cardiovascular morbidities.

关键词： Ala16Val MnSOD Polymorphism Obesity Oxidative Stress Inflammation Oxidized LDL Anti-Oxidized LDL Hs-PCR

Effect of a Single Shot Sciatic Nerve Block Combined with a Continuous Femoral Block on Pain Scores After Knee Arthroplasty.A Randomized Controlled Trial

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Open Journal of Anesthesiology 2012年第4期2卷 107-112页

作者： raul Carvalho Luisa Calixto Jose Pedro Braganca Servico de Anestesia Centro Hospitalar do PortoPortoPortugal Departamento de Ciencias da Informacao e da Decisao em Saude Faculdade de MedicinaUniversidade do PortoPortoPortugal

Background and Purpose: Postoperative pain after knee arthroplasty (TKA) is reported as severe in up to 60% of patients. Continuous femoral nerve blocks (CFNB) are a choice for major knee repair, but controversies remain about the need of supplemental sciatic nerve blocks (SNB) for better analgesia. Our aim is to assess the effect of the association of a SNB to a CFNB to reduce postoperative pain after TKA. Methods: A prospective randomized, single blinded, controlled study, on 50 patients undergoing TKA. Control group received a CFNB before general anesthesia;in the intervention group a single shot SNB was added after the CFNB was done. After the end of surgery all patients started a continuous local anesthetic infusion through the femoral catheter in the PACU (post-anesthesia care unit). Pain scores were measured in the PACU and at 12 h and 24 h postoperative using a visual analog scale (VAS). Results: VAS pain scores (mm) were lower and statistically significant for the intervention group up to 12 h postoperative: PACU admission mean VAS = 59.4 vs 30.2, P = 0.001;at 12 h mean VASr = 26.1 vs 9.2, P = 0.006;at 24 h mean VASr = 30.1 vs 32.7, P = 0.723. Conclusions: The association of a single shot SNB with a CFNB significantly reduces postoperative pain scores after TKA up to 12 h. At 24 h there are no differences between groups.

关键词： Postoperative Pain Knee Arthroplasty Regional Anesthesia Nerve Blocks

Fabrication of Polymeric Visual Decoys for the Male Emerald Ash Borer （Agrilus planipennis）

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Journal of Bionic Engineering 2013年第2期10卷 129-138页

作者： Drew P. Pulsifer Akhlesh Lakhtakia Mahesh S. Narkhede Michael J. Domingue Beverly G. Post Jayant Kumar raul J. Martln-Palma Thomas C. Baker Department of Engineering Science & Mechanics Pennsylvania State University University Park Pennsylvania 16802 USA Center for Advanced Materials and Department of Plastics Engineering University of Massachusetts Lowell Lowell MA 01854 USA Department of Entomology Pennsylvania State University University Park PA 16802 USA Center for Advanced Materials and Department of Physics & Applied Physics University of Massachusetts Lowell Lowell MA 01854 USA Department of Materials Science & Engineering Pennsylvania State University University Park Pennsylvania 16802 USA

Through a bioreplication approach, we have fabricated artificial visual decoys for the invasive species Agrilus planipen- nis--commonly known as the Emerald Ash Borer （EAB）. The mating behavior of this species involves an overflying EAB male pouncing on an EAB female at rest on an ash leaflet before copulating. The male spots the female on the leaflet by visually detecting the iridescent green color of the female＇s elytra. As rearing EAB and then deploying dead females as decoys for trapping is both arduous and inconvenient, we decided to fabricate artificial decoys. We used a dead female to make a negative die of nickel and a positive die of epoxy. Decoys were then made by first depositing a quarter-wave-stack Bragg reflector on a polymer sheet and then stamping it with a pair of matched negative and positive dies to take the shape of the upper surface of an EAB female. As nearly 100 artificial decoys were fabricated from just one EAB female, this bioreplication process is industrially scalable. Preliminary results from a field trapping test are indicative of success.

关键词： bioreplication conformal-evaporated-film-by-rotation method electroforming negative die positive die stampingCopyright ~ 2013 Jilin University. Published by Science Press and Elsevier Limited. All rights reserved.

Hummingbirds and the Upper Limits to Vertebrate Design and Performance

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Hummingbirds and the Upper Limits to Vertebrate Design and P...

Stem cell therapy in the management of shoulder rotator cuff disorders

23rd International Ornithological Congress

作者： raul K.Suarez Dept. of Ecology Evol. and Marine Biology. Univ. of California Santa Barbara. CA 93106-9610 USA

＜正＞ Hummingbirds in flight achieve some of the highest mass-specific rates of aerobic metabolism known among vertebrates. These are made possible by high capacities for oxygen flux through the cardiovascular and respiratory systems, as well as high mitochondrial volume and cristae surface densities in the flight muscles. The flight muscles display high enzymatic capacities for glucose and long-chain fatty acid oxidation. In flight,

关键词： muscle mitochondria metabolism

来源： cnki会议评论

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World Journal of Stem Cells 2015年第4期7卷 691-699页

作者： Maria Valencia Mora Miguel A Ruiz Ibán Jorge Díaz Heredia raul Barco Laakso Ricardo Cuéllar Mariano García Arranz Unidad de Hombro y Codo Hospital Universitario Ramón y Cajal Hospital Universitario La Paz Departamento de Traumatología y Cirugía Ortopédica Hospital Universitario Donostia Instituto de Investigación Sanitaria Fundación Jiménez Diaz Departamento de Cirugía Universidad Autónoma de Madrid

Rotator cuff tears are frequent shoulder problems that are usually dealt with surgical repair. Despite improved surgical techniques, the tendon-to-bone healing rate is unsatisfactory due to difficulties in restoring the delicate transitional tissue between bone and tendon. It is essential to understand the molecular mechanisms that determine this failure. The study of the molecular environment during embryogenesis and during normal healing after injury is key in devising strategies to get a successful repair. Mesenchymal stem cells(MSC) can differentiate into different mesodermal tissues and have a strong paracrine, anti-inflammatory, immunoregulatory and angiogenic potential. Stem cell therapy is thus a potentially effective therapy to enhance rotator cuff healing. Promising results have been reported with the use of autologous MSC of different origins in animal studies: they have shown to have better healing properties, increasing the amount of fibrocartilage formation and improving the orientation of fibrocartilage fibers with less immunologic response and reduced lymphocyte infiltration. All these changes lead to an increase in biomechanical strength. However, animal research is still inconclusive and more experimental studies are needed before human application. Future directions include expanded stem cell therapy in combination with growth factors or different scaffolds as well as new stem cell types and gene therapy.

关键词： Rotator cuff Enthesis Biologic Stem cells

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墨西哥Ispat钢厂提高板坯质量的措施

钢铁 2004年第Z1期39卷 40-43页

作者： raul Torres H.Thomas Tsai 　美国Ispat钢铁公司

墨西哥Ispat钢厂是墨西哥最大的钢厂,也是世界上最大的板坯供应商之一.为了满足客户的需求,Ispat钢厂采取一系列措施来提高板坯质量,包括纯净钢技术、连铸工艺优化、优化水口设计和结晶器锥度、优化二冷冷却等,减少了连铸坯的缺陷.

关键词：表面缺陷纯净钢工艺连铸工艺

Velocity Monitoring of Molten Steel in a Continuous Casting Mold Using Three Submerged Entry Nozzle Designs

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Modeling and Numerical Simulation of Material Science 2016年第4期6卷 59-68页

作者： raul Miranda Miguel A. Barron Carlos A. Hernandez Departamento de Electronica Universidad Autonoma Metropolitana Azcapotzalco Ciudad de Mexico Mexico Departamento de Materiales Universidad Autonoma Metropolitana Azcapotzalco Ciudad de Mexico Mexico

The horizontal and vertical velocity components of molten steel in a slab continuous casting mold produced by three different two-port Submerged Entry Nozzle (SEN) designs are monitored and compared using Computational Fluid Dynamics (CFD) simulations. These two ports designs correspond to a conventional cylindrical SEN, a plate SEN and an anchor-shaped SEN. Four monitoring points at the molten steel in the centered vertical plane were selected to track the horizontal and the vertical component of the velocity vector. Two of them are located near the free surface and the remaining two are located in the vicinity of the SEN discharge nozzles. Some statistical values of the time series of above the velocity components are analyzed and correlated with the Kelvin-Helmholtz instability and the Karman vortex streets, which cause mold powder entrapment in the molten steel.

关键词： Computational Fluid Dynamics Continuous Casting Molten Steel Mold Powder Entrapment Submerged Entry Nozzle Velocity Monitoring

Anchor-Shaped Design of a Submerged Entry Nozzle for the Continuous Casting of Steel

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Open Journal of Applied Sciences 2016年第9期6卷 593-600页

作者： Carlos A. Hernandez Miguel A. Barron raul Miranda Departamento de Materiales Universidad Autonoma Metropolitana Azcapotzalco Mexico City Mexico Departamento de Electronica Universidad Autonoma Metropolitana Azcapotzalco Mexico City Mexico

An anchor-shaped geometrical design for a Submerged Entry Nozzle for the slab continuous casting of steel is presented in this work. To evaluate its performance, transient 3D multiphase numerical simulations were carried out using the Computational Fluid Dynamics technique. The performance of the proposed nozzle is numerically compared with that of a conventional cylindrical nozzle. Computer results show that the chance of formation of Karman’s vortexes and powder entrapment becomes small for the anchor-shaped SEN.

关键词： Anchor-Shaped SEN Computational Fluid Dynamics Continuous Casting Numerical Simulations Slab Casting Submerged Entry Nozzle

Science Letters:Effects of polyurethane matrices on fungal tannase and gallic acid production under solid state culture

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2007年第10期8卷 771-776页

作者： TREVI■O Lucia CONTRERAS-ESQUIVEL Juan C. RODRíGUEZ-HERRERA raul AGUILAR Cristóbal Noé Department of Food Research Autonomous University of Coahuila Saltillo Coahuila 25000 Mexico

The influence of the physical structure of polyurethane matrix as a support in a solid state culture in tannase production and gallic acid accumulation by Aspergillus niger Aa-20 was evaluated. Three different polyurethane matrices were used as the support: continuous, semi-discontinuous and discontinuous. The highest tannase production at 2479.59 U/L during the first 12 h of culture was obtained using the discontinuous matrix. The gallic acid was accumulated at 7.64 g/L at the discontinuous matrix. The results show that the discontinuous matrix of polyurethane is better for tannase production and gallic acid accumulation in a solid state culture bioprocess than the continuous and semi-discontinuous matrices.

关键词： Tannase Gallic acid Polyurethane matrix support Solid state culture Aspergillus niger Aa-20