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天然二萜化合物抗肿瘤作用的研究进展

华西药学杂志 2024年第4期39卷 471-475页

作者：石小艺程菊陈建军杨立苑陈晓峥刘秀珠 Amna rasheed 谢小冬甘肃中医药大学甘肃兰州730000 兰州大学基础医学院遗传学研究所甘肃兰州730000 兰州大学功能有机分子化学国家重点实验室甘肃兰州730000

二萜化合物在植物、真菌、昆虫、海洋生物等中广泛存在,结构复杂、多变,生物活性多样。现概述天然二萜化合物抗肿瘤作用的相关通路及机制,从肿瘤信号通路的角度解析药物的抗肿瘤机制,为二萜化合物在抗肿瘤新药的研发及临床应用提供依据。

关键词：天然化合物二萜化合物肿瘤高效低毒信号通路分子机制综述

Association between acute peripancreatic fluid collections and early readmission in acute pancreatitis:A propensity-matched analysis

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World Journal of Experimental Medicine 2024年第2期14卷 75-88页

作者： Hassam Ali Faisal Inayat Waqas rasheed Arslan Afzal Ahtshamullah Chaudhry Pratik Patel Attiq Ur Rehman Muhammad Sajeel Anwar Gul Nawaz Muhammad Sohaib Afzal Amir H Sohail Subanandhini Subramanium Dushyant Singh Dahiya Deepa Budh Babu P Mohan Douglas G Adler Department of Gastroenterology and Hepatology East Carolina University Brody School of MedicineGreenvilleNC 27834United States Department of Internal Medicine Allama Iqbal Medical CollegeLahorePunjab 54550Pakistan Department of Internal Medicine Texas Tech University Health Sciences CenterLubbockTX 79430United States Department of Internal Medicine St.Dominic’s HospitalJacksonMS 39216United States Department of Gastroenterology Mather Hospital and Hofstra University Zucker School of MedicinePort JeffersonNY 11777United States Department of Hepatology Geisinger Wyoming Valley Medical CenterWilkes-BarrePA 18711United States Department of Internal Medicine UHS Wilson Medical CenterJohnson CityNY 13790United States Department of Internal Medicine Louisiana State University HealthShreveportLA 71103United States Department of Surgery University of New Mexico School of MedicineAlbuquerqueNM 87106United States Division of Gastroenterology Hepatologyand MotilityThe University of Kansas School of MedicineKansas CityKS 64108United States Department of Internal Medicine St.Barnabas Hospital and Albert Einstein College of MedicineBronxNY 10457United States Department of Gastroenterology and Hepatology University of Utah School of MedicineSalt Lake CityUT 84132United States Center for Advanced Therapeutic Endoscopy Porter Adventist HospitalCentura HealthDenverCO 80210United States

BACKGROUND Patients with acute pancreatitis(AP)frequently experience hospital readmissions,posing a significant burden to healthcare *** peripancreatic fluid collection(APFC)may negatively impact the clinical course of *** could worsen symptoms and potentially lead to additional ***,clinical evidence regarding the specific association between APFC and early readmission in AP remains *** the link between APFC and readmission may help improve clinical care for AP patients and reduce healthcare *** To evaluate the association between APFC and 30-day readmission in patients with *** This retrospective cohort study is based on the Nationwide Readmission Database for *** with a primary diagnosis of AP were *** were categorized into those with and without APFC.A 1:1 propensity score matching for age,gender,and Elixhauser comorbidities was *** primary outcome was early readmission *** outcomes included the incidence of inpatient complications and healthcare *** analyses used Mann-Whitney U andχ2 tests,while Cox regression models assessed 30-day readmission risks and reported them as adjusted hazard ratios(aHR).Kaplan-Meier curves and log-rank tests verified readmission *** A total of 673059 patients with the principal diagnosis of AP were *** these,5.1%had APFC on initial *** propensity score matching,each cohort consisted of 33914 *** with APFC showed a higher incidence of inpatient complications,including septic shock(3.1%vs 1.3%,P<0.001),portal venous thrombosis(4.4%vs 0.8%,P<0.001),and mechanical ventilation(1.8%vs 0.9%,P<0.001).The length of stay(LOS)was longer for APFC patients[4(3-7)vs 3(2-5)days,P<0.001],as were hospital charges($29451 vs$24418,P<0.001).For 30-day readmissions,APFC patients had a higher rate(15.7%vs 6.5%,P<0.001)and a longer median readmission LOS(4 vs 3 days,P<0.001).The APF

关键词： Acute pancreatitis Acute peripancreatic fluid collections Readmission predictors Inpatient complications Healthcare utilization and costs

Partial Fusion (F) Gene Analysis of Newcastle Disease Virus Detected in Pakistan during 2021-2022

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Journal of Biosciences and Medicines 2024年第5期12卷 256-275页

作者： Muhammad Danish Mehmood Huma Anwar Ul-Haq Rauf Khalid Yasir Amin Muhammad Usman Ghani Muhammad Ismail Rabia Habib Fareeha Arshed Abdul rasheed Shaukat Institute of Molecular Biology & Biotechnology University of Lahore Lahore Pakistan Research & Development Division Ottoman Pharma Lahore Pakistan Quality Assurance Department Ottoman Pharma Lahore Pakistan Veterinary Research and Disease Investigation Center Abbottabad Pakistan Quality Control Department Ottoman Pharma Immuno Lahore Pakistan Production Department Ottoman Pharma Lahore Pakistan Poultry Production Department Sabir&#8217s Poultry Pvt. Ltd. Sabroso Pakistan

Newcastle disease (ND) virus is a leading threat to commercial and domestic poultry in Pakistan. The virus infects and constitutes irreversible impairment to the nervous system, damages the respiratory system, and marks severe gastrointestinal lesions leading to heavy mortality in short-living birds and substantial losses in layers and breeders. The continuous emergence and evolution of the virus made it inclined to evade the humoral response and indirectly the circumvention of artificial active immunization. Newcastle disease is caused by the orthoavula genus of the paramyxoviridae family and has shown high genetic diversity even in their genotypes while information regarding enzootic trends of the virus is scanty in Pakistan. A total of 40 tracheal samples of NDV were collected from different commercial broiler farms and 11 isolates of NDV were identified. In the current study, we determined the genetic diversity of the Newcastle disease virus based on the partial sequencing of the fusion protein gene available in the NCBI database. Genetic analysis showed that seven isolates belonged to class I genotype VII and four belonged to class II genotype II. Interestingly, two isolates had epidemiological connections with vaccine-like class II genotype II. Our findings, concerning the recent outbreaks of class I genotype VII and class II genotype II of NDV in vaccinated commercial flocks, suggest possible potential partial mutations in the fusion protein gene. Genetic diversity and formation of the new cleavage site in an important neutralizing protein of wild strain are linked with the potency of artificial active immunization and a major cause of vaccine failure.

关键词： Newcastle Disease Virus Haemagglutination Inhibition Polymerase Chain Reaction Phylogenetic Tree Mutation Analysis

Validation of a Method for Characterization of Ethanol in Water by HS-GC-FID to Serve the Traceability of Halal Measurements

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Green and Sustainable Chemistry 2024年第2期14卷 17-28页

作者： Adel B. Shehata Abdulrahman R. Al Askar Mohammed A. Al rasheed Abdulrahman M. Al Zahrany Fahd A. Al Kharraa Sowailem A. Al Sowailem Chemistry Department/National Measurement and Calibration Center (NMCC) Saudi Standards Metrology and Quality Organization (SASO) Riyadh Kingdom of Saudi Arabia

The determination of the ethanol content in food products is of fundamental importance for HALAL certification. In this work, an analytical method for the determination of ethanol in water by headspace gas chromatography with flame ionization detector (HS-GC-FID) has been developed and validated for the use in characterization of ethanol reference materials. The validation study was carried out in the linear calibration range 100 - 1500 mg/kg using the NIST SRM 2900, nominal 95.6%. The studied performance characteristics of the method were the limit of detection, LOD, the limit of quantification LOQ, selectivity, linearity, precision, recovery and bias. The validation results showed that the method is selective, precise, accurate and free from any significant bias. The LOD and LOQ were 1.27 and 3.86 mg/kg respectively and the estimated expanded uncertainty was 2% indicating that the method is fit for the purpose of certification of ethanol in water reference materials.

关键词： Ethanol HS-GC-FID Validation Linearity Precision Bias

A Hybrid Deep Fused Learning Approach to Segregate Infectious Diseases

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Computers, Materials & Continua 2023年第2期74卷 4239-4259页

作者： Jawad rasheed Shtwai Alsubai Department of Software Engineering Nisantasi UniversityIstanbul34398Turkey Dapartment of Computer Science College of Computer Engineering and Sciences in Al-KharjPrince Sattam Bin Abdulaziz UniversityP.O.Box 151Al-Kharj11942Saudi Arabia

Humankind is facing another deadliest pandemic of all times in history,caused by *** from this challenging pandemic,World Health Organization(WHO)considers tuberculosis(TB)as a preeminent infectious disease due to its high infection ***,both TB and COVID-19 severely affect the lungs,thus hardening the job of medical practitioners who can often misidentify these diseases in the current ***,the time of need calls for an immediate and meticulous automatic diagnostic tool that can accurately discriminate both *** one of the preliminary smart health systems that examine three clinical states(COVID-19,TB,and normal cases),this study proposes an amalgam of image filtering,data-augmentation technique,transfer learning-based approach,and advanced deep-learning classifiers to effectively segregate these *** first employed a generative adversarial network(GAN)and Crimmins speckle removal filter on X-ray images to overcome the issue of limited data and *** pre-processed image is then converted into red,green,and blue(RGB)and Commission Internationale de l’Elcairage(CIE)color spaces from which deep fused features are formed by extracting relevant features using DenseNet121 and *** feature extractor extracts 1000 most useful features which are then fused and finally fed to two variants of recurrent neural network(RNN)classifiers for precise discrimination of threeclinical *** analysis showed that the proposed Bi-directional long-short-term-memory(Bi-LSTM)model dominated the long-short-termmemory(LSTM)network by attaining an overall accuracy of 98.22%for the three-class classification task,whereas LSTM hardly achieved 94.22%accuracy on the test dataset.

关键词： Computer-aided diagnosis decision support system deep transfer learning deep fused features tuberculosis COVID-19

Topic Modelling and Sentimental Analysis of Students’Reviews

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Computers, Materials & Continua 2023年第3期74卷 6835-6848页

作者： Omer S.Alkhnbashi rasheed Mohammad Nassr Information and Computer Science Department King Fahd University of Petroleum and Minerals31261Kingdom Saudi Arabia Computer Science Department School of Computing and Digital TechnologyBirmingham City UniversityBirminghamB55JUUnited Kingdom

Globally,educational institutions have reported a dramatic shift to online learning in an effort to contain the COVID-19 *** fundamental concern has been the continuance of *** a result,several novel solutions have been developed to address technical and pedagogical ***,these were not the only difficulties that students *** implemented solutions involved the operation of the educational process with less regard for students’changing circumstances,which obliged them to study from *** should be asked to provide a full list of their *** a result,student reflections,including those from Saudi Arabia,have been analysed to identify obstacles encountered during the COVID-19 ***,most of the analyses relied on closed-ended questions,which limited student *** delve into students’responses,this study used open-ended questions,a qualitative method(content analysis),a quantitative method(topic modelling),and a sentimental *** study also looked at students’emotional states during and after the COVID-19 *** terms of determining trends in students’input,the results showed that quantitative and qualitative methods produced similar *** had unfavourable sentiments about studying during COVID-19 and positive sentiments about the face-to-face ***,topic modelling has revealed that the majority of difficulties are more related to the environment(home)and social *** were less accepting of online *** a result,it is possible to conclude that face-to-face study still attracts students and provides benefits that online study cannot,such as social interaction and effective eye-to-eye communication.

关键词： Topic modelling sentimental analysis COVID-19 students’input

Effects of plant growth-promoting rhizobacteria on the molecular responses of maize under drought and heat stresses: A review

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Pedosphere 2022年第1期32卷 90-106页

作者： Iviwe NOTUNUNU Lucy MOLELEKI Ashira ROOPNARAIN rasheed ADELEKE Department of Biochemistry Genetics and MicrobiologyForestry and Agricultural Biotechnology InstituteUniversity of PretoriaLynnwood RdHatfieldPretoria 0002South Africa Microbiology and Environmental Biotechnology Research Group Agricultural Research Council—Natural Resources and EngineeringPrivate Bag X79Pretoria 0001South Africa Unit for Environment Science and Management North-West University(Potchefstroom Campus)Potchefstroom 2520South Africa

Drought and heat are major environmental stresses that continually influence plant growth and development. Under field conditions, these stresses occur more frequently in combination than alone, which magnifies corresponding detrimental effects on the growth and productivity of agriculturally important crops. Plant responses to such abiotic stresses are quite complex and manifested in a range of developmental, molecular, and physiological modifications that lead either to stress sensitivity or tolerance/resistance. Maize (Zea mays L.) is known for its sensitivity to abiotic stresses, which often results in substantial loss in crop productivity. Bioaugmentation with plant growth-promoting rhizobacteria (PGPR) has the potential to mitigate the adverse effects of drought and heat stresses on plants. Hence, this is considered a promising and eco-friendly strategy to ensure sustainable and long-term maize production under adverse climatic conditions. These microorganisms possess various plant growth-promoting (PGP) characteristics that can induce drought and heat tolerance in maize plants by directly or indirectly influencing molecular, metabolic, and physiological stress responses of plants. This review aims to assess the current knowledge regarding the ability of PGPR to induce drought and heat stress tolerance in maize plants. Furthermore, the drought and heat stress-induced expression of drought and heat stress response genes for this crop is discussed with the mechanisms through which PGPR alter maize stress response gene expression.

关键词： abiotic stress drought stress gene expression heat stress stress response gene stress tolerance Zea Mays L.

A New Discovery towards Novel Skeleton of Benzimidazole-Conjugated Pyrimidinones as Unique Effective Antibacterial Agents

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Chinese Journal of Chemistry 2022年第22期40卷 2642-2654页

作者： Xi Yang rasheed Syed Bo Fang Cheng-He Zhou Institute of Bioorganic&Medicinal Chemistry Key Laboratory of Applied Chemistry of Chongqing MunicipalitySchool of Chemistry and Chemical EngineeringSouthwest UniversityChongqing400715China College of Pharmacy National&Local Joint Engineering Research Center of Targeted and Innovative TherapeuticsChongqing Key Laboratoryof KinaseModulators as InnovativeMedicineChongqing University of Arts and SciencesChongqing 402160China

A class of new potential antibacterial agents with distinctive pyrimidinone benzimidazole skeleton was developed through nucleophilic substitution and Biginelli reaction starting from urea,ethyl 4-chloroacetoacetate and various *** target molecules exhibited strong antibacterial activities,especially pyrimidinone benzimidazole hybrid 9e possessed the strongest inhibitory effects on the growth of *** and *** with a lower MIC value of 1μg/mL than ***,compound 9e displayed strong antibiofilm capacity,low drug resistance and excellent biosafety toward human red blood *** research revealed that compound 9e could disrupt membrane integrity and cause leakage of cellular components such as proteins and nucleic ***,compound 9e could decrease lactate dehydrogenase activity,block cell metabolism and interact with DNA in an intercalation manner.

关键词： Pyrimidinone Benzimidazole Antibacterial Resistance Membrane

Portraying Diabetic Foot Ulcers: Comparative Evaluation of Diabetic Foot Infections versus Diabetic Foot Ulcers

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Advances in Infectious Diseases 2024年第2期14卷 297-309页

作者： Jamal Wadi Al Ramahi Leen Sharqawi Sarah AL-Najafi Eman Awwad Haya M. Al-Obaidi Abdel Hafez Mohammad Sara Nofal Dina Riyadh Al-Janabi Ibrahim Zuhair Hamza Jamal Al-Masaeid Mohammed Al-Ithawi Dina rasheed Bellal O. Al-Far Osama Al-Izi Qutaiba Al-Bustanji School of Medicine The University of Jordan Amman Jordan Department of the Internal Medicine The Specialty Hospital Amman Jordan Department of Pharmacy The Specialty Hospital Amman Jordan Department of the Medical Al Khalidi Hospital Amman Jordan Department of Pharmacy Jordan Hospital Amman Jordan Department of Internal Medicine Jordan Hospital Amman Jordan Department of General Surgery Jordan Hospital Amman Jordan

Background: Confusion often arises in caring for diabetic foot infections and ulcers, especially with antimicrobials;we aim to shed light on this entity and alert healthcare workers to its stewardship. Methods: Records were reviewed between February 2016 and September 2023. Data for patients diagnosed with diabetes and foot ulcers, infected or not, were examined following ICD 9 search terms. Records for patients were included if they were prediabetic/diabetic adults with foot ulcers, more than 18 years old, and on antidiabetic treatment. Patients were excluded if they insulin resistant, with normal HgbA1c levels, wheel-chair dependent, bed-bound, non-diabetic patients, diabetic patients who had vascular lower limb surgery earlier to ulcers, diabetic patients who had aortocoronary bypass, deep venous thrombosis within six months, malignancy, and severe clinical depression. A modified IWGDF/IDSA guidelines definitions for DFI and DFU was considered. Statistical analysis was done using R programming. Statistical methods were employed as appropriate, and a significant P-value was considered for P Results: Most characteristics were well balanced between DFI and DFU, on imaging osteomyelitis and tissue swelling were significantly more in DFI. Endovascular radiological procedures showed angiograms to be considerably more in DFI, while angioplasty was more in DFU, in addition to smoking. Bacteremia was uncommon, and swab cultures were mostly polymicrobial in both ulcers;no clear association with blood bacteria was detected with the polymicrobial growth, though few were concordant. Antimicrobials prescribed for both ulcers were not statistically different except for carbapenems, which were more in DFI (P Conclusion: Attention should be paid to best practices while caring for diabetic ulcers. These include swab culture interpretations, the use of antimicrobials, and plan management according to DFI or DFU to utilize either local care or combination with antimicrobials.

关键词： Diabetic Foot Ulcers Diabetic Limb Amputation Antimicrobials Stewardship Broad-Spectrum Antimicrobials in Diabetic Foot Ulcers