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Biphasic Insulin Aspart 30 Therapy in Insulin-Naïve and Insulin-Experienced Patients with Type 2 Diabetes: Results from the Jordanian Subgroup of the A<sub>1</sub>chieve Study

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Journal of Diabetes Mellitus 2014年第4期4卷 379-387页

作者： Jihad Haddad Fares H. Haddad rashad nasser Abdel-Ellah Al-Shudifat Firas Abbas Annabi Levent Sandalci Moawia Al-Kilani Prince Hamzah Hospital Amman Jordan King Hussein Medical Center Amman Jordan Italian Hospital Amman Jordan Islamic Hospital Amman Jordan Novo Nordisk Business Area Near East Istanbul Turkey Jabal Al Zayton Hospital Zarqa Jordan

Objective: To analyse the safety and effectiveness of biphasic insulin aspart 30 (BIAsp 30) in a Jordanian subgroup of the 24-week, non-interventional A1chieve study. Methods: A total of 509 Jordanian patients with type 2 diabetes (392 insulin-naive and 117 insulin-experienced) starting BIAsp30, alone or in combination with oral glucose-lowering drugs, were included. Safety and effectiveness outcomes were analysed over 24 weeks. Results: Patients had a mean age of 55.8 years, body mass index of 28.8 kg/m2 and diabetes duration of 9.4 years at baseline. Two serious adverse drug reactions of hypoglycaemia were reported. The proportion of patients who reported major hypoglycaemic events decreased (2.4% at baseline vs. 0.2% at Week 24, p = 0.0039). The proportion of patients reporting overall hypoglycaemia increased marginally (6.3% at baseline vs. 9.9% at Week 24, p = 0.0378), primarily attributed to a rise in minor and nocturnal hypoglycaemia reported in insulin-naive patients. From baseline to Week 24, the mean ± SD glycated haemoglobin A1c level decreased from 9.8% ± 1.4% to 7.4% ± 0.9% (p < 0.001). Significant reductions after 24 weeks were also noted in the mean fasting plasma glucose, postprandial plasma glucose, lipids, systolic blood pressure and quality of life (all p < 0.001), while the mean body weight increased by 1.8 ± 6.5 kg (p < 0.001). Conclusion: Overall, BIAsp 30 therapy was well-tolerated and resulted in improved glycaemic control in this Jordanian subgroup over 24 weeks.

关键词： Biphasic Insulin Aspart 30 Jordan Type 2 Diabetes A1chieve Clinical Practice

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Bayesian and Frequentist Prediction Using Progressive Type-II Censored with Binomial Removals

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Intelligent Information Management 2013年第5期5卷 162-170页

作者： Ahmed A. Soliman Ahmed H. Abd Ellah nasser A. Abou-Elheggag rashad M. El-Sagheer Faculty of Science Islamic University Madinah Saudi Arabia Mathematics Department Faculty of Science Al-Azhar University Cairo Egypt Mathematics Department Faculty of Science Sohag University Sohag Egypt

In this article, we study the problem of predicting future records and order statistics (two-sample prediction) based on progressive type-II censored with random removals, where the number of units removed at each failure time has a discrete binomial distribution. We use the Bayes procedure to derive both point and interval bounds prediction. Bayesian point prediction under symmetric and symmetric loss functions is discussed. The maximum likelihood (ML) prediction intervals using “plug-in” procedure for future records and order statistics are derived. An example is discussed to illustrate the application of the results under this censoring scheme.

关键词： Bayesian Prediction Burr-X Model Progressive Censoring Random Removals

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Estimation Based on Progressive First-Failure Censored Sampling with Binomial Removals

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Intelligent Information Management 2013年第4期5卷 117-125页

作者： Ahmed A. Soliman Ahmed H. Abd Ellah nasser A. Abou-Elheggag rashad M. El-Sagheer Faculty of Science Islamic University Madinah Saudi Arabia Mathematics Department Faculty of Science Al-Azhar University Nasr-City Cairo Egypt Mathematics Department Sohag University Sohag Egypt

In this paper, the inference for the Burr-X model under progressively first-failure censoring scheme is discussed. Based on this new censoring were the number of units removed at each failure time has a discrete binomial distribution. The maximum likelihood, Bootstrap and Bayes estimates for the Burr-X distribution are obtained. The Bayes estimators are obtained using both the symmetric and asymmetric loss functions. Approximate confidence interval and highest posterior density interval (HPDI) are discussed. A numerical example is provided to illustrate the proposed estimation methods developed here. The maximum likelihood and the different Bayes estimates are compared via a Monte Carlo simulation study.

关键词： Burr-X Distribution Progressive First-Failure Censored Bayesian and Non-Bayesian Estimations Loss Function Bootstrap Random Removals

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