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The Frequency of the v-AKT Murine Thymoma Viral Oncogene Homologue 1 Gene Amplification among Sudanese Women with Ovarian Cancer: A Cross-Sectional Study

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Open Journal of Genetics 2023年第2期13卷 75-82页

作者： Rawia Eljaili Elmassry Aisha Osman Mohammed Amina Ibrahim Badawy rasha saad abdalhamid Huda Abdalla Eltahir Safa Abass Mohammed Hammad Yahia Abdou Adil Abdelrahim Yousif Zubaida Abohumeda Adam Nazik Elmalaika Husaim College of Health Sciences and Nursing Al-Rayan Colleges Al Madinah Al Munawwarah Kingdom of Saudi Arabia Faculty of Medical Laboratory Sciences Alzaiem Alazhari University Khartoum Sudan College of Applied Medical Sciences King Khalid University Abha Kingdom of Saudi Arabia Faculty of Medicine Omdurman Islamic University Khartoum Sudan

Background: Protein kinase B (AKT/PKB) family is frequently amplified in ovarian cancer (OC). To the greatest of our knowledge, there is a lack of published reports about the amplification of the genes belonging to the AKT family among Sudanese women with OC. The present study was conducted to detect the AKT1 gene amplification and its association with tumour types, grades, and ages among Sudanese women with OC, bearing in mind the ethnic variation. Methods: This institution-based study included 79 cases of women diagnosed with ovarian cancer (OC) at Omdurman Maternity Hospital in the period 2013-2018. Formalin-fixed, paraffin-embedded (FFPE) tissue sections were used to extract RNA. AKT1 gene amplification was assessed using quantitative real-time PCR. Results: The mean age (±SD) of included women was 49.29 (±13.612). The amplification of AKT1 gene was observed in 18/79 (22.8%) of OC women, with a high frequency in women with undifferentiated 1/2 (50%), clear cell 2/6 (33.3%), mucinous 3/11 (27.3%), endometrioid 3/17 (17.6%), and serous carcinomas 5/30 OC (16.7%). High frequency was seen in women with low (26.3%;n = 10/28) rather than in higher (19.5%;n = 8/33) grade carcinoma, and in older (25.8%;n = 8/23) rather than younger (18.2%;n = 2/9) women. No significant association between AKT1 gene amplification and tumour types, grades, and ages of women was observed (Fisher’s Exact test: p = 0.405, 0.593 and 0.851, respectively). Conclusion: AKT1 gene amplification arises in around one-fifth of Sudanese women with ovarian cancer (OC). It is seen more in undifferentiated, clear cell, and mucinous tumours types, and more frequently in low tumour grade and older women, but not to a statistically significant level. These outcomes sustenance previous studies suggesting that activated AKT genes have a vital role in OC progression and may offer a plan for targeted therapy and prognostic evaluation.

关键词： AKT1 Gene Amplification Ovarian Cancer Cross-Sectional Study Quantitative Real-Time PCR Sudan

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Natural Convection and Thermal Radiation Influence on Nanofluid Flow over a Nonlinearly Stretching Sheet

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Journal of Applied Mathematics and Physics 2022年第11期10卷 3301-3315页

作者： Emad M. Abo-Eldahab rasha Adel Yasmin M. saad Department of Mathematics Faculty of Science Helwan University Cairo Egypt Basic Science Department School of Engineering Canadian International Collage Giza Egypt

This paper studies the effects of Natural convection and Thermal radiation on nanofluid over a non-linearly stretching sheet. The governing equation of nonlinear partial differential equations of the flow is transformed to nonlinear ordinary differential equations by using similarity transformation, earlier than being solved numerically through a Rung-Kutta-Fehlberg method with shooting technique. The numerical results have been obtained for The influence of Brownian motion number (Nb), thermophoresis number (Nt), Grashof number (Gr), Lewis number (Le), stretching parameter (n), and thermal radiation parameter (Ra) on the velocity, temperature, and nanoparticles concentration profiles are shown graphically.

关键词： Nanofluid Stretching Sheet Thermal Radiation Free Convection

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Management of early-onset sepsis in a teaching hospital: A descriptive retrospective study

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Journal of Acute Disease 2020年第2期9卷 78-82页

作者： Sana H.Mohamed rasha R.Binni Bashir A.Yousef Department of Clinical Pharmacy Faculty of PharmacyUniversity of KhartoumAl-Qasr AveKhartoum 11111Sudan Department of Pharmacology Faculty of PharmacySudan International UniversityEbid-Khatim StreetKhartoum 11111Sudan Department of Pharmacology Faculty of PharmacyUniversity of KhartoumAl-Qasr AveKhartoum 11111Sudan

Objective: To evaluate the management of early-onset sepsis at saad Abul-Ella Teaching Hospital, Sudan. Methods: A descriptive retrospective hospital-based study was carried out at the Nursery Department of saad Abul-Ella Teaching Hospital. All medical records of neonates with suspected or confirmed sepsis during the year 2017 were reviewed to evaluate the management of antibiotics for sepsis using a data collection form. Results: Out of the 205 cases, 82 neonates (40%) were diagnosed as early-onset sepsis, among which the majority was male (68%). All neonates were given cefotaxime plus vancomycin as empirical therapy which was changed to other antibiotics in 23% of the cases. The common risk factors associated with early-onset sepsis wereprolonged rupture of membrane (41.8%), preterm delivery (26.3%) and low birth weight (15.1%). Blood cultures were performed in 168 cases, and 19% had bacterial growth of Staphylococcus aureus which is the most common isolated pathogen. Conclusions: Cefotaxime plus vancomycin are the main empirical antibiotic for sepsis, and Staphylococcus aureus is the most common pathogen associated with early-onset sepsis.

关键词： Umbelliferone Type 2 diabetes mellitus Oxidative stress Inflammation Glycation

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