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Comparison of intraocular pressure measurements with different contact tonometers in young healthy persons

International Journal of Ophthalmology(English edition) 2016年第1期9卷 76-80页

作者： saulius galgauskas rasa strupaite ernesta strelkauskaite rimvydas asoklis Center of Eye Diseases Vilnius University Vilnius LT-08661 Lithuania

AIM：To analyze the correlation of Goldmann applanation tonometer（GAT）,I-Care tonometer and Tono-Pen tonometer results in young healthy persons,and to investigate the influence of central corneal thickness（CCT）on intraocular pressure（IOP）measurements recorded with these tonometers.·M ETHODS：We conducted a pilot clinical study in 78eyes of 78 subjects aged 22-28 years old（44 women and34 men;mean age 23.8±1.19y）.IOP was measured using GAT,I-Care and Tono-Pen tonometers,followed by measurements of *** analysis was performed using SPSS 20.0.·RESULTS：The mean IOPs and standard deviation（±SD）for GAT,I-Care and Tono-Pen were 15.62±2.281 mm Hg,16.29±2.726 mm Hg and 16.32±2.393 mm Hg,*** mean CCT was 555.15±29.648μ*** positive correlations between GAT and I-Care,GAT and TonoPen,and I-Care and Tono-Pen tonometers were found（=0.867,〈0.001;=0.861,〈0.001;=0.915,〈0.001,respectively）.In comparison between devices,BlandAltman analysis showed a significant mean difference（MD）in the measurements by GAT and I-Care of-0.679 mm Hg and by GAT and Tono-Pen of-0.705 mm Hg（〈0.001）,but there was no significant difference between I-Care and Tono-Pe（〉0.05）.Both non-gold standard tonometers were affected by CCT;that is,both I-Care and Tono-Pen tonometer values were significantly higher with higher CCT means（〉555μm;MD=-1.282,〈0.001;MD=-0.949,〈0.001,respectively）compared with GAT.·CONCLUSION：Both I-Care and Tono-Pen tonometers overestimated IOP compared with the GAT *** the I-Care or Tono-Pen tonometer could be used instead of GAT because there was no significant difference between their *** CCT values（〉555μm）were associated with overestimated IOP values.

关键词： Goldmann tonometer I-Care tonometer Tono-Pen tonometer comeal thickness intraocular pressure

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X-linked juvenile retinoschisis： phenotypic and genetic characterization

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International Journal of Ophthalmology(English edition) 2018年第11期11卷 1875-1878页

作者： rasa strupaite Laima Ambrozaityte Loreta Cimbalistiene Rimvydas Asoklis Algirdas Utkus Center of Eye Diseases Clinic of Ear Nose Throat and EyeDiseases Institute of Clinical Medicine Faculty of MedicineVilnius University Vilnius LT-01513 Lithuania Department of Human and Medical Genetics Institute ofBiomedical Sciences Faculty of Medicine Vilnius UniversityVilnius LT-01513 Lithuania Center for Medical Genetics Vilnius University HospitalSantaros Klinikos Vilnius LT-08661 Lithuania

Juvenile X-linked retinoschisis（XLRS, MIM#312700） belongs to a group of the vitreoretinal dystrophies. We aimed to describe the phenotype-genotype correlation of three XLRS cases in juveniles with different novel mutations from the Lithuanian population. The patients demonstrated macular retinoschisis and typical cyst-like cavities on spectral-domain optical coherence tomography（SD-OCT） images. The mean central foveal thickness was 569.7 μm. Two patients presented with peripheral retinoschisis. Flash electroretinogram demonstrated a reduced b/a ratio（〈1.0） in all patients. RS1（NM_000330.3） gene coding exons Sanger sequencing was performed. RS1 c.599 G〉T（p.R200 L） mutation was detected in one case, showing to be pathogenic in silico analysis. c.（92_97） ins C（p.W33 fs） mutation was identified for another patient, indicating the variant is possibly damaging in silico analysis. The third case was identified with a pathogenic mutation c.422 C〉G（p.R141 H）, HGMD CM981753. These are the first cases of XLRS in the Lithuanian population confirmed by molecular genotyping. Presented patients had a different genotype but similar phenotypic traits.

关键词： RS1 mutation X-linked retinoschisis electroretinogram optical coherence tomography

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