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Optimum profiles of Endwall Contouring for Enhanced Net Heat Flux Reduction and Aerodynamic performance

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Journal of Harbin Institute of Technology(New series) 2024年第2期31卷 80-92页

作者： Arjun K s Tide p s Biju N Division of Mechanical Engineering School of EngineeringCochin University of Science&TechnologyKalamassery 682022India

successfully utilized non-axisymmetric endwalls to enhance turbine efficiencies(aerodynamic and turbine inlet temperatures)by controlling the characteristics of the secondary flow in a blade *** is accomplished by steady-state numerical hydrodynamics and deep knowledge of the field of *** of the interaction between mainstream and purge flow contributing supplementary losses in the stage,non-axisymmetric endwalls are highly susceptible to the inception of purge flow exit compared to the flat and any advantage rapidly *** conclusions reveal that the supreme endwall pattern could yield a lowering of the gross pressure loss at the design stage and is related to the size of the top-loss location being productively *** has led to diminished global thermal exchange lowered in the passage of the vane *** reverse flow adjacent to the suction side corner of the endwall is migrated farther from the vane surface,as the deviated pressure spread on the endwall accelerates the flow and progresses the reverse flow core still *** depleted association between the tornado-like vortex and the corner vortex adjacent to the suction side corner of the endwall is the dominant mechanism of control in the contoured end *** this publication,we show that the non-axisymmetric endwall contouring by selective numerical shape change method at most prominent locations is advantageous in lowering the thermal load in turbines to augment the net heat flux reduction as well as the aerodynamic performance using multi-objective optimization.

关键词： endwall contouring turbine vane heat transfer phantom cooling coolant injection net heat flux reduction aerodynamic performance

A multi-platform analysis of human gingival crevicular fluid reveals ferroptosis as a relevant regulated cell death mechanism during the clinical progression of periodontitis

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International Journal of Oral science 2024年第2期16卷 265-279页

作者： Alfredo Torres M.Angélica Michea Ákos Végvári Marion Arce Valentina pérez Marcela Alcota Alicia Morales Rolando Vernal Mauricio Budini Roman A.Zubarev Fermín E.González Laboratory of Experimental Immunology&Cancer Faculty of DentistryUniversity of ChileSantiagoChile Department of Conservative Dentistry Faculty of DentistryUniversity of ChileSantiagoChile Division of Chemistry I Department of Medical Biochemistry and BiophysicsKarolinska InstitutetStockholmSweden periodontal Biology Laboratory Faculty of DentistryUniversidad de ChileSantiagoChile Laboratory of Cellular and Molecular pathology Institute for Research in Dental SciencesFaculty of DentistryUniversity of ChileSantiagoChile

Ferroptosis is implicated in the pathogenesis of numerous chronic-inflammatory diseases,yet its association with progressive periodontitis remains *** investigate the involvement and significance of ferroptosis in periodontitis progression,we assessed sixteen periodontitis-diagnosed *** progression was clinically monitored over twelve weeks via weekly clinical evaluations and gingival crevicular fluid(GCF)collection was performed for further *** metrics,proteomic data,in silico methods,and bioinformatics tools were combined to identify protein profiles linked to periodontitis progression and to explore their potential connection with *** western blot analyses validated key ***,a single-cell RNA sequencing(scRNA-seq)dataset(GsE164241)for gingival tissues was analyzed to elucidate cellular dynamics during periodontitis *** progression was identified as occurring at a faster rate than traditionally *** samples from progressing and non-progressing periodontal sites showed quantitative and qualitatively distinct proteomic *** addition,specific biological processes and molecular functions during progressive periodontitis were revealed and a set of hub proteins,including sNCA,CA1,HBB,sLC4A1,and ANK1 was strongly associated with the clinical progression status of ***,we found specific proteins-drivers or suppressors-associated with ferroptosis(sNCA,FTH1,HspB1,CD44,and GCLC),revealing the co-occurrence of this specific type of regulated cell death during the clinical progression of ***,the integration of quantitative proteomic data with scRNA-seq analysis suggested the susceptibility of fibroblasts to *** analyses reveal proteins and processes linked to ferroptosis for the first time in periodontal patients,which offer new insights into the molecular mechanisms of progressive periodontal *** findings may le

关键词： finding progression faster

Interdigitated terahertz metamaterial sensors:design with the dielectric perturbation theory

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photonics Research 2024年第6期12卷 1115-1128页

作者： LEI CAO FANQI MENG EsRAÖZDEMIR YANNIK LOTH MERLE RICHTER ANNA KATHARINA WIGGER MAIRA BEATRIZ pÉrez sOsA ALAA JABBAR JUMAAH sHIHAB AL-DAFFAIE pETER HARING BOLÍVAR HARTMUT G.ROsKOs state Key Laboratory of Advanced Electromagnetic Technology Huazhong University of Science and TechnologyWuhan 430074China physikalisches Institut Johann Wolfgang Goethe-UniversitätFrankfurt am MainGermany University of siegen Institute for High Frequency and Quantum ElectronicsSiegenGermany Department of Electrical Engineering Eindhoven University of Technology5612 AE EindhovenThe Netherlands

Designing terahertz sensors for highly sensitive detection of nanoscale thin films and a few biomolecules poses a substantial challenge but is crucial for unlocking their full potential in scientific research and advanced *** work presents a strategy for optimizing metamaterial sensors in detecting small quantities of dielectric *** amount of frequency shift depends on intrinsic properties(electric field distribution,Q-factor,and mode volume)of the bare cavity as well as the overlap volume of its high-electric-field zone(s)and the *** by the simplified dielectric perturbation theory,interdigitated electric split-ring resonators(ID-esRRs)are devised to significantly enhance the detection sensitivity compared with esRRs without interdigitated ***-esRR’s fin-gers redistribute the electric field,creating strongly localized enhancements,which boost analyte *** periodic change of the inherent antiphase electric field reduces radiation loss,leading to a higher *** with ID-esRR sensors operating at around 300 GHz demonstrate a remarkable 33.5 GHz frequency shift upon depositing a 150 nm siO_(2)layer as an analyte simulant,with a figure of merit improvement of over 50 times compared with structures without interdigitated *** rational design offers a promising avenue for highly sensitive detection of thin films and trace biomolecules.

关键词： dielectric perturbation theory

Work Ability Index and Work Ability score: A Comparation between both scores in a persistent COVID-19 Cohort

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Occupational Diseases and Environmental Medicine 2024年第1期12卷 49-57页

作者： Carmen Muñoz-Ruiperez Diego Alvaredo Rodrigo Daniel Arroyo-sánchez Juan Francisco Álvarez Zarallo Ignacio sánchez-Arcilla Conejo José Lorenzo Bravo Grande Department of Occupational Health Hospital Universitario 12 de Octubre Madrid Spain Instituto de Investigación Biomédica Hospital 12 de Octubre (Imas12) Madrid Spain Department of Occupational Health Hospital Universitario Virgen Macarena Andalucía Sevilla Spain Department of Occupational Health Hospital Universitario Gregorio Mara&#241ón Madrid Spain Department of Occupational Health Complejo Asistencial Universitario de Salamanca Castilla y León Salamanca Spain

Aims: The present study aims to compare the assessment of work ability based on the use of the Work Ability Index (WAI) with another questionnaire base only on the use of WAI’s first item, termed as the “Work Ability score” (WAs). study design: A cohort of 384 spanish workers included in a post COVID-19 condition or persistent COVID-19 multicenter research was utilized. place and Duration of study: This cohort was enlisted in four hospitals (Hospital Universitario 12 de Octubre, Madrid;Hospital Universitario Virgen Macarena, sevilla, Andalucía;Hospital Universitario Gregorio Marañón, Madrid and Complejo Asistencial Universitario de salamanca, Castilla y León), since 2021 until 2022. Methodology: 384 spanish workers (176 men and 208 women;aged 20 to 70 years) with post COVID-19 condition or persistent COVID-19 were included. Descriptive analysis of primary scores was conducted. Given the non-normal distribution of data, the Mann-Whitney and Kruskal-Wallis tests were employed. spearman and Kendall correlations were employed to assess the relationship between WAI and WAs, also used weighted Kappa to estimate the degree agreement between WAI and WAs. Logistic regression models were utilized to study determinants influencing WAI and WAs, categorized as poor or moderate. Results: WAI had an average score of 32.98 (sD = 10.28), whereas WAs had an average of 5.95 (sD = 2.77). significant differences were observed in both WAI and WAs across the same variables. strong and statistically significant correlations were evident between WAI and WAs (rs = 0.83, p s used in the logistic regression model (gender, the sector employment, and previous chronic diseases) were statistically significant in both questionnaires. Conclusion: WAs questionnaire could be used as a tool for reliable assessment of work ability among spanish workers with post COVID-19 condition or persistent CO-VID-19.

关键词： Work Ability Index Work Ability score post COVID-19 Condition Occupational Health Occupational Medicine

Wood anatomical acclimation in the endemic genus polylepis in peruvian Andean forests

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Journal of Mountain science 2024年第9期21卷 2986-3000页

作者： Anthony GUERRA Fressia N.AMEs-MARTÍNEZ Ernesto C.RODRÍGUEZ-RAMÍrez postgraduate programme in Agronomy/plant physiology Department of Biology-Institute of Natural sciences Federal University of LavrasLavras 37203-202Minas Gerais 30000-31999Brazil Laboratory of Biotechnology and Molecular Biology Continental UniversitySan Antonio UrbanizationHuancayo 12000Peru Ecology and Biodiversity Research programme ANDINUS AssociationMiguel Grau Street 370Huancayo 12000Peru Dendrochronology Laboratory Continental UniversitySan Carlos Avenue 1980Huancayo 12000Peru

polylepis(Queñua)is a dominant woody plant genus in Andean puna forests that occurs in a wide range of montane habitats and is ecologically diverse in endemism,which may be particularly threatened by climate *** anatomical traits are essential for understanding how plants adjust their ecophysiological requirements and maximize their resilience,resistance,and recovery to extreme *** the effects of extreme climatic conditions in high altitude ecosystems have been studied extensively,our knowledge is relatively limited to quantitative differences in the main xylem *** address this gap,we assessed the acclimation of wood anatomical traits in six peruvian Andean polylepis species with different water availability(semi-dry with high moisture and semiarid with dry winters).We selected hydraulic diameter,vessel density,vessel grouping index,solitary vessel index,vulnerability index,mesomorphy index,vessel element length,fiber length,fiber wall thickness,fiber lumen diameter,and total fiber diameter that can provide relevant eco-wood anatomical acclimation to hydric *** performed multivariate analysis to determine the leading dimensions of covariation among polylepis species and climatic *** wood anatomical traits(vessel grouping index,vulnerability index,and fiber wall thickness)were dissimilar between xeric-and mesic-polyelpis *** study demonstrates that wood anatomical traits in peruvian Andean polylepis species provides high-resolution and long-term eco-wood anatomical signals on how climate oscillations drive the acclimation processes of fiber and vessel *** findings underscore the significance of xylem hydraulic adjustment to various hydrological environments in Andean puna *** evaluating the effects of drought on wood anatomical characteristics and ecological function,we demonstrate the capacity of tree species to adapt and endure climate-related changes,thereby emphasizing their resilience and ada

关键词： Carlquist indices Climatic resilience Vessel traits Fiber Functional trait Hydric stress

Detection of progesterone Receptor as a Method of Diagnosing Mammary Cancer in Female Dogs

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Open Journal of Veterinary Medicine 2024年第8期14卷 217-227页

作者： José de Jesús Vázquez pérez Angel Ramses Figueroa Hernandez Jorge peregrina sandoval Guillermo Nolasco Rodríguez Manuel Rosales Cortés Department of Veterinary Medicine University Center of Biological and Agricultural Sciences University of Guadalajara Zapopan Mexico Department of Cellular and Molecular Biology University Center for Biological and Agricultural Sciences University of Guadalajara Zapopan Mexico

Introduction: Canine mammary gland tumor is the most common type of neoplasia in non-ovariectomized bitches. Approximately 50% of tumors are malignant. Neoplasms originating from the mammary gland represent the most common neoplastic disease in canines in Veterinary Medicine. Aim: Relate the expression of the receptor to progesterone (pR) with the tumor stage of canine mammary carcinoma. Material and Methods: Analytical-cross-sectional study, samples of paraffinized tumor tissue obtained from 30 canine patients with breast cancer were used. The expression of pR was performed by immunohistochemical labeling, using murine anti-pR (anti-pR Biocare brand). A descriptive analysis was carried out with the results using the spss program. Results: The predominant histological subtype of breast cancer was tubular carcinoma with 12 patients, followed by papillary cystic carcinoma with 6 patients, solid carcinoma 5, carcinosarcoma 4 and comedocarcinoma 3. There was a significant trend between breast cancer subtypes, histological grade G1. Among the histopathological findings, the degree of invasion is related to the presence of tumor cells in adjacent lymph nodes, which is why it is a prognostic indicator. The expression of pR in the tumor tissue samples it was 42.8% positive versus 57.14% negative, of which 75% correspond to G1, 8.3% to G2 and 16.6% to G3. With respect to the relationship of the expression of pR vs type of tumor, it was found that 50% correspond to tubular carcinoma, 33.3% to papillary cystic carcinoma, 8.3% to solid carcinoma and 8.3% to comedocarcinoma. Conclusion: The hormone receptor was negative in more than half of the patients and histological grade is significantly associated with tumor subtypes, this study emphasizes the need to introduce receptor testing into our routine clinical practice to offer the best treatment for breast cancer.

关键词： Cancer Mammary Gland progesterone Immunohistochemistry progesterone Membrane Receptor Component 1 (pGRMC 1)

structural build-up model for three-dimensional concrete printing based on kinetics theory

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Frontiers of structural and Civil Engineering 2024年第7期18卷 998-1014页

作者： prabhat Ranjan pREM p.s.AMBILY shankar KUMAR Greeshma GIRIDHAR Dengwu JIAO Advanced Materials Laboratory CSIR-Structural Engineering Research CentreChennai 600113India Department of Architecture and Civil Engineering City University of Hong KongHong Kong 999077China

The thixotropic structural build-up is crucial in extrusion-based three-dimensional(3D)concrete *** paper uses a theoretical model to predict the evolution of static and dynamic yield stress for printed *** model employs a structural kinetics framework to create a time-independent constitutive link between shear stress and shear *** model considers flocculation,deflocculation,and chemical hydration to anticipate structural *** reversible and irreversible contributions that occur throughout the build-up,breakdown,and hydration are defined based on the proposed structural ***,detailed parametric studies are conducted to evaluate the impact of model *** is revealed that the proposed model is in good agreement with the experimental results,and it effectively characterizes the structural build-up of 3D printable concrete.

关键词： structural build-up rheology thixotropy 3D printable concrete kinetics theory ultra high performance concrete

Morphometric Attributes of Two Native Forage species According to Water source Distance in semiarid Central Grasslands of Argentina

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phyton-International Journal of Experimental Botany 2024年第8期93卷 2063-2074页

作者： Carla Etel suárez María sol Rossini Ernesto Francisco Atilio Morici Héctor Daniel Esterlich Laboratorio de Ecología en Ambientes semiáridos Ecología VegetalFacultad de AgronomíaUNLPamSanta Rosa6300Argentina Facultad de Ciencias Veterinarias UNLPamGeneral Pico6360Argentina Becaria Doctoral CONICET APNFacultad de AgronomíaUNLPamSanta Rosa6300Argentina

The semiarid grasslands of Argentina’s central region have been modified by domestic livestock grazing,both in their composition and *** increase in the proportion of woody and non-forage species and the decrease in forage species are some of the most evident results of this *** is limited available information about the effect of differential grazing pressures on morphometric attributes of native species,and it also depends on the life histories of the species in this *** objective of this work was to evaluate some morphometric aspects in the grasses poa ligularis Nees ex steud and piptochaetium napostaense(speg.).Hack according to distance from the water source in communities in the central semiarid region of *** study area included areas of low grassland,golden forests,and secondary forests in grasslands(6 fields with 9 paddocks).Grazing pressure was established based on the distance to the water source,so sampling areas were designated near the water source(grazing pressure is greater)and far from the water source(grazing pressure light)in each of the *** both species,specimens were selected at random,and the following attributes were measured:crown diameter at ground level(cm),burial depth(cm),average tiller weight per plant(***^(−1)),and the density of tillers per unit of crown surface(***^(−2)crown).The morphometric attributes evaluated showed differences according to the distance to the watering hole and in the different *** species presented similar behaviors for the *** were significant differences in the depth of burial and the average weight of tillers per plant,being greater in the areas close to the water *** the distance to the watering hole,there were no significant differences in crown diameter and tiller density,but the highest values were recorded for the former near the watering hole and for the second far from the watering *** pastures with low

关键词： Grazing pressure tiller density tiller weight crown burial depth poa ligularis piptochaetium napostaense

Impact of device resistances in the performance of graphene‑based terahertz photodetectors

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Frontiers of Optoelectronics 2024年第2期17卷 87-97页

作者： O.Castelló sofía M.López Baptista K.Watanabe T.Taniguchi E.Diez J.E.Velázquez-pérez Y.M.Meziani J.M.Caridad J.A.Delgado-Notario Department of Applied physics University of Salamanca37008 SalamancaSpain Unidad de Excelencia en Luz y Materia Estructurada(LUMEs) University of Salamanca37008 SalamancaSpain Research Center for Electronic and Optical Materials National Institute for Materials Science1-1 NamikiTsukuba 305-0044Japan Research Center for Materials Nanoarchitectonics National Institute for Materials Science1-1 NamikiTsukuba 305-0044Japan Nanotechnology Group USAL-NanolabUniversity of Salamanca37008 SalamancaSpain

In recent years,graphene field-effect-transistors(GFETs)have demonstrated an outstanding potential for terahertz(THz)photodetection due to their fast response and *** features are essential to enable emerging THz applications,including 6G wireless communications,quantum information,bioimaging and ***,the overall performance of these photodetectors may be utterly compromised by the impact of internal resistances presented in the device,so-called access or parasitic *** this work,we provide a detailed study of the influence of internal device resistances in the photoresponse of high-mobility dual-gate GFET *** dual-gate architectures allow us to fine tune(decrease)the internal resistance of the device by an order of magnitude and consequently demonstrate an improved responsivity and noise-equivalent-power values of the photodetector,*** results can be well understood by a series resistance model,as shown by the excellent agreement found between the experimental data and theoretical *** findings are therefore relevant to understand and improve the overall performance of existing high-mobility graphene photodetectors.

关键词： Graphene THz photodetector Field-effect transistor plasmonic