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Object-Based Method Outperforms Per-Pixel Method for Land Cover Classification in a Protected Area of the Brazilian Atlantic Rainforest Region

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Pedosphere 2013年第3期23卷 290-297页

作者： T.RITTL M.COOPER R.J.HECK M.V.R.ballester Department of Soil Quality University of Wageningen Department of Soil Science University of So Paulo School of Environmental Sciences University of Guelph Center for Nuclear Energy in Agriculture (CENA) University of So Paulo

Conventional image classification based on pixels hinders the possibilities to obtain information contained in images, while modern object-based classification methods increase the acquisition of information about the object and the context in which it is inserted in the image. The objective of this study was to investigate the performance of different classification methods for land cover mapping in the vicinity of the Alto Ribeira Tourist State Park, a Brazilian Atlantic rainforest area. Two classification methods were tested, including i) a hybrid per-pixel classification using the image processing software ERDAS Imagine version 9.1 and ii) an object-based classification using the software eCognition version 5. In the first method, six different classes were established, while in the second method, another two classes were established in addition to the six classes in the first method. Accuracy assessment of the classification results presented showed that the object-based classification with a Kappa index value of 0.8687 outperformed the per-pixel classification with a Kappa index value of 0.2224. Application of the user's knowledge during the object-based classification process achieved the desired quality; therefore, the use of inter-relationships between objects, superclasses, subclasses, and neighboring classes were critical to improving the efficiency of land cover classification.

关键词：土地覆盖分类分类方法基于对象大西洋像素巴西 eCognition 保护区

Novel human immunomodulatory T cell receptors and their double-edged potential in autoimmunity,cardiovascular disease and cancer

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Cellular & Molecular Immunology 2021年第4期18卷 919-935页

作者： Pilar Martin Rafael Blanco-Dom fnguez raquel Sanchez-Diaz Vascular Pathophysiology Area Centro Nacional de Investigaciones Cardiovasculares(CNIC)MadridSpain CIBERCV MadridSpain

In the last decade,approaches based on T cells and their immunomodulatory receptors have emerged as a solid improvement in treatments for various types of ***,the roles of these molecules in the therapeutic context of autoimmune and cardiovascular diseases are still relatively ***,we review the best known and most com m only used immunomodulatory T cell receptors in clinical practice(PD-1 and CTLA-4),along with the rest of the receptors with known functions in animal models,which have great potential as modulators in human pathologies in the medium *** ong these other receptors is the receptor CD69,which has recently been described to be expressed in mouse and human T cells in autoimmune and cardiovascular diseases and ***,inhibition of these receptors individually or in combination by drugs or monoclonal antibodies generates a loss of immunological tolerance and can trigger multiple autoimmune disorders in different organs and immune-related adverse *** the coming decades,knowledge on the functions of different immunomodulatory receptors will be pivotal for the development of new and better therapies with less harmful side *** this review,we discuss the roles of these receptors in the control of immunity from a perspective focused on therapeutic potential in not only cancer but also autoimmune diseases,such as systemic lupus erythematosus,autoimmune diabetes and rheumatoid arthritis,and cardiovascular diseases,such as atherosclerosis,acute myocardial infarction,and myocarditis.

关键词： Immunomodulatory receptors Autoimmune diseases T cells Immunotherapy

Higher rates of autism and attention deficit/hyperactivity disorder in American children:Are food quality issues impacting epigenetic inheritance?

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World Journal of Clinical Pediatrics 2023年第2期12卷 25-37页

作者： Renee J Dufault raquel A Crider Richard C Deth Roseanne Schnoll Steven G Gilbert Walter J Lukiw Amanda L Hitt Department of Research Food Ingredient and Health Research InstituteNaalehuHI 96772United States College of Graduate Health Studies A.T.Still UniversityKirksvilleMO 63501United States Department of Pharmaceutical Sciences Nova Southeastern UniversityFort LauderdaleFL 33314United States Department of Health and Nutrition Sciences Brooklyn College of CUNYBrooklynNY 11210United States Department of Research Institute of Neurotoxicology and Neurological DisordersSeattleWA 98105United States LSU Neuroscience Center Louisiana State University Health Sciences CenterNew OrleansLA 70112United States Food Integrity Campaign Government Accountability ProjectColumbiaWA 20006United States Department of Legal Food Ingredient and Health Research InstituteNaalehuHI 96772United States

In the United States,schools offer special education services to children who are diagnosed with a learning or neurodevelopmental disorder and have difficulty meeting their learning *** may play a key role in helping children access special education *** number of children ages 6-21 in the United States receiving special education services increased 10.4%from 2006 to *** receiving special education services under the autism category increased 242%during the same *** demand for special education services for children under the developmental delay and other health impaired categories increased by 184%and 83%*** student enrollment in American schools has remained stable since 2006,the percentage distribution of children receiving special education services nearly tripled for the autism category and quadrupled for the developmental delay category by *** heavy metal residues remain persistent in the American food supply due to food ingredient manufacturing *** clinical trial data indicate heavy metal exposures and poor diet are the primary epigenetic factors responsible for the autism and attention deficit hyperactivity disorder *** heavy metal exposures,especially inorganic mercury and lead may impact gene behavior across *** 2021,the United States Congress found heavy metal residues problematic in the American food supply but took no legislative *** health warning labels on select foods may be the only way to reduce dietary heavy metal exposures and improve child learning across generations.

关键词： Lead exposure Mercury Oxidative stress Methylation patterns Epigenetic inheritance Autism

Communication between bone marrow mesenchymal stem cells and multiple myeloma cells:Impact on disease progression

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World Journal of Stem Cells 2023年第5期15卷 421-437页

作者： Daniel García-Sánchez Alberto González-González Ana alfonso-Fernández Mónica Del Dujo-Gutiérrez Flor M Pérez-Campo Department of Molecular Biology_IDIVAL Faculty of MedicineUniversity of CantabriaSantander 39011CantabriaSpain Servicio de Traumatología y Cirugía Ortopédica Hospital Universitario Marqués de ValdecillaInstituto de Investigación Sanitaria Valdecilla(IDIVAL)Facultad de MedicinaUniversidad de CantabriaSantander 39008CantabriaSpain

Multiple myeloma(MM)is a hematological malignancy characterized by the accumulation of immunoglobulin-secreting clonal plasma cells at the bone marrow(BM).The interaction between MM cells and the BM microenvironment,and specifically BM mesenchymal stem cells(BM-MSCs),has a key role in the pathophysiology of this *** data support the idea that BM-MSCs not only enhance the proliferation and survival of MM cells but are also involved in the resistance of MM cells to certain drugs,aiding the progression of this hematological *** relation of MM cells with the resident BM-MSCs is a two-way *** modulate the behavior of BM-MSCs altering their expression profile,proliferation rate,osteogenic potential,and expression of senescence *** turn,modified BM-MSCs can produce a set of cytokines that would modulate the BM microenvironment to favor disease *** interaction between MM cells and BM-MSCs can be mediated by the secretion of a variety of soluble factors and extracellular vesicles carrying microRNAs,long non-coding RNAs or other ***,the communication between these two types of cells could also involve a direct physical interaction through adhesion molecules or tunneling ***,understanding the way this communication works and developing strategies to interfere in the process,would preclude the expansion of the MM cells and might offer alternative treatments for this incurable disease.

关键词： Multiple myeloma Mesenchymal stem cells Bone marrow microenvironment Soluble factors Extra-cellular vesicles Cells adhesion molecules Tunnellingnanotubes

Prevention of ventilator-associated pneumonia through care bundles:A systematic review and meta-analysis

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Journal of Intensive Medicine 2023年第4期3卷 352-364页

作者： raquel Martinez-Reviejo Sofia Tejada Miia Jansson Alfonsina Ruiz-Spinelli Sergio Ramirez-Estrada Duygu Ege Tarsila Vieceli Bert Maertens Stijn Blot Jordi Rello Centro de Investigación Biomédica en Red de Enfermedades Respiratorias(CIBERES) Instituto de Salud Carlos IIIMadrid 28029Spain Clinical Research Epidemiology in Pneumonia&Sepsis(CRIPS) Vall d'Hebron Institute of Research(VHIR)Barcelona 08035Spain Research Unit of Health Sciences and Technology University of OuluOulu90570Finland RMIT University Melbourne3010Australia Critical Care Department Hospital de Clínicas Dr.Manuel QuintelaMontevideo11600Uruguay Critical Care Department Clínica CorachanBarcelona08017Spain Emergency Medicine Department Adnan Menderes UniversityAydin09010Turkey Infectious Diseases Department Hospital de Clínicas de Porto AlegrePorto Alegre90035-903Brazil Department of Internal Medicine and Pediatrics Ghent UniversityGhent9000Belgium FOREVA Clinical Research CHU NimesUniversitéde Nîmes-MontpellierNîmes30012France Medicine Department Universitat Internacional de Catalunya(UIC)Barcelona08017Spain

Background Ventilator-associated pneumonia(VAP)represents a common hospital-acquired infection among mechanically ventilated *** summarized evidence concerning ventilator care bundles to prevent *** A systematic review and meta-analysis were *** controlled trials and controlled observational studies of adults undergoing mechanical ventilation(MV)for at least 48 h were considered for *** of interest were the number of VAP episodes,duration of MV,hospital and intensive care unit(ICU)length of stay,and mortality.A systematic search was conducted in the MEDLINE,the Cochrane Library,and the Web of Science between 1985 and *** are reported as odds ratio(OR)or mean difference(MD)with 95%confidence intervals(CI).The PROSPERO registration number is *** Thirty-six studies including 116,873 MV participants met the inclusion criteria.A total of 84,031 participants underwent care bundles for VAP *** most reported component of the ventilator bundle was head-of-bed elevation(n=83,146),followed by oral care(n=80,787).A reduction in the number of VAP episodes was observed among those receiving ventilator care bundles,compared with the non-care bundle group(OR=0.42,95%CI:0.33,0.54).Additionally,the implementation of care bundles decreased the duration of MV(MD=−0.59,95%CI:−1.03,−0.15)and hospital length of stay(MD=−1.24,95%CI:−2.30,−0.18)in studies where educational activities were part of the *** regarding mortality were *** The implementation of ventilator care bundles reduced the number of VAP episodes and the duration of MV in adult *** application in combination with educational activities seemed to improve clinical outcomes.

关键词： Hospital-acquired pneumonia Ventilator bundle Prevention Quality improvement intervention

Discriminatory capacity of serum interleukin-6 between complicated and uncomplicated acute appendicitis in children:a prospective validation study

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World Journal of Pediatrics 2022年第12期18卷 810-817页

作者： Javier Arredondo Montero Giuseppa Antona Adriana Rivero Marcotegui Carlos BardajíPascual Mónica Bronte Anaut raquel Ros Briones Amaya Fernández-Celis Natalia López-Andrés Nerea Martín-Calvo Pediatric Surgery Department Hospital Universitario de NavarraIrunlarrea 331008PamplonaSpain Clinical Analysis Department Hospital Universitario de NavarraPamplonaSpain Pathology Department Hospital Universitario de NavarraPamplonaSpain Cardiovascular Translational Research NavarraBiomed(Miguel Servet Foundation)Hospital Universitario de NavarraUniversidad Pública de Navarra(UPNA)IdiSNAPamplonaSpain School of Medicine Department of Preventive Medicine and Public HealthUniversity of NavarraPamplonaSpain CIBER Fisiopatología de la Obesidad y Nutrición(CIBERobn) Health Institute Carlos IIIMadridSpain Instituto de Investigación Sanitaria de Navarra IdiSNAPamplonaNavarraSpain

Background Serum interleukin-6(IL-6)has a moderate diagnostic performance in pediatric acute appendicitis(PAA).The evidence regarding its capacity to discern between complicated and uncomplicated PAA is *** We designed a prospective observational study to validate serum IL-6 as a marker for diagnostic classification between complicated and uncomplicated *** study included 205 patients divided into three groups:(1)patients who underwent major outpatient surgery(n=57);(2)patients with non-surgical abdominal pain(NSAP)in whom the diagnosis of PAA was excluded(n=53),and(3)patients with a confirmed diagnosis of PAA(n=95).The PAA patients were further classified as uncomplicated or complicated ***-6 concentration was determined in all patients at *** statistical analysis was performed using the Mann-Whitney U test,the Fisher exact test and the Kruskall Wallis *** area under the receiver operating characteristic curves(AUC)were *** Median(interquartile range,IQR)serum IL-6 values were 2 pg/mL(2.0–3.4)in group 1,3.9 pg/mL(2.4–11.9)in group 2,and 23.9 pg/mL(11.1–61.0)in group 3(P<0.001).Among the participants in group 3,those with uncomplicated PAA had median(IQR)serum IL-6 values of 17.2 pg/mL(8.5–36.8),and those with complicated PAA had 60.25 pg/mL(27.1–169)serum IL-6(P<0.001).At the cut-off point of 19.55 pg/mL,the AUC for the discrimination between patients in group 2 vs.3 was 0.83[95%confidence interval(CI)0.76–0.90],with a sensitivity of 61.3%and a specificity of *** AUC for the discrimination between patients with uncomplicated and complicated PAA was 0.77(95%CI 0.68–0.86)and the cut-off point was 25.90 pg/mL,with a sensitivity and specificity of 84.6%and 65.6%,*** Serum IL-6 has a good performance in discerning between complicated and uncomplicated PAA.A score including clinical and radiological variables may increase the diagnostic performance of this molecule.

关键词： Acute Appendicitis Complicated Diagnostic Interleukin-6 Pediatric Uncomplicated

Engineering operando methodology： Understanding catalysis in time and space

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Frontiers of Chemical Science and Engineering 2018年第3期12卷 509-536页

作者： raquel Portela Susana Perez-Ferreras Ana Serrano-Lotina Miguel A. Banares Instituto de Catalisis y Petroleoquimica ICP-CSIC Marie Curie 2 Madrid Spain

The term operando was coined at the begin- ning of this century to gather the growing efforts devoted to establish structure-activity relationships by simulta- neously characterizing a catalyst performance and the relevant surface chemistry during genuine catalytic opera- tion. This approach is now widespread and consolidated; it has become an increasingly complex but efficient junction where spectroscopy, materials science, catalysis and engineering meet. While for some characterization techni- ques kinetically relevant reactor cells with good resolution are recently developing, the knowledge gained with magnetic resonance and X-ray and vibrational spectro- scopy studies is already huge and the scope of operando methodology with these techniques is recently expanding from studies with small amounts of powdered solids to more industrially relevant catalytic systems. Engineering catalysis implies larger physical domains, and thus all sort of gradients. Space- and time- resolved multi-technique characterization of both the solid and fluid phases involved in heterogeneous catalytic reactions （including temperature data） is key to map processes from different perspectives, which allows taking into account existing heterogeneities at different scales and facing up- and down-scaling for applications ranging from microstructured reactors to industrial-like macroreactors （operating with shaped catalytic bodies and/or in integral regime）. This work reviews how operando methodology is evolving toward engineered reaction systems.

关键词： operando structured catalysts spaceresolved time-resolved spectroscopy

Detection with High Resolution Radar: Advanced Topics & Potential Applications

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Journal of Systems Engineering and Electronics 1992年第1期3卷 21-34页

作者： alfonso Farina Flavio A.Studer ALENIA S.p.A. ALENIA S.p.A. Via Tiburtina Km. 12.400-00131-Rome-Italy

In a previous companion paper [1], the potential advantages of high resolution radar for improved target detection were introduced. In particular, the concept of shaping both the transmitted waveform and the receiving processor in accordance to the expected target down-range profile was highlighted and performance predictions were provided. In this paper, we present and evaluate an adaptive scheme devised to on-line estimate the target profile, in order to overcome a limited a-priori knowledge. In addition, we introduce a more general model of target impulse response, based on a statistical description, and we discuss the corresponding processing scheme and detection performance.

关键词： High resolution radar Radar detection Adaptive imaging Design criteria.

Bats and their vital ecosystem services:a global review

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Integrative Zoology 2022年第1期17卷 2-23页

作者： Leidy Azucena RAMÍREZ-FRÁNCEL Leidy Viviana GARCÍA-HERRERA Sergio LOSADA-PRADO Gladys REINOSO-FLÓREZ alfonso SÁNCHEZ-HERNÁNDEZ Sergio ESTRADA-VILLEGAS Burton KLIM Giovany GUEVARA Programa de Doctorado en Ciencias Biológicas&Grupo de Investigación en Zoología(GIZ) Facultad de CienciasUniversidad del TolimaIbaguéColombia Programa para la Conservación de los Murciélagos de Colombia BogotáD.C.Colombia Departamento de Biología&Grupo de Investigación en Zoología(GIZ) Facultad de CienciasUniversidad del TolimaIbaguéColombia Departamento de Matemáticas y Estadística Facultad de CienciasUniversidad del TolimaIbaguéColombia Yale School of the Environment Yale UniversityNew HavenConnecticutUSA Smithsonian Tropical Research Institute BalboaRepublic of Panama Department of Natural History Royal Ontario MuseumTorontoOntarioCanada

Bats play crucial ecosystem services as seed dispersers,pollinators,controllers of insects,and nutrient ***,there has not been a thorough global review evaluating these roles in bats across all biogeographical regions of the *** reviewed the literature published during the last two decades and identified 283 relevant studies:78 dealt with the control of potential insect pests by bats,80 related to the suppression of other arthropods,60 on the dispersal of native or endemic seeds,11 dealt with the dispersal of seeds of introduced plants,29 on the pollination of native or endemic plants,1 study on pollination of introduced plants,and 24 on the use of guano as *** literature search showed that queries combining the terms“seed dispersal,”“insectivorous bats,”“nectarivorous bats,”“use of guano,”and“ecosystem services”returned 577 studies,but half were experimental in *** found that the evaluation of ecosystem services by bats has been mostly conducted in the Neotropical and Palearctic *** detect differences across relevant studies,and to explain trends in the study of ecosystem services provided by bats,we performed generalized linear mixed models(GLMM)fitted with a Poisson distribution to analyze potential differences among sampling *** identified 409 bat species that provide ecosystem services,752 insect species consumed by bats and 549 plant species either dispersed or pollinated by *** review summarizes the importance of conserving bat populations and the ecological services they provide,which is especially important during the current pandemic.

关键词： chiroptera ecosystem services frugivory,guano,insectivory nectarivory pest control pollination seed dispersal