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Contribution of glial cells to the neuroprotective effects triggered by repetitive magnetic stimulation:a systematic review

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Neural Regeneration Research 2024年第1期19卷 116-123页

作者： Susana A.Ferreira Nuno Pinto Inês Serrenho Maria Vaz pato Graça Baltazar Centro de Investigação em Ciências da Saúde(CICS-UBI) Universidade da Beira InteriorCovilhãPortugal Faculdade de Ciências da Saúde Universidade da Beira InteriorCovilhãPortugal GRUBI-Systematic Reviews Group University of Beira InteriorCovilhãPortugal

Repetitive transcranial magnetic stimulation has been increasingly studied in different neurological diseases,and although most studies focus on its effects on neuronal cells,the contribution of nonneuronal cells to the improvement trigge red by repetitive transcranial magnetic stimulation in these diseases has been increasingly *** systematically review the effects of repetitive magnetic stimulation on non-neuronal cells two online *** of Science and PubMed were searched fo r the effects of high-frequency-repetitive transcranial magnetic stimulation,low-frequencyrepetitive transcranial magnetic stimulation,intermittent theta-bu rst stimulation,continuous thetaburst stimulation,or repetitive magnetic stimulation on non-neuronal cells in models of disease and in unlesioned animals or cells.A total of 52 studies were *** protocol more frequently used was high-frequency-repetitive magnetic stimulation,and in models of disease,most studies report that high-frequency-repetitive magnetic stimulation led to a decrease in astrocyte and mic roglial reactivity,a decrease in the release of pro-inflammatory cyto kines,and an increase of oligodendrocyte *** trend towards decreased microglial and astrocyte reactivity as well as increased oligodendrocyte proliferation occurred with intermittent theta-burst stimulation and continuous theta-burst *** papers analyzed the low-frequency-repetitive transcranial magnetic stimulation protocol,and the parameters evaluated were restricted to the study of astrocyte reactivity and release of pro-inflammatory cytokines,repo rting the absence of effects on these paramete *** what concerns the use of magnetic stimulation in unlesioned animals or cells,most articles on all four types of stimulation reported a lack of *** is also important to point out that the studies were developed mostly in male rodents,not evaluating possible diffe rential effects of repetitive transcranial magneti

关键词： astrocyte glia high-frequency repetitive magnetic stimulation inflammation low-frequency repetitive magnetic stimulation microglia neurologic disorders oligodendrocyte repetitive magnetic stimulation theta-burst stimulation

Safety and Tolerability of Transdermal Rotigotine in a Clinical Practice Cohort for 2 Years

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World Journal of Neuroscience 2014年第5期4卷 443-449页

作者： Iria Rodriguez Constenla Antonio pato pato Icíar Cimas Hernando José Ramón Lorenzo Gonzalez Servicio de Neurología Hospital Povisa Vigo Spain

Background: Parkinson’s disease (PD) is a progressive neurodegenerative disease that occurs as a result of loss of dopaminergic neurons from the substantia nigra. Rotigotine is a non-ergolinic dopamine agonist available as a silicone-based transdermal patch for the treatment of PD. In the European Union, rotigotine transdermal patch is indicated for use as monotherapy in early idiopathic PD, or in combination with levodopa through the disease course to the late stages where motor complications with levodopa become an issue. Objective: To investigate the safety and tolerability of transdermal rotigotine, in patients with PD being treated during routine clinical practice for 2 years. Results: 114 patients were enrolled, and evaluated for adverse events over a 24-month period. Adverse events occurred in 39 patients (34.21%). 23 patients (20.17%) reported application site reactions (dermatitis, erythema, itching), and 16 (14.03%) had systemic adverse events. Sleep disorders were the most common problem;the others were hallucinations, depression, dizziness, and syncope. No patient experienced dyskinesia. Adverse events necessitated the discontinuation of rotigotine for application site reactions in fourteen patients (12.28%) and 11 patients (9.64%);reasons for discontinuation were systemic adverse events. Conclusion: Rotigotine is safe and well tolerated when used to treat PD in routine clinical practice.

关键词： Rotigotine Parkinson’s Disease Tolerability Safety Clinical Practice

Structure and Curvatures of Trajectories of a 2D Log-Gas

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Journal of Applied Mathematics and Physics 2014年第5期2卷 32-38页

作者： M.P.pato O.Bohigas Instituto de Fisica Universidade de Sao Paulo Caixa PostalSao PauloS.P.Brazil CNRS Universite Paris-SudUMR8626LPTMSOrsay CedexFrance

A model is constructed to study the statistical properties of irregular trajectories of a log-gas whose positions are those of the complex eigenvalues of the unitary Ginibre ensemble. It is shown that statistically the trajectories form a structure that reveals the eigenvalue departure positions. It is also shown that the curvatures of the ensemble of trajectories are Cauchy distributed.

关键词： Statistical Mechanics Random Matrix Theory Quantum Hall Effect

Rational design of nanoarray structures for lithium-sulfur batteries:recent advances and future prospects

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Materials Futures 2023年第4期2卷 53-78页

作者： Longtao Ren Jun Liu Abdul Hameed pato Yan Wang Xiwen Lu Imran Ali Chandio Mingyue Zhou Wen Liu Haijun Xu Xiaoming Sun College of Chemistry Beijing University of Chemical TechnologyBeijing 100029People’s Republic of China State Key Laboratory of Chemical Resource Engineering Beijing 100029People’s Republic of China Beijing Advanced Innovation Center for Soft Matter Science and Engineering Beijing 100029People’s Republic of China Beijing Key Laboratory of Green Chemical Reaction Engineering and Technology Department of Chemical EngineeringTsinghua UniversityBeijing 100084People’s Republic of China College of Mathematics and Physics Beijing University of Chemical TechnologyBeijing 100029People’s Republic of China

Lithium-sulfur(Li-S)batteries are considered as promising candidates for future-generation energy storage systems due to their prominent theoretical energy ***,their application is still hindered by several critical issues,e.g.,the low conductivity of sulfur species,the shuttling effects of soluble lithium polysulfides,volumetric expansion,sluggish redox kinetics,and uncontrollable Li dendritic *** research efforts have been devoted to breaking through the obstacles that are preventing Li-S batteries from realizing practical ***,benefiting from the no additives/binders,buffer of volume change,high sulfur loading and suppression of lithium dendrites,nanoarray(NA)structures have have emerged as efficient and durable electrodes in Li-S *** this work,recent advances in the design,synthesis and application of NA structures in Li-S batteries are ***,the multifunctional merits and typical synthetic strategies of employing NA structure electrodes for Li-S batteries are ***,the applications of NA structures in Li-S batteries are discussed ***,the challenge and rational design of NA structure for Li-S batteries are analyzed in depth,with the aim of providing promising orientations for the commercialization of high-energy-density Li-S batteries.

关键词： nanoarrays electrocatalysts surface and interface engineering lithium–sulfur batteries modulated strategies

镁铁质变质火山岩的地球化学——捷克斯洛伐克Zlaté Hory泥盆纪块状硫化物矿床的成因

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世界地质 1989年第2期8卷 54-60页

作者： F.pato ka 贾大成

ZlateHory块状硫化物矿床区域内的镁铁质变质火山岩被解释为是经受了绿片岩相变质作用的聚合板块边缘的玄武岩和玄武质安山岩。根据主要元素和微量之素组份,这些变质基性岩显示为岛弧拉斑玄武质到低钾、钙—碱性组成。所研究近50％的镁... 详细信息

ZlateHory块状硫化物矿床区域内的镁铁质变质火山岩被解释为是经受了绿片岩相变质作用的聚合板块边缘的玄武岩和玄武质安山岩。根据主要元素和微量之素组份,这些变质基性岩显示为岛弧拉斑玄武质到低钾、钙—碱性组成。所研究近50％的镁铁质变质火山岩样品,在球粒陨石标准化的稀土元素模式中具显著的Ce负异常。Ce衰减绿片岩是岛弧拉斑玄武质组份的变质基性岩热液蚀变表现,蚀变伴有硫化物矿化作用。这从Ce衰减岩石中,Ba和S共同富集与Ce/Ce值和CO_2高含量的相互关系得到指示。Ce异常可能由成矿蚀变、海水衍生的溶解作用引起。Ce衰减绿片岩的产生,支持了兹拉特霍尔区域内矿床的火山成因说。

关键词：变质火山岩 Hory Zlat 块状硫化物绿片岩相铁质矿床形成玄武质变质作用聚合板块

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热带高蛋白发酵食品中蛋白酶高产菌株的分离

云南工业大学学报 1997年第2期13卷 51-57页

作者：陈朝银 pato.,CA 云南工业大学化工轻工工程学院

本研究从几种热带高蛋白发酵食品中分离蛋白酶高产菌株，在所分离的２０株菌株中，有三株在蔗糖废蜜培养基试管培养中即超过５单位ｍＬ比１９９０年的Ｍａｒｇａｒｉｔａ分离到的枯杆菌ＢＩＯＴＥＣＨ１１３的１．３单位／ｍＬ和１９９... 详细信息

本研究从几种热带高蛋白发酵食品中分离蛋白酶高产菌株，在所分离的２０株菌株中，有三株在蔗糖废蜜培养基试管培养中即超过５单位ｍＬ比１９９０年的Ｍａｒｇａｒｉｔａ分离到的枯杆菌ＢＩＯＴＥＣＨ１１３的１．３单位／ｍＬ和１９９３年Ｍｏｏｎ分离到的芽胞杆菌ＮＲＳ的１．３单位／ｍＬ高三倍多。初步鉴定为芽胞杆菌属第一群的Ｂ亚群。其中一株用蔗糖废蜜培养基在３Ｌ搅拌通气发酵罐中发酵于７ｈ内产生１．

关键词：高蛋白发酵食品蛋白酶分离发酵食品生长菌

镁铁质变质火山岩的地球化学及其在研究捷克斯洛伐克兹拉特山地区泥盆纪块状硫化物矿床成因方面的意义

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地球与环境 1988年第6期 17-20页

作者： F.patoǒka 云雅娟沈阳黄金专科学校图书馆

兹拉特山矿区位于捷克斯洛伐克耶塞尼克（Jeseniky）山,即靠近波希米亚地块东北部边缘的地方。该矿区由几个层控铜矿床和块状锌铅（±Cu）硫化物矿床组成（图1）。矿体产出在一火山沉积建造（约1,600m厚）中,该建造的时代为泥盆纪,属弗... 详细信息

兹拉特山矿区位于捷克斯洛伐克耶塞尼克（Jeseniky）山,即靠近波希米亚地块东北部边缘的地方。该矿区由几个层控铜矿床和块状锌铅（±Cu）硫化物矿床组成（图1）。矿体产出在一火山沉积建造（约1,600m厚）中,该建造的时代为泥盆纪,属弗尔布诺群。在底部石英岩中见有齐根阶（D;）化石;在东部,弗尔诺群被法门阶-杜内阶杂砂岩和页岩

关键词：绿片岩相玄武岩基性岩铁质变火山岩变质火山岩变质岩泥盆纪块状硫化物矿床黄铁矿型多金属矿床拉特地球化学地球科学捷克斯洛伐克

用抗-TNFα(英利昔单抗)长期治疗难治性后葡萄膜炎

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世界核心医学期刊文摘（眼科学分册） 2005年第12期1卷 49-49页

作者： Benitez-del-Castillo J.M Martinez-de-la-Casa J.M pato-Cour E 吴琼 Cavanilles 33 3A 28007 Madrid Spain

Purpose: To evaluate the long-term efficacy and safety of infliximab as treatment for noninfectious posterior uveitis. Methods: An open-label clinical trial including seven patients (12 eyes)-with posterior uveitis refractory to conventional treatment regimens with corticosteroids and at least one immunosuppressive agent. Three intravenous doses of 5 mg/kg of infliximab were administered at weeks 0, 2, and 6. Infliximab infusion was repeated in patients undergoing a relapse of uveitis after initial remission. Improvement was defined as amelioration of visual acuity or disappearance of retinal exudates and/or haemorrhages, decreased macular oedema and/or vitreous opacities. All patients were followed up for at least 36 months. Results: Six of the seven patients (five diagnosed with Beh et’s disease and one diagnosed with sarcoidosis) showed a significant improvement after the first infliximab dose. Only in one patient diagnosed with chronic idiopathic multifocal choroiditis did the drug have no effect, and this patient was withdrawn from the study. At the end of follow-up, one eye had lost one line of vision and three eyes showed improved vision. All eyes had improved in terms of signs of infla, mmation. No adverse effects of treatment were observed. Conclusion: Infliximab is efficient and safe for the long-term management of refractory posterior uveitis, especially in patients with predominant retinal vasculitis and vitritis.

关键词：葡萄膜炎英利昔单抗视网膜血管炎玻璃体混浊黄斑水肿常规治疗方案临床试验研究远期疗效脉络膜炎慢性特发性