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现代科技译丛（大连） 1991年第1期 48-51,31页

作者： rubio,JF 张耀华

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穿梭于空间中的个性呐喊

缤纷 2003年第6期 35-40,34页

作者： Hariri & Hariri-Architect 姚京 Cesar rubio

Hariri & Hariri 建筑设计事务所,由 Hariri 姐妹二人于1986年共同创建。与其说她们是姐妹,更不如把她们称为合伙人。学生时代,姐妹二人便积极涉足各种设计比赛和项目规划。从科内尔大学毕业并完成了在世界著名建筑师事务所的实习深造后... 详细信息

Hariri & Hariri 建筑设计事务所,由 Hariri 姐妹二人于1986年共同创建。与其说她们是姐妹,更不如把她们称为合伙人。学生时代,姐妹二人便积极涉足各种设计比赛和项目规划。从科内尔大学毕业并完成了在世界著名建筑师事务所的实习深造后,这对伊朗出生的姐妹在纽约城开始了她们的创业历程,全身心地投入到创新建筑概念的探索和缔造中。

关键词：建筑设计事务所建筑师事务所项目规划学生时代合伙人大学毕业世界著名建筑概念空间个性

Wireless capsule endoscopy: Perspectives beyond gastrointestinal bleeding

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World Journal of Gastroenterology 2014年第42期20卷 15664-15673页

作者： Eduardo Redondo-Cerezo Antonio Damián Sánchez-Capilla Paloma De La Torre-rubio Javier De Teresa Endoscopy Unit Department of Gastroenterology University Hospital Virgen de Las Nieves Department of Gastroenterology University Hospital Virgen de Las Nieves

Wireless capsule endoscopy(CE) is a technology developed for the endoscopic exploration of the small bowel. The first capsule model was approved by the Food and Drug Administration in 2001, and its first and essential indication was occult gastrointestinal(GI) bleeding. Over subsequent years, this technology has been refined to provide superior resolution, increased battery life, and capabilities to view different parts of the GI tract. Indeed, cases for which CE proved useful have increased significantly over the last few years, with new indications for the small bowel and technical improvements that have expanded its use to other parts of the GI tract, including the esophagus and colon. The main challenges in the development of CE are new devices with the ability to provide therapy, air inflation for a better vision of the small bowel, biopsy sampling systems attached to the capsule and the possibility to guide and move the capsule with an external motion control. In this article we review the current and new indications of CE, and the evolving technological changes shaping this technology, which has a promising potential in the coming future of gastroenterology.

关键词： Wireless capsule endoscopy Obscure gas-trointestin

Immunotherapy combinations and chemotherapy sparing schemes in first line non-small cell lung cancer

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World Journal of Clinical Oncology 2021年第12期12卷 1182-1192页

作者： María Sereno Oliver Higuera Patricia Cruz Castellanos Sandra Falagan Xabier Mielgo-rubio Juan Carlos Trujillo-Reyes Felipe Couñago Medical Oncology Department Hospital Universitario Infanta SofíaSan Sebastián de los Reyes 28702MadridSpain Medical Oncology Department Hospital Universitario La PazMadrid 28046Spain Medical Oncology Department Hospital Universitario Fundación AlcorcónAlcorcón 28922MadridSpain Department of Thoracic Surgery Hospital de la Santa Creu I Sant PauBarcelona 08029CataloniaSpain Department of Surgery Universitat Autonoma de BarcelonaBarcelona 08029CataloniaSpain Department of Radiation Oncology Hospital Universitario Quirónsalud MadridPozuelo de Alarcón 28223MadridSpain Department of Radiation Oncology Hospital La LuzMadrid 28003Spain Medicine Department School of Biomedical SciencesUniversidad Europea de MadridVillaviciosa de Odón 28670MadridSpain

In recent years,studies have explored different combinations of immunotherapy and *** rationale behind these is the improved survival outcomes of new immunologic therapies used in first-line-treatment of advanced non-small cell lung ***,for the most-studied combinations of anti-programed death-1(PD-1)/programed death ligand-1(PD-L1)with the addition of platinumbased chemotherapy,recent research is investigating whether combining different immunologic antitumoral mechanisms of action,such as anti-PD-1/PD-L1 and anti-CTLA-4,or anti-PD-L1 and anti-TIGIT,with or without chemotherapy,can improve efficacy outcomes compared with more classical combinations,or compared with standard chemotherapy ***,we present the data of the main randomized studies that have evaluated these combinations,focusing on the basic rationale behind the different combinations,and the efficacy and tolerability data available to date.

关键词： Immunotherapy combinations Anti-programmed cell death protein Antiprogrammed cell death ligand 1 anti-TIGIT anti-CTLA-4 Combo Non-small cell lung cancer

Translational pancreatic cancer research:a comparative study on patient-derived xenograft models

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World Journal of Gastroenterology 2018年第7期24卷 794-809页

作者： Mercedes rubio-Manzanares Dorado Luis Miguel Marín Gómez Daniel Aparicio Sánchez Sheila Pereira Arenas Juan Manuel Praena-Fernández Juan Jose Borrero Martín Francisco Farfán López Miguel ángel Gómez Bravo Jordi Muntané Relat Javier Padillo Ruiz Department of Hepatobiliary and Pancreatic Surgery Virgen del Rocio University Hospital Oncology Surgery Cell Therapy and Organ Transplantation Group Institute of Biomedicine of Seville (IBiS) Virgen del Rocio University Hospital University of Seville Statistics Methodology and Evaluation of Research Unit Virgen del Rocio University Hospital Pathology Department Virgen del Rocio University Hospital

AIM To assess the viability of orthotopic and heterotopic patient-derived pancreatic cancer xenografts implanted into nude *** This study presents a prospective experimental analytical follow-up of the development of tumours in mice upon implantation of human pancreatic adenocarcinoma samples. Specimens were obtained surgically from patients with a pathological diagnosis of pancreatic adenocarcinoma. Tumour samples from pancreatic cancer patients were transplanted into nude mice in three different locations(intraperitoneal, subcutaneous and pancreatic). Histological analysis(haematoxylin-eosin and Masson's trichrome staining) and immunohistochemical assessment of apoptosis(TUNEL), proliferation(Ki-67), angiogenesis(CD31) and fibrogenesis(α-SMA) were performed. When a tumour xenograft reached the target size, it was reimplanted in a new nude mouse. Three sequential tumour xenograft generations were generated(F1, F2 and F3).RESULTS The overall tumour engraftment rate was 61.1%. The subcutaneous model was most effective in terms of tissue growth(69.9%), followed by intraperitoneal(57.6%) and pancreatic(55%) models. Tumour development was faster in the subcutaneous model(17.7 ± 2.6 wk) compared with the pancreatic(23.1 ± 2.3 wk) and intraperitoneal(25.0 ± 2.7 wk) models(P = 0.064). There was a progressive increase in the tumour engraftment rate over successive generations for all three models(F1 28.1% vs F2 71.4% vs F3 80.9%, P < 0.001). There were no significant differences in tumour xenograft differentiation and cell proliferation between human samples and the three experimental models among the sequential generations of tumour xenografts. However, a progressive decrease in fibrosis, fibrogenesis, tumour vascularisation and apoptosis was observed in the three experimental models compared with the human samples. All three pancreatic patient-derived xenograft models presented similar histological and immunohistochemical *** In our experie

关键词： Immunohistological analysis Pancreatic cancer Patient-derived xenograft Animal model Nude mice

Discussion:Food security and sustainable food systems:The role of soil

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International Soil and Water Conservation Research 2015年第2期3卷 154-159页

作者： Matheus Alves Zanella Maryam Rahmanian Leisa Nicola Perch Carolin Callenius JoséLuis rubio Faustin Vuningoma Stephan Rist Paul Mapfumo Institute for Advanced Sustainability Studies(IASS) PotsdamGermany 14467 Centre for Development and Environment(CDE) University of BernSwitzerland CH-3012 Centre for Sustainable Development(CENESTA) No 108Azarbaijan StreetTehranIran World Centre for Sustainable Development(RIO+Centre) Rio de JaneiroBrazil 20031-145 Bread for the World-Protestant Development Service BerlinGermany10115 Centro de Investigaciones sobre Desertificación/Consejo Superior de Investigaciones Científicas(CIDE-CSIC) ValenciaSpain 46113 Participatory Ecological Land Use Management(PELUM Association) 902Premium HouseIndependence AvenueLusakaZambia Soil Fertility Consortium for Southern Africa(SOFECSA) University of ZimbabweMt PleasantZimbabwe

Editorial notes This discussion is edited from a dialogue session of‘3rd Global Soil Week 2015'(***).The‘Global Soil Week'(GSW)is a multi-stakeholder platform of high-level policy-makers,scientists,NGOs,CSOs,farmers,artists,international organizations,and the private *** of the main purposes of the GSW is to raise public awareness of the issues of soil and ***‘Global Soil Week'advocates soil management in the context of sustainable development and promote equitable access to ***‘3rd Global Soil Week 2015'was held from 19 to 23 April 2014 in *** session,on April 202015,2015,discussed the topic of‘Food Security and Sustainable Food System:the Role of Soil'.

关键词： policy soil sustainable

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哺乳期仔猪梭状芽杆菌性腹泻

国外畜牧学（猪与禽） 2012年第4期32卷 14-17页

作者：石永峰 Ana Carvajal Pedro rubio Nistal

梭状芽孢杆菌属包括许多种类的大的杆状孢子厌氧菌，这些菌能产生许多具有很强致病性的病菌毒素。因此梭状芽孢杆菌疫苗常含有灭活的毒素，以抵抗毒素的作用。所幸的是，许多这类毒素都是高分子量的蛋白质，因此具有很好的免疫原性，能... 详细信息

梭状芽孢杆菌属包括许多种类的大的杆状孢子厌氧菌，这些菌能产生许多具有很强致病性的病菌毒素。因此梭状芽孢杆菌疫苗常含有灭活的毒素，以抵抗毒素的作用。所幸的是，许多这类毒素都是高分子量的蛋白质，因此具有很好的免疫原性，能诱导高水平的抗体。

关键词：芽孢杆菌属哺乳期仔猪腹泻梭状芽孢杆菌抗毒素高分子量免疫原性厌氧菌

SARS-CoV-2 outbreak impact on a trauma unit

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World Journal of Orthopedics 2021年第10期12卷 751-759页

作者： Sarah Mills Aitor Ibarzábal-Gil José M Martínez-Diez Javier Pallarés-Sanmartín Carlos Kalbakdij-Sánchez Juan C rubio-Suárez Itsaso Losantos-García E Carlos Rodríguez-Merchán Department of Orthopedic Surgery La Paz University HospitalMadridSpain Department of Biostatistics La Paz University HospitalMadrid 28046Spain Osteoarticular Surgery Research Hospital La Paz Institute for Health Research–IdiPAZ(La Paz University Hospital–Autonomous University of Madrid)MadridSpain

BACKGROUND From February 2020 onwards,our country has been hit by the coronavirus severe acute respiratory syndrome-2(SARS-CoV-2)*** a glance,hospitals became overrun and had to reformulate all the assistance guidelines,focusing on the coronavirus disease *** year after the start of the pandemic,we present the results of a morbimortality *** To analyze how our department was affected by the outbreak in terms of morbimortality,and to analyze demographic data,admission to hospital-related data,and subgroups analyses for patients with hip fractures and *** We designed a study comparing data from patients who were admitted to our unit due to a lower limb fracture or a high energy trauma during the pandemic(from March to April 2020)to those admitted during the same period in 2019 before the *** the pandemic *** cohorts completed a minimum of 6 mo of *** The number of patients admitted to hospital in 2020 was nearly half of those in *** fractures in the elderly represented 52 out of 73 of the admitted *** patients had a positive test result for SARS-CoV-2 *** with SARS-CoV-2 infection were admitted to the hospital for a longer time than the non-infected(P<0.001),and had a higher mortality rate during hospitalization and follow-up(P=0.02).Patients with a hip fracture associated with a severe respiratory syndrome were mostly selected for conservative treatment(P=0.03).CONCLUSION Mortality and readmission rates were higher in the 2020 cohort and during follow-up,in comparison with the cohort in 2019.

关键词： Trauma department COVID-19 pandemic SARS-CoV-2 outbreak Hip fractures Morbimortality Polytraumatic patients

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中间件在应用集成中的作用

Internet（共创软件） 2002年第10期 54-58,53页

作者：五洲 Mauricio rubio Gianpaolo Rinetti

今天在IT领域到处充斥着电子商务，CRM、XML和B2B等一系列流行词语。这些词语背后隐藏着一些共同的东西．那就是它们都可以实现应用集成．或者更简单的说,它们都可以使计算机更好的相互通讯和“交流”。现在中间件的概念把这些都统一起... 详细信息

今天在IT领域到处充斥着电子商务，CRM、XML和B2B等一系列流行词语。这些词语背后隐藏着一些共同的东西．那就是它们都可以实现应用集成．或者更简单的说,它们都可以使计算机更好的相互通讯和“交流”。现在中间件的概念把这些都统一起来了。

关键词：计算机中间件企业系统集成类型发展趋势商务策略应用集成网络连接管理软件

Genetic Diversity of the Endemic Xantus’ Hummingbird Using 16 Novel Polymorphic Microsatellite Loci, and Their Cross Amplification between Six Related Species

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Open Journal of Genetics 2016年第1期6卷 19-27页

作者： Cristina González-rubio Sanvicente Ricardo Rodríguez-Estrella Oscar Adrián Lozano-Garza Francisco J. García-De-León Laboratorio de Genética para la Conservación Centro de Investigaciones Biológicas del Noroeste La Paz Mexico Laboratorio de Análisis Espacial Ecología y Conservación Centro de Investigaciones Biológicas del Noroeste La Paz Mexico

A set of 16 microsatellite loci was developed and characterized for the Xantus’ hummingbird (Hylocharis xantusii) by using 454 next-generation sequencing. Twenty-five H. xantusii samples from one population were genotyped;all loci were polymorphic, with the number of alleles ranging from three to ten. The mean observed heterozygosity was 0.681 for all loci. No significant linkage disequilibrium was detected, but five loci (Hxan05, 06, 09, 13 and 14) showed deviation from Hardy-Weinberg equilibrium. These microsatellite loci are the first to be characterized for H. xantusii. A moderate to high level of cross-species amplification was observed across the six hummingbird species (31% - 87.5%), with the best cross amplification results observed in the closest related species (H. leucotis, Cynanthus latirostris, Calypte costae). The availability of these molecular tools allows assessing questions integrating population genetics, ecology, conservation, and evolutionary history for H. xantusii and for other phyogenetically related species.

关键词： Baja California Peninsula Hylocharis xantusii Microsatellites Pyrosequencing Cross-Species Amplification