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The ρ-variation of the Hermitian Riesz Transform

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Acta Mathematica Sinica,English Series 2010年第10期26卷 1827-1838页

作者： raquel crescimbeni Francisco Javier MARTíN-REYES Alberto DE LA TORRE José L.TORREA Departamento de Matemática Universidad Nacional del Comahue Facultad de Economía y Administración Departamento de Análisis Matemático Facultad de Ciencias Universidad de Málaga Facultad de Ciencias Universidad Autónoma de Madrid ICMAT-CSIC-UAM-UCM-UC3M

In this paper we prove the behaviour in weighted Lp spaces of the oscillation and variation of the Hilbert transform and the Riesz transform associated with the Hermite operator of dimension 1. We prove that this operator maps LP（R, w（x）dx） into itself when w is a weight in the Ap class for 1 〈 p 〈 ∞. For p = 1 we get weak type for the A1 class. Weighted estimated are also obtained in the extreme case p = ∞.

关键词： Oscillation-p-variation-singular integral-Hermite operator

In silico analysis of lncRNA-miRNA-mRNA signatures related to Sorafenib effectiveness in liver cancer cells

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World Journal of Gastroenterology 2025年第3期31卷 84-102页

作者： Patricia de la Cruz-Ojeda Ester Parras-Martínez raquel Rey-Pérez Jordi Muntané Functional Genomics of Solid Tumors Laboratory Centre de Recherche des CordeliersParis 75006France Department of Oncology Surgery Cell Therapy and Organ TransplantationInstitute of Biomedicine of SevilleVirgen del Rocio University HospitalSeville 41013Spain Biomedical Research Center for Hepatic and Digestive Diseases CIBERehdMadrid 28029Spain Department of Medical Physiology and Biophysics University of SevilleSeville 41009Spain

BACKGROUND Hepatocellular carcinoma(HCC)is the most common subtype of primary liver cancer with varied incidence and epidemiology *** is still a recommended treatment for a large proportion of patients with advanced *** patterns of treatment responsiveness have been identified in differentiated hepatoblastoma HepG2 cells and metastatic HCC SNU449 *** To define the long non-codingRNA-microRNA-mRNA(lncRNA-miRNA-mRNA)predicted signatures related to selected hallmarks of cancer(apoptosis,autophagy,cell stress,cell dedifferentiation and invasiveness)in RNAseq studies using Sorafenib-treated HepG2 and SNU449 *** available software analyses allowed us to establish the lncRNA-miRNA-mRNA regulatory axes following treatment in HepG2 and SNU449 *** HepG2 and SNU449 cells were treated with Sorafenib(10μmol/L)for 24 *** RNA,including small and long RNA,was extracted with a commercial miRNeasy *** was carried out for the identification of changes in lncRNA-miRNA-mRNA regulatory *** MALAT,THAP9-AS1 and SNGH17 appeared to coordinately regulate miR-374b-3p and miR-769-5p that led to upregulation of SMAD7,TIRARP,TFAP4 and FAXDC2 in HepG2 ***12,EPB41 L4A-AS1,LINC01578,SNHG12 and GAS5 interacted with let-7b-3p,miR-195-5p and VEGFA in SNU449 *** axes MALAT1/hsamir-374b-3p/SMAD7 and MALAT1/hsa-mir-769-5p/TFAP4 were of high relevance for Sorafenib response in HepG2 cells,whereas PVT1/hsa-miR-195-5p/VEGFA was responsible for the differential response of SNU449 cells to Sorafenib *** Critical lncRNAs acting as sponges of miRNA were identified that regulated mRNA expression,whose proteins mainly increased the antitumor effectiveness of the treatment(SMAD7,TIRARP,TFAP4,FAXDC2 and ADRB2).However,the broad regulatory axis leading to increased VEGFA expression may be related to the side effect of Sorafenib in SNU449 cells.

关键词： Cell culture Hepatocellular carcinoma Non-coding RNA RNAseq Sorafenib

Physiology and health assessment,risk balance,and model for endstage liver disease scores:Postoperative outcome of liver transplantation

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World Journal of Transplantation 2025年第1期15卷 86-94页

作者： raquel Hohenreuther Andresa ThoméSilveira Edison Moraes Rodrigues Filho Anderson Garcez Bruna Goularth Lacerda Sabrina Alves Fernandes Claudio Augusto Marroni Postgraduate Program in Hepatology Universidade Federal de Ciências da Saúde de Porto AlegrePorto Alegre 90050-170Brazil Department of Intensive Medicine Hospital de Clínicas de Porto AlegrePorto Alegre 90035-903Brazil Department of Public Health University of Vale do Rio dos SinosSao Leopoldo 93022-750Brazil

BACKGROUND Liver transplantation aims to increase the survival of patients with end-stage liver diseases and improve their quality of *** number of organs available for transplantation is lower than the *** provide fair organ distribution,predictive mortality scores have been *** To compare the Acute Physiology and Chronic Health Evaluation IV(APACHE IV),balance of risk(BAR),and model for end-stage liver disease(MELD)scores as predictors of *** Retrospective cohort study,which included 283 adult patients in the postoperative period of deceased donor liver transplantation from 2014 to *** The transplant recipients were mainly male,with a mean age of 58.1 *** were mostly male,with a mean age of 41.6 *** median cold ischemia time was 3.1 hours,and the median intensive care unit stay was 5 *** APACHE IV,a mean of 59.6 was found,BAR 10.7,and MELD *** 28-day mortality rate was 9.5%,and at 90 days,it was 3.5%.The 28-day mortality prediction for APACHE IV was very good[area under the curve(AUC):0.85,P<0.001,95%CI:0.76-0.94],P<0.001,BAR(AUC:0.70,P<0.001,95%CI:0.58–0.81),and MELD(AUC:0.66,P<0.006,95%CI:0.55-0.78),P<*** 90 days,the data for APACHE IV were very good(AUC:0.80,P<0.001,95%CI:0.71–0.90)and moderate for BAR and MELD,respectively,(AUC:0.66,P<0.004,95%CI:0.55–0.77),(AUC:0.62,P<0.026,95%CI:0.51–0.72).All showed good discrimination between deaths and *** for the best value for liver transplantation,it was significant only for APACHE IV(P<0.001).CONCLUSION The APACHE IV assessment score was more accurate than BAR and MELD in predicting mortality in deceased donor liver transplant recipients.

关键词： Liver transplantation Acute physiology and chronic health evaluation IV Balance of risk Model for end-stage liver disease Mortality Intensive care unit

OSCILLATION AND VARIATION OF THE LAGUERRE HEAT AND POISSON SEMIGROUPS AND RIESZ TRANSFORMS

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Acta Mathematica Scientia 2012年第3期32卷 907-928页

作者： J.J.Betancor R.crescimbeni J.L.Torrea Departamento de An'aisis Matema'ico Universidad de La Laguna38271-La LagunaTenerifeIslas CanariasSpain Departamento de Matema'ica Universidad Nacional del ComahueBuenos Aires 14008300 Neuqu'enArgentina Departamento de Matem'aticas Facultad de CienciasUniversidad Auto'noma de Madrid28049 MadridSpain

In this article, we study LP-boundedness properties of the oscillation and vari- ation operators for the heat and Poissson semigroup and Riesz transforms in the Laguerre settings. Also, we characterize Hardy spaces as... 详细信息

关键词： Oscillation variation heat Laguerre semigroup Riesz transforms

Cdk5 and aberrant cell cycle activation at the core of neurodegeneration

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Neural Regeneration Research 2023年第6期18卷 1186-1190页

作者： raquel Requejo-Aguilar Department of Biochemistry and Molecular Biology University of CórdobaCórdobaSpain Maimónides Biomedical Research Institute of Córdoba(IMIBIC) 14071 CórdobaSpain

Neurodegenerative diseases are caused by the progressive loss of specific *** exact mechanisms of action of these diseases are unknown,and many studies have focused on pathways related to abnormal accumulation and processing of proteins,mitochondrial dysfunction,and oxidative stress leading to apoptotic ***,a growing body of evidence indicates that aberrant cell cycle re-entry plays a major role in the pathogenesis of *** activation of the cell cycle in mature neurons could be promoted by several signaling mechanisms,including c-Jun N-terminal kinases,p38 mitogen-activated protein kinases,and mitogen-activated protein kinase/extracellular signal-regulated kinase cascades;post-translational modifications such as Tau-phosphorylation;and DNA damage *** all these events,implicated Cdk5,a proline-directed serine/threonine protein kinase,seems to be responsible for several cellular processes in neurons including axon growth,neurotransmission,synaptic plasticity,neuronal migration,and maintenance of neuronal ***,under pathological conditions,Cdk5 dysregulation may lead to cell cycle re-entry in post-mitotic ***,Cdk5 hyperactivation,by its physiologic activator p25,hyper-phosphorylates downstream substrates related to neurodegenerative *** review summarizes factors such as oxidative stress,DNA damage response,signaling pathway disturbance,and Ubiquitin proteasome malfunction contributing to cell cycle re-entry in post-mitotic *** also describes how all these factors are linked to a greater or lesser extent with ***,it offers a global vision of the function of cell cycle-related proteins in mature neurons with a focus on Cdk5 and how this protein contributes to the development of Alzheimer’s disease,Parkinson’s disease,amyotrophic lateral sclerosis,and Huntington’s disease by cell cycle activation.

关键词： Alzheimer´s disease amyotrophic lateral sclerosis apoptosis Cdk5 cell cycle Huntington´s disease neurodegeneration neuron oxidative stress Parkinson´s disease signaling Tau phosphorylation

Microglial exosomes in retinal neuroinflammation: focus in glaucoma

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Neural Regeneration Research 2021年第9期16卷 1801-1802页

作者： Ines Dinis Aires Ana raquel Santiago University of Coimbra Coimbra Institute for Clinical and Biomedical Research(iCBR)Faculty of MedicineCoimbraPortugal University of Coimbra Center for Innovative Biomedicine and Biotechnology(CIBB)CoimbraPortugal Clinical Academic Center of Coimbra(CACC) CoimbraPortugal Association for Innovation and Biomedical Research on Light and Image(AIBILI) CoimbraPortugal

Glaucoma is a leading cause of irreversible blindness, expected to affect 140 million people worldwide by the year 2040. The pathophysiology of glaucoma involves retinal ganglion cell loss, optic nerve atrophy and cupping of the optic disk, culminating in visual field loss(Boia et al., 2020). Glaucoma is a multifactorial disease in which increased intraocular pressure is the main risk factor.

关键词： glaucoma inflammation al.

Oxidative desulfurization of diesel fuel oil using supported Fenton catalysts and assisted with ultrasonic energy

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Petroleum Science 2019年第5期16卷 1176-1184页

作者： Roberto Flores Arturo Rodas raquel Gasperin Facultad de Ciencias Químicas e Ingeniería Universidad Autónoma del Estado de MorelosAv.Universidad No.1001Col.Chamilpa62209 CuernavacaMorelosMexico Gerencia de Materiales y Procesos Químicos Instituto Nacional de Electricidad y Energías LimpiasCalle Reforma 113Col.Palmira62490 CuernavacaMorelosMexico

An ultrasound-assisted heterogeneous catalytic oxidation process was applied to eliminate sulfur from commercial diesel fuel *** studied variables were catalyst concentration,type of catalyst(homogeneous or heterogeneous),oxidizing agent concentration,and the application of ultrasound *** catalysts were prepared by impregnation of coal fly ash with an iron(Ⅱ)sulfate aqueous solution using ultrasound *** drying,the catalyst was calcined at 500℃for 4 *** oxidizing agent was hydrogen *** energy was applied with a frequency of 47 kHz and an intensity of 147 *** was employed for extracting the oxidized compounds from the hydrocarbon *** fly ash and ethanol were used with the purpose of applying low-cost raw materials in chemical *** was found that under the studied conditions,increasing oxidizing agent concentration and the application of ultrasound energy can enhance the sulfur removal from commercial diesel fuel *** concentration did not play a significant role in the *** results were obtained using homogeneous or heterogeneous catalyst,which is important since the heterogeneous catalyst could be recovered,reactivated,and used in many cycles.

关键词： Oxidative desulfurization Diesel Ultrasound energy Supported catalyst Low-cost raw materials

Multi-Step Clustering of Smart Meters Time Series: Application to Demand Flexibility Characterization of SME Customers

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CMES-COMPUTER MODELING IN ENGINEERING & SCIENCES 2024年第1期142卷 869-907页

作者： Banales, Santiago Dormido, raquel Duro, Natividad Univ Nacl Educ Distancia UNED Dept Comp Sci & Automat Control Madrid 28040 Spain Iberdrola Innovat Middle East Doha 210177 Qatar

Customer segmentation according to load-shape profiles using smart meter data is an increasingly important application to vital the planning and operation of energy systems and to enable citizens' participation in the energy transition. This study proposes an innovative multi-step clustering procedure to segment customers based on load-shape patterns at the daily and intra-daily time horizons. Smart meter data is split between daily and hourly normalized time series to assess monthly, weekly, daily, and hourly seasonality patterns separately. The dimensionality reduction implicit in the splitting allows a direct approach to clustering raw daily energy time series data. The intraday clustering procedure sequentially identifies representative hourly day-unit profiles for each customer and the entire population. For the first time, a step function approach is applied to reduce time series dimensionality. Customer attributes embedded in surveys are employed to build external clustering validation metrics using Cramer's V correlation factors and to identify statistically significant determinants of load-shape in energy usage. In addition, a time series features engineering approach is used to extract 16 relevant demand flexibility indicators that characterize customers and corresponding clusters along four different axes: available Energy (E), Temporal patterns (T), Consistency (C), and Variability (V). The methodology is implemented on a real-world electricity consumption dataset of 325 Small and Medium-sized Enterprise (SME) customers, identifying 4 daily and 6 hourly easy-to-interpret, well-defined clusters. The application of the methodology includes selecting key parameters via grid search and a thorough comparison of clustering distances and methods to ensure the robustness of the results. Further research can test the scalability of the methodology to larger datasets from various customer segments (households and large commercial) and locations with different weat

关键词： Electric load clustering load profiling smart meters machine learning data mining demand flexibility demand response

On the chiral covariant approach to ρρ scattering

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Chinese Physics C 2017年第12期41卷 24-32页

作者：耿立升 raquel Molina Eulogio Oset School of Physics and Nuclear Energy Engineering & International Research Center for Nuclei and Particles in the Cosmos & Beijing Key Laboratory of Advanced Nuclear Materials and Physics Beihang University Beijing 100191 China Physics Department The George Washington University Washington DC 20052 USA Departamento de Física Teórica and IFIC Centro Mixto Universidad de Valencia-CSIC Institutos de Investigación de Paterna Aptdo 22085 46071 Valencia Spain

We examine in detail a recent work（D. Gülmez, U. G. Mei？ner and J. A. Oller, Eur. Phys. J. C,77： 460（2017））, where improvements to make ρρ scattering relativistically covariant are made. The paper has the remarkable conclusion that the J =2 state disappears with a potential which is much more attractive than for J =0,where a bound state is found. We trace this abnormal conclusion to the fact that an ＂on-shell＂ factorization of the potential is done in a region where this potential is singular and develops a large discontinuous and unphysical imaginary part. A method is developed, evaluating the loops with full ρ propagators, and we show that they do not develop singularities and do not have an imaginary part below threshold. With this result for the loops we define an effective potential, which when used with the Bethe-Salpeter equation provides a state with J =2 around the energy of the f2（1270）. In addition, the coupling of the state to ρρ is evaluated and we find that this coupling and the T matrix around the energy of the bound state are remarkably similar to those obtained with a drastic approximation used previously, in which the q2 terms of the propagators of the exchanged ρ mesons are dropped, once the cut-off in the ρρ loop function is tuned to reproduce the bound state at the same energy.

关键词： rho-rho scattering unitary chiral approaches on-shell approximations