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Health production and risk of obesity among Chilean adolescents: Understanding health related behaviors in youth

Health 2012年第12期4卷 1413-1419页

作者： Paulina Correa-burrows raquel burrows Ricardo Uauy Cecilia Albala Department of Applied Economics II Rey Juan Carlos University Madrid Spain Institute of Nutrition and Food Technology University of Chile Santiago de Chile Chile

Background: Adolescent obesity is associated with high cardiovascular and metabolic risk. Western diet and reduced physical activity are strong environmental determinants. The “Health Production” model posits that individuals born with a certain amount of health stock, which depreciates over life, but can be augmented by individual behaviors, including exercise and dieting. Objective: To study the association between health production and obesity in a random sample of 1692 Chilean adolescents (14.8 ± 0.7 years old), and to study the effect of gender and socioeconomic characteristics on health production. Method: We used an indicator that considered the quality of food intake and physical activity, establishing three categories: good (GHP), intermediate (IHP) and poor health producers (PHP). Multivariate analysis was used to study the odds of obesity and good health production. Results: There was 31% of GHP, 32% of IHP and 38% of PHP. Obesity (Adj. OR: 1.59;95%CI: 1.04 - 2.42) and abdominal obesity (Adj. OR: 2.24;95%CI: 1.35 - 3.40) were significantly higher in the PHP group, compared to the GHP and IHP group. Health production was significantly associated with socioeconomic factors and gender. Female sex and coming from a less wealthy household significantly reduced the odds of good health production. Conclusions: Poor health production in adolescence, as defined by food intake and physical activity, depreciates individuals’ “health stock”, increasing the risk of obesity. In our sample, health production was strongly associated with socio-economic factors and gender.

关键词： Adolescent Health Adolescent Obesity Health Behavior Health Promotion Non-Communicable Diseases Chile

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Multi-Step Clustering of Smart Meters Time Series:Application to Demand Flexibility Characterization of SME Customers

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 869-907页

作者： Santiago Bañales raquel Dormido Natividad Duro Department of Computer Sciences and Automatic Control Universidad Nacional de Educación a Distancia(UNED)Madrid28040Spain Iberdrola Innovation Middle East Doha210177Qatar

Customer segmentation according to load-shape profiles using smart meter data is an increasingly important application to vital the planning and operation of energy systems and to enable citizens’participation in the energy *** study proposes an innovative multi-step clustering procedure to segment customers based on load-shape patterns at the daily and intra-daily time *** meter data is split between daily and hourly normalized time series to assess monthly,weekly,daily,and hourly seasonality patterns *** dimensionality reduction implicit in the splitting allows a direct approach to clustering raw daily energy time series *** intraday clustering procedure sequentially identifies representative hourly day-unit profiles for each customer and the entire *** the first time,a step function approach is applied to reduce time series *** attributes embedded in surveys are employed to build external clustering validation metrics using Cramer’s V correlation factors and to identify statistically significant determinants of load-shape in energy *** addition,a time series features engineering approach is used to extract 16 relevant demand flexibility indicators that characterize customers and corresponding clusters along four different axes:available Energy(E),Temporal patterns(T),Consistency(C),and Variability(V).The methodology is implemented on a real-world electricity consumption dataset of 325 Small and Medium-sized Enterprise(SME)customers,identifying 4 daily and 6 hourly easy-to-interpret,well-defined *** application of the methodology includes selecting key parameters via grid search and a thorough comparison of clustering distances and methods to ensure the robustness of the *** research can test the scalability of the methodology to larger datasets from various customer segments(households and large commercial)and locations with different weather and socioeconomic conditio

关键词： Electric load clustering load profiling smart meters machine learning data mining demand flexibility demand response

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Physiology and health assessment,risk balance,and model for endstage liver disease scores:Postoperative outcome of liver transplantation

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World Journal of Transplantation 2025年第1期15卷 86-94页

作者： raquel Hohenreuther Andresa ThoméSilveira Edison Moraes Rodrigues Filho Anderson Garcez Bruna Goularth Lacerda Sabrina Alves Fernandes Claudio Augusto Marroni Postgraduate Program in Hepatology Universidade Federal de Ciências da Saúde de Porto AlegrePorto Alegre 90050-170Brazil Department of Intensive Medicine Hospital de Clínicas de Porto AlegrePorto Alegre 90035-903Brazil Department of Public Health University of Vale do Rio dos SinosSao Leopoldo 93022-750Brazil

BACKGROUND Liver transplantation aims to increase the survival of patients with end-stage liver diseases and improve their quality of *** number of organs available for transplantation is lower than the *** provide fair organ distribution,predictive mortality scores have been *** To compare the Acute Physiology and Chronic Health Evaluation IV(APACHE IV),balance of risk(BAR),and model for end-stage liver disease(MELD)scores as predictors of *** Retrospective cohort study,which included 283 adult patients in the postoperative period of deceased donor liver transplantation from 2014 to *** The transplant recipients were mainly male,with a mean age of 58.1 *** were mostly male,with a mean age of 41.6 *** median cold ischemia time was 3.1 hours,and the median intensive care unit stay was 5 *** APACHE IV,a mean of 59.6 was found,BAR 10.7,and MELD *** 28-day mortality rate was 9.5%,and at 90 days,it was 3.5%.The 28-day mortality prediction for APACHE IV was very good[area under the curve(AUC):0.85,P<0.001,95%CI:0.76-0.94],P<0.001,BAR(AUC:0.70,P<0.001,95%CI:0.58–0.81),and MELD(AUC:0.66,P<0.006,95%CI:0.55-0.78),P<*** 90 days,the data for APACHE IV were very good(AUC:0.80,P<0.001,95%CI:0.71–0.90)and moderate for BAR and MELD,respectively,(AUC:0.66,P<0.004,95%CI:0.55–0.77),(AUC:0.62,P<0.026,95%CI:0.51–0.72).All showed good discrimination between deaths and *** for the best value for liver transplantation,it was significant only for APACHE IV(P<0.001).CONCLUSION The APACHE IV assessment score was more accurate than BAR and MELD in predicting mortality in deceased donor liver transplant recipients.

关键词： Liver transplantation Acute physiology and chronic health evaluation IV Balance of risk Model for end-stage liver disease Mortality Intensive care unit

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Cdk5 and aberrant cell cycle activation at the core of neurodegeneration

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Neural Regeneration Research 2023年第6期18卷 1186-1190页

作者： raquel Requejo-Aguilar Department of Biochemistry and Molecular Biology University of CórdobaCórdobaSpain Maimónides Biomedical Research Institute of Córdoba(IMIBIC) 14071 CórdobaSpain

Neurodegenerative diseases are caused by the progressive loss of specific *** exact mechanisms of action of these diseases are unknown,and many studies have focused on pathways related to abnormal accumulation and processing of proteins,mitochondrial dysfunction,and oxidative stress leading to apoptotic ***,a growing body of evidence indicates that aberrant cell cycle re-entry plays a major role in the pathogenesis of *** activation of the cell cycle in mature neurons could be promoted by several signaling mechanisms,including c-Jun N-terminal kinases,p38 mitogen-activated protein kinases,and mitogen-activated protein kinase/extracellular signal-regulated kinase cascades;post-translational modifications such as Tau-phosphorylation;and DNA damage *** all these events,implicated Cdk5,a proline-directed serine/threonine protein kinase,seems to be responsible for several cellular processes in neurons including axon growth,neurotransmission,synaptic plasticity,neuronal migration,and maintenance of neuronal ***,under pathological conditions,Cdk5 dysregulation may lead to cell cycle re-entry in post-mitotic ***,Cdk5 hyperactivation,by its physiologic activator p25,hyper-phosphorylates downstream substrates related to neurodegenerative *** review summarizes factors such as oxidative stress,DNA damage response,signaling pathway disturbance,and Ubiquitin proteasome malfunction contributing to cell cycle re-entry in post-mitotic *** also describes how all these factors are linked to a greater or lesser extent with ***,it offers a global vision of the function of cell cycle-related proteins in mature neurons with a focus on Cdk5 and how this protein contributes to the development of Alzheimer’s disease,Parkinson’s disease,amyotrophic lateral sclerosis,and Huntington’s disease by cell cycle activation.

关键词： Alzheimer´s disease amyotrophic lateral sclerosis apoptosis Cdk5 cell cycle Huntington´s disease neurodegeneration neuron oxidative stress Parkinson´s disease signaling Tau phosphorylation

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Singular Integrals with Variable Kernels in Dyadic Settings

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Acta Mathematica Sinica,English Series 2023年第8期39卷 1565-1579页

作者： Hugo AIMAR raquel CRESCIMBENI Luis NOWAK IMAL-CONICET and UNL Santa FeArgentina Departamento de Matemática FaEAUNCo.and IITCI-CONICETNeuquenArgentina

In this paper we explore conditions on variable symbols with respect to Haar systems,defining Calderón–Zygmund type operators with respect to the dyadic metrics associated to the Haar bases. We show that Petermichl’s dyadic kernel can be seen as a variable kernel singular integral and we extend it to dyadic systems built on spaces of homogeneous type.

关键词： Singular integrals spaces of homogeneous type Petermichl’s operator Haar basis

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Microglial exosomes in retinal neuroinflammation: focus in glaucoma

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Neural Regeneration Research 2021年第9期16卷 1801-1802页

作者： Ines Dinis Aires Ana raquel Santiago University of Coimbra Coimbra Institute for Clinical and Biomedical Research(iCBR)Faculty of MedicineCoimbraPortugal University of Coimbra Center for Innovative Biomedicine and Biotechnology(CIBB)CoimbraPortugal Clinical Academic Center of Coimbra(CACC) CoimbraPortugal Association for Innovation and Biomedical Research on Light and Image(AIBILI) CoimbraPortugal

Glaucoma is a leading cause of irreversible blindness, expected to affect 140 million people worldwide by the year 2040. The pathophysiology of glaucoma involves retinal ganglion cell loss, optic nerve atrophy and cupping of the optic disk, culminating in visual field loss(Boia et al., 2020). Glaucoma is a multifactorial disease in which increased intraocular pressure is the main risk factor.

关键词： glaucoma inflammation al.

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Oxidative desulfurization of diesel fuel oil using supported Fenton catalysts and assisted with ultrasonic energy

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Petroleum Science 2019年第5期16卷 1176-1184页

作者： Roberto Flores Arturo Rodas raquel Gasperin Facultad de Ciencias Químicas e Ingeniería Universidad Autónoma del Estado de MorelosAv.Universidad No.1001Col.Chamilpa62209 CuernavacaMorelosMexico Gerencia de Materiales y Procesos Químicos Instituto Nacional de Electricidad y Energías LimpiasCalle Reforma 113Col.Palmira62490 CuernavacaMorelosMexico

An ultrasound-assisted heterogeneous catalytic oxidation process was applied to eliminate sulfur from commercial diesel fuel *** studied variables were catalyst concentration,type of catalyst(homogeneous or heterogeneous),oxidizing agent concentration,and the application of ultrasound *** catalysts were prepared by impregnation of coal fly ash with an iron(Ⅱ)sulfate aqueous solution using ultrasound *** drying,the catalyst was calcined at 500℃for 4 *** oxidizing agent was hydrogen *** energy was applied with a frequency of 47 kHz and an intensity of 147 *** was employed for extracting the oxidized compounds from the hydrocarbon *** fly ash and ethanol were used with the purpose of applying low-cost raw materials in chemical *** was found that under the studied conditions,increasing oxidizing agent concentration and the application of ultrasound energy can enhance the sulfur removal from commercial diesel fuel *** concentration did not play a significant role in the *** results were obtained using homogeneous or heterogeneous catalyst,which is important since the heterogeneous catalyst could be recovered,reactivated,and used in many cycles.

关键词： Oxidative desulfurization Diesel Ultrasound energy Supported catalyst Low-cost raw materials

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On the chiral covariant approach to ρρ scattering

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Chinese Physics C 2017年第12期41卷 24-32页

作者：耿立升 raquel Molina Eulogio Oset School of Physics and Nuclear Energy Engineering & International Research Center for Nuclei and Particles in the Cosmos & Beijing Key Laboratory of Advanced Nuclear Materials and Physics Beihang University Beijing 100191 China Physics Department The George Washington University Washington DC 20052 USA Departamento de Física Teórica and IFIC Centro Mixto Universidad de Valencia-CSIC Institutos de Investigación de Paterna Aptdo 22085 46071 Valencia Spain

We examine in detail a recent work（D. Gülmez, U. G. Mei？ner and J. A. Oller, Eur. Phys. J. C,77： 460（2017））, where improvements to make ρρ scattering relativistically covariant are made. The paper has the remarkable conclusion that the J =2 state disappears with a potential which is much more attractive than for J =0,where a bound state is found. We trace this abnormal conclusion to the fact that an ＂on-shell＂ factorization of the potential is done in a region where this potential is singular and develops a large discontinuous and unphysical imaginary part. A method is developed, evaluating the loops with full ρ propagators, and we show that they do not develop singularities and do not have an imaginary part below threshold. With this result for the loops we define an effective potential, which when used with the Bethe-Salpeter equation provides a state with J =2 around the energy of the f2（1270）. In addition, the coupling of the state to ρρ is evaluated and we find that this coupling and the T matrix around the energy of the bound state are remarkably similar to those obtained with a drastic approximation used previously, in which the q2 terms of the propagators of the exchanged ρ mesons are dropped, once the cut-off in the ρρ loop function is tuned to reproduce the bound state at the same energy.

关键词： rho-rho scattering unitary chiral approaches on-shell approximations

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Numerical investigation of wave propagation in the Liverpool Bay,NW England

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Acta Oceanologica Sinica 2011年第5期30卷 1-13页

作者： LI Ming RAYMOND Ip WOLF Judith CHEN Xueen burrows Richard School of Engineering University of Liverpool Liverpool L69 3GQ UK National Oceanography Centre Joseph Proudman Building Liverpool L3 5DA UK College of Physical and Environmental Oceanography Ocean University of China Qingdao 266100 China

The computer model for near shore wave propagation,SWAN,was used to study wave climates in Liverpool Bay,northwest England with various input parameters,including bottom friction factor,white capping,wind drag formulation and effects of tidal *** were compared with in-situ measurements and reveal the impacts from these inputs on the predictions of wave height and propagation *** particular,the model results were found very sensitive to different input formulations,and tend to underestimate the wave parameters under storm conditions in comparison with the *** is therefore important to further validate the model against detailed field measurements,particularly under large storms that are often of the primary concern.

关键词： coastal engineering flooding wave model near shore tide

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Challenges in estimating ancestral state reconstructions:the evolution of migration in Sylvia warblers as a study case

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Integrative Zoology 2020年第3期15卷 161-173页

作者： raquel PONTI Angel ARCONES David R.VIEITES National Museum of Natural Sciences MadridSpain Department of Evolutionary Biology Ecology and Environmental SciencesFaculty of BiologyUniversity of BarcelonaBarcelonaSpain Biodiversity Research Institute(IRBIO) University of BarcelonaBarcelonaSpain

Our current understanding of how species have evolved is mainly based on comparative phylogenetic methods,which use phylogenies to infer the evolution of *** development of ancestral state reconstruction(ASR)methods has provided the tools to reconstruct trait evolution,which are widely used in fields like evolutionary biology,macroecology and *** there are different elements involved in those analyses,with different levels of uncertainty(*** to branch length estimation,trait coding,statistical framework,taxon sampling or software),the various combinations of these elements likely have a strong impact on the reconstruction of the evolution of traits,potentially leading to opposite *** assess the impact of these different elements in ASR,we performed a set of analyses,including all possible combinations of such elements and using the evolution of migratory behavior in Sylvia warblers as a case study,which was coded as a continuous or as a discrete *** results show that taxon sampling,character coding,tree shape,statistical framework and software all significantly affect ASR,both individually and in *** all reconstructed tree nodes show discrepancies,but in the critical ones most pairwise comparisons between analyses lead to conflicting and unexpectedly antagonistic results(zero migration vs fully migratory),thus challenging interpretations of trait *** propose some possible solutions to partly inform decisions,involving the method selection and the incorporation of biological or fossil evidence regarding how traits evolve,but our results demand serious rethinking about how the research community currently uses ASR.

关键词： ancestral state reconstruction conflicting methods evolution of migration Sylvia warblers

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