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Transarterial embolization is an acceptable bridging therapy to hepatocellular carcinoma prior to liver transplantation

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World Journal of Transplantation 2024年第2期14卷 126-134页

作者： Gabriel Lazzarotto-da-Silva Leandro A Scaffaro Mauricio Farenzena Lucas Prediger Rafaela K Silva Flávia Heinz Feier Tomaz J M Grezzana-Filho Pablo D Rodrigues Alexandre de Araujo Mario Reis Alvares-da-Silva Roberta C Marchiori Cleber Rosito pinto Kruel Marcio Fernandes Chedid Department of Liver Transplant and Hepatobiliary Surgery Unit Hospital de Clínicas de Porto AlegrePorto Alegre 90035-007Brazil Department of Interventional Radiology Unit Hospital de Clínicas de Porto AlegrePorto Alegre 90035-007Brazil Department of Gastroenterology and Hepatology Hospital de Clínicas de Porto AlegrePorto Alegre 90035-007Brazil

BACKGROUND Hepatocellular carcinoma(HCC)is an aggressive malignant neoplasm that requires liver transplantation(LT).Despite patients with HCC being prioritized by most organ allocation systems worldwide,they still have to wait for long *** therapies(LRTs)are employed as bridging therapies in patients with HCC awaiting *** largely used in the past,transarterial embolization(TAE)has been replaced by transarterial chemoembolization(TACE).However,the superiority of TACE over TAE has not been consistently shown in the *** To compare the outcomes of TACE and TAE in patients with HCC awaiting *** All consecutive patients with HCC awaiting LT between 2011 and 2020 at a single center were *** patients underwent LRT with either TACE or *** patients also underwent percutaneous ethanol injection(PEI),concom-itantly or in different treatment *** choice of LRT for each HCC nodule was determined by a multidisciplinary *** primary outcome was waitlist dropout due to tumor progression,and the secondary outcome was the occurrence of adverse *** the subset of patients who underwent LT,complete pathological response and post-transplant recurrence-free survival were also *** Twelve(18.5%)patients in the TACE group(only TACE and TACE+PEI;n=65)and 3(7.9%)patients in the TAE group(only TAE and TAE+PEI;n=38)dropped out of the waitlist due to tumor progression(P log-rank test=0.29).Adverse events occurred in 8(12.3%)and 2(5.3%)patients in the TACE and TAE groups,respectively(P=0.316).Forty-eight(73.8%)of the 65 patients in the TACE group and 29(76.3%)of the 38 patients in the TAE group underwent LT(P=0.818).Among these patients,complete pathological response was detected in 7(14.6%)and 9(31%)patients in the TACE and TAE groups,respectively(P=0.145).Post-LT,HCC recurred in 9(18.8%)and 4(13.8%)patients in the TACE and TAE groups,respectively(P=0.756).Posttransplant recurrence-free survival was simila

关键词： Hepatocellular carcinoma Transarterial embolization Transarterial chemoembolization Liver transplantation Locoregional therapy Bridging

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Natural orifice transluminal endoscopy surgery:A review

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World Journal of Gastroenterology 2011年第33期17卷 3795-3801页

作者： Joo Moreira-pinto Estevo Lima Jorge Correia-pinto Carla Rolanda Life and Health Sciences Research Institute(ICVS) School of Health SciencesUniversity of MinhoBragaPortugal ICVS/3B's-PT Government Associate Labora-tory Braga/GuimaresPortugal Pediatric Surgery division Centro Hospitalar do Porto4099-001 PortoPortugal Department of Urology Hospital de Braga4709-057 BragaPortugal Department of Pediatric Surgery Hospital de Braga4709-057 BragaPortugal Department of Gastroenterology Hospital de Braga4709-057 BragaPortugal

Minimally invasive surgery started spreading worldwide in 1987,when the first laparoscopic cholecystectomy was ***,improvement of endoscopic equipment and instruments allowed gastroenterologists to attempt more aggressive endoluminal interventions,even beyond the wall *** first transgastric peri-toneoscopy,in 2004,brought to light the concept of natural orifice transluminal endoscopic surgery(NOTES).The idea of incisionless surgery is attractive and has become a new goal for both surgeons and other people interested in this field of *** authors present a review of all developments concerning NOTES,including animal studies and human experience.

关键词： Transesophageal Transgastric Transvesical Transvaginal Transcolonic Natural orifice trans-luminal endoscopic surgery Minimally invasive tech-niques

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Variation of Parameters Formula and Gronwall Inequality for Differential Equations with a General Piecewise Constant Argument

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Acta Mathematicae Applicatae Sinica 2011年第4期27卷 561-568页

作者： Kuo-Shou CHIU Manuel pinto Departamento de Matemótica Facultad de Ciencias BósicasUniversidad Metropolitana de Ciencias de la EducacinJ.P.Alessandri 774SantiagoChile Departamento de Matemóticas Facultad de CienciasUniversidad de ChileCasilla 653SantiagoChile

A variation of parameters formula and Gronwall type integral inequality are proved for a differential equation involving general piecewise alternately advanced and retarded argument.

关键词： variation of parameters formula Gronwall integral inequality alternately advanced and retarded argument

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Analysis of the Cicatricial Acceleration Method (MAC®) in Skin Repair in Wistar Rattus norvegicus with Induced Chemical Burns

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Journal of Biosciences and Medicines 2024年第9期12卷 204-214页

作者： Marcus Vinicius de Mello pinto Sandroval Francisco Torres Aline Ronis Sampaio Karin Yuri Fernandez Iturra Miriam Viviane Baron Patricia Froes Carlos Ruiz da Silva Daiane Paza Maria Elena Silva Alvarez Josefa Jeanette Ugalde Juliano Tibola Esteban Fortuny Celulare Institute Petrpolis Brazil State University of Santa Catarina (UDESC) Florianopolis Brazil Bienus Clinic Santiago Chile Pontifical Catholic University of Rio Grande do Sul (PUC/RS) Porto Alegre Brazil International Research Group (IRG) Natal Brazil Academic Training Center (CTA) College So Paulo Brazil Fibrafisio Clinic Brusque Brazil Fisiocare Clinic Curic Chile Lua Clinic Coyhaique Chile Finis Terrae University Santiago Chile

Introduction: The cicatricial acceleration method (MAC®) promotes photobiological effects of an anti-inflammatory and healing nature. Its therapeutic radiation is emitted, producing photobiostimulant effects that result in rapid tissue repair and better tissue quality. The treatment of burns has always been a challenge, which involves both performing surgery and controlling and guiding scar regeneration, avoiding possible morbidities. Objective: To evaluate the effects of applying the MAC methodology with an AlGa (aluminum, gallium arsenide) laser on the time and quality of tissue repair in the skin of rats after induced chemical burns. Method: 22 adult male rats were subjected to a second-degree chemical burn on the back using 50% trichloroacetic acid. After the burns, the animals were randomly separated into 2 groups: control and experimental. The control group (G1) received placebo laser therapy and the laser group (G2) underwent laser irradiation with an energy density of 100 J/cm2. Histological analysis and macroscopic evaluation were carried out by means of the paper template method. Results: Group G1 showed (53%) of the necrosis area and group G2 showed (11%) necrosis area. Conclusion: The cicatricial acceleration method (MAC®) favored the repair of wounds caused by a 2nd-degree chemical burn, optimizing time and improving quality.

关键词： Chemical Burn Healing Scarring Cicatricial Acceleration Method (MAC®) Tissue Repair

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Organic Light Emitting Diodes with Lithium Contained Alq3 as Electron Injection Layer

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Chemical Research in Chinese Universities 2002年第2期18卷 121-123页

作者： Zugang Liu J.L.pinto Department of Materials University of OxfordParks RoadOxford OX13PFUK Departamento de Física Universidade de Aveiro3810194 AveiroPortuga

lNovel lithium doped tris 8 hydroxylquinoline aluminium(Alq3:Li) layer is deposited between emission layer and electron injection aluminium electrode as an electron injection assistant layer in different organic light emitting diodes(OLED) to lower the electron injection barrier. In these devices, Alq3 is used as emission layer, and a bilayer film of N,N bis (1 naphhyl) N,N diphenyl 1,1 biphenyle 4,4' diamine(NPB) and 4,4,4' tris(3 methyl phenylphenylamino) triphenylamine( m MTDATA) used as hole transport layer(HTL). The electroluminescent performance of devices with different thicknesses of Alq3∶Li shows that the insertion of the lithium doped Alq3 layer can reduce the turn on voltage by at least 2 volts, and the stability of devices with this lithium doped Alq3 layer is improved too. It can also change the efficiency of devices. Compared with an ultra thin lithium fluoride(LiF) layer, Alq3∶Li sheet gives similar effects but higher efficiency and can be much thicker and hence it is easier to control the deposition.

关键词： Organic light emitting diodes Lithium layer Alq3 EI

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Biotechnology of the multipurpose tree species Arbutus unedo:a review

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Journal of Forestry Research 2022年第2期33卷 377-390页

作者： João Martins Glória pinto Jorge Canhoto Centre for Functional Ecology Department of Life SciencesUniversity of CoimbraCoimbraPortugal Centre for Environmental and Marine Studies Department of BiologyUniversity of AveiroAveiroPortugal

Arbutus unedo L.(strawberry tree,Ericaceae)is a woody species with a circum-Mediterranean *** has considerable ecological relevance in southern European forests due to its resilience to abiotic and biotic *** edible red berries are used in the production of traditional products,including an expensive *** compounds extracted from the species have bioactive prop-erties used by the cosmetic and pharmaceutical *** strawberry tree has gone from a neglected species to become a highly valuable crop with large cultivated areas in southern European and North African *** to an increasing demand from farmers for plants with improved features,researchers have been trying to improve this spe-cies through conventional and biotechnological tools,focus-ing mainly on population analysis using molecular markers,in vitro cloning,tolerance to biotic and abiotic stresses,and intraspecific crosses to obtain genotypes with new *** objective of this review is to gather and update information about the species and make it available to researchers and *** research areas that are considered a priority for this species are highlighted.

关键词： Breeding Chemical profiling Ericaceae Microbiome Micropropagation

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t-SNE:A study on reducing the dimensionality of hyperspectral data for the regression problem of estimating oenological parameters

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Artificial Intelligence in Agriculture 2023年第1期7卷 58-68页

作者： Rui Silva Pedro Melo-pinto CITAB-Centre for the Research and Technology of Agro-Environmental and Biological Sciences Inov4Agro-Institute for InnovationCapacity Building and Sustainability of Agri-Food ProductionUniversidade de Trás-os-Montes e Alto DouroQuinta dos PradosVila Real 5000-801Portugal Departamento de Engenharias Escola de Ciências e TecnologiaUniversidade de Trás-os-Montes e Alto DouroQuinta dos PradosVila Real 5000-801Portugal

In recent years there is a growing importance in using machine learning techniques to improve procedures in precision agriculture:in this work we perform a study on models capable of predicting oenological parameters from hyperspectral images of wine grape berries,a specially relevant topic to boost production tasks for ***,we explore the capabilities of a novel technique mostly used for visualization,t-Distributed Stochastic Neighbor Embedding(t-SNE),for reducing the dimensionality of the highly complex hyperspectral data and compare its performance with Principal Component Analysis(PCA)method,which despite the introduction of many nonlinear dimensionality reduction techniques over the years,had achieved the best results for real-world data across several studies in *** we explore the potential of Kernel t-SNE,an extension to the t-SNE method that allows for the usage of the technique in streaming data or online *** results show that,in a direct comparison,t-SNE achieves better metrics than PCA for most of the data sets in this work and that the regressor(Support Vector Regression,SVR)performs better with the t-SNE reduced features as inputs,accomplishing better predictions with lower error *** the results with current literature,our shallow learning model paired with t-SNE achieves either better or on par results than those reported,even competing with more advanced models that use deep learning techniques,which should propel the introduction of t-SNE in more studies that require dimensionality reduction.

关键词： Hyperspectral images Dimensionality reduction Regression T-SNE Support vector machines Wine grape berries

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Residuated Completely Simple Semigroups

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Algebra Colloquium 2014年第2期21卷 181-194页

作者： T.S. Blyth G.A. pinto Mathematical Institute University of St Andrews Scotland Instituto Piaget Campus Universitario de Almada Quinta da Arreinela de Cima 2800-305 Almada Portugal Universidade Atlantica Instituto de Investigagao Cientifica e Tecnologica Fabrica da Polvora 2730-036 Barcarena Portugal

We consider particular compatible orders on a given completely simple semi- group Sx= M（（x）; I, A; P） where （x） is an ordered cyclic group with x 〉 1 and p11= x-1. Of these, only the lexicographic and bootlace orders yield residuated semigroups. With the lexicographic order, Sx is orthodox and has a biggest idempotent. With the bootlace order, the maximal idempotents of Sx are identified by specific locations in the sandwich matrix. In the orthodox case there is also a biggest idempotent and, for sandwich matrices of a given size, uniqueness up to ordered semigroup isomorphism is established.

关键词： lexicographic order bootlace order residuated completely simple semigroup

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Exploring spatial relationships between stream channel features,water depths and flow velocities during flash floods using HEC-GeoRAS and Geographic Information Systems

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Journal of Geographical Sciences 2022年第4期32卷 757-782页

作者： Miguel LEAL Eusébio REIS Pedro pinto SANTOS Centre of Geographical Studies and Associated Laboratory TERRA Institute of Geography and Spatial PlanningUniversidade de Lisboa1600-276 LisbonPortugal Forest Research Centre and Associated Laboratory TERRA School of AgricultureUniversidade de LisboaTapada da Ajuda1349-017 LisbonPortugal

Water depths and flow velocities decisively influence the damage caused by flash *** Information System(GIS)is a powerful and useful tool,allowing the spatial analysis of results obtained by hydraulic modelling,namely from the HEC-RAS/HEC-GeoRAS *** GIS spatial analysis performed in this study seeks to explain and quantify the spatial relationships between the stream channel features and flow components during flash flood *** these relationships are generically known,there are few studies exploring this subject in different geographic contexts.A 1D hydraulic model was applied in a small watershed in Portugal,providing good results in the definition of floodable areas,water depths and longitudinal *** direct relationship was found between water depths and velocities in the floodable areas;however,negative strong correlations were found between the two flow components along the stream *** slope,channel and flood width,and roughness prove to be highly relevant on the longitudinal variations of water depths and velocities and on the location of maximum *** peak discharges and return periods(R;)can change the relationships between water depths and velocities at the same *** can be improved with more accurate elevation data for stream channels and floodplains.

关键词： flash floods water depth flow velocity geographic information systems(GIS) spatial analysis

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Enabling data-driven anomaly detection by design in cyber-physical production systems

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Cybersecurity 2022年第3期5卷 34-51页

作者： Rui pinto Gil Goncalves Jerker Delsing Eduardo Tovar Department of Informatics Engineering Faculty of EngineeringUniversity of PortoPortoPortugal EISLAB Lulea University of TechnologyLuleaSweden Research Centre in Real-Time and Embedded Computing Systems Polytechnic of Porto-School of EngineeringPortoPortugal

Designing and developing distributed cyber-physical production systems(CPPS)is a time-consuming,complex,and error-prone *** systems are typically heterogeneous,i.e.,they consist of multiple components implemented with different languages and development *** of the main problems nowadays in CPPS implementation is enabling security mechanisms by design while reducing the complexity and increasing the system’s *** the IEC 61499 standard is an excellent approach to tackle these challenges by enabling the design,deployment,and management of CPPS in a model-based engineering *** propose a method for CPPS design based on the IEC 61499 *** method allows designers to embed a bio-inspired anomaly-based host intrusion detection system(A-HIDS)in Edge *** A-HIDS is based on the incremental Dendritic Cell Algorithm(iDCA)and can analyze OPC UA network data exchanged between the Edge devices and detect attacks that target the CPPS’Edge *** study’s findings have practical implications on the industrial security community by making novel contributions to the intrusion detection problem in CPPS considering immune-inspired solutions,and cost-effective security by design system *** to the experimental data,the proposed solution can dramatically reduce design and code complexity while improving application maintainability and successfully detecting network attacks without negatively impacting the performance of the CPPS Edge devices.

关键词： Artificial immune systems Cyber-physical production systems IEC 61499 Function blocks Industrial Internet of Things Anomaly-based host intrusion detection system Model-based engineering

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