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不卧床持续腹膜透析与维生素D

国外医学（泌尿系统分册） 1989年第1期9卷 28-29页

作者： rapoport j 陈维恩

不卧床持续腹膜透析(CAPD)已成为终未期肾衰的一种极为重要的治疗手段。与血透相比,CAPD虽能较好地维持血钙、磷浓度,但肾性骨营养不良发生率高。有研究表明,经1—2年的CAPD后,骨病的组织学变化获改善,然而经长期随访,发现骨营养不良呈... 详细信息

不卧床持续腹膜透析(CAPD)已成为终未期肾衰的一种极为重要的治疗手段。与血透相比,CAPD虽能较好地维持血钙、磷浓度,但肾性骨营养不良发生率高。有研究表明,经1—2年的CAPD后,骨病的组织学变化获改善,然而经长期随访,发现骨营养不良呈持续性变化。CAPD患者骨养营不良难以改善的原因之一可能与维生素D代谢障碍有关。本文对此进行探讨。众所周知,尿毒症患者有维生素D代谢异常,主要是1.25(OH)_2D_3的缺乏。这是由于肾组织减少,使1-α羟化酶活性降低,尿毒症的高磷血症及各种毒素引起。1,25(OH)_2D_3的活性随着肾小球滤过率的下降而降低。

关键词： CAPD 透析维生素D 肾衰竭

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超声微泡作为基因或药物载体的研究进展

药学学报 2009年第9期44卷 961-966页

作者：沈圆圆高钟镐 Natalya rapoport 中国医学科学院北京协和医学院药物研究所北京100050 美国犹他大学生物工程学院盐湖城84112

随着新型超声微泡造影剂的研究和应用,超声微泡不仅能增强超声造影,而且也能作为运送基因或药物的载体。在超声作用下,含基因或药物的微泡能穿透血管内皮,释放基因或药物,达到靶向治疗目的。本文综述了超声微泡的生物学效应、制备和应... 详细信息

随着新型超声微泡造影剂的研究和应用,超声微泡不仅能增强超声造影,而且也能作为运送基因或药物的载体。在超声作用下,含基因或药物的微泡能穿透血管内皮,释放基因或药物,达到靶向治疗目的。本文综述了超声微泡的生物学效应、制备和应用等方面的研究进展。

关键词：超声微泡纳米药物递送靶向

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异位甲状腺与甲状腺肿瘤

中国肿瘤临床 2000年第2期27卷 112-115页

作者：杨红健 rapoport Yoram 浙江省肿瘤医院头颈外科杭州市310022 以色列Ichilov医院耳鼻咽喉-头颈外科

目的 :探讨异位甲状腺及其肿瘤的临床病理学特点及诊治原则。方法 :对32例舌根甲状腺及6例其它中线部位的异位甲状腺之临床病理学资料进行了分析。对59例因“侧方异位甲状腺”而行同侧或双侧甲状腺切除的术后病理亦作了分析。结果 :32... 详细信息

目的 :探讨异位甲状腺及其肿瘤的临床病理学特点及诊治原则。方法 :对32例舌根甲状腺及6例其它中线部位的异位甲状腺之临床病理学资料进行了分析。对59例因“侧方异位甲状腺”而行同侧或双侧甲状腺切除的术后病理亦作了分析。结果 :32例舌根甲状腺无症状者11例 ,有症状性者21例 ,完全性异位16例 ,部分性异位16例 ,16例给予甲状腺素治疗仅1例无效 ,8例行手术切除术后病理显示2例腺瘤性甲状腺肿、2例甲状腺腺瘤、1例甲状腺滤泡癌和3例正常甲状腺组织。所有的因“侧方异位甲状腺”而行正常位置甲状腺切除术后病理均找到甲状腺原发癌。结论 :甲状腺胚胎发育异常是异位甲状腺的主要原因。通常位于中线部位。异位甲状腺可以发生正常位置甲状腺可发生的所有病变。“侧方异位甲状腺”应定义为颈动脉鞘外侧 ,基本上都是隐性甲状腺癌的转移灶。

关键词：异位甲状腺甲状腺肿瘤临床病理学诊断

Conquering Headache : An Illustrated Guide to Understanding the Treatment and Control of Headache 4th

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The Influence of Gene Polymorphisms on Tobacco and Alcohol-Induced Oral Cancer Risk

2003年

作者： rapoport, Alan M. Sheftell, Fred D. Tepper, Stewart j.

Includes index.

ISBN: (纸本)9781550092332;9780585489216

Includes index.

关键词： Headache--Popular works

来源：畅想之星图书光盘版（南... 评论

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journal of Cancer Therapy 2013年第5期4卷 978-988页

作者： Otávio A.Curioni Marcos B.de Carvalho Rogerio A.Dedivitis Abrao rapoport Gilka j.F.Gattas Department of Head and Neck Surgery and Otorhinolaryngology of the Heliopolis Hospital Sao PauloBrazil Department of Legal Medicine Bioethics and Occupational HealthSchool of MedicineSao PauloBrazil Head and Neck Surgeon of Sao jose Hospital Sao PauloBrazil Department of Head and Neck Surgery Hospital das ClinicasSao Paulo School of MedicineUniversity of Sao PauloSao PauloBrazil

Aims: This study examined whether genetic polymorphisms of tobacco and alcohol-related metabolic genes such as GSTM1, GSTT1, GSTP1, CYP1A1, CYP2E1 and DNA repair genes (XRCC1 194Trp, XRCC1 399Gln, and XRCC3 Met) contribute to the risk of developing OSCC. Methods: Patients eligible for inclusion were over 18 years, had pathologically confirmed OSCC and were followed prospectively for at least two years or until death, from December 2000 to December 2004. Ninety-two OSCC patients were included along with 244 subjects from the same hospital, evaluated in the same period as patients without cancer, as the control group. Results: GSTM1 null and XRCC1-194Trp alone increased the risk of OSCC (OR, 2.15;95% CI, 1.2 - 3.6 and OR, 2.02;95% CI, 1.01 - 4.03, respectively). The joint effect of GSTM1 null with CYP1A1 or CYP2E1 polymorphism increased the risk two to threefold. Similar results were observed when XRCC1-194Trp was combined with GSTM1 null or the CYP2E1 polymorphism. By contrast, XRCC1- 399Gln was associated with protection against OSCC. Gene-gene and gene-environmental interactions were mainly detected for CYP1A1 and GSTP1 associated with more than 20 p/y of tobacco and XRCC1-194Trp when more than 30 g/L/d of alcohol was consumed (OR, 8.8;95% CI;1.3 - 45.7). Conclusions: The drug metabolizing and DNA repair enzyme polymorphisms may be informative for clinicians in the preventive management of patients at risk, particularly those with strong smoking and drinking habits.

关键词： Mouth Neoplasms Head and Neck Neoplasms Polymorphism Genetic Smoking Alcohol Drinking

A systematic review of cytoreductive prostatectomy outcomes and complications in oligometastatic disease

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Asian journal of Urology 2024年第2期11卷 208-220页

作者： Andrey Morozov Leonid Chuvalov Mark Taratkin Mikhail Enikeev Leonid rapoport Nirmish Singla Eric Barret Elena Poddubskaya Maria Borodina Georg Salomon juan Gomez Rivas Dmitry Enikeev Institute for Urology and Reproductive Health Sechenov UniversityMoscowRussia Young Academic Urologists EAUthe Netherlands Department of Urology James Buchanan Brady Urological InstituteThe Johns Hopkins University School of MedicineBaltimoreUSA Department of Urology Institut Mutualiste MontsourisParisFrance Sechenov University MoscowRussia Hertsen Moscow Oncology Research InstituteMoscowRussia Hertsen Moscow Oncology Research Institute MoscowRussia Martini Clinic University Medical Center Hamburg-EppendorfHamburgGermany Department of Urology Clinico San Carlos University HospitalMadridSpain Department of Urology Medical University of ViennaViennaAustria

Objective: To analyze outcomes and complications of cytoreductive prostatectomy (CRP) for oligometastatic prostate cancer (PCa) in order to elucidate its role in this ***: We performed a systematic literature search using three databases (Medline, Scopus, and Web of Science). The primary endpoints were oncologic outcomes. The secondary endpoints were complication rates and functional ***: In all studies, overall survival was better or at least comparable variable in the groups with CRP compared to no local treatment. The greatest benefit from CRP in 5-year overall survival in one study was 67.4% for CRP versus 22.5% for no local treatment. Cancer-specific survival (CSS) showed the same trend. Several authors found significant benefits from CSS in the CRP group: from 79% vs. 46% to 100% vs. 61%. CRP was a predictor of better CSS (hazard ratio 0.264, p=0.004). Positive surgical margin rates differed widely from 28.6% to 100.0%. Urinary continence in CRP versus RP for localized PCa was significantly lower (57.4% vs. 90.8%, p<0.0001). Severe incontinence occurred seldom (2.5%-18.6%). Total complication rates after CRP differed widely, from 7.0% to 43.6%. Rates of grades 1 and 2 events prevailed. Patients on ADT alone also showed a considerable number of complications varying from 5.9% to 57.7%.Conclusion: CRP improves medium-term cancer control in patients with oligometastatic PCa. The morbidity and complication rates of this surgery are comparable with other approaches, but postoperative incontinence rate is higher compared with RP for localized disease.

关键词： Systematicreview Prostatecancer Oligometastatic Bone metastases Cytoreductive prostatectomy

Determining the utility of standard hospital microbiology testing: Comparing standard microbiology cultures with DNA sequence analysis in patients with chronic sinusitis

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World journal of Otorhinolaryngology-Head and Neck Surgery 2019年第2期5卷 82-87页

作者： Sarah K.rapoport Alyssa j.Smith Maxwell Bergman Kelly A.Scriven Itzhak Brook Suzette K.Mikula Medstar Georgetown University Hospital Department of OtolaryngologyHeadεt Neck SurgeryWashington DCUSA Mayo Clinic Department of OtolaryngologyHeadεt Neck SurgeryRochesterMNUSA Georgetown University Medical School Washington DCUSA Medstar Georgetown University Hospital Department of Pediatricsεt Infectious DiseasesWashington DCUSA

Objective:To demonstrate DNA sequencing analysis (DNAsa) of sinus cultures in patients with CRS is a reliable method of detecting pathogens in polymicrobial CRS ***:After obtaining Institutional Review Board approval for this prospective cohort study,we selected a random sample of 50 patients with CRS at Medstar Georgetown University Hospital between September 2016 and March *** defined CRS as a history of rhinosinusitis refractory to maximal medical therapy and prior endoscopic sinus *** demonstrating active purulence in a sinus cavity were prospectively selected to undergo standard hospital cultures (SHC) and DNAsa *** identified in both methods were compared for each ***:Specimens were obtained from 29 female and 16 male patients with a mean age of 50 years.A total of 45 cultures were included in our final analysis;five cultures were excluded after inappropriate laboratory *** from these patients were compared and ***'s weighted kappa analysis showed agreement between the two testing methods in identifying predominant *** detected 31.9% more microorganisms compared to SHC (P < 0.05).When multiple microorganisms were detected,DNAsa yielded more positive results compared to SHC (P < 0.05).Conclusions:DNAsa detects all microorganisms identified by SHC as well as predominant microorganisms not detected by *** molecular pathogen identification may be more reliable for identifying multiple microorganisms as compared to standard culture techniques that identify only one or two *** recalcitrant cases of CRS,DNAsa may provide better guidance in selection of appropriate antimicrobial treatment.

关键词： Chronic rhinosinusitis (CRS) DNA sequencing analysis (DNAsa) Microbiome Molecular sequencing Microbiology culture

比较第2版头痛疾病国际分类和选择性诊断标准对青少年慢性每日头痛分类的差异

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世界核心医学期刊文摘（神经病学分册） 2005年第10期1卷 20-21页

作者： Bigal M.E. rapoport A.M. Tepper S.j. 袁海峰 New England Cent er for Headache 778 Long Ridge Road Stamford CT 06902 United States Dr.

Objectives.- To compare the second edition of the International Classificati on of Headache Disorders (ICHD- 2) and the Silberstein- Lipton (S- L) criteri a in the classification of adolescents with chronic daily headache (CDH). Method s.- We reviewed the clinical records and the headache diaries of 170 adolescent s (13 to 17 years) seen between 1998 and 2003 at a headache center. Relevant inf ormation was transferred to a standardized form that included operational criter ia for the ICHD- 2. CDH subtypes were classified according the criteria propose d by S- L into transformed migraine (TM) with (TM+ ) and without medication ov eruse (TM- ), chronic tension- type headache (C- TTH), new daily persistent h eadache (NDPH), and he micrania continua (HC). Results.- From the 69 patients with TM- according t he S- L criteria, most (71% ) could be classified as chronic migraine (CM), wh ile a minority of patients required a combination of diagnosis, mainly migraine and CTTH (14.4% ). Of the patients with TM+ , just 39.6% met the criteria fo r probable CM (PCM) with probable medication overuse (PMO). If instead of 15 mig raine days per month, we considered 15 or more days of migraine or probable migr aine, 84% of the subjects with TM- and 68.7% of those with TM+ could be classified. Of the 27 subjects classified as NDPH without medication overuse acc ording to the S- L system, the majority (51.2% ) were also classified as NDPH according the ICHD- 2. Interestingly, three (11.1% of the subjects with NDPH without medication overuse) were classified as CM in the ICHD- 2 because these patients had an abrupt onset of 15 or more days of migraine per month. All patie nts with NDPH with medication overuse according to the S- L criteria required a combination of diagnoses in the ICHD- 2. All subjects with CTTH received a sin gle diagnosis in both classification systems. Conclusions.- (i) Among adolescen ts with TM, the majority (58.1% ) could be classified as CM, according to the I C

关键词：慢性每日头痛国际分类诊断标准慢性紧张型头痛持续状态持续头痛操作标准转换型标化诊断系统

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婴儿腹泻症酸中毒后状态—症状及化学记录

中华医学杂志 1950年第5期36卷 162-162页

作者： S.rapoport et al. Am.j.Dis.Child. 孙宗鲁李世英富立民李平