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Retention of eucalyptus harvest residues reduces soil compaction caused by deep subsoiling

Journal of Forestry Research 2022年第2期33卷 643-651页

作者： raphael oliveira de melo AymbiréAngeletti da Fonseca Nairam Félix de Barros raphael Bragança Alves Fernandes Rafael da Silva Teixeira Iago Nery melo Ricardo Previdente Martins Soil Science department Universidade Federal de ViçosaViçosaMinas GeraisBrazil BRACELL Company AlagoinhasBahiaBrazil

Eucalyptus harvesting,forwarding and soil tillage operations are among the main causes for compaction of forest soils,with potential impacts on *** concern is especially important in areas with soils that are naturally compacted(fragipans and duripans).In these soils,tillage operations include the use of subsoilers that can reach depths of more than one meter and require heavy tractors that exert high pressure on the *** of the ways to try to minimize the effect of this compaction is by retaining harvest *** objective of this study was to evaluate the impacts of eucalyptus harvesting on soil physical attributes,as well as to determine the potential of different types of residue management to reduce compaction from the soil tillage *** experiments were conducted in the same area with a Yellow *** the first experiment,compaction caused by mechanized harvesting with harvester+forwarder was *** the second experiment,different managements of harvest residues were examined as potential modifiers of soil compaction during tillage for new *** this,three managements systems were tested:(1)retention of all harvest residues and litter from the previous rotation(HR+L),(2)retention of litter from the previous rotation(L),and(3)removal of harvest residues and litter from the previous rotation(WR).Before and after harvest,sampling was carried out in the planting rows and inter-rows,and after tillage,samples were collected in the traffic line of the subsoiler-tractor *** both experiments,undisturbed soil samples were collected from the center of the 0-10,10-20,20-40,40-60,and 60-100 cm layers to determine soil density and total *** each period and site of evaluation,mechanical resistance to penetration up to the 60-cm depth was also *** harvesting operation increased soil density at 0-10 and 60-100 cm depths only in the *** of harvest residues and litter(HR+L)after harvesting avoi

关键词： Soil penetration resistance Harvester+forwarder Soil tillage Soil density Cohesive soils

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Three-dimensional models: from cell culture to Patient-derived Organoid and its application to future liposarcoma research

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Oncology research 2025年第1期33卷 1-13页

作者： Sayumi Tahara Sydney Rentsch Fernanda Costas Casal de Faria Patricia Sarchet Roma Karna Federica Calore raphael E Pollock department of Surgery Division of Surgical Oncology The James Comprehensive Cancer Center The Ohio State University Wexner Medical Center Columbus OH 43210 USA. department of Cancer Biology and Genetics The James Comprehensive Cancer Center The Ohio State University Wexner Medical Center Columbus OH 43210 USA.

Liposarcoma is one of the most common soft tissue sarcomas, however, its occurrence rate is still rare compared to other cancers. Due to its rarity, experiments are an essential approach to elucidate liposarcoma pathobiology. Conventional cell culture-based research (2D cell culture) is still playing a pivotal role, while several shortcomings have been recently under discussion. , mouse models are usually adopted for pre-clinical analyses with expectations to overcome the issues of 2D cell culture. However, they do not fully recapitulate human dedifferentiated liposarcoma (DDLPS) characteristics. Therefore, three-dimensional (3D) culture systems have been the recent research focus in the cell biology field with the expectation to overcome at the same time the disadvantages of 2D cell culture and animal models and fill in the gap between them. Given the liposarcoma rarity, we believe that 3D cell culture techniques, including 3D cell cultures/co-cultures, and Patient-derived tumor Organoids (PDOs), represent a promising approach to facilitate liposarcoma investigation and elucidate its molecular mechanisms and effective therapy development. In this review, we first provide a general overview of 3D cell cultures compared to 2D cell cultures. We then focus on one of the recent 3D cell culture applications, Patient-derived Organoids (PDOs), summarizing and discussing several PDO methodologies. Finally, we discuss the current and future applications of PDOs to sarcoma, particularly in the field of liposarcoma.

关键词： Cell culture Liposarcoma Patient-derived Organoid (PDO) Spheroid Three-dimensional (3D) cell culture

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Predictors of residual force enhancement in voluntary contractions of elbow flexors

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Journal of Sport and Health Science 2018年第3期7卷 318-325页

作者： Heiliane de Brito Fontana Daiani de Campos raphael Luiz Sakugawa Biological Sciences Center Federal University of Santa CatarinaCampus Reitor Joao David Ferreira LimaFlorianopoilsSC 88040-900Brazil Biomechanic Laboratory Federal University of Santa CatarinaCampus Reitor Joao David Ferreira LimaFlorianopolisSC 88040-900Brazil

Background:The steady-state increase in muscle force generating potential following a lengthening contraction is called residual force enhancement(RFE).In this study,we aimed to test for differences in torque,electromyographic activity(EMG),and the associated neuromuscular efficiency(NME)between isometric voluntary contractions of elbow flexors preceded and not preceded by a lengthening *** dependence of such differences on(i)stretch amplitude,(ii)the region of the force-length(FxL)relationship where contraction occurs,and(iii)the individual's ability to produce(negative)work during the stretch was ***:Sixteen healthy adults participated in the *** flexor torque,angle,and biceps brachii EMG for purely isometric contractions(reference contractions)and for isometric contractions preceded by active stretches of 20°and 40°were measured at the ascending,plateau,and descending regions of subject-specific FxL *** contractions were performed in an isokinetic ***-factor(stretch×FxL region)repeated measures analysis of variance ANOVAs was used to analyze the effect of active stretch on EMG,torque,and NME across *** relationships between mechanical work during stretch-calculated as the torque-angular displacement integral-and the changes in EMG,torque,and NME were analyzed using Pearson ***:In general,torque,EMG,and NME following active stretches differed from the values observed for the purely isometric reference *** although the detailed effects of active stretch on torque and EMG differed between regions of the FxL relationship,NME increased by about 19%for all muscle *** to 30%of the interindividual variability in torque generating potential change in response to active stretching was accounted for by differences in(negative)work capacity between ***:Our results suggest that(i)RFE contributes to"flatten"the elbow flexor torque-angle relationship,favoring

关键词： Force-length History-dependent properties Neuromuscular efficiency Upper limb Voluntary contractions

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Trends and predictions for gastric cancer mortality in Brazil

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World Journal of Gastroenterology 2016年第28期22卷 6527-6538页

作者： Angela Carolina Brandao de Souza Giusti Pétala Tuani Candido de oliveira Salvador Juliano dos Santos Karina Cardoso Meira Amanda Rodrigues Camacho raphael Mendonca Guimaraes Dyego LB Souza Federal University of Rio Grande do Norte Graduate Program in Collective Health Natal 59010-000 Brazil Health School Federal University of Rio Grande do Norte Natal 59010-000 Brazil National Cancer Institute Cancer Hospital III Rio de Janeiro Natal 59010-000 Brazil Federal University of Rio Grande do Norte University Hospital Onofre Lopes Natal 59010-000 Brazil Polytechnic Health School Joaquim Venancio Oswaldo Cruz Foundation (FIOCRUZ) Natal 59010-000 Brazil department of Collective Health Graduate Program in Collective Health Federal University of Rio Grande do Norte Natal 59010-000 Brazil

AIM: To analyze the effect of age-period and birth cohort on gastric cancer mortality, in Brazil and across its five geographic regions, by sex, in the population over 20 years of age, as well as make projections for the period ***: An ecological study is presented herein,which distributed gastric cancer-related deaths in Brazil and its geographic regions. The effects of ageperiod and birth cohort were calculated by the Poisson regression model and projections were made with the age-period-cohort model in the statistical program R. RESULTS: Progressive reduction of mortality rates was observed in the 1980's, and then higher and lower mortality rates were verified in the 2000's, for both sexes, in Brazil and for the South, Southeast and Midwest regions. A progressive decrease in mortality rates was observed for the Northeast(both sexes) and North(men only) regions within the period 1995-1999, followed by rising rates. CONCLUSION: Regional differences were demonstrated in the mortality rates for gastric cancer in Brazil, and the least developed regions of the country will present increases in projected mortality rates.

关键词： Gastric neoplasms Brazil Projections Mortality

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Ultra-hot Mesoproterozoic evolution of intracontinental central Australia

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Geoscience Frontiers 2015年第1期6卷 23-37页

作者： Weronika Gorczyk Hugh Smithies Fawna Korhonen Heather Howard raphael Quentin de Gromard Center for Exploration Targeting School of Earth and EnvironmentThe University of Western Australia Geological Survey of Western Australia

The Musgrave Province developed at the nexus of the North, West and South Australian cratons and its Mesoproterozoic evolution incorporates a 100 Ma period of ultra-high temperature （UHT） meta- morphism from ca. 1220 to ca. 1120 Ma. This was accompanied by high-temperature A-type granitic magmatism over an 80 Ma period, sourced in part from mantle-derived components and emplaced as a series of pulsed events that also coincide with peaks in UHT metamorphism. The tectonic setting for this thermal event （the Musgrave Orogeny） is thought to have been intracontinental and the lithospheric architecture of the region is suggested to have had a major influence on the thermal evolution. We use a series of two dimensional, fully coupled thermo-mechanical-petrological numerical models to investi- gate the plausibility of initiating and prolonging UHT conditions under model setup conditions appro- priate to the inferred tectonic setting and lithospheric architecture of the Musgrave Province. The results support the inferred tectonic framework for the Musgrave Orogeny, predicting periods of UHT meta- morphism of up to 70 Ma, accompanied by thin crust and extensive magmatism derived from both crustal and mantle sources. The results also appear to be critically dependent upon the specific location of the Mus^rave Province. constrained between thicker cratonic masses.

关键词： Ultra-high temperature (UHT) metamorphism Numerical modeling Intra-continental orogeny

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Diagnostic, prognostic, and therapeutic implications of genetic profiling in pleural mesothelioma

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Journal of Cancer Metastasis and Treatment 2023年第1期9卷 131-147页

作者： Ahmed Sadek Assunta de Rienzo raphael Bueno Division of Thoracic Surgery and the Lung Center Brigham and Women’s Hospitaland Harvard Medical SchoolBostonMA 02115USA

Pleural mesothelioma(PM)is an aggressive malignancy of the pleural lining that typically arises secondary to asbestos *** the advent of next-generation sequencing,major progress has been made in the molecular characterization of pleural mesothelioma over the past three ***,these advances have been largely unable to identify effective targeted therapies for ***,there remains an absence of accepted gold-standard consensus for staging and treatment,which partly explains the overall poor outcomes in patients with *** recent years,genetic profiling of PM tumors has proved to be an effective tool in the diagnosis and prognosis of *** sequencing has identified several potential targets for the development of novel therapeutics in *** review summarizes the progress in diagnosis,prognosis,and therapeutics derived by genomics and tumor profiling of PM tumors.

关键词： Pleural mesothelioma gene-profiling next generation sequencing gene ratio profiling tumor biomarkers targeted therapies

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An overview of the endogenous and environmental factors related to the Coffea arabica flowering process

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Beverage Plant Research 2021年第1期1卷 106-121页

作者： Marlon Enrique López Iasminy Silva Santos raphael Ricon de oliveira AndréAlmeida Lima Carlos HenriqueCardon Antonio Chalfun-Junior Laboratory of Plant Molecular Physiology Plant Physiology SectorDepartment of BiologyFederal University of LavrasLavras-Minas GeraisBrazil37200-900

The transition of vegetative meristems to a reproductive state followed by floral development and flowering is a complex process regulated by many regulatory pathways that integrate(epi)genetic and environmental factors to guarantee the reproductive success in *** woody and perennial species,such as coffee trees,the extended life cycle reflects adaptive strategies,i.e.,two-year cycle,sequential flowering and bud latency during the winter,that ensure reproductive success in a variable *** dynamics of coffee flowering integrate multiple stimuli to induce morpho-physiological changes,especially during the reproductive *** discussed diverse stimuli which are directly and indirectly associated with molecular pathways related to the reproductive meristem transition and floral development until ***,we propose to redefine some concepts regarding coffee floral development,such as:i)a summary of genes possibly involved in the flowering pathways;ii)a new classification of buds by position in the node(B1-B4)to avoid misunderstandings with the uneven developmental stages;iii)comparative ABC model to Arabidopsis and tomato to allow evolutionary discussions of whorls development in Coffea *** this,we expect to collaborate to drive future studies towards coffee breeding and production,for example,improving floral bud activation,controlling the flowering time,anthesis synchronization to produce more homogeneous ripening fruits,reducing abortion or early flower openings,and increasing ***,we think that the explored relationship between physiological and molecular approaches during the coffee flowering may be extended to understand other tropical perennial species,especially those with asynchronous flowering behavior,and to understand evolutive aspects in Rubiaceae.

关键词： breeding process flowering

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Vine pruning waste-based activated carbon for cerium and lanthanum adsorption from water and real leachate

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Journal of Rare Earths 2024年第10期42卷 1960-1968页

作者： raphael Forgearini Pinheiro Alejandro Grimm Kátia da Boit Martinello Mohammad Rizwan Khan Naushad Ahmad Luis Felipe oliveira Silva Irineu Antônio Schadach de Brum Guilherme Luiz Dotto Glaydson Simões dos Reis Research Group on Adsorptive and Catalytic Process Engineering(ENGEPAC) Federal University of Santa MariaAv.Roraima1000-797105900Santa MariaRSBrazi department of Forest Biomaterials and Technology Biomass Technology CentreSwedish University of Agricultural SciencesUmed SE-90183Sweden Universidad de La Costa Calle 58#55-66080002BarranquillaAtlanticoColombia department of Chemistry College of ScienceKing Saud UniversityRiyadh11451Kingdom of Saudi Arabia Institute of Chemistry Federal University of Rio Grande do Sul90040-060Porto AlegreBrazil

In this study,vine pruning wastes(VPW)were used as raw material to develop an alternative activated carbon(VPW-AC)for adsorbing and concentrating rare earth elements cerium(Ce(Ⅲ))and lanthanum(La(Ⅲ))from synthetic and real leachate *** Ce and La adsorption studies evaluated the effects of VPW-AC dosage,pH,contact time,rare earth initial concentration,and *** VPW-AC adsorbent was subjected to many physicochemical characterization methods to correlate and understand its adsorptive *** characterization data indicate a carbonaceous adsorbent with a specific surface area of 467 m^(2)/*** potential indicates a material with a negatively charged surface at a pH higher than 3.1,which is extremely beneficial to cations *** both rare earths elements(REEs),the adsorption capacity increases with the increase of the pH,reaching its maximum at pH *** kinetic data are well fitted by Avrami-fractional o rder,while the Liu model agreeably fits equilibrium *** maximum adsorption capacities for Ce(Ⅲ)and La(Ⅲ)are 48.45 and 53.65 mg/g at 298 K,*** thermodynamic studies suggest that the adsorption process is favorable,spontaneous,and exothermic for both *** filling,surface complexation,and ion exchange are the dominant ***,the VPW-AC was subjected to the recovery of REEs from real phosphogypsum leachate,and it is proved that it can be successfully used to recover REEs in a real process.

关键词： Vine pruning wastes Sustainable carbon adsorbent Rare earth elements Phosphogypsum leachate Ion-exchange mechanism

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Molecular profiling and patient selection for the multimodal approaches for patients with resectable colorectal liver metastases

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Hepatobiliary Surgery and Nutrition 2024年第2期13卷 273-292页

作者： raphael L.C.Araujo Leonardo G.Fonseca raphael oliveira Silva Marcelo Moura Linhares Pedro L.S.Uson Junior department of Surgery Universidade Federal de São PauloSão PauloSPBrazil Hospital e Maternidade Brasil-Rede D’Or São Luiz Santo AndréSPBrazil department of Oncology Hospital Israelita Albert EinsteinSão PauloSPBrazil department of Oncology Instituto do Cancer do Estado de São PauloUniversity of Sao PauloSão PauloSPBrazil department of Oncology Hospital Ministro Costa CavalcantiFoz do IguaçuPRBrazil Center for Personalized Medicine Hospital Israelita Albert EinsteinSão PauloSPBrazil

Colorectal cancer represents the third most common cancer and about 20%are diagnosed with synchronous metastatic *** a historical point of view,surgery remains the mainstream treatment for resectable colorectal liver metastases(CRLM).Furthermore,disease outcomes are improving due significant advances in systemic treatments and diagnostic ***,the optimal timing for neoadjuvant chemotherapy or upfront surgery for CRLM has not yet been established and remains an open ***,patient selection combining image workouts,time of recurrence,positive lymph nodes,and molecular biomarkers can improve the decision-making ***,molecular profiling is rising as a promising field to be incorporated in the multimodal approach and guide patient selection and sequencing of *** biomakers,genetic profiling,and circulating tumor DNA have been used to offer as much personalized treatment as possible,based on the precision oncology concept of tailored care rather than a guideline-based *** review article discusses the role of molecular pathology and biomarkers as prognostic and predictor factors in the diagnosis and treatment of resectable CRLM.

关键词： Colorectal liver metastases(CRLM) surgery chemotherapy molecular pathology circulating tumor DNA tumor markers

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Braking distance prediction for vehicle consist in low-speed on-sight operation:a Monte Carlo approach

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Railway Engineering Science 2023年第2期31卷 135-144页

作者： raphael Pfaff FH Aachen University of Applied Sciences Goethestr.152064 AachenGermany

The first and last mile of a railway journey, in both freight and transit applications, constitutes a high effort and is either non-productive(e.g. in the case of depot operations) or highly inefficient(e.g. in industrial railways). These parts are typically managed on-sight, i.e. with no signalling and train protection systems ensuring the freedom of movement. This is possible due to the rather short braking distances of individual vehicles and shunting consists. The present article analyses the braking behaviour of such shunting units. For this purpose, a dedicated model is developed. It is calibrated on published results of brake tests and validated against a high-definition model for lowspeed applications. Based on this model, multiple simulations are executed to obtain a Monte Carlo simulation of the resulting braking distances. Based on the distribution properties and established safety levels, the risk of exceeding certain braking distances is evaluated and maximum braking distances are derived. Together with certain parameters of the system, these can serve in the design and safety assessment of driver assistance systems and automation of these processes.

关键词： Freight rail Shunting Braking curves Brake set-up Driver assistance system Automatic train operation

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