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新加坡一所教学医院对肺栓塞病人的回顾

中华结核和呼吸杂志 1997年第ZK期20卷 111-111页

作者： Lee SC Stebbings ael Tan L Tan WC 孙越(译) DepartmentofMedicine NationalUniversityHospitalSingapore

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新加坡一所教学医院对肺栓塞病人的回顾

中华结核和呼吸杂志 1997年第Z1期 111页

作者： Lee SC Stebbings ael Tan L Tan WC 孙越(译) DepartmentofMedicine NationalUniversityhospital Singapore

CAR-T cells: Early successes in blood cancer and challenges in solid tumors

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Acta Pharmaceutica Sinica B 2021年第5期11卷 1129-1147页

作者： hassan Dana Ghanbar Mahmoodi Chalbatani Seyed Amir Jalali hamid Reza Mirzaei Stephan A.Grupp Eloah Rabello Suarez Catarina raposo Thomas J.Webster Cancer Research Center Cancer Institute of IranTehran University of Medical SciencesTehran 13145-158Iran Department of Medical Immunology School of MedicineTehran University of Medical SciencesTehran ***Iron Department of Immunology School of MedicineShahid Beheshti University of Medical SciencesTehran ***Iran Division of oncology Department of Pediatricsthe Children's Hospital of PhiladelphiaPhiladelphiaPA 19104USA Center for Natural and human Sciences Federal University of ABCSanto AndreSP 09210-580Brazil Faculty of Pharmaceutical Sciences State University of Campinas(UNICAMP)CampinasSP 13083-87JBrazil Department of Chemical Engineering Northeastern UniversityBostonMA 02115USA

New approaches to cancer immunotherapy have been developed, showing the ability to harness the immune system to treat and eliminate cancer. For many solid tumors, therapy with checkpoint inhibitors has shown promise. For hematologic malignancies, adoptive and engineered cell therapies are being widely developed, using cells such as T lymphocytes, as well as natural killer(NK) cells, dendritic cells, and potentially others. Among these adoptive cell therapies, the most active and advanced therapy involves chimeric antigen receptor(CAR)-T cells, which are T cells in which a chimeric antigen receptor is used to redirect specificity and allow T cell recognition, activation and killing of cancers, such as leukemia and lymphoma. Two autologous CAR-T products have been approved by several health authorities,starting with the U.S. Food and Drug Administration(FDA) in 2017. These products have shown powerful, inducing, long-lasting effects against B cell cancers in many cases. In distinction to the results seen in hematologic malignancies, the field of using CAR-T products against solid tumors is in its infancy. Targeting solid tumors and trafficking CAR-T cells into an immunosuppressive microenvironment are both significant challenges. The goal of this review is to summarize some of the most recent aspects of CAR-T cell design and manufacturing that have led to successes in hematological malignancies, allowing the reader to appreciate the barriers that must be overcome to extend CAR-T therapies to solid tumors successfully.

关键词： Immunotherapy T cell therapy Chimeric antigen receptor(CAR) Genetic engineering

Coarsening rate of microstructure in semi-solid aluminium alloys

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Transactions of Nonferrous Metals Society of China 2010年第9期20卷 1672-1676页

作者： h.V.ATKINSoN D.LIU Mechanics of Materials Research Group Department of EngineeringUniversity of LeicesterUniversity Rd. Now with Wolfson Microelectronics PLC.

The rate of microstructural coarsening of recrystallisation and partial melting (rap) and cooling slope (CS) processed materials in the semi-solid state is compared with rates found in the *** rate of coarsening depended on the liquid fraction but rap route 2014 alloy with 37% liquid coarsened slightly more slowly than the CS route 2014 alloy with a lower liquid fraction of 17%, contrary to *** the CS route, an increase in liquid fraction resulted in faster coarsening.A modified 2014 alloy with Fe, Mn and Zn stripped out of the composition gave a relatively high coarsening *** coarsening rate was also relatively high for CS 201 alloy in comparison with either rap 2014 or CS *** coarsening rates are thought to be associated with the presence of particles which inhibit the migration of liquid film grain *** could be the result of pinning or of the liquid film impeding diffusion at the boundary.

关键词： coarsening semi-solid metal 2014 alloy recrystallisation and partial melting cooling slope

Microstructure and Mechanical Properties of 7005 Aluminum Alloy Components Formed by Thixoforming

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Journal of Materials Science & Technology 2017年第4期33卷 379-388页

作者： Jufu Jiang h.V.Atkinson Ying Wang School of Materials Science and Engineering Harbin Institute of Technology Harbin 150001 China Department of Engineering University of Leicester University Road Leices-ter LE1 7RH UK School of Mechatronics Engineering Harbin Institute of Technology Harbin 150001 China

In the present research, semisolid billet of 7005 aluminum alloy was fabricated by using recrystallization and partial remelting（rap）, then thixoformed at different isothermal temperatures, preheating temperatures and load routes. Mechanical properties and microstructure of the thixoformed product were investigated. The results showed that microstructure achieved by three-step induction heating warm extruded 7005 aluminum alloy consists of a uniform and spheroidal microstructure suitable for *** temperature of the die affected significantly the filling status of semisolid billet of 7005 aluminum alloy. Complete filling status with good surface quality was obtained at a preheating temperature of 365 ℃. Thixoformed microstructures consisting of relatively spheroidal grains illustrate the dependence of filling process on the sliding and rotating of solid grains rather than plastic deformation of solid grains. A non-uniform distribution of liquid phase was found in the different regions of the thixoformed product due to the slower adjustable velocity of solid grains as compared with liquid phase. Increase of isothermal temperatures led to a slight decrease of mechanical properties of the thixoformed product due to coarsening of solid grains. The highest yield strength, ultimate tensile strength and elongation of thixoformed components with T6 heat treatment are 237 MPa, 361 MPa and 16.8%, respectively, which were achieved at the isothermal temperature of 605℃. Load route has a significant effect on mechanical properties and microstructure of the thixoformed product. Defects, such as crack and microporosity occurred in the microstructure of the thixoformed product obtained under load route 2. It led to an obvious reduction of mechanical properties as compared with route 1. A better compatibility of deformation caused by more liquid fraction at the isothermal temperature of 612℃ is beneficial to reducing nonuniformity of liquid phase in the different r

关键词： 7005 aluminum alloy Microstructure Mechanical properties Semisolid billet Thixoforming

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固定式和可移动式灌溉系统的比较

节水灌溉 1986年第1期 59-59页

作者： ael Walker S Maclellan 琼

对固定式和可移动式喷灌系统的研究,是准备在不同条件下,为选择合理的灌溉系统给出各种要求的计算机模型的基础。在这些系统的比较中,经济、物理、机械和外界的参数由实验中得出或推证得出。系统的选择同时受物理和经济因素的影响。物... 详细信息

对固定式和可移动式喷灌系统的研究,是准备在不同条件下,为选择合理的灌溉系统给出各种要求的计算机模型的基础。在这些系统的比较中,经济、物理、机械和外界的参数由实验中得出或推证得出。系统的选择同时受物理和经济因素的影响。物理因素是指那些影响田间作业性能的

关键词：灌溉系统水文系统固定喷灌系统固定式

Chromosome-scale assembly and evolution of the tetraploid Salvia splendens (Lamiaceae) genome

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horticulture Research 2021年第1期8卷 2721-2735页

作者： Kai-hua Jia hui Liu Ren-Gang Zhang Jie Xu Shan-Shan Zhou Si-Qian Jiao Xue-Mei Yan Xue-Chan Tian Tian-Le Shi hang Luo Zhi-Chao Li Yu-Tao Bao Shuai Nie Jing-Fang Guo Ilga Porth Yousry ael-Kassaby Xiao-Ru Wang Charles Chen Yves Van de Peer Wei Zhao Jian-Feng Mao Beijing Advanced Innovation Center for Tree Breeding by Molecular Design National Engineering Laboratory for Tree BreedingKey Laboratory of Genetics and Breeding in Forest Trees and Ornamental PlantsMinistry of EducationCollege of Biological Sciences and TechnologyBeijing Forestry UniversityBeijing 100083China ori(Shandong)Gene Science and Technology Co. LtdWeifang 261000 ShandongChina Department des Sciences du Bois et de la Foret Facultede Foresteriede Geographie et GeomatiqueUniversite LavalQuebec CityQC G1V 0A6Canada Department of Forest and Conservation Sciences Faculty of ForestryUniversity of British ColumbiaVancouverBC V6T 1Z4Canada Department of Ecology and Environmental Science UmeåPlant Science CentreUmeåUniversitySE-90187 UmeåSweden Department of Biochemistry and Molecular Biology 246 Noble Research CenterOklahoma State UniversityStillwaterOKUSA Department of Plant Biotechnology and Bioinformatics Ghent UniversityGhentBelgium VIB Center for Plant Systems Biology 9052 GhentBelgium Centre for Microbial Ecology and Genomics Department of BiochemistryGenetics and Microbiology GeneticsUniversity of PretoriaPrivate Bag X20Pretoria 0028South Africa College of horticulture Academy for Advanced Interdisciplinary StudiesNanjing Agricultural UniversityNanjing 210095China

Polyploidization plays a key role in plant evolution,but the forces driving the fate of homoeologs in polyploid genomes,i.e.,paralogs resulting from a whole-genome duplication(WGD)event,remain to be ***,we present a chromosome-scale genome assembly of tetraploid scarlet sage(Salvia splendens),one of the most diverse ornamental *** found evidence for three WGD events following an older WGD event shared by most eudicots(theγevent).A comprehensive,spatiotemporal,genome-wide analysis of homoeologs from the most recent WGD unveiled expression asymmetries,which could be associated with genomic rearrangements,transposable element proximity discrepancies,coding sequence variation,selection pressure,and transcription factor binding site *** observed differences between homoeologs may reflect the first step toward sub-and/or *** assembly provides a powerful tool for understanding WGD and gene and genome evolution and is useful in developing functional genomics and genetic engineering strategies for scarlet sage and other Lamiaceae species.

关键词： species evolution assembly

Vibrio *** Macrobrachium amazonicum prawn farming are inhibited by Moringa oleifera extracts

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Asian Pacific Journal of Tropical Medicine 2015年第11期8卷 899-902页

作者： Raimunda Samia Nogueira Brilhante Jamille Alencar Sales Celia Maria de Souza Sampaio Francisco Geraldo Barbosa Manoel de araujo Neto Paiva Glaucia Morgana de Melo Guedes Lucas Pereira de Alencar Yago Brito de Ponte Tereza de Jesus Pinheiro Gomes Bandeira Jose Luciano Bezerra Moreira Debora de Souza Collares Maia Castelo-Branco Waldemiro de Aquino Pereira-Neto Rossana de Aguiar Cordeiro Jose Julio Costa Sidrim Marcos Fabio Gadelha Rocha Department of Pathology and Legal Medicine Postgraduate Program in Medical MicrobiologySpecialized Medical Mycology CenterFederal University of Ceara School of Veterinary Medicine Postgraduate Program in Veterinary SciencesState University of Ceara Department of organic and Inorganic Chemistry Federal University of Ceara

objective:To investigate the in vitro antimicrobial potential of extracts of stem,leaves,flowers,pods and seeds of Moringu okifera(***) against Vibrio *** hatchery water and the prawn Mmrobrachium ***:The ethanol extracts of stem,leaves,pods and seeds and chloroform extract of flowers of *** were tested against Vibrio cholerue(***) serogroups non-o1/non-o139(n=4).Vibrio vulnificus(n=l) and Vibrio mimicus(n=1).Escherichia coli(***)(ATCC(?) 25922) was used as quality *** species were obtained from Macmbrachium amazonicum prawns and from hatchery water from prawn *** Minimum Inhibitory Concentration(MIC) was determined by broth microdilution ***:The best result was obtained with the ethanol extract of pods,which inhibited three strains of the ***,Vibrio vulnificus,Vibrio minimis and ***(MIC range 0.312-5.000 mg/mL).The chloroform extract of flowers was effective against all *** strains and ***(MIC range 0.625-1.250 mg/mL).however,the ethanol extracts of stem and seeds showed low effectiveness in inhibiting the bacterial ***:The extracts of pods,flowers and leaves of *** have potential for the control of Vibrio *** studies are necessary to isolate the bioaetive compounds responsible for this antimicrobial activity.

关键词： Prawn Macrobrachium amazonicum Moringa oleifera Vi

儿童反复腹痛多维度量方法的创建:在3个机构进行的基于人口的研究

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世界核心医学期刊文摘（儿科学分册） 2006年第9期2卷 58-60页

作者： Malaty h.M. Abudayyeh S. o'Malley K.J. 贺莉 Veterans Affairs Medical Center (111D) 2002 Holcombe BlvdHoustonTX 77030United States Dr.

objective. Recurrent abdominal pain (rap) is a common problem in children and adolescents. Evaluation and treatment of children with rap continue to challenge physicians because of the lack of a psychometrically sound measure for rap. A major obstacle to progress in research on rap has been the lack of a biological marker for rap and the lack of a reliable and valid clinical measure for rap. The objectives of this study were (1) to develop and test a multidimensional measure for rap (MM-rap) in children to serve as a primary outcome measure for clinical trials,(2) to evaluate the reliability of the measure and compare its responses across different populations,and (3) to examine the reliabilities of the measure scales in relation to the demographic variables of the studied population. Methods. We conducted 3 cross-sectional studies. Two studies were clinic-based studies that enrolled children with rap from 1 pediatric gastroenterology clinic and 6 primary care clinics. The third study was a community-based study in which children from 1 elementary and 2 middle schools were screened for frequent episodes of abdominal pain. The 3 studies were conducted in houston,Texas. Inclusion criteria for the clinicbased studies were (1) age of 4 to 18 years; (2) abdominal pain that had persisted for 3 or more months; (3) abdominal pain that was moderate to severe and interfered with some or all regular activities; (4) abdominal pain that may or may not be accompanied by upper-gastrointestinal symptoms; and (5) children were accompanied by a parent or guardian who was capable of giving informed consent,and children over the age of 10 years were capable of giving informed assent. The community-based study used standardized questionnaires that were offered to 1080 children/parents from the 3 participating schools; 700 completed and returned the questionnaires (65% response rate). The questionnaire was designed to elicit data concerning the history of abdominal pain or discomfort. A

关键词：儿童反复腹痛上消化道症状度量标准反复性腹痛疼痛强度失能因子分析横断面研究疾病特异性