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Hepatobiliary Surgery and Nutrition 2020年第2期9卷 257-259页

作者： raoel maan Adriaan J.van der Meer Department of Gastroenterology and Hepatology Erasmus MC University Medical Center RotterdamRotterdamthe Netherlands

The highly effective direct-acting antivirals(DAAs)for the treatment of chronic hepatitis C virus(HCV)infection were well-received by both patients and physicians as sustained virological response(SVR)was associated with an improved overall survival in patients with stable liver disease,even in case of cirrhosis(1).Yet,at that time these results were derived from retrospective cohort studies with long-term follow-up after interferon-based *** patients with compensated liver disease there is confidence that SVR is a clinically relevant endpoint based on consistent positive results with smart use of statistics in numerous cohort ***,however,there remains a need for long-term follow-up data showing a clinical benefit of DAA-induced SVR,preferably with high-quality prospective *** results from the French ANRS CO22 Hepather cohort,as published by *** and colleagues in the April issue of the Lancet,thus bring an important contribution to the field(2).It’s the first prospective cohort study with reasonable follow-up time to assess all-cause mortality after DAA therapy.

关键词： patients infection clinical

Hepatocellular carcinoma (HCC) risk stratification after virological cure for hepatitis C virus (HCV)-induced cirrhosis: time to refine predictive models

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Hepatobiliary Surgery and Nutrition 2021年第3期10卷 385-387页

作者： raoel maan Adriaan J.van der Meer Department of Gastroenterology and Hepatology Erasmus MC University Medical Center RotterdamRotterdamThe Netherlands

Direct-acting antivirals(DAAs)have revolutionized antiviral treatment for chronic hepatitis C virus(HCV)infection,especially with the interferon-free regimens of the past 5 *** a cure for a virus that has been identified(only)30 years ago is unique in medical ***,even in case of advanced liver disease,cohort studies showed that patients attaining a sustained virological response(SVR)have a 3-to 4-fold reduced risk of hepatocellular carcinoma(HCC)(1-3).

关键词： sustained interferon hepatitis

Regulation of sleep by astrocytes in the hypothalamic ventrolateral preoptic nucleus

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Neural Regeneration Research 2025年第4期20卷 1098-1100页

作者： Jae-Hong Kim Ruqayya Afridi Il-Sung Jang maan Gee Lee Kyoungho Suk Brain Korea 21 four KNU Convergence Educational Program of Biomedical Sciences for Creative Future Talents School of MedicineKyungpook National UniversityDaeguRepublic of Korea Department of Pharmacology School of MedicineKyungpook National UniversityDaeguRepublic of Korea Department of Pharmacology School of DentistryKyungpook National UniversityDaeguRepublic of Korea Brain Science&Engineering Institute Kyungpook National UniversityDaeguRepublic of Korea

Astrocytes are functionally dynamic cells that support neurons in multiple ways throughout an organism’s *** astrocytic regulation of neuronal activity has been increasingly recognized in recent *** are now recognized as playing a more complex role than mere bystanders in the central nervous ***,their role in regulating the sleep neurocircuitry is not well *** this perspective,we highlight the role of astrocytes in sleep modulation,with a particular focus on regulatory mechanisms related to the ventrolateral preoptic nucleus(VLPO)of the *** briefly discuss recent literature reporting the role of VLPO astrocytes in regulating sleep-associated behaviors.

关键词： sleep ventrolateral astrocytes

A Pair of Pseudo-differential Operators Involving Index Whittaker Transform in L_(2)^(a) (R_(+);m_(a)(x)dx)

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Acta Mathematica Sinica,English Series 2024年第6期40卷 1420-1430页

作者： Jeetendrasingh maan Akhilesh PRASAD Department of Mathematics and Computing Indian Institute of Technology(Indian School of Mines)Dhanbad-826004India

Pseudo-differential operators(PDO)Q(x,L_(a,x))and Q(x,L_(a,x))involving the index Whittaker transform are *** for these operators in Hilbert space L_(2)^(a)(R+;m_(a)(x)dx)are obtained.A symbol classΩis *** product an... 详细信息

关键词： Pseudo-differential operator index Whittaker transform confluent hypergeometric functions Hilbert space

Deep eutectic solvents:Green multi-task agents for sustainable super green hydrogen technologies

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Journal of Energy Chemistry 2024年第5期92卷 357-382页

作者： Raiyan Al-Farsi maan Hayyan Renewable Energy Engineering Program Faculty of Engineering and TechnologyMuscat UniversityMuscat 130Oman Chemical Engineering Program Faculty of Engineering and TechnologyMuscat UniversityMuscat 130Oman

While reliance on renewable energy resources has become a reality, there is still a need to deploy greener and more sustainable methods in order to achieve sustainable development goals. Indeed, green hydrogen is currently believed to be a reliable solution for global warming and the pollution challenges arising from fossil fuels, making it the resilient fuel of the future. However, the sustainability of green hydrogen technologies is yet to be achieved. In this context, generation of green hydrogen with the aid of deep eutectic solvents(DESs) as green mixtures has been demonstrated as a promising research area. This systematic review article covers green hydrogen generation through water splitting and biomass fermentation when DESs are utilized within the generation process. It also discusses the incorporation of DESs in fuel cell technologies. DESs can play a variety of roles such as solvent, electrolyte, or precursor;colloidal suspension and reaction medium;galvanic replacement, shape-controlling, decoration, or extractive agent;finally oxidant. These roles are relevant to several methods of green hydrogen generation, including electrocatalysis, photocatalysis, and fermentation. As such, it is of utmost importance to screen potential DES formulations and determine how they can function in and contribute throughout the green hydrogen mobility stages. The realization of super green hydrogen generation stands out as a pivotal milestone in our journey towards achieving a more sustainable form of development;DESs have great potential in making this milestone achievable. Overall, incorporating DESs in hydrogen generation constitutes a promising research area and offers potential scalability for green hydrogen production, storage,transport, and utilization.

关键词： Watersplitting Biohydrogen Super green hydrogen Electrocatalysis Photocatalysis Fuel cell Power-to-X

Mechanisms of species divergence through visual adaptation and sexual selection:Perspectives from a cichlid model system

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Current Zoology 2010年第3期56卷 285-299页

作者： Martine E.maan Ole SEEHAUSEN Institute of Ecology & Evolution University of Bern Eawag Centre of Ecology Evolution and Biogeochemistry(CEEB)

The theory of ecological speciation suggests that assortative mating evolves most easily when mating preferences aredirectly linked to ecological traits that are subject to divergent selection. Sensory adaptation can play a major role in this process,because selective mating is often mediated by sexual signals: bright colours, complex song, pheromone blends and so on. Whendivergent sensory adaptation affects the perception of such signals, mating patterns may change as an immediate ***, mating preferences can diverge as a result of indirect effects: assortative mating may be promoted by selectionagainst intermediate phenotypes that are maladapted to their (sensory) environment. For Lake Victoria cichlids, the visual environmentconstitutes an important selective force that is heterogeneous across geographical and water depth gradients. We investigatethe direct and indirect effects of this heterogeneity on the evolution of female preferences for alternative male nuptial colours(red and blue) in the genus Pundamilia. Here, we review the current evidence for divergent sensory drive in this system, extractgeneral principles, and discuss future perspectives [Current Zoology 56 (3): 285-299, 2010].

关键词： Cichlid Sexual selection Species divergence Visual adaptation

Versatile applications of deep eutectic solvents in drug discovery and drug delivery systems:Perspectives and opportunities

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Asian Journal of Pharmaceutical Sciences 2023年第2期18卷 1-3页

作者： maan Hayyan Chemical Engineering Program Faculty of Engineering and TechnologyMuscat UniversityMuscat P.C.130Oman

Recent years have seen notable progress in the use of deep eutectic solvents(DESs)in pharmaceutical *** is ascribed to the high preparation flexibility of DES mixtures and the ability tomulti-tune their physicochemical properties and biopharmaceutical *** aim of this article is to provide perspective concerning the applications of DESs in pharmaceutical systems and their potential based on the current state of the ***,there is some disagreement about whether some mixtures are in fact DESs or ionic liquids(ILs)[1].This indicates the need for more robust standards and definitions so as to avoid confusion within the scientific *** studies consider DESs to either constitute a subclass of ILs,analogs of ILs,or alternatives to *** this regard,it would be best for the IUPAC to standardize DES classification and their similarity/dissimilarity with ILs.

关键词： field mixtures concerning

Synthesis and characterization of pyrimidines analogues as anti-Alzheimer's agents

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Journal of Chinese Pharmaceutical Sciences 2017年第11期26卷 834-846页

作者： Yadav Rakesh maan Monika Yadav Divya Department of Pharmacy Banasthali University Banasthali-304022 Rajasthan India

Pyrimidine derivatives have been reported as neuroprotective agents useful for the treatment of various neurodegenerative disorders. In the present study, several pyrimidine analogues have been evaluated as neuroprotective agents in Morris water maze model. It was observed that pyrimidine derivatives 8–17 considerably improve learning, memory, and movement deficits in animal models. Biochemical estimations of brain serum of treated animals revealed suppression of oxidative and nitrosative stress, acetylcholinesterase activity, and other parameters which leads to neurodegeneration of brain. Of all the pyrimidine derivatives, thiomorpholine derivative 8 and piperazine ethanol derivative 17 were found to be the most active neuroprotective agents and produced effects comparable to standard drug rivastigmine in terms of behavioral, biochemical, and molecular aspects.

关键词： Alzheimer's disease Neurodegeneration Pyrimidine derivatives Biochemical tests

Analysis of series RL and RC circuits with time-invariant source using truncated M,Atangana beta and conformable derivatives

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Journal of Ocean Engineering and Science 2021年第3期6卷 217-227页

作者： Sania Qureshi Mokhi maan Chang Asif Ali Shaikh Department of Basic Sciences and Related Studies Mehran University of Engineering and Technology Jamshoro76062SindhPakistan Department of Electrical Engineering Mehran University of Engineering and Technology Jamshoro76062SindhPakistan

Complex processes of the physical world require novel and sophisticated mathematical notions to get deep *** this research analysis,two standard mathematical models for the series RL and RC circuits having time-invariant sources taken from the discipline of electrical engineering have been investigated with the help of differential operators known with the name of truncated M-derivative,Atangana beta-derivative,and the conformable derivative *** exact solutions for these two models have been found in terms of the transcendental exponential function of time under the truncated M-derivative,Atangana beta-derivative,and the conformable derivative *** numerical simulations carried out via MATLAB”9.***.0.813654(R2018a)”have been interpreted to explore new behavior for solutions of the models not possible to obtain through standard classical calculus wherein one is restricted to have integer-order derivatives unlike the differential operators used in the present research *** models under consideration for the three differential operators have been investigated with varying parameters’values including the differential ordersαandβwhereupon the classical case is resumed forα=β=1 andτ=0.

关键词： Mittag-Leffler function M-integral Constant voltage Kirchoff’s laws Numerical simulations.

Distribution Patterns of Medicinal Plants along an Elevational Gradient in Central Himalaya,Nepal

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Journal of Mountain Science 2012年第2期9卷 201-213页

作者： maan B.ROKAYA Zuzana MÜNZBERGOVÁ Mani R.SHRESTHA Binu TIMSINA Institute of Botany Academy of Sciences of the Czech Republic Department of Botany Faculty of SciencesCharles University School of Biological Sciences Monash UniversityClayton Campus Institute for Environmental Studies Faculty of ScienceCharles University

This study aimed to compare the distribution patterns and trends of plant parts used among different groups of medicinal plants, geographical regions,and between medicinal plants and all vascular *** used the published sources for elevation records of 2,331 medicinal plant species to interpolate presence between minimum and maximum elevations and estimated medicinal plant richness for each 100-m elevational band. Monte Carlo simulations were used to test whether differences in elevational distribution between different groups of medicinal plants were significant. Total number of medicinal plants as well as different groups showed unimodal relationship with elevation. The elevational distributions of medicinal plants significantly differ between regions and between medicinal plant *** comparing the richness of all medicinal plants to all vascular plants,Monte Carlo simulations indicated that the numbers of medicinal plants are higher than expected at low *** highest richness of medicinal plants at low elevation could be possibly due to favorable environmental factors such as high temperature, rainfall,sunlight or due to higher density of human population and thus higher pressure on use of any plants in lower elevations.

关键词： Species richness Rapoport's elevational rule Mid-domain effect Randomization test Unimodal pattern Himalaya Nepal