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Flow and thermal modeling of liquid metal in expanded microchannel heat sink

Frontiers in Energy 2023年第6期17卷 796-810页

作者： Mingkuan ZHANG Xudong ZHANG Luna GUO Xuan LI Wei rao Tianjin Key Laboratory for Advanced Mechatronic System Design and Intelligent Control School of Mechanical EngineeringTianjin University of TechnologyTianjin 300384China National Demonstration center for Experimental Mechanical and Electrical Engineering Education Tianjin University of TechnologyTianjin 300384China Key Laboratory for Thermal Science and Power Engineering of the Ministry of Education Department of Engineering MechanicsTsinghua UniversityBeijing 100084China School of Mechanical Engineering Tianjin University of CommerceTianjin 300134China Institute of Refrigeration and Cryogenics Shanghai Jiao Tong UniversityShanghai 200240China Beijing Key Laboratory of CryoBiomedical Engineering and Key Laboratory of Cryogenics Beijing 100190China

Liquid metal-based microchannel heat sinks (MCHSs) suffer from the low heat capacity of coolant, resulting in an excessive temperature rise of coolant and heat sink when dealing with high-power heat dissipation. In this paper, it was found that expanded space at the top of fins could distribute the heat inside microchannels, reducing the temperature rise of coolant and heat sink. The orthogonal experiments revealed that expanding the top space of channels yielded similar temperature reductions to changing the channel width. The flow and thermal modeling of expanded microchannel heat sink (E-MCHS) were analyzed by both using the 3-dimensional (3D) numerical simulation and the 1-dimensional (1D) thermal resistance model. The fin efficiency of E-MCHS was derived to improve the accuracy of the 1D thermal resistance model. The heat conduction of liquid metal in Z direction and the heat convection between the top surface of fins and the liquid metal could reduce the total thermal resistance (Rt). The above process was effective for microchannels with low channel aspect ratio, low mean velocity (Um) or long heat sink length. The maximum thermal resistance reduction in the example of this paper reached 36.0%. The expanded space endowed the heat sink with lower pressure, which might further reduce the pumping power (P). This rule was feasible both when fins were truncated (h_(2) 0, h_(2) is the height of expanded channel for E-MCHS) and when over plate was raised (h_(2) > 0).

关键词： liquid metal cooling heat sink expanded microchannel flow and thermal modeling

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Role of autoreactive Tc17 cells in the pathogenesis of experimental autoimmune encephalomyelitis

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Neuroprotection 2024年第1期2卷 49-59页

作者： Yong Peng Xiuli Zhang Yandan Tang Shunqing He Guilan rao Quan Chen Yahui Xue Hong Jin Shu Liu Ziyang Zhou Yun Xiang Department of Neurology Affliated First Hospitalof HunanTraditional Chinese Medical CollegeZhuzhouHunanChina Department of Neurology The Third Affiliated Hospital of Hunan University of Chinese MedicineZhuzhouHunanChina Science and technology Innovation center HunanUniversityof ChineseMedicineChangshaHunanChina

Background:The pathogenesis of multiple sclerosis(MS)and experimental autoimmune encephalomyelitis(EAE-an animal model of MS)is primarily mediated by T ***,recent studies have only focused on interleukin(IL)-17-secreting CD4^(+)T-helper cells,also known as Th17 *** study aimed to compare Th17 cells and IL-17-secreting CD8^(+)T-cytotoxic cells(Tc17)in the context of MS/***:Female C57BL/6 mice were immunized with myelin oligodendrocyte glycoprotein peptides 35-55(MOG35-55),pertussis toxin,and complete Freund's adjuvant to establish the EAE animal model.T cells were isolated from the spleen(12-14 days postimmunization).CD4^(+)and CD8^(+)T cells were purified using isolation kit and then differentiated into Th17 and Tc17,respectively,using MOG35-55 and *** secretion levels of interferon-(IFN-γ)and IL-17 were measured via enzyme-linked immunosorbent assay using cultured CD4^(+)and CD8^(+)T cell *** pathogenicity of Tc17 and Th17 cells was assessed through adoptive transfer(tEAE),with the clinical course assessed using an EAE score(0-5).Hematoxylin and eosin as well as Luxol fast blue staining were used to examine the spinal *** CD8^(+)CD3^(+)and CD4^(+)CD3^(+)cells differentiated into Tc17 and Th17 cells,respectively,were stimulated with MOG35-55 peptide for proliferation ***:The results showed that Tc17 cells(15,951±19855VS.55,709±4196cpm;p0.050)exhibited a weaker response to highest dose(20μg/mL)MOG35-55 than Th17 ***,this response was not dependent on Th17 *** the 48h stimulation,at the highest dose(20μg/mL)of ***17 cells secreted lower levels of IFN-(280.00±15.00vs.556.67±15.28pg/mL,p0.050)and IL-17(102.67±5.86 pg/mL vs.288.33±12.58 pg/mL;p0.050)than Th17 *** patterns were observed for IFN-γsecretion at 96 and ***,Tc17 cell-induced tEAE mice exhibited similar EAE scores to Th17 cell-induced tEAE mice and also showed similar inflammation and demyelinati

关键词： CD8^(+)T cells experimental autoimmune myelitis IFN-y IL-17 multiple sclerosis Tc17 cells

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片剂连续制造中在线检测技术应用进展

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中国新药杂志 2024年第8期33卷 774-784页

作者：梁钧杰张尧潘浩敏饶小勇刘微罗晓健何雁江西中医药大学南昌330004 中药固体制剂制造技术国家工程研究中心南昌330006

连续制造模式在食品、化学等行业应用多年,极大地促进了行业的发展。其有绿色节能、智能化等特点,可提升药品质量和生产效率,是未来药品生产的发展趋势。近些年已引起制药行业的广泛关注,但目前只有少量药品以连续制造模式生产获准上市...

连续制造模式在食品、化学等行业应用多年,极大地促进了行业的发展。其有绿色节能、智能化等特点,可提升药品质量和生产效率,是未来药品生产的发展趋势。近些年已引起制药行业的广泛关注,但目前只有少量药品以连续制造模式生产获准上市。而连续过程中产品质量的检测十分重要,在线检测技术可快速分析待测性质,也可为设备间的工艺调控提供依据。本文总结近年来各制剂单元操作间使用近红外技术、拉曼光谱、微波传感等手段对原材料、中间产物及最终产品的关键质量属性进行检测的应用,描述了设备中检测位置对测量的影响,并简单介绍了不同连续制造产线构造及设备,以期对制药连续过程中进行在线检测技术应用及进一步研究提供参考。

关键词：连续制造在线检测关键质量属性设备

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Numerical analysis and geotechnical assessment of mine scale model

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International Journal of Mining Science and technology 2012年第5期22卷 693-698页

作者： Khanal Manoj Adhikary Deepak Balusu rao Earth Science and Resource Engineering Commonwealth Scientific and Industrial Research OrganizationQueensland Center for Advanced TechnologyTechnology CourtPullenvale QLD 4069Australia

Various numerical methods are available to model,simulate,analyse and interpret the results;however a major task is to select a reliable and intended tool to perform a realistic assessment of any *** a model to be a representative of the realistic mining scenario,a verified tool must be chosen to perform an assessment of mine roof support requirement and address the geotechnical risks associated with longwall *** dependable tools provide a safe working environment,increased production,efficient management of resources and reduce environmental impacts of *** various methods,for example,analytical,experimental and empirical are being adopted in mining,in recent days numerical tools are becoming popular due to the advancement in computer hardware and numerical *** rules based on past experiences do provide a general guide,however due to the heterogeneous nature of mine geology(i.e.,none of the mine sites are identical),numerical simulations of mine site specific conditions would lend better insights into some underlying *** paper highlights the use of a continuum mechanics based tool in coal mining with a mine scale *** continuum modelling can provide close to accurate stress fields and *** paper describes the use of existing mine data to calibrate and validate the model parameters,which then are used to assess geotechnical issues related with installing a new high capacity longwall mine at the mine site.A variety of parameters,for example,chock convergences,caveability of overlying sandstones,abutment and vertical stresses have been estimated.

关键词： Mining Coal Chock Abutment

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糖基化修饰对小麦面筋蛋白致敏性的影响

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中国粮油学报 2024年第8期39卷 1-8页

作者：侯天宇李晓鸾侯向楠田雅涵饶欢郝建雄河北科技大学食品与生物学院石家庄050018 河北省功能食品技术创新中心石家庄050018 河北医科大学第一医院变态反应科石家庄050030

食物过敏是全球范围内广泛关注的食品安全问题之一。为探究一种有效的降低小麦致敏蛋白致敏性的方法,本研究采用单糖(葡萄糖、果糖、半乳糖)与小麦致敏蛋白进行糖基化反应制备复合物,并利用SDS-PAGE、Western blot、ELISA等方法对糖基...

食物过敏是全球范围内广泛关注的食品安全问题之一。为探究一种有效的降低小麦致敏蛋白致敏性的方法,本研究采用单糖(葡萄糖、果糖、半乳糖)与小麦致敏蛋白进行糖基化反应制备复合物,并利用SDS-PAGE、Western blot、ELISA等方法对糖基化反应前后小麦致敏蛋白的致敏性差异进行分析。实验结果显示,糖基化修饰降低了小麦面筋蛋白的致敏性,对麦醇溶蛋白致敏性的影响效果强于麦谷蛋白。半乳糖作为糖基供体时降低致敏性的效果比葡萄糖、果糖的效果显著,葡萄糖和果糖效果相当。研究结果可为降低小麦致敏蛋白致敏性和研发低致敏性小麦制品提供一种新的参考方法。

关键词：小麦致敏蛋白糖基化反应接枝度致敏性评价

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车身参数对平台翻滚耐撞性影响规律研究

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机械设计与制造 2024年第5期399卷 173-178页

作者：梁永彬宾怀成刘开勇饶思敏上汽通用五菱汽车有限公司广西柳州545007 武汉理工大学机电工程学院摩擦学研究所湖北武汉430070

基于平台翻滚的实车试验,建立有限元与多刚体两种整车仿真模型,并对比实车试验结果验证模型的可靠性。结合仿真与理论分析,研究翻滚角速度与车身参数之间的关系,得出翻滚角速度可作为量化车辆翻滚性能的评价指标结论。通过单因素研究,...

基于平台翻滚的实车试验,建立有限元与多刚体两种整车仿真模型,并对比实车试验结果验证模型的可靠性。结合仿真与理论分析,研究翻滚角速度与车身参数之间的关系,得出翻滚角速度可作为量化车辆翻滚性能的评价指标结论。通过单因素研究,得出各车身参数(质心高度、车身高度和车辆轮距)对翻滚性能影响的基本规律,以翻滚角速度为指标,结合二次回归正交组合设计方法和多刚体仿真技术,构建车辆翻滚性能与车身参数间的经验公式,实现车身参数与翻滚性能间的定量分析,并通过回归检验与实车对比试验检验公式的有效性。

关键词：微型汽车翻滚性能车身参数仿真分析回归分析

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Evaluation of mine scale longwall top coal caving parameters using continuum analysis

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Mining Science and technology 2011年第6期21卷 787-796页

作者： Manoj Khanal Deepak Adhikary rao Balusu Earth Science and Resource Engineering Commonwealth Scientific and Industrial Research OrganizationQueensl and Center for Advanced Technology1Technology CourtPullenvaleQLD4069Australia

A mine-scale analysis of Longwall Top Coal Caving (LTCC) is performed using a continuum mechanics finite element solver called COSFLOW. The uniqueness of COSFLOW is that it incorporates Cosserat continuum theory in its formulation for describing the load deformation of bedded rocks. It is shown that such a continuum based code is valuable for assessing the feasibility of introducing LTCC in any mine. Various LTCC parameters, for example chock convergences, top coal failure behavior, strata cavingmechanism, abutment stresses and vertical stresses, were evaluated for a mine using COSFLOW.

关键词： LTCC COSFLOW Cosserat FEM Modeling Simulation

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大规模分布式光纤水听拖曳阵列及其湖试性能测试

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光学学报 2024年第1期44卷 333-342页

作者：龙俊求江浪肖春郭汝乾严国锋王德麟冉曾令龚元饶云江之江实验室光纤传感研究中心浙江杭州310027 浙江大学海洋学院浙江舟山316021 电子科技大学信息与通信工程学院四川成都611731

报道了一种高性能大孔径分布式光纤水听拖曳阵列,其总长度为150 m,声学传感段长度为100 m,具有192个传感单元,采用单根光纤离散增敏制备而成,无需其他分离器件。传感基元通过驻波桶标定,在20~1000 Hz,平均声压灵敏度达到-127.44 dB(re r...

报道了一种高性能大孔径分布式光纤水听拖曳阵列,其总长度为150 m,声学传感段长度为100 m,具有192个传感单元,采用单根光纤离散增敏制备而成,无需其他分离器件。传感基元通过驻波桶标定,在20~1000 Hz,平均声压灵敏度达到-127.44 dB(re rad/μPa)。阵列同时装配了自研的姿态感知模块,可实现拖曳过程的实时姿态获取。针对所研制的大规模分布式光纤水听拖曳阵列,开展了湖试综合测试,6 kn拖速下阵列声学段的倾角仅为7.8°,将192个传感单元数据波束合成后得到了16.87 dB的空间增益,传感器表现出了优异的综合性能。该高性能大规模分布式光纤水听拖曳阵列为光纤水听器发展提供了一条全新的技术路线,有力推动了基于DAS的“第三代声呐技术”的发展。

关键词：光纤光学光纤水听器光纤水听拖曳阵列分布式光纤声波传感声压灵敏度姿态感知目标轨迹跟踪

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Changes in Ecosystem Service of Soil Conservation Between 2000 and 2010 and Its Driving Factors in Southwestern china

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Chinese Geographical Science 2016年第2期26卷 165-173页

作者： rao Enming XIAO Yi OUYANG Zhiyun ZHENG Hua State Key Laboratory of Urban and Regional Ecology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeij'ing 100085China University of Chinese Academy of Sciences Beijing 100049China

Human activities significantly alter ecosystems and their services; however, quantifying the impact of human activities on ecosystems has been a great challenge in ecosystem management. We used the Universal Soil Loss Equation and county-level socioeconomic data to assess the changes in the ecosystem service of soil conservation between 2000 and 2010, and to analyze its spatial characteristics and driving factors in the southwestern china. The results showed that cropland in the southwestern china decreased by 3.74%, while urban land, forest, and grassland areas increased by 46.78%, 0.86%, and 1.12%, respectively. The soil conservation increased by 1.88 × 10^(11) kg, with deterioration only in some local areas. The improved and the degraded areas accounted for 6.41% and 2.44% of the total land area, respectively. Implementation of the Sloping Land Conversion Program and urbanization explained 57.80% and 23.90% of the variation in the soil conservation change, respectively, and were found to be the main factors enhancing soil conservation. The 2008 Wenchuan earthquake was one of the factors that led to the degradation of soil conservation. Furthermore, industrial adjustment, by increasing shares of Industry and Service and reducing those of Agriculture, has also promoted soil conservation. Our results quantitatively showed and emphasized the contributions to soil conservation improvement made by implementing ecological restoration programs and promoting urbanization. Consequently, these results provide basic information to improve our understanding of the effects of ecological restoration programs, and help guide future sustainable urban development and regional industrial restructuring.

关键词： soil conservation ecosystem service Sloping Land Conversion Program(SLCP) ecological restoration urbanization southwestern china

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熔覆速度对激光-电复合丝材熔覆630不锈钢熔覆层组织及性能的影响

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应用激光 2024年第2期44卷 27-33页

作者：杨文选吕燕郭雅琪饶容荣赵璐西安思源学院陕西西安710038 西安科技大学机械工程学院陕西西安710054 增材制造技术应用陕西省高校工程研究中心陕西西安710038

针对矿用液压支架立柱表面修复问题,利用新工艺激光-电复合熔覆丝材修复方法进行工艺研究,设置熔覆速度为30mm/s、40mm/s、50mm/s、60mm/s、70mm/s、80mm/s来研究熔覆速度对熔覆层组织结构、硬度以及耐磨损性能的影响。分别使用金相显...

针对矿用液压支架立柱表面修复问题,利用新工艺激光-电复合熔覆丝材修复方法进行工艺研究,设置熔覆速度为30mm/s、40mm/s、50mm/s、60mm/s、70mm/s、80mm/s来研究熔覆速度对熔覆层组织结构、硬度以及耐磨损性能的影响。分别使用金相显微镜和钨灯丝电子扫描显微镜进行显微组织分析,采用显微硬度计测量其熔覆层结合面到顶部的硬度,采用往复式摩擦磨损试验机对其耐磨损性能进行分析。试验表明,随着熔覆速度的增加,熔覆层与基体接触面波浪状纹路变浅,熔覆层厚度稳定在1300mm,熔覆层单道与单道之间夹杂的基体组织逐渐减少,熔覆层微观组织从熔覆层底部到顶部依次为柱状晶、混乱的等轴晶和树枝等轴晶,熔覆层硬度逐渐降低,摩擦系数先减小后增大,在熔覆速度为80mm/s时摩擦量最大,磨损形式主要为疲劳剥落。

关键词：激光电复合丝材摩擦磨损 630不锈钢

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