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Natural history of Barrett's esophagus

World Journal of Gastroenterology 2012年第27期18卷 3483-3491页

作者： rao milind Stephen E Attwood Department of Surgery North Tyneside General HospitalNorth ShieldsTyne and Wear NE29 8NHUnited Kingdom

The natural history of Barrett's esophagus (BE) is difficult to quantify because,by definition,it should describe the course of the condition if left ***,we assume that patients with BE will receive symptomatic treatment with acid suppression,usually a proton pump inhibitor,to treat their *** paper describes the development of complications of stricture,ulcer,dysplasia and adenocarcinoma from this *** over the definition of BE and its implications in clinical practice are *** presence of intestinal metaplasia and its relevance to cancer risk is discussed,and the need to measure the extent of the Barrett's epithelium (long and short segments) using the Prague guidelines is *** and international consensus over the diagnosis and management of BE are being regularly *** need for expert consensus is important due to the lack of randomized trials in this *** searching the literature,we have tried to collate the important studies regarding progression of Barrett's to dysplasia and *** therapeutic studies yet reported show a clear reduction in the development of cancer in *** effect of pharmacological and surgical intervention on the natural history of Barrett's is a subject of ongoing research,including the Barrett's Oesophagus Surveillance Study and the aspirin and esomeprazole cancer chemoprevention trial with interesting *** geographical variation and the wide range of outcomes highlight the difficulty of providing an individualized risk profile to patients with *** studies on the interaction of genome wide abnormalities in Barrett's and their interaction with environmental factors may allow individualization of the risk of cancer developing in BE.

关键词： Barrett's esophagus Columnar lined esoph-agus Dysplasia Adenocarcinoma Gastroesophagealreflux Surgery

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