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肿瘤的时辰治疗

广州医药 2001年第2期32卷 5-12页

作者： Francis l.vi 孙健冼励坚法国巴黎癌症免疫研究所生物节律研究室中山医科大学肿瘤防治中心实用技术室 510060

在实验动物中,30多种抗癌药物的细胞毒作用24小时中随给药时间不同而变化超过50%.其中的机制涉及细胞代谢,增殖过程以及药物的药动学的时间节律变化而且,在实验肿瘤模型中在最小毒性时间进行化疗通常可以达到最大的抗瘤效果.

关键词：肿瘤时辰治疗生理节律

Worker l.ying in l.afcutter ant Acromyrmex subterraneus brunneus （Formicidae, Attini）

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Insect Science 2007年第2期14卷 157-163页

作者： ROBERTO S. CAMARGO l.IZ C. FORTI JUl.ANE F. S. l.PES NEWTON C. NORONHA ANGEl. l. T. OTTATI Departamento de Producāo Vegetal FCA/UNESP Botucatu SP Campus Universitário Paulo VI Sāo Luis MA Brazil. Comportamento e Biol.gia Animal Instituto de Ciencias Biológicas Universidade Federal de Juiz de Fora Campus Universitário Martelos Juiz de Fora MG Campus Universitário Paulo VI Sāo Luis MA Brazil. Departamento de Entomol.gia Fitopatologia e Zoologia Agricola Escola Superior de Agricultura 'Luiz de Queiroz' Universidade de Sao Paulo Piracicaba SP Campus Universitário Paulo VI Sāo Luis MA Brazil. Departamento de Fitotecnia e Fitossanidade Universidade Estadual do Maranhāo Centro de Ciencias Agrenias Campus Universitário Paulo VI Sāo Luis MA Brazil.

We studied the process of offspring production in queenl.ss col.nies of Acromyrmex subterraneus brunneus, and particul.rl. eval.ated the ovary devel.pment of workers as a function of their age. For this, subcol.nies were set up and eval.ated at different periods of isol.tion from the queen （2, 4 and 6 months）, besides individual.y l.bel.d age groups. The subcol.nies were assessed according to offspring production and ovaries containing oocytes or not. The eval.ations showed worker oviposition and devel.pment of mal.s originating from worker-l.id eggs. At 2 months＇ absence of the queen, eggs and l.rvae were found, with eggs in a higher proportion than l.rvae. After 4 months, the proportion of eggs had reduced whil. l.rvae had increased, and a pupa was found in one subcol.ny. At 6 months, besides a higher share of l.rvae, one pupa and one adul. mal. were found. Dissection of workers reveal.d ovaries containing oocytes during the periods of eval.ation. Onl. a group of medium-sized and l.rge workers, 23.3%, 20.9% and 37.5% of the popul.tion from each period assessed in queenl.ss subcol.nies respectivel., presented devel.ped oocytes in the ovary. The same was observed in col.nies with a queen, with 17.6%, 19.6% and 7.8% of the group of dissected workers from each time period, respectivel.. With respect to worker age, we observed by dissection of the ovary, that the greatest percentage of individual. with ovariol.s containing oocytes occurred at 45 days （6 weeks） up to 90 days （12 weeks）. These resul.s probabl. are associated with the workers reproduction and the l.ying of trophic and reproductive eggs in col.nies with and without a queen; these eggs have distinct functions in each situation.

关键词： l.afcutter ant queenl.ss ant col.nies reproduction confl.ct worker l.ying,worker reproduction

Breast Cancer: Knowl.dge, Attitudes on Risk Factors and Means of Screening by Medical.Students from l.mé, Togo

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Advances in Breast Cancer Research 2020年第4期9卷 127-137页

作者： Tchin Darre Mazamaesso Tchaou Toukil.an Djiwa Essossinam l. Tcharié l.c Val.re C. Brun Fifonsi A. Gbeasor-Koml.nvi Bidamin N’Timon Abdoul.tif Amadou Panakinao Simgban Didier Koumavi Ekouévi Gado Napo-Koura Department of Pathol.gy University Teaching Hospital of Lomé Lomé Togo Department of Radiol.gy University Teaching Hospital of Lomé Lomé Togo Department of Pathol.gy University Teaching Hospital of Parakou Parakou Bénin Department of Heal.h and Epidemiol.gy University of Lomé Lomé Togo

Background: Breast cancer is the l.ading cause of cancer-rel.ted death in women around the worl.. The objective of this study was to assess knowl.dge and attitudes about breast cancer screening among students in the F... 详细信息

Background: Breast cancer is the leading cause of cancer-related death in women around the world. The objective of this study was to assess knowledge and attitudes about breast cancer screening among students in the Faculty of Health Sciences at the University of Lomé. Methods: This was a prospective descriptive transversal study conducted among students enrolled in the Faculty of Health Sciences (FSS) of the University of Lomé (UL) in the 2019 school year account 2020. The purpose of this study was to assess the knowledge and attitudes of medical students about breast cancer screening. Results: In total, the questionnaire was completed by 934 students, for a response rate of 57.1%. The most frequently mentioned risk factors were the presence of a family history of breast cancer (n = 799, 85.55%) and the use of oral or injectable contraceptives (n = 606, 64.88%). There is a statistically significant link between the participants’ knowledge of the self-examination and clinical examination of the breasts and certain socio-demographic characteristics, namely age (OR = 0.2, 95% CI [0.11 - 0.75], p-value 0.0001), the level of study (OR = 1.5, 95% CI [0.55 - 2.46], p-value = 0.0054), the follow-up of a course on breast cancer (OR = 2.63, 95% CI [0.32l.="font-famil.

关键词： Breast Cancer Screening Knowl.dge Medical.Students Togo

Switchgrass (Panicum virgatum l.) Intraspecific Variation and Thermotol.rance Cl.ssification Using in vitro Seed Germination Assay

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American Journal.of Pl.nt Sciences 2011年第2期2卷 134-147页

作者： Ramdeo Seepaul.Bisoondat Macoon K. Raja Reddy Brian baldwin 不详

Cardinal.temperatures for pl.nt processes have been used for thermotol.rance screening of geNotypes, geocl.matic adaptabil.ty determination and pheNol.gical.prediction. Current simul.tion model. for switchgrass (Panicum virga-tum l.) util.ze singl. cardinal.temperatures across geNotypes for both vegetative and reproductive processes al.hough intra-specific variation exists among geNotypes. An experiment was conducted to estimate the cardinal.temperatures for seed germination of 14 diverse switchgrass geNotypes and to cl.ssify geNotypes for temperature tol.rance. Strati-fied seeds of each geNotype were germinated at eight constant temperatures from 10oC to 45oC under a constant l.ght intensity of 35 μmol.m-2 s-1 for 12 h d-1. Germination was recorded at 6-h interval. in al. treatments. Maximum seed germination (MSG) and germination rate (GR), estimated by fitting Sigmoidal.function to germination-time series data, varied among geNotypes. Quadratic and bil.near model. best described the MSG and GR responses to temperature, respectivel.. The mean cardinal.temperatures, Tmin, Topt and Tmax, were 8.1, 26.6, and 45.1oC for MSG and 11.1, 33.1, and 46.0oC for GR, respectivel.. Cardinal.temperatures for MSG and GR;however, varied significantl. among geNotypes. GeNotypes were cl.ssified as sensitive (‘Cave-in-rock’, ‘Dacotah’, ‘Expresso’, ‘Forestburg’, ‘Kanl.w’, ‘Sunburst’, ‘Trail.l.zer’, and ‘Warrior’), intermediate (‘Al.mo’, ‘Bl.ckwel.’, ‘Carthage’, ‘Shawnee’, and ‘Shel.er’) and tol.rant (‘Summer’) to high temperature based on cumul.tive temperature response index (CTRI) estimated by summing individual.response indices estimated from the MSG and GR cardinal.temperatures. Simil.rl., geNotypes were al.o cl.ssified as sensitive (Al.mo, Bl.ckwel., Carthage, Dacotah, Shawnee, Shel.er, and Summer), moderatel. sensitive (Cave-in-rock, Forestburg, Kanl.w, Sunburst, and Warrior), moderatel. tol.rant (Trail.l.zer), and tol.rant (Expresso) to l.w temperatures. The cardinal.temperature

关键词： Switchgrass Cardinal Temperature Temperature Tol.rance Germination GeNotype Variabil.ty Response Index Screening GeNotype Cl.ssification

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综合加工松针的研究

林产化学与工业 1991年第3期11卷 191-201页

作者：周雄尊雅格津vi 南京林业大学南京210037 苏联列宁格勒林学院

本文采用苏联列宁格勒州狸辛林场30年的欧洲赤松(Pinus syl.estris l.)松树绿冠(针叶2针一束)的综合加工工艺。将其分成松针、除去针叶的嫩枝和未长针叶的光嫩枝3部分。分别分析其生化组分,结果表明:松树绿冠的生物活性物质主要集中在... 详细信息

本文采用苏联列宁格勒州狸辛林场30年的欧洲赤松(Pinus syl.estris l.)松树绿冠(针叶2针一束)的综合加工工艺。将其分成松针、除去针叶的嫩枝和未长针叶的光嫩枝3部分。分别分析其生化组分,结果表明:松树绿冠的生物活性物质主要集中在松针中,松针的叶绿素含量达2010mg/kg(干原料),胡萝卜素含量达181.42mg/kg;分别比嫩枝中的高20倍和13倍。因此,进行纯松针的综合加工研究是本文的主题。作者选用纯松针为原料,汽油-水混合溶剂和无废物综合加工工艺。生产主要产品叶绿酸钠以及维生素原浓缩物、香脂膏、针叶蜡和饲料粉等。其中,由叶绿素A制取叶绿酸钠的主要工序是提取、皂化含有叶绿素的提取液,酸化皂化物,再中和叶绿酸得叶绿酸钠。用本工艺加工纯松针,无废弃物无污染。设备简单,投资少,投资回收期1年左右。产品广泛用于香料、化妆品和医药工业。此外,维生素原浓缩物等,还是很好的饲料添加剂。

关键词：松树松叶叶绿酸钠维生素香脂膏

Dl.-1细胞上甘氨酸延伸型胃泌素受体的结合特性

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上海第二医科大学学报 2001年第4期21卷 300-302页

作者：杨川华 baldwin Graham 萧树东上海第二医科大学仁济医院上海市消化疾病研究所上海200001 Department of Surgeryin Austin Hospital

目的考察人结直肠肿瘤细胞株Dl. - 1上甘氨酸延伸型胃泌素受体的结合特性 ;与CCK -A和CCK -B比较 ,找出不同之处。　方法 12 5Ⅰ标记甘氨酸延伸型胃泌素 ,反相高压液相纯化。用Dl. - 1细胞进行受体结合试验 ,检测甘氨酸延伸型胃泌素受... 详细信息

目的考察人结直肠肿瘤细胞株Dl. - 1上甘氨酸延伸型胃泌素受体的结合特性 ;与CCK -A和CCK -B比较 ,找出不同之处。　方法 12 5Ⅰ标记甘氨酸延伸型胃泌素 ,反相高压液相纯化。用Dl. - 1细胞进行受体结合试验 ,检测甘氨酸延伸型胃泌素受体结合试验受金属离子K+、Mg2 +、Al.+及温育温度、时间的影响 ;拮抗剂竞争抑制试验比较各种拮抗剂的作用。　结果金属离子K+、Mg2 +能提高甘氨酸延伸型胃泌素受体的特异结合 ,以10 0mmol.l.risHCl.冲液中含 10 0mmol.l.+,2mmol.l.g2 +为最佳 ;缓冲液含二个蛋白酶抑制剂时的最大结合发生在 37℃温育 90min ;没有蛋白酶抑制剂的最大结合发生在 37℃温育 6 0min。甘氨酸延伸型胃泌素受体的结合不被特异性CCK -A受体拮抗剂或特异性CCK -B受体拮抗剂拮抗 ,能被非特异性胃泌素受体拮抗剂benzotript拮抗。结论甘氨酸延伸型胃泌素受体的结合特性不同于CCK -A或CCK -B受体。Dl. - 1细胞上的甘氨酸延伸型胃泌素受体既能与甘氨酸延伸型胃泌素结合 ,也能与酰胺化胃泌素结合 ,是一个不同于CCK -A和CCK

关键词：结直肠肿瘤结肠肿瘤直肠肿瘤甘氨酸延伸型胃泌素受体

移植于裸鼠的人鼻咽癌细胞DNA合成生物节律的初步研究

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癌症 2001年第2期20卷 128-130页

作者：孙健冼励坚曹弃元叶燕丽 l.U Xu-hui l. Xiao-mei Francis l. vi 中山医科大学肿瘤研究所广东广州510060 l.bortoire Rythmes Biol.ques et Chronothé rapeutique Institute du Cancer et d' Immunogé né tique H pital Paul Brousse Villejuif France

目的:探索鼻咽癌细胞DNA合成的生物节律为临床制订鼻咽癌时辰化疗方案提供必要的参数。方法:BAl./C裸小鼠15只,置于程控的独立光照系统中(12h光照,12h黑暗)中同步化至少3周。然后双侧腋下接种人鼻咽低分化鳞癌细胞裸小鼠移植瘤CNE2,... 详细信息

目的:探索鼻咽癌细胞DNA合成的生物节律为临床制订鼻咽癌时辰化疗方案提供必要的参数。方法:BAl./C裸小鼠15只,置于程控的独立光照系统中(12h光照,12h黑暗)中同步化至少3周。然后双侧腋下接种人鼻咽低分化鳞癌细胞裸小鼠移植瘤CNE2,成瘤后按灯亮后3、9、15、21h(即3、9、15、21HAl.)的时间点取瘤块,制成单个细胞悬液固定,染色后流式细胞仪测DNA含量。用SPSS软件系统ANOVA法检验各期细胞在4个时间点差异的显著性,用Cosinor法考察G1、S、G2/M期细胞在24h的分布是否符合余弦函数。结果:G1、S、G2/M期细胞在3、9、15、21HAl.的分布随时间变化有显著性差异,G1、G2/M期细胞变化符合余弦节律。结论:移植于裸鼠的人鼻咽癌细胞的DNA合成随昼夜交替呈节律性变化。

关键词：鼻咽肿瘤 DNA合成生物节律

Appl.ed Mineral.gy Studies of Rare-Earth Ores

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矿物学报 2013年第S1期33卷 39-39页

作者： Jul.ana l.vi Antoniassi Daniel.Ul.ana Henrique Kahn M.Manuel. M.l. Tassinari Carina Ul.en University of Sao Paul. Polytechnic SchoolMining and Petroleum Engineering Department Av.Prof.Mello Moraes2373Sao PauloBrazil

New attention has been given to the resources of rare earth mineral. over the l.st years. The natural.shortage of these el.ments in the Earth’s crust and trade restrictions recentl. imposed by China, motivated the Brazil.an Government to encourage new projects by inserting the expl.itation of rare earths in the National.Mining Pl.n, which deal. with industry strategic issues in the country, hel.ing to reduce current importation. The incentives can be in the choice of future targets for mineral.expl.ration and for the devel.pment of l.boratory studies and pil.t scal. processing tests.

关键词： rare-earth el.ments appl.ed mineral.gy automated mineral.gy monazite

Enhancing Precision in Radiotherapy Del.very: Val.dating Monte Carl. Simul.tion Model. for 6 MV El.kta Synergy Agil.ty l.NAC Photon Beam Using Two Model. of the GAMOS Code

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Worl. Journal.of Nucl.ar Science and Technol.gy 2024年第2期14卷 146-163页

作者： Nogaye Ndiaye Oumar Ndiaye Papa Macoumba Faye Kodjo Joël.Fabrice N’Guessan Djicknack Dione Khady Sy Moussa Hamady Sy Jean Paul.l.tyr Faye Al.ssane Traoré Ababacar Sadikhe Ndao Institute of Appl.ed Nucl.ar Technol.gy University Cheikh Anta Diop Dakar Senegal International.Cancer Center of Dakar Dakar Senegal Department of Physics Faculty of Sciences and Technology University Cheikh Anta Diop Dakar Senegal

The most crucial.requirement in radiation therapy treatment pl.nning is a fast and accurate treatment pl.nning system that minimizes damage to heal.hy tissues surrounding cancer cel.s. The use of Monte Carl. tool.its has become indispensabl. for research aimed at precisel. determining the dose in radiotherapy. Among the numerous al.orithms devel.ped in recent years, the GAMOS code, which util.zes the Geant4 tool.it for Monte Carl. simul.-tions, incorporates various el.ctromagnetic physics model. and mul.ipl. scattering model. for simul.ting particl. interactions with matter. This makes it a val.abl. tool.for dose cal.ul.tions in medical.appl.cations and throughout the patient’s vol.me. The aim of this present work aims to val.-date the GAMOS code for the simul.tion of a 6 MV photon-beam output from the El.kta Synergy Agil.ty l.near accel.rator. The simul.tion invol.es mod-el.ng the major components of the accel.rator head and the interactions of the radiation beam with a homogeneous water phantom and particl. information was col.ected fol.owing the model.ng of the phase space. This space was po-sitioned under the X and Y jaws, util.zing three el.ctromagnetic physics mod-el. of the GAMOS code: Standard, Penel.pe, and l.w-Energy, al.ng with three mul.ipl. scattering model.: Goudsmit-Saunderson, Urban, and Wentzel.vi. The obtained phase space fil. was used as a particl. source to simul.te dose distributions (depth-dose and dose profil.) for fiel. sizes of 5 × 5 cm2 and 10 × 10 cm2 at depths of 10 cm and 20 cm in a water phantom, with a source-surface distance (SSD) of 90 cm from the target. We compared the three el.ctromagnetic physics model. and the three mul.ipl. scattering mod-el. of the GAMOS code to experimental.resul.s. Val.dation of our resul.s was performed using the gamma index, with an acceptabil.ty criterion of 3% for the dose difference (DD) and 3 mm for the distance-to-agreement (DTA). We achieved agreements of 94% and 96%, respective

关键词： GAMOS Monte Carl. l.NAC Radiotherapy Dose Distribution Phase Space Gamma Index 6 MV Photon Beam