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高等工程教育研究 1998年第1期46卷 82-86页

作者： rank.,PG 郑传治机械电子工程一系

Finite cell method compared to h-version finite element method for elasto-plastic problems

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Applied Mathematics and Mechanics(English Edition) 2014年第10期35卷 1239-1248页

作者： A.ABEDIAN J.PARVIZIAN A.DSTER E.rank Department of Mechanical Engineering Daneshpajoohan Higher Education Institute Department of Mechanical Engineering Isfahan University of Technology Numerische Strukturanalyse mit Anwendungen in der Schiffstechnik (M-10) Technische Universitt Hamburg-Harburg Lehrstuhl fr Computation in Engineering Fakultt fr Bauingenieur-und Vermessungswesen Technische Universitt Mnchen

The finite cell method （FCM） combines the high-order finite element method （FEM） with the fictitious domain approach for the purpose of simple meshing. In the present study, the FCM is used to the Prandtl-Reuss flow theory of plasticity, and the results are compared with the h-version finite element method （h-FEM）. The numerical results show that the FCM is more efficient compared to the h-FEM for elasto-plastic problems, although the mesh does not conform to the boundary. It is also demonstrated that the FCM performs well for elasto-plastic loading and unloading.

关键词： finite cell method (FCM) h-version finite element method (h-FEM),Prandtl-Reuss quadtree octree

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加拿大卫星移动地面站应用的经验

电信快报 1989年第4期 13-14页

作者： rank.,LM 余佩芳

重质油在CoMo／碳载体催化剂上的加氢处理

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世界石油科学 1995年第A1期 82-93页

作者： rank.,LA 张学富

本研究以阿拉伯３４５℃＋常压重油为原料油，对几种ＣｏＭｏ／活性炭催化剂进行了约１７天的加氢工业实验研究，着重考察了所用催化剂的活性，并将实验结果与传统的ＣｏＭｏ／Ａｌ２Ｏ３催化剂的实验研究结果作了比较。主要研究结果如... 详细信息

本研究以阿拉伯３４５℃＋常压重油为原料油，对几种ＣｏＭｏ／活性炭催化剂进行了约１７天的加氢工业实验研究，着重考察了所用催化剂的活性，并将实验结果与传统的ＣｏＭｏ／Ａｌ２Ｏ３催化剂的实验研究结果作了比较。主要研究结果如下：ＣｏＭｏ／活性炭催化剂的脱金属活性与所选择的活性炭的物性及Ｃｏ、Ｍｏ金属在活性炭上的担载方式有关；

关键词：重油钴钼活性碳载体催化剂加氢处理

添加H2S对新的和使用过程的CoMo催化剂性能的影响

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石油炼制译丛 1992年第6期 28-32页

作者： rank.,LA 张若野

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美容手术后的生活质量

世界医学杂志 1999年第7期3卷 7-11页

作者： rank.,M Bora.,GL

美容手术是一种正在普遍化的医疗方法,其对病人的利益尚无定量的客观标准。本文目的是前瞻性地研究选择性美容手术病人的长期生活质量。本文对连续105名选择性美容外科手术病人的生活质量进行了前瞻性相关研究,分别于术前、术后1个月和... 详细信息

美容手术是一种正在普遍化的医疗方法,其对病人的利益尚无定量的客观标准。本文目的是前瞻性地研究选择性美容手术病人的长期生活质量。本文对连续105名选择性美容外科手术病人的生活质量进行了前瞻性相关研究,分别于术前、术后1个月和6个月检查生活质量指数、抑郁、社会支持和应变。将四种研究手段所得资料用Pearson相关法分析,不同时间各变量的差异用重复测量多变量方差分析。多变量方差分析示生活质量指数从手术前基数平均值3.24改善至术后1个月时的2.56,6个月时的2.11(f=518.5,P≤0.0001)。抑郁平均得分[用流行病学研究中心抑郁量表(CES-D)]从术前11.2改善为术后1个月的6.5,6个月时的6.3(f=79.3,P≤0.0001)。手术前后患者应变方式和社会支持得分无显著差异。美容手术产生了正面的心理效应,明显改进了长期生活质量,对社会支持和应变方式方面无不良影响。

关键词：美容手术生活质量疗效

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地基加固灌浆技术新进展

探矿技术 1997年第3期 27-29页

作者： rank.,WJ 彭新明

Screening of antiproliferative activity mediated through apoptosis pathway in human non-small lung cancer A-549 cells by active compounds present in medicinal plants

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Asian Pacific Journal of Tropical Medicine 2018年第12期11卷 666-675页

作者： Nutan V.Badgujar Kinnari N.Mistry Dharamshibhai N.rank.Chaitanya G.Joshi Ashok and Rita Patel Institute of Integrated Study and Research in Biotechnology and Allied Sciences (ARIBAS) Affiliated to Sardar Patel University Department of Animal Breeding and Genetics College of Veterinary Science and Animal Husbandry Anand Agricultural University Department of Animal Biotechnology College of Veterinary Science and Animal Husbandry Anand Agricultural University

Objective: To explore the antiproliferative activity and apoptosis in cells caused by active compounds present in plants using different techniques. Methods: We investigated the antiproliferative effects of methanolic extracts from different parts of seven plants on A-549(lung cancer) cells and primary cell culture(chick embryo fibroblast cells, as normal cells) using MTT assay and the potent plant was fractioned further. All these fractions were screened again for anti-proliferative activity. DNA fragmentation and DAPI staining were used to study apoptosis. Quantitative real-time was used to investigate the expression of apoptoticrelated genes. LC-MS and 1 H-NMR techniques were used to identify the active compounds present. EnzCheck caspase-3 assay kit was used to measure caspase-3 activity. Results: Methanolic extract of Vitex negundo(V. negundo) was selected as a potent fraction. Among all fractions screened, ethylacetate fraction of V. negundo was selected as the most potent antiproliferative fraction and phytochemical analysis of the extract revealed the presence of secondary metabolites. Ethaylacetate fraction of V. negundo was found to cause characteristic apoptotic morphological changes and generation of ROS in A-549 cells. Ethaylacetate fraction of V. negundo also induced apoptosis in A-549 which was supported by DNA fragmentation and DAPI staining. To investigate the molecular mechanism behind the cytotoxic effect of ethaylacetate fraction of V. negundo, quantitative real-time PCR was used to measure expression levels of p53, bax, bcl2, casp-3 and casp-9. Using LC-MS and 1 H-NMR techniques, cytotoxic compounds(luteolin and p-hydroxy benzoic acid) were identified which increased casp-3 activity in a dose and time-dependent manner in A-549 treated cells. Conclusions: It is concluded from the present study that V. negundo is capable of triggering growth-inhibitive and apoptosis effects in A-549 cells, signifying that V. negundo may possesses anti-lung cancer

关键词： Apoptosis DNA fragmentation assay ROS MTT assay Real time assay DAPI staining

DNA Copy Number Aberrations in Breast Cancer by Array Comparative Genomic Hybridization

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Genomics,Proteomics & Bioinformatics 2009年第Z1期 13-24页

作者： Vera Timmermans-Wielenga Fritz rank.Carsten Wiuf Lars Bolund Department of Pathology Center of Diagnostic InvestigationsDK-2100 Copenhagen Denmark 2. Danish Center for Translational Breast Cancer ResearchDK-2100 Copenhagen Denmark 3. Bioinformatics Research Center University of AarhusDK-8000 Aarhus Denmark 4. Institute of Human Genetics University of AarhusDK-8000 Aarhus Denmark Beijing Genomics Institute at Shenzhen

Array comparative genomic hybridization (CGH) has been popularly used for analyzing DNA copy number variations in diseases like cancer. In this study, we investigated 82 sporadic samples from 49 breast cancer patients using 1-Mb resolution bacterial artificial chromosome CGH arrays. A number of highly frequent genomic aberrations were discovered, which may act as "drivers" of tumor progression. Meanwhile, the genomic profiles of four "normal" breast tissue samples taken at least 2 cm away from the primary tumor sites were also found to have some genomic aberrations that recurred with high frequency in the primary tumors, which may have important implications for clinical therapy. Additionally, we performed class comparison and class prediction for various clinicopathological parameters, and a list of characteristic genomic aberrations associated with different clinicopathological phenotypes was compiled. Our study provides clues for further investigations of the underlying mechanisms of breast carcinogenesis.

关键词： breast cancer genomic aberration array CGH clinicopathological parameter

DNA Copy Number Aberrations in Breast Cancer by Array Comparative Genomic Hybridization

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Genomics, Proteomics & Bioinformatics 2009年第1期7卷 13-24页

作者： Jian Li Kai Wang Shengting Li Vera Timmermans-Wielenga Fritz rank.Carsten Wiuf Xiuqing Zhang Huanming Yang Lars Bolund Institute of Human Genetics University ofAarhus DK-8000 Aarhus Denmark Beijing Genomics Institute at Shenzhen Shenzhen 518083 China Bioinformatics Research Center University of Aarhus DK-8000 Aarhus Denmark Department of Pathology Center of Diagnostic Investigations DK-2100 Copenhagen Denmark Danish Center for Translational Breast Cancer Research DK-2100 Copenhagen Denmark

Array comparative genomic hybridization （CGH） has been popularly used for analyzing DNA copy number variations in diseases like cancer. In this study, we investigated 82 sporadic samples from 49 breast cancer patients using 1-Mb resolution bacterial artificial chromosome （2GH arrays. A number of highly frequent genomic aberrations were discovered, which may act as ＂drivers＂ of tumor progression. Meanwhile, the genomic profiles of four ＂normal＂ breast tissue samples taken at least 2 cm away from the primary tumor sites were also found to have some genomic aberrations that recurred with high frequency in the primary tumors, which may have important implications for clinical therapy. Additionally, we performed class comparison and class prediction for various clinicopathological parameters, and a list of characteristic genomic aberrations associated with different clinicopathological phenotypes was compiled. Our study provides clues for further investigations of the underlying mechanisms of breast carcinogenesis.

关键词： breast cancer genomic aberration array CGH clinicopathological parameter