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NIR-switchable local hydrogen generation by tandem bimetallic MOFs nanocomposites for enhanced chemodynamic therapy

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Regenerative Biomaterials 2024年第1期3卷 58-68页

作者： Jun Zhong Xiang Zheng Yuan Wen Yuewei Li Jianting Zhang ranjith kumar Kankala Shibin Wang Aizheng Chen Institute of Biomaterials and Tissue Engineering Huaqiao UniversityXiamen 361021China Fujian Provincial Key Laboratory of Biochemical Technology Huaqiao UniversityXiamen 361021China Fujian Provincial Key Laboratory of Biomass Low-Carbon Conversion Huaqiao UniversityXiamen 361021China

The inadequate quantity of hydrogen peroxide(H_(2)O_(2))in cancer cells promptly results in the constrained success of chemodynamic therapy(CDT).Significant efforts made throughout the years;nevertheless,researchers are still facing the great challenge of designing a CDT agent and securing H_(2)O_(2) supply within the tumor *** this study,taking advantage of H_(2)O_(2) level maintenance mechanism in cancer cells,a nanozyme-based bimetallic metal-organic frameworks(MOFs)tandem reactor is fabricated to elevate intracellular H_(2)O_(2) levels,thereby enhancing *** addition,under nearinfrared excitation,the upconversion nanoparticles(UCNPs)loaded into the MOFs can perform photocatalysis and generate hydrogen,which increases cellular susceptibility to radicals induced from H_(2)O_(2),inhibits cancer cell energy,causes DNA damages and induces tumor cell apoptosis,thus improving CDT therapeutic efficacy *** proposed nanozyme-based bimetallic MOFs-mediated CDT and UCNPs-mediated hydrogen therapy act as combined therapy with high efficacy and low toxicity.

关键词： chemodynamic therapy nanozyme bimetallic MOFs gas therapy

Effect of samarium doping on structural, optical and magnetic properties of vertically aligned ZnO nanorod arrays

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Journal of Rare Earths 2017年第10期35卷 1002-1007页

作者： D.ranjith kumar K.S.ranjith L.R.Nivedita R.T.Rajendra kumar Department of Nanoscience and Technology Bharathiar University Coimbatore India Advanced Materials and Devices Laboratory (AMDL) Department of Physics Bharathiar University Coimbatore India

Samarium doped vertically aligned one dimensional ZnO nanorod（NR） arrays were grown by vapor phase transport（VPT） method through vapor solid（VS） growth process. Influence of different concentrations（0% to 8%） of Sm（all Sm contents in the paper are in mass fraction） on the ZnO NR arrays were investigated by X-ray diffraction（XRD）, field emission scanning electron microscopy（FESEM）, photoluminescence（PL）, Raman spectroscopy and vibrating sample magnetometry（VSM） techniques, respectively. X-ray diffraction studies revealed that the ZnO NR arrays were perfectly oriented along（002） crystallographic orientation with wurtzite crystal structure. Photoluminescence results showed an increase in oxygen vacancies due to increase in Sm doping. M-H curves revealed enhanced ferromagnetic behavior, and the magnetic moment values were 0.45, 0.363, 1.694, 3.613 and 2.197 emu/cm^3 for（0–8%） Sm doped ZnO NR arrays respectively. The curve revealed that paramagnetic behavior was observed for undoped ZnO NR arrays and on increasing the Sm dopant to 4%, paramagnetic switched to ferromagnetic behavior.

关键词： Sm doped ZnO room temperature ferromagnetism(RTFM) defects rare earths

Supercritical fluid-assisted controllable fabrication of open and highly interconnected porous scaffolds for bone tissue engineering

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Science China(Life Sciences) 2019年第12期62卷 1670-1682页

作者： Hanxiao Tang ranjith kumar Kankala Shibin Wang Aizheng Chen College of Chemical Engineering Huaqiao UniversityXiamen 361021China Institute of Biomaterials and Tissue Engineering Huaqiao UniversityXiamen 361021China Fujian Provincial Key Laboratory of Biochemical Technology(Huaqiao University) Xiamen 361021China

Recently tremendous progress has been evidenced by the advancements in developing innovative three-dimensional(3 D)scaffolds using various techniques for addressing the autogenous grafting of bone. In this work, we demonstrated the fabrication of porous polycaprolactone(PCL) scaffolds for osteogenic differentiation based on supercritical fluid-assisted hybrid processes of phase inversion and foaming. This eco-friendly process resulted in the highly porous biomimetic scaffolds with open and interconnected architectures. Initially, a 2^3 factorial experiment was designed for investigating the relative significance of various processing parameters and achieving better control over the porosity as well as the compressive mechanical properties of the scaffold. Then, single factor experiment was carried out to understand the effects of various processing parameters on the morphology of scaffolds. On the other hand, we encapsulated a growth factor, i.e., bone morphogenic protein-2(BMP-2), as a model protein in these porous scaffolds for evaluating their osteogenic differentiation. In vitro investigations of growth factor loaded PCL scaffolds using bone marrow stromal cells(BMSCs) have shown that these growth factor-encumbered scaffolds were capable of differentiating the cells over the control experiments. Furthermore, the osteogenic differentiation was confirmed by measuring the cell proliferation, and alkaline phosphatase(ALP) activity, which were significantly higher demonstrating the active bone growth. Together, these results have suggested that the fabrication of growth factor-loaded porous scaffolds prepared by the eco-friendly hybrid processing efficiently promoted the osteogenic differentiation and may have a significant potential in bone tissue engineering.

关键词： supercritical foaming polycaprolactone bone tissue engineering osteogenic differentiation bone morphogenic protein-2

Nature-inspired nanocarriers for improving drug therapy of atherosclerosis

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Regenerative Biomaterials 2023年第1期10卷 1314-1331页

作者： Weihong Ji Yuanxing Zhang Yuanru Deng Changyong Li ranjith kumar Kankala Aizheng Chen Institute of Biomaterials and Tissue Engineering Huaqiao UniversityXiamenFujian 361021PR China Fujian Provincial Key Laboratory of Biochemical Technology Huaqiao UniversityXiamenFujian 361021PR China The Institute of Forensic Science Xiamen Public Security BureauXiamenFujian 361104PR China

Atherosclerosis(AS)has emerged as one of the prevalent arterial vascular diseases characterized by plaque and inflammation,primarily causing disability and mortality *** therapy remains the main treatment for ***,a series of obstacles hinder effective drug ***,from natural micro-/nano-structural biological particles like natural cells and extracellular vesicles to the distinctions between the normal and pathological microenvironment,offers compelling solutions for efficient drug ***-inspired nanocarriers of synthetic stimulus-responsive materials and natural components,such as lipids,proteins and membrane structures,have emerged as promising candidates for fulfilling drug delivery *** nanocarriers offer several advantages,including prolonged blood circulation,targeted plaque delivery,targeted specific cells delivery and controlled drug release at the action *** this review,we discuss the nature-inspired nanocarriers which leverage the natural properties of cells or the microenvironment to improve atherosclerotic drug ***,we provide an overview of the challenges and opportunities of applying these innovative nature-inspired nanocarriers.

关键词： nature-inspired nanocarriers drug delivery membrane-coating stimuli-responsive atherosclerosis

The growth of biopolymers and natural earthen sources as membrane/separator materials for microbial fuel cells:A comprehensive review

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Journal of Energy Chemistry 2023年第5期80卷 402-431,I0010页

作者： Gowthami Palanisamy Sadhasivam Thangarasu ranjith kumar Dharman Chandrashekar S.Patil Thakur Prithvi Pal Singh Negi Mahaveer D.Kurkuri ranjith Krishna Pai Tae Hwan Oh School of Chemical Engineering Yeungnam UniversityGyeongsan 38541Republic of Korea Centre for Research in Functional Materials(CRFM) JAIN(Deemed-to-be University)Jain Global CampusBengaluru 562112KarnatakaIndia Technology Mission Division-(Energy&Water) Department of Science and Technology(DST)Ministry of Science and Technology-Govt.of IndiaNew Delhi 110016India

Microbial fuel cell(MFC)technology has emerged as an effective solution for energy insecurity and ***,identifying suitable components(particularly separators or membranes)with the required properties,such as low cost and high performance,remains challenging and restricts practical *** membranes,such as Nafion,exhibit excellent performance in ***,these membranes have high production costs,which considerably increase the overall MFC unit cell *** the numerous types,the separators or membranes developed from biopolymers and naturally occurring earthen sources have proven to be a novel and efficient concept due to their natural abundance,cost-effectiveness(approximately$20 m^(-2),$5 m^(-2),and$1 kg-1for biopolymers,ceramics,and earthensources,respectively),structural properties,proton transportation,manufacturing and modification ease,and environmental *** this review,we emphasize cost-effective renewable green materials(biopolymers,bio-derived materials,and naturally occurring soil,clay,ceramics or minerals)for MFC applications for the first *** with good thermal,mechanical,and water retention properties,sustainability,and environmental friendliness,such as cellulose and chitosan,are typically ***,the modification or introduction of various functional groups in biopolymers to enhance their functional properties and scale MFC power density is ***,separator/membrane development using various bio-sources(such as coconut shells,banana peels,chicken feathers,and tea waste ash)is ***,naturally occurring sources such as clay,montmorillonite,and soils(including red,black,rice-husk,and Kalporgan soil)for MFC were *** conclusion,the existing gap in MFC technology was filled by providing recommendations for future aspects based on the barriers in cost,environment,and characteristics.

关键词： Biomembrane Bioseparator Microbial fuel cell Energy harvesting Bioenergy Wastewater treatment

Advances in hydrogel-based vascularized tissues for tissue repair and drug screening

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Bioactive Materials 2022年第3期7卷 198-220页

作者： Ying Wang ranjith kumar Kankala Caiwen Ou Aizheng Chen Zhilu Yang Affiliated Dongguan Hospital Southern Medical UniversityDongguanGuangdong523059PR China Guangdong Provincial Key Laboratory of Shock and Microcirculation GuangzhouGuangdong510080PR China Institute of Biomaterials and Tissue Engineering Huaqiao UniversityXiamenFujian361021PR China

The construction of biomimetic vasculatures within the artificial tissue models or organs is highly required for conveying nutrients,oxygen,and waste products,for improving the survival of engineered tissues in *** recent times,the remarkable progress in utilizing hydrogels and understanding vascular biology have enabled the creation of three-dimensional(3D)tissues and organs composed of highly complex vascular *** this review,we give an emphasis on the utilization of hydrogels and their advantages in the vascularization of ***,the significance of vascular elements and the regeneration mechanisms of vascularization,including angiogenesis and vasculogenesis,are briefly ***,we highlight the importance and advantages of hydrogels as artificial microenvironments in fabricating vascularized tissues or organs,in terms of tunable physical properties,high similarity in physiological environments,and alternative shaping mechanisms,among ***,we discuss the utilization of such hydrogels-based vascularized tissues in various applications,including tissue regeneration,drug screening,and ***,we put forward the key challenges,including multifunctionalities of hydrogels,selection of suitable cell phenotype,sophisticated engineering techniques,and clinical translation behind the development of the tissues with complex vasculatures towards their future development.

关键词： Hydrogel Vascularization Vascular biology Angiogenesis Tissue regeneration Drug screening Vascularized tissue models

Supercritical fluid-assisted fabrication of C-doped Co_(3)O_(4) nanoparticles based on polymer-coated metal salt nanoreactors for efficient enzyme-mimicking and glucose sensor properties

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Nano Research 2023年第5期16卷 7431-7442页

作者： Ze-Wen Kang Jun-Yu Zhang Ze-Zhen Li ranjith kumar Kankala Shi-Bin Wang Ai-Zheng Chen Institute of Biomaterials and Tissue Engineering Huaqiao UniversityXiamen 361021China Fujian Provincial Key Laboratory of Biochemical Technology(Huaqiao University) Xiamen 361021China Instrumental Analysis Center Laboratory and Equipment Management DepartmentHuaqiao UniversityXiamen 361021China

Nanomaterials doped with non-metallic C have attracted tremendous attention as potential nano-artificial enzymes due to their ability to change the energy band structure to improve their intrinsic ***,we report a green,facile,efficient,fast strategy to access high-performance nanozymes via supercritical CO_(2)fluid technology-fabricated polymer nanoreactor of poly-(methyl vinyl ether-co-maleic anhydride)(PVM/MA)coated Co(NO_(3))_(2)into C-doped Co_(3)O_(4)(C-Co_(3)O_(4))nanozyme by a onestep calcination *** PVM/MA to C doping into Co_(3)O_(4)shortens the entire lattice constant of the crystal structure,and the overall valence band energy level below the Fermi level shifts toward the lower energy *** as-prepared CCo_(3)O_(4)demonstrated significant peroxidase-like catalytic activity,significantly greater than the undoped Co_(3)O_(4)nanoparticle *** following density functional theory(DFT)calculations revealed that the doped nano-enzyme catalytic site displayed a unique electronic structure,altering the material surface with more electrons to fill the anti-bond of the two molecular orbitals,significantly improving the peroxidase-like enzyme catalytic and glucose sensor *** resultant enzymatic glucose sensing in a linear range of 0.1–0.6 mM with a detection limit of 3.86μM is in line with standard Michaelis–Menten ***,this work demonstrates that converting polymers into nanozymes of C-doped form by supercritical CO_(2)fluid technology in a step is an effective strategy for constructing high-performance glucose sensor *** cost-effective,reliable,precise system offers the potential for rapid analyte detection,facilitating its application in a variety of fields.

关键词： supercritical fluid poly-(methyl vinyl ether-co-maleic anhydride)(PVM/MA) C-doped Co_(3)O_(4) nanozymes density functional theory(DFT)calculation

Effective and Efficient Video Compression by the Deep Learning Techniques

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Computer Systems Science & Engineering 2023年第5期45卷 1047-1061页

作者： Karthick Panneerselvam K.Mahesh V.L.Helen Josephine A.ranjith kumar Department of Computer Applications Alagappa UniversityKaraikudiIndia Department of Computer Science and Engineering lovely professional UniversityPhagwaraPunjabIndia School of Business and Management Christ UniversityBengaluruKarnatakaIndia

Deep learning has reached many successes in Video *** has become a growing important part of our daily digital *** advancement of better resolution content and the large volume offers serious challenges to the goal of receiving,distributing,compressing and revealing highquality video *** this paper we propose a novel Effective and Efficient video compression by the Deep Learning framework based on the flask,which creatively combines the Deep Learning Techniques on Convolutional Neural Networks(CNN)and Generative Adversarial Networks(GAN).The video compression method involves the layers are divided into different groups for data processing,using CNN to remove the duplicate frames,repeating the single image instead of the duplicate images by recognizing and detecting minute changes using GAN and recorded with Long Short-Term Memory(LSTM).Instead of the complete image,the small changes generated using GAN are substituted,which helps with frame-level *** wise comparison is performed using K-nearest Neighbours(KNN)over the frame,clustered with K-means and Singular Value Decomposition(SVD)is applied for every frame in the video for all three colour channels[Red,Green,Blue]to decrease the dimension of the utility matrix[R,G,B]by extracting its latent *** frames are packed with parameters with the aid of a codec and converted to video format and the results are compared with the original *** experiments on several videos with different sizes,duration,Frames per second(FPS),and quality results demonstrated a significant resampling *** normal,the outcome delivered had around a 10%deviation in quality and over half in size when contrasted,and the original video.

关键词： Convolutional neural networks(CNN) generative adversarial network(GAN) singular value decomposition(SVD) K-nearest neighbours(KNN) stochastic gradient descent(SGD) long short-term memory(LSTM)

Preparation of alumina-carbon composites with phloroglucinol-formaldehyde resin and their application in asymmetric hydrogenation

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Chinese Chemical Letters 2020年第5期31卷 1322-1326页

作者： Wenrui Cai Renjie Xiong Cong Mao Meitian Xiao Yongjun Liu ranjith kumar Kankala Xueqin Zhang College of Chemical Engineering Huaqiao UniversityXiamen 361021China

To overcome the shortcomings of single component carrier supported platinum(Pt)-based catalysts,herein,we demonstrate the fabrication of alumina combined mesoporous carbon to prepare a series of alumina-carbon composites and their corresponding Pt-based *** alumina-carbon composites Al@PhFC are synthesized by using phloroglucinol-formaldehyde resin as carbon source and aluminum acetylacetone as the aluminum ***,the effect of alumina content on the properties of the composites is *** composites and catalysts are characterized by using XRD,XPS,N2 sorption,and *** Pt/Al@PhFC-1.8 composite with appropriate amounts of alumina,pore diameter,and moderate Pt nanoparticle size,resulted in 99.5%of conversion efficiency and 77.4%of optical selectivity in the asymmetric hydrogenation of ethyl 2-oxo-4-phenylbutanoate(EOPB).Intere stingly,this composite can be used more than 20 times without a significant decrease in its performance.

关键词： Phloroglucinol-formaldehyde resin Alumina-carbon composite Asymmetric hydrogenation Pt nanoparticles