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Supercritical fluid-assisted controllable fabrication of open and highly interconnected porous scaffolds for bone tissue engineering

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Science China(Life Sciences) 2019年第12期62卷 1670-1682页

作者： Hanxiao Tang ranjith kumar kankala Shibin Wang Aizheng Chen College of Chemical Engineering Huaqiao UniversityXiamen 361021China Institute of Biomaterials and Tissue Engineering Huaqiao UniversityXiamen 361021China Fujian Provincial Key Laboratory of Biochemical Technology(Huaqiao University) Xiamen 361021China

Recently tremendous progress has been evidenced by the advancements in developing innovative three-dimensional(3 D)scaffolds using various techniques for addressing the autogenous grafting of bone. In this work, we demonstrated the fabrication of porous polycaprolactone(PCL) scaffolds for osteogenic differentiation based on supercritical fluid-assisted hybrid processes of phase inversion and foaming. This eco-friendly process resulted in the highly porous biomimetic scaffolds with open and interconnected architectures. Initially, a 2^3 factorial experiment was designed for investigating the relative significance of various processing parameters and achieving better control over the porosity as well as the compressive mechanical properties of the scaffold. Then, single factor experiment was carried out to understand the effects of various processing parameters on the morphology of scaffolds. On the other hand, we encapsulated a growth factor, i.e., bone morphogenic protein-2(BMP-2), as a model protein in these porous scaffolds for evaluating their osteogenic differentiation. In vitro investigations of growth factor loaded PCL scaffolds using bone marrow stromal cells(BMSCs) have shown that these growth factor-encumbered scaffolds were capable of differentiating the cells over the control experiments. Furthermore, the osteogenic differentiation was confirmed by measuring the cell proliferation, and alkaline phosphatase(ALP) activity, which were significantly higher demonstrating the active bone growth. Together, these results have suggested that the fabrication of growth factor-loaded porous scaffolds prepared by the eco-friendly hybrid processing efficiently promoted the osteogenic differentiation and may have a significant potential in bone tissue engineering.

关键词： supercritical foaming polycaprolactone bone tissue engineering osteogenic differentiation bone morphogenic protein-2

Nature-inspired nanocarriers for improving drug therapy of atherosclerosis

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Regenerative Biomaterials 2023年第1期10卷 1314-1331页

作者： Weihong Ji Yuanxing Zhang Yuanru Deng Changyong Li ranjith kumar kankala Aizheng Chen Institute of Biomaterials and Tissue Engineering Huaqiao UniversityXiamenFujian 361021PR China Fujian Provincial Key Laboratory of Biochemical Technology Huaqiao UniversityXiamenFujian 361021PR China The Institute of Forensic Science Xiamen Public Security BureauXiamenFujian 361104PR China

Atherosclerosis(AS)has emerged as one of the prevalent arterial vascular diseases characterized by plaque and inflammation,primarily causing disability and mortality *** therapy remains the main treatment for ***,a series of obstacles hinder effective drug ***,from natural micro-/nano-structural biological particles like natural cells and extracellular vesicles to the distinctions between the normal and pathological microenvironment,offers compelling solutions for efficient drug ***-inspired nanocarriers of synthetic stimulus-responsive materials and natural components,such as lipids,proteins and membrane structures,have emerged as promising candidates for fulfilling drug delivery *** nanocarriers offer several advantages,including prolonged blood circulation,targeted plaque delivery,targeted specific cells delivery and controlled drug release at the action *** this review,we discuss the nature-inspired nanocarriers which leverage the natural properties of cells or the microenvironment to improve atherosclerotic drug ***,we provide an overview of the challenges and opportunities of applying these innovative nature-inspired nanocarriers.

关键词： nature-inspired nanocarriers drug delivery membrane-coating stimuli-responsive atherosclerosis

Advances in hydrogel-based vascularized tissues for tissue repair and drug screening

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Bioactive Materials 2022年第3期7卷 198-220页

作者： Ying Wang ranjith kumar kankala Caiwen Ou Aizheng Chen Zhilu Yang Affiliated Dongguan Hospital Southern Medical UniversityDongguanGuangdong523059PR China Guangdong Provincial Key Laboratory of Shock and Microcirculation GuangzhouGuangdong510080PR China Institute of Biomaterials and Tissue Engineering Huaqiao UniversityXiamenFujian361021PR China

The construction of biomimetic vasculatures within the artificial tissue models or organs is highly required for conveying nutrients,oxygen,and waste products,for improving the survival of engineered tissues in *** recent times,the remarkable progress in utilizing hydrogels and understanding vascular biology have enabled the creation of three-dimensional(3D)tissues and organs composed of highly complex vascular *** this review,we give an emphasis on the utilization of hydrogels and their advantages in the vascularization of ***,the significance of vascular elements and the regeneration mechanisms of vascularization,including angiogenesis and vasculogenesis,are briefly ***,we highlight the importance and advantages of hydrogels as artificial microenvironments in fabricating vascularized tissues or organs,in terms of tunable physical properties,high similarity in physiological environments,and alternative shaping mechanisms,among ***,we discuss the utilization of such hydrogels-based vascularized tissues in various applications,including tissue regeneration,drug screening,and ***,we put forward the key challenges,including multifunctionalities of hydrogels,selection of suitable cell phenotype,sophisticated engineering techniques,and clinical translation behind the development of the tissues with complex vasculatures towards their future development.

关键词： Hydrogel Vascularization Vascular biology Angiogenesis Tissue regeneration Drug screening Vascularized tissue models

NIR-switchable local hydrogen generation by tandem bimetallic MOFs nanocomposites for enhanced chemodynamic therapy

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Regenerative Biomaterials 2024年第1期3卷 58-68页

作者： Jun Zhong Xiang Zheng Yuan Wen Yuewei Li Jianting Zhang ranjith kumar kankala Shibin Wang Aizheng Chen Institute of Biomaterials and Tissue Engineering Huaqiao UniversityXiamen 361021China Fujian Provincial Key Laboratory of Biochemical Technology Huaqiao UniversityXiamen 361021China Fujian Provincial Key Laboratory of Biomass Low-Carbon Conversion Huaqiao UniversityXiamen 361021China

The inadequate quantity of hydrogen peroxide(H_(2)O_(2))in cancer cells promptly results in the constrained success of chemodynamic therapy(CDT).Significant efforts made throughout the years;nevertheless,researchers are still facing the great challenge of designing a CDT agent and securing H_(2)O_(2) supply within the tumor *** this study,taking advantage of H_(2)O_(2) level maintenance mechanism in cancer cells,a nanozyme-based bimetallic metal-organic frameworks(MOFs)tandem reactor is fabricated to elevate intracellular H_(2)O_(2) levels,thereby enhancing *** addition,under nearinfrared excitation,the upconversion nanoparticles(UCNPs)loaded into the MOFs can perform photocatalysis and generate hydrogen,which increases cellular susceptibility to radicals induced from H_(2)O_(2),inhibits cancer cell energy,causes DNA damages and induces tumor cell apoptosis,thus improving CDT therapeutic efficacy *** proposed nanozyme-based bimetallic MOFs-mediated CDT and UCNPs-mediated hydrogen therapy act as combined therapy with high efficacy and low toxicity.

关键词： chemodynamic therapy nanozyme bimetallic MOFs gas therapy

Supercritical fluid-assisted fabrication of C-doped Co_(3)O_(4) nanoparticles based on polymer-coated metal salt nanoreactors for efficient enzyme-mimicking and glucose sensor properties

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Nano Research 2023年第5期16卷 7431-7442页

作者： Ze-Wen Kang Jun-Yu Zhang Ze-Zhen Li ranjith kumar kankala Shi-Bin Wang Ai-Zheng Chen Institute of Biomaterials and Tissue Engineering Huaqiao UniversityXiamen 361021China Fujian Provincial Key Laboratory of Biochemical Technology(Huaqiao University) Xiamen 361021China Instrumental Analysis Center Laboratory and Equipment Management DepartmentHuaqiao UniversityXiamen 361021China

Nanomaterials doped with non-metallic C have attracted tremendous attention as potential nano-artificial enzymes due to their ability to change the energy band structure to improve their intrinsic ***,we report a green,facile,efficient,fast strategy to access high-performance nanozymes via supercritical CO_(2)fluid technology-fabricated polymer nanoreactor of poly-(methyl vinyl ether-co-maleic anhydride)(PVM/MA)coated Co(NO_(3))_(2)into C-doped Co_(3)O_(4)(C-Co_(3)O_(4))nanozyme by a onestep calcination *** PVM/MA to C doping into Co_(3)O_(4)shortens the entire lattice constant of the crystal structure,and the overall valence band energy level below the Fermi level shifts toward the lower energy *** as-prepared CCo_(3)O_(4)demonstrated significant peroxidase-like catalytic activity,significantly greater than the undoped Co_(3)O_(4)nanoparticle *** following density functional theory(DFT)calculations revealed that the doped nano-enzyme catalytic site displayed a unique electronic structure,altering the material surface with more electrons to fill the anti-bond of the two molecular orbitals,significantly improving the peroxidase-like enzyme catalytic and glucose sensor *** resultant enzymatic glucose sensing in a linear range of 0.1–0.6 mM with a detection limit of 3.86μM is in line with standard Michaelis–Menten ***,this work demonstrates that converting polymers into nanozymes of C-doped form by supercritical CO_(2)fluid technology in a step is an effective strategy for constructing high-performance glucose sensor *** cost-effective,reliable,precise system offers the potential for rapid analyte detection,facilitating its application in a variety of fields.

关键词： supercritical fluid poly-(methyl vinyl ether-co-maleic anhydride)(PVM/MA) C-doped Co_(3)O_(4) nanozymes density functional theory(DFT)calculation

Synergistic chemo-/photothermal therapy based on supercritical technology-assisted chitosan–indocyanine green/luteolin nanocomposites for wound healing

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Regenerative Biomaterials 2022年第1期9卷 844-857页

作者： Pei-Yao Xu ranjith kumar kankala Yue-Wei Li Shi-Bin Wang Ai-Zheng Chen Institute of Biomaterials and Tissue Engineering Huaqiao UniversityXiamenFujian 361021PR China Fujian Provincial Key Laboratory of Biochemical Technology(Huaqiao University) XiamenFujian 361021PR China

Despite the success,it is highly challenging to battle against pathogenic biofilms-based chronic bacterial infections by conventional antibiotic ***,we report a near-infrared(NIR)/acid-induced nanoplatform based on chitosan(CS)-coated indocyanine green(ICG,photosensitizer)/luteolin(LUT,a natural quorum sensing inhibitor)nanocomposites(ICG/LUT-CS)as antibacterial and antibiofilm agents for skin wound ***,the ICG/LUT nanoplatforms are prepared by the supercritical antisolvent technology and coated with the CS *** obtained ICG/LUT-CS with ultra-high encapsulation efficiency exhibited more favorable photothermal conversion effects and improved NIR laser/acid dual-induced drug release behavior than individual modalities,achieving exceptional bacteria-killing and biofilm elimination ***,the ICG/LUT-CS realized the synergetic effects of chemotherapy and photothermal therapy outcomes for wound ***,our findings provided an appealing strategy for the rapid preparation and future translational application of ICG/LUT-CS as an ideal agent for fighting against biofilm infections.

关键词： photothermal therapy supercritical carbon dioxide antibacterial antibiofilm wound healing

NIR-responsive carrier-free nanoparticles based on berberine hydrochloride and indocyanine green for synergistic antibacterial therapy and promoting infected wound healing

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Regenerative Biomaterials 2023年第1期10卷 1429-1441页

作者： Youyu Duan Peiyao Xu Panyuan Ge Linfei Chen Ying Chen ranjith kumar kankala Shibin Wang Aizheng Chen Institute of Biomaterials and Tissue Engineering Huaqiao UniversityXiamenFujian 361021PR China Fujian Provincial Key Laboratory of Biochemical Technology Huaqiao UniversityXiamenFujian 361021PR China

Bacterial infections cause severe health conditions,resulting in a significant economic burden for the public health *** natural phytochemicals are considered promising anti-bacterial agents,they suffer from several limitations,such as poor water solubility and low bioavailability in vivo,severely restricting their wide ***,we constructed a near-infrared(NIR)-responsive carrier-free berberine hydrochloride(BH,phytochemicals)/indocyanine green(ICG,photosensitizer)nanoparticles(BI NPs)for synergistic antibacterial of an infected *** electrostatic interaction andπ-πstacking,the hydrophobic BH and amphiphilic ICG are initially self-assembled to generate carrier-free *** obtained BI NPs demonstrated NIR-responsive drug release behavior and better photothermal conversion efficiency of up to 36%.In addition,BI NPs stimulated by NIR laser exhibited remarkable antibacterial activity,which realized the synergistic antibacterial treatment and promoted infected wound *** summary,the current research results provided a candidate strategy for self-assembling new BI NPs to treat bacterial infections synergistically.

关键词： phytochemicals photothermal therapy antibacterial wound healing

Preparation of alumina-carbon composites with phloroglucinol-formaldehyde resin and their application in asymmetric hydrogenation

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Chinese Chemical Letters 2020年第5期31卷 1322-1326页

作者： Wenrui Cai Renjie Xiong Cong Mao Meitian Xiao Yongjun Liu ranjith kumar kankala Xueqin Zhang College of Chemical Engineering Huaqiao UniversityXiamen 361021China

To overcome the shortcomings of single component carrier supported platinum(Pt)-based catalysts,herein,we demonstrate the fabrication of alumina combined mesoporous carbon to prepare a series of alumina-carbon composites and their corresponding Pt-based *** alumina-carbon composites Al@PhFC are synthesized by using phloroglucinol-formaldehyde resin as carbon source and aluminum acetylacetone as the aluminum ***,the effect of alumina content on the properties of the composites is *** composites and catalysts are characterized by using XRD,XPS,N2 sorption,and *** Pt/Al@PhFC-1.8 composite with appropriate amounts of alumina,pore diameter,and moderate Pt nanoparticle size,resulted in 99.5%of conversion efficiency and 77.4%of optical selectivity in the asymmetric hydrogenation of ethyl 2-oxo-4-phenylbutanoate(EOPB).Intere stingly,this composite can be used more than 20 times without a significant decrease in its performance.

关键词： Phloroglucinol-formaldehyde resin Alumina-carbon composite Asymmetric hydrogenation Pt nanoparticles

3D bioprinting of conductive hydrogel for enhanced myogenic differentiation

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Regenerative Biomaterials 2021年第5期8卷 14-24页

作者： Ying Wang Qingshuai Wang Shengchang Luo Zhoujiang Chen Xiang Zheng ranjith kumar kankala Aizheng Chen Shibin Wang Institute of Biomaterials and Tissue Engineering Huaqiao UniversityXiamen 361021P.R.China School of Pharmaceutical Engineering and Life Science Changzhou UniversityChangzhou 213164P.R.China Fujian Provincial Key Laboratory of Biochemical Technology(Huaqiao University) Xiamen 361021P.R.China

Recently,hydrogels have gained enormous interest in three-dimensional(3D)bioprinting toward developing functional substitutes for tissue ***,it is highly challenging to transmit electrical signals to cells due to the limited electrical conductivity of the bioprinted ***,we demonstrate the 3D bioprinting-assisted fabrication of a conductive hydrogel scaffold based on poly-3,4-ethylene dioxythiophene(PEDOT)nanoparticles(NPs)deposited in gelatin methacryloyl(GelMA)for enhanced myogenic differentiation of mouse myoblasts(C2C12 cells).Initially,PEDOT NPs are dispersed in the hydrogel uniformly to enhance the conductive property of the hydrogel ***,the incorporated PEDOT NPs showed minimal influence on the printing ability of ***,C2C12 cells are successfully encapsulated within GelMA/PEDOT conductive hydrogels using 3D extrusion ***,the proliferation,migration and differentiation efficacies of C2C12 cells in the highly conductive GelMA/PEDOT composite scaffolds are demonstrated using various in vitro investigations of live/dead staining,F-actin staining,desmin and myogenin immunofluorescence ***,the effects of electrical signals on the stimulation of the scaffolds are investigated toward the myogenic differentiation of C2C12 cells and the formation of myotubes in ***,our findings demonstrate that the fabrication of the conductive hydrogels provides a feasible approach for the encapsulation of cells and the regeneration of the muscle tissue.

关键词： 3D bioprinting conductive hydrogel electrical stimulation myoblasts myogenic differentiation