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Impact of Selenium on Microtubules Polymarisation of Spermatozoa of Endosulfan Exposed Swiss Albino Mice

Journal of Life Sciences 2011年第2期5卷 132-135页

作者： ranjit kumar jitendra kumar singh mohammad ali arun kumar Mahavir Cancer Sansthan ＆ Research Centre Phulwarisharif Patna 801505 India

Pesticide plays a vital role in agricultural, industrial and residemial pest control. In recent years the ‘pesticide problem＇ has been the focus of public interest because these chemicals have a very important role in agriculture but these chemicals also act like endocrine disruptor. Experiments were carried out on 12 weeks old mice with 30 ± 2 gm. b.w. Endosulfan were administered at 3 mg/kg b.w daily by gavage method for five weeks followed by selenium treatment at 10 μg/kg.b.w./day for five weeks. 9 ＋ 2 arrangment were clearly observed in control group mice with well structured dynein and nexin arm while Endosulfan treated group show depolymerised microtubule and 9 ＋ 1 arrangment with degenerated mitochondria. While selenium treated group shows restoration of 9 ＋ 2 arrangement of microtubule. It is evident from study that endosulfan causes depolymerisation of microtubule while selenium administered group show normal polymerized microtubule and restores normal fertility in mice.

关键词： Spermatozoa selenium microtubules dynein arm nexin axoneme depolymerisation Swiss albino mice

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Endosulfan Causes Neoplastic Changes in the Liver Cells of Mice

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Open Journal of Pathology 2014年第3期4卷 86-93页

作者： arun kumar mohammad ali jitendra kumar singh Akhileshwari Nath Sudhir kumar Srivastava ranjit kumar Department of Zoology Patna University Patna India Research Centre Mahavir Institute and Research Centre Patna India

The rapid growth in global population continues to challenge the world’s ability to provide enough food. As one of the most crucial issues for human development, food production must increase to offset hunger and poverty as well as social unrest. To augment the yield of crops a variety of pesticides like Endosulfan, Rogor, Aldrin, Chlorpyrifos, etc. are being used liberally by the farmers. In the present investigation, Endosulfan was administered orally (daily) by gavage method to female Swiss albino mice group for 4 weeks @ 3.0 mg/kg b.w. After that, they were left for 6 months and then sacrificed and liver tissues were fixed for light microscopy and Transmission Electron Microscopic study. The histopathological study of Endosulfan administered group liver showed hepatocytes with congestion in central vein with less dense cytoplasm, haemorrhaged bile duct, degenerated cytoplasm and central vein with vacuolations in sinusoidal spaces. Neoplastic changes in hepatocytes are the major finding of study. The ultrastuctural study revealed dilation in the nuclear pore complex and massive movement of cytoplasmic material from cytoplasm to the nucleus which is major finding which denotes neoplastic changes. Presence of abundant free lying polyribosomes in the cytoplasm, which denotes neoplastic changes in the cellis also one of theimportant finding observed. The present study thus deciphers that Endosulfan toxicity leads to onset of neoplasia thence carcinogenesis in liver cells in Swiss albino mice which is the novel finding in the field of toxicology.

关键词： Endosulfan Neoplasia Liver Cell Light Microscopy Transmission Electron Microscopy

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