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Critical Review on Balanites aegyptiaca Delile:Phytoconstituents,Pharmacological Properties and Nanointerventions

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Chinese Journal of Integrative Medicine 2024年第7期30卷 653-663页

作者： Surendra kumar Gautam Rakesh kumar paul Devesh M.Sawant Amita Sarwal Kaisar Raza Department of Pharmacy School of Chemical Sciences and PharmacyCentral University of RajasthanBandarsindriAjmerRajasthan305817India University Institute of Pharmaceutical Sciences Panjab UniversityChandigarh160014India

Balanites aegyptiaca Delile(BA)is an enduring xerophytic woody and spinous flowering tree and is commonly known as desert date or Ingudi(Hingot).It belongs to the family Zygophyllaceae,which is specific to be drought areas of Nigeria,Africa,South Asia and India(Rajasthan).In Ayurveda,this traditional medicinal plant is reported for the management of jaundice,syphilis,yellow fever,metabolic disorders,liver,and spleen *** main aim of the review is to compile its medicinal uses and further advancements to showcase the promises inherited in various parts of the plant for the benefit of *** per the literature survey,various researchers have focused on the detailed investigation of BA including the phytopharmacological evidence,chemical constituents,nano-formulations,commercialized products,and clinical *** remarkable scaffolds and isolated compounds like diosgenin,yamogenin,balanitin1/2,balanitin 3,bal4/5,bal6/7,rutin-3-glycosides,3,7-diglycosides,(3,12,14,16)–(12-hydroxycholest-5-ene-3,16-diyl-bis)-D-glucopyranoside and balanitoside have been ***,this traditional plant has been scientifically proven by in vitro and in *** on the complete review of this plant,most of the compounds have been isolated from the fruit and kernel ***,based on the literature,a histogram was developed for pharmacological activity in which antidiabetic study was found to be more compared to other pharmacological *** a spinous desert dates,this plant needs to be explored more to bring out newer phytochemicals in the management of various diseases.

关键词： Delile desert date phytochemicals nano-phytopharmaceutical pharmacological activities traditional medicine

Palaeodepositional environment,implications of Glossopteris flora,and organic matter characteristics from the Lower Permian,Karo Open Cast Mine,East Bokaro Coalfield,Damodar Basin,India

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Journal of Palaeogeography 2024年第3期13卷 528-546页

作者： Sankar Suresh kumar Pillai Rose Ann Sebastian Runcie paul Mathews Srikanta Murthy Anju Saxena Mrutyunjaya Sahoo Suraj kumar Sahu Gulshan kumar Dhingra Birbal Sahni Institute of Palaeosciences 53 University RoadLucknow-226007UPIndia Academy of Scientific and Innovative Research(AcSIR) Ghaziabad-201002India Department of Geology School of Earth Science SystemsCentral University of KeralaKasaragod-671316KeralaIndia Department of Geology Ravenshaw UniversityCuttack-753003OdishaIndia Department of Botany Sri Dev Suman Uttarakhand UniversityUttarakhand-249145India

The present study deals with the Early Permian floral diversity,palaeoenvironment,palaeoclimate and depositional setting using a multiproxy approach that includes morphotaxonomy,palynology,and organic geochemistry of Karo OCM(Open Cast Mine),East Bokaro Coalfield,Damodar Gondwana Basin,*** Permian sediments of Peninsular India are widely regarded as fluvial,along with some marine *** macroplant fossil assemblage exhibits the presence of Glossopteridales,comprising Glossopteris,Gangamopteris,and Vertebraria,as well as Coniferales,which includes *** palynological assemblage encompasses the dominance of the striate bisaccate pollen Faunipollenites *** the subdominance of the non-striate bisaccate pollen Scheuringipollenites *** glossopterid *** megafloral and palynofloral assemblage confirms the biostratigraphical age to be Late Barakar palynoflora of Kungurian *** studied morphological characteristics,including small to large Glossopteris leaves exhibiting a lanceolate shape,acute apices,and acute cuneate or tapering bases,as well as entire margins with narrower lamina and narrow meshes,suggest the existence of a dense forest with the prevalence of a warm and humid climate during their *** organic geochemical characterization based on functional group and biomarker analyses reveals the diagenetic effects on organic *** symmetric(~2865-2855 cm^(-1))and asymmetric stretching(~2930-2910 cm^(-1))peaks are identifiable in coal samples,whereas they are absent in carbonaceous *** A-factor vs.C-factor plot suggests that the kerogen type is type Ⅲ,which can generate mainly gaseous *** vitrinite reflectance studies(R_(r) av.1.1%)show increased maturity of the samples,which is supported by the n-alkane distribution pattern and the absence of hopane *** Indian floral assemblages in contemporary of southern Gondwana continents reveal a stronger inclination/affinity with th

关键词： Glossopteris Palynomorph FTIR GCMS Gondwana Permian Palaeoclimate

Dual-wavelength all-fiber Q-switched fiber laser using bismuth-doped fiber as saturable absorber

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Optoelectronics Letters 2024年第3期20卷 147-151页

作者： Aruna Ghosh Abdulkadir Mukhtar Diblawe Uttam kumar Samanta Moh Yasin Sulaiman Wadi Harun Mukul Chandra paul Fiber Optics and Photonics Division CSIR-Central Glass and Ceramic Research InstituteKolkata 700032India Physics Department Jadavpur UniversityKolkata 700032India Photonics Engineering Laboratory Department of Electrical EngineeringUniversity of MalayaKuala Lumpur 50603Malaysia Department of Physics Faculty of Science and TechnologyAirlangga UniversitySurabayaIndonesia

A passively Q-switched all-fiber laser is demonstrated using a 10-cm-long bismuth-doped fiber(BDF) as a saturable absorber(SA). The dual-wavelength operation was obtained due to the nonlinear effect inside the fabricated BDF, which has a high germanium content. Stable Q-switched pulses were obtained at the dual synchronous wavelengths of 1 530.1 nm and 1 531.1 nm. When the pump power is tuned from 105.3 mW to 191.0 mW, the repetition rate can be varied from 82.6 kMz to 117.6 kHz. The maximum pulse energy and average output power were 83.4 nJ and 9.8 mW, respectively while the minimum pulse width was 8.5 μs at the maximum pump power of 191.0 mW. Our results indicate that BDF could be a promising alternative optical modulator for pulsed fiber laser application.

关键词： fiber switched pump

Clinical profile and outcomes of hepatocellular carcinoma in primary Budd-Chiari syndrome

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 699-715页

作者： Ankit Agarwal Sagnik Biswas Shekhar Swaroop Arnav Aggarwal Ayush Agarwal Gautam Jain Anshuman Elhence Arun Vaidya Amit Gupte Ravi Mohanka Ramesh kumar Ashwani kumar Mishra Shivanand Gamanagatti Shashi Bala paul Subrat kumar Acharya Akash Shukla Shalimar Department of Gastroenterology and Human Nutrition All India Institute of Medical SciencesNew Delhi 110029DelhiIndia Department of Gastroenterology Seth Gordhandas Sunderdas Medical College and KEM HospitalMumbai 400012MaharashtraIndia Department of Gastroenterology Sir HN Reliance Foundation HospitalMumbai 400004India Department of Liver Transplant and HPB Sir HN Reliance Foundation HospitalMumbai 400004India Department of Gastroenterology All India Institute of Medical SciencesPatna 801507India Professor of Biostatistics National Drug Dependence Treatment Centre(NDDTC)All India Institute of Medical SciencesNew Delhi 110029India Department of Radiodiagnosis All India Institute of Medical SciencesNew Delhi 110029DelhiIndia

BACKGROUND There is scant literature on hepatocellular carcinoma(HCC)in patients with Budd-Chiari syndrome(BCS).AIM To assess the magnitude,clinical characteristics,feasibility,and outcomes of treatment in *** A total of 904 BCS patients from New Delhi,India and 1140 from Mumbai,India were *** prevalence and incidence of HCC were determined,and among patients with BCS-HCC,the viability and outcomes of interventional therapy were *** In the New Delhi cohort of 35 BCS-HCC patients,18 had HCC at index presentation(prevalence 1.99%),and 17 developed HCC over a follow-up of 4601 person-years,[incidence 0.36(0.22-0.57)per 100 person-years].BCS-HCC patients were older when compared to patients with BCS alone(P=0.001)and had a higher proportion of inferior vena cava block,cirrhosis,and long-segment vascular *** median alpha-fetoprotein level was higher in patients with BCS-HCC at first presentation than those who developed HCC at follow-up(13029 ng/mL vs 500 ng/mL,P=0.01).Of the 35 BCS-HCC,26(74.3%)underwent radiological interventions for BCS,and 22(62.8%)patients underwent treatment for HCC[transarterial chemoembolization in 18(81.8%),oral tyrosine kinase inhibitor in 3(13.6%),and transarterial radioembolization in 1(4.5%)].The median survival among patients who underwent interventions for HCC compared with those who did not was 3.5 years vs 3.1 mo(P=0.0001).In contrast to the New Delhi cohort,the Mumbai cohort of BCS-HCC patients were predominantly males,presented with a more advanced HCC[Barcelona Clinic Liver Cancer C and D],and 2 patients underwent liver *** HCC is not uncommon in patients with *** interventions and liver transplantation are feasible in select primary BCS-HCC patients and may improve outcomes.

关键词： Budd chiari syndrome Cancer Cirrhosis Thrombosis Liver Varices Transarterial chemoembolization Hepatic venous outflow tract obstruction

MicroRNA-502-3p regulates GABAergic synapse function in hippocampal neurons

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Neural Regeneration Research 2024年第12期19卷 2698-2707页

作者： Bhupender Sharma Melissa MTorres Sheryl Rodriguez Laxman Gangwani Subodh kumar Center of Emphasis in Neuroscience Department of Molecular and Translational MedicinePaul L.Foster School of MedicineTexas Tech University Health Sciences CenterEl PasoTXUSA Bond Life Sciences Center and Department of Veterinary Pathobiology University of MissouriColumbiaMOUSA L.Frederick Francis Graduate School of Biomedical Sciences Texas Tech University Health Sciences CenterEl PasoTXUSA

Gamma-aminobutyric acid(GABA)ergic neurons,the most abundant inhibitory neurons in the human brain,have been found to be reduced in many neurological disorders,including Alzheimer's disease and Alzheimer's disease-related *** previous study identified the upregulation of microRNA-502-3p(miR-502-3p)and downregulation of GABA type A receptor subunitα-1 in Alzheimer's disease *** study investigated a new molecular relationship between miR-502-3p and GABAergic synapse *** vitro studies were perfo rmed using the mouse hippocampal neuronal cell line HT22 and miR-502-3p agomiRs and *** silico analysis identified multiple binding sites of miR-502-3p at GABA type A receptor subunitα-1 *** assay confirmed that miR-502-3p targets the GABA type A receptor subunitα-1 gene and suppresses the luciferase ***,quantitative reve rse transcription-polymerase chain reaction,miRNA in situ hybridization,immunoblotting,and immunostaining analysis confirmed that overexpression of miR-502-3p reduced the GABA type A receptor subunitα-1 level,while suppression of miR-502-3p increased the level of GABA type A receptor subunitα-1 ***,as a result of the overexpression of miR-502-3p,cell viability was found to be reduced,and the population of necrotic cells was found to be *** whole cell patch-clamp analysis of human-GABA receptor A-α1/β3/γ2L human embryonic kidney(HEK)recombinant cell line also showed that overexpression of miR-502-3p reduced the GABA current and overall GABA function,suggesting a negative correlation between miR-502-3p levels and GABAergic synapse ***,the levels of proteins associated with Alzheimer s disease were high with miR-502-3p overexpression and reduced with miR-502-3p *** present study provides insight into the molecular mechanism of regulation of GABAergic synapses by *** propose that micro-RNA,in particular miR-502-3p,could be a potential the

关键词： Alzheimer's disease GABAergic synapse gamma-aminobutyric acid type A receptor subunitα-1(GABRα1) microRNA-502-3p(miR-502-3p) miRNA in situ hybridization Patch-clamp

Electro-magnetohydrodynamic Flow of Biofluid Induced by Peristaltic Wave： A Non-newtonian Model

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Journal of Bionic Engineering 2016年第3期13卷 436-448页

作者： Gopal Chandra Shit Nayan kumar ranjit Aniruddha Sinha Department of Mathematics Jadavpur University Kolkata - 700032 India Yogoda Satsanga Palpara Mahavidyalaya Purba Medinipur - 721458 India

This article aims to develop a mathematical model for peristaltic transport of magnetohydrodynamic flow of biofluids through a micro-channel with rhythmically contracting and expanding walls under the influence of an applied electric field. The couple stress fluid model is considered to represent the non-Newtonian characteristics ofbiofluids. The velocity slip condition at the channel walls is taken into account because of the hyclrophilic/hydrophobic interaction with negatively charged walls. The essential features of the electromagnetohydrodynamic flow of biofluid through micro-channels are clearly highlighted in the variations of the non-dimensional parameters of the physical quantities of interest such as the velocity, wall shear stress, pressure gradient, pressure rise per wave length, frictional force at the channel walls and the distribution of stream function. It reveals that the flow ofhiofluid is appreciably influenced by the sufficient strength of externally applied magnetic field and electro-osmotic parameter. The velocity slip condition reduces the frictional force at the channel wall. Moreover, the formation of the trapping bolus strongly depends on electro-osmotic parameter and magnetic field strength.

关键词： peristaltic transport couple stress fluid magnetohydrodynamics electro-osmosis

Modeling the transmission dynamics of a time-delayed epidemic model with saturated treatment rate

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生物数学学报:英文版 2023年第7期16卷 11-45页

作者： ranjit kumar Upadhyay Sattwika Acharya Department of Mathematics&Computing Indian Institute of Technology(Indian School of Mines)Dhanbad Jharkhand-826004 India

In this paper,an attempt has been made to explore a new delayed epidemiological model assuming that the disease is transmitted among the susceptible population and possessing nonlinear incidence function along with a saturated treatment *** attention is paid to the positivity and boundedness of the solutions and the bifurcation of the dynamical system as *** reproduction number is being calculated,and considering the latent period as a bifurcation parameter,it has been examined that a Hopf-bifurcation occurs near the endemic equilibrium point while the parameter attains critical *** have also discussed the stability and direction of Hopf-bifurcation near the endemic equilibrium point,the global stability analysis and the optimal control *** conclude that the system reveals chaotic dynamics through a specific time-delay *** simulations are being performed in order to explain the accuracy and effectiveness of the acquired theoretical results.

关键词： Infectious disease treatment rate chaotic dynamics bifurcation theory incidence function transmission dynamics global stability optimal control

Impact of geomorphometric parameters on the occurrence and distribution of landslides in Yamuna River Basin,North-Western Himalaya,India

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Journal of Mountain Science 2022年第8期19卷 2374-2396页

作者： Ravi SHANKAR Gyan Prakash SATYAM Prakash kumar SINGH Nilesh kumar RAI ranjit kumar PASWAN REED CSIR-Central Institute of Mining and Fuel ResearchDhanbad 826001India Department of Applied Geology Indian Institute of Technology(ISM)Dhanbad 826004India Department of Earth and Planetary Sciences University of AllahabadPrayagraj 211002Uttar PradeshIndia

The majority of landslides in the Indian Himalayas are triggered by rainfall and *** geology and geomorphology also play an important role and constitute the major predisposing factor controlling ***,active tectonics modify the landscape,impacting the occurrence and distribution of *** objective of this study is to investigate the role of some of the major predisposing factors to assess landslide patterns in the Yamuna River Basin as it is prone to recurrent landslide *** approach mainly deals with the application of geographical information system-based statistical analysis and quantifying frequency-area distribution of rainfalltriggered landslides for the years 2015 to *** analysis shows that the frequency of landslides is highest in the slope range 40°-70°and the mean landslide size is higher in the slope range 0°-20°and 30°-40°,remaining constant on further increase in slope *** study shows that some critical slope range controls both the frequency and size of *** were mostly restricted to south facing *** 91%of the landslide occur in the drainage density range of 1.2 to 2.1 km/km^(2) while landslides show very low occurrence in either lower(2.1)drainage *** distribution analysis of landslides depicts a distinct cutoff point but an indistinct rollover ***-sampling of small landslides can be a reasonable cause for *** other studies,the present data fits very well for medium and large landslides following an inverse power law with a scaling exponent *** 80% of landslides are smaller than the cutoff size and 20% larger than this *** geology and tectonics of Lesser Himalayas and Sivaliks offer favorable conditions for frequent *** such as Dehradun,Uttarkashi,Sirmaur,Shimla,and Solan are very prone to landslide activity owing to the presence of poorly consolidated sandstone,conglomerate,quartzites,phylli

关键词： Himalaya Geomorphometry Landslide Yamuna River Basin

Aspects of high-performance and bio-acceptable magnetic nanoparticles for biomedical application

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Asian Journal of Pharmaceutical Sciences 2021年第6期16卷 704-737页

作者： Preeti Kush Parveen kumar ranjit Singh Ajeet Kaushik School of Pharmacy Adarsh Vijendra Institute of Pharmaceutical SciencesShobhit University GangohSaharanpurUttar Pradesh 247341India Nanotechnology Division(H-1) CSIR-Central Scientific Instruments OrganizationChandigarh 160030India NanoBioTech Laboratory Health System EngineeringDepartment of Natural SciencesFlorida Polytechnic UniversityLakelandFL 33805-8531United States

This review covers extensively the synthesis&surface modification,characterization,and application of magnetic *** biomedical applications,consideration should be given to factors such as design strategies,the synthesis process,coating,and surface *** synthesis method regulates post-synthetic change and specific applications in vitro and in vivo imaging/diagnosis and pharmacotherapy/*** insights have been provided on biodistribution,pharmacokinetics,and toxicity in a living system,which is imperative for their wider application in *** nanoparticles can be decorated with multiple contrast agents and thus can also be used as a probe for multi-mode imaging or double/triple imaging,for example,MRI-CT,*** loading with different drug molecules/dye/fluorescent molecules and integration with other carriers have found application not only in locating these particles in vivo but simultaneously target drug delivery/hyperthermia inside the *** are underway to collect the potential of these magnetically driven nanoparticles in various scientific fields such as particle interaction,heat conduction,imaging,and ***,this comprehensive data will help in the further development of advanced techniques for theranostics based on high-performance magnetic nanoparticles and will lead this research area in a new sustainable direction.

关键词： Magnetism Synthesis Characterization Delivery Imaging Biodistribution Pharmacokinetic