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Nuclei Segmentation in Histopathology Images Using Structure-Preserving Color Normalization Based Ensemble Deep Learning Frameworks

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Computers, Materials & Continua 2023年第12期77卷 3077-3094页

作者： Manas ranjan Prusty Rishi Dinesh Hariket Sukesh kumar Sheth Alapati Lakshmi Viswanath Sandeep kumar Satapathy Centre for Cyber-Physical Systems Vellore Institute of TechnologyChennai600127India School of Computer Science and Engineering Vellore Institute of TechnologyChennai600127India Centre for Advanced Data Science Vellore Institute of TechnologyChennai600127India

This paper presents a novel computerized technique for the segmentation of nuclei in hematoxylin and eosin(H&E)stained histopathology *** purpose of this study is to overcome the challenges faced in automated nuclei segmentation due to the diversity of nuclei structures that arise from differences in tissue types and staining protocols,as well as the segmentation of variable-sized and overlapping *** this extent,the approach proposed in this study uses an ensemble of the UNet architecture with various Convolutional Neural Networks(CNN)architectures as encoder backbones,along with stain normalization and test time augmentation,to improve segmentation ***,this paper employs a Structure-Preserving Color Normalization(SPCN)technique as a preprocessing step for stain *** proposed model was trained and tested on both single-organ and multi-organ datasets,yielding an F1 score of 84.11%,mean Intersection over Union(IoU)of 81.67%,dice score of 84.11%,accuracy of 92.58%and precision of 83.78%on the multi-organ dataset,and an F1 score of 87.04%,mean IoU of 86.66%,dice score of 87.04%,accuracy of 96.69%and precision of 87.57%on the single-organ *** findings demonstrate that the proposed model ensemble coupled with the right pre-processing and post-processing techniques enhances nuclei segmentation capabilities.

关键词： Nuclei segmentation image segmentation ensemble U-Net deep learning histopathology image convolutional neural networks

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Morphological Changes During Annealing of Electrodeposited Ni-Cr Coating on Steel and Their Effect on Corrosion in 3% of NaCl Solution

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Journal of Iron and Steel Research International 2011年第3期18卷 72-78页

作者： Manpreet Singh Marwah Vajjala Srinivas Ajoy kumar Pandey Shyam ranjan kumar Koushik Biswas Joydeep Maity Material Engineering Division(Quality Assurance) Tata Motors Limited Materials Engineering Department Ashok Leyland Technical Center Department of Metallurgical and Materials Engineering Indian Institute of Technology Department of Applied Science National Institute of Foundry and Forge Technology Department of Metallurgical and Materials Engineering National Institute of Technology

Steel containing carbon of 0.2% was coated with Ni and Cr through electrodeposition,and subsequently annealed at 400 and 600 ℃ for 5 min,30 min,1 h and 2 *** annealing at 400 ℃,the formation and growth of oxides occurred in the form of petals along with voids,cracks and ***,at 600 ℃,the nucleation and growth of chromium oxide whiskers produced a surface almost free from crack,porosity and void for 1 h and 2 h of *** accordance with the surface morphology,the bare steel,as-deposited steel,all specimens deposited and annealed at 400 ℃,and specimens deposited and annealed at 600 ℃ for 5 and 30 min exhibited continuous corrosion in 3% of NaCl ***,the specimens deposited and annealed at 600 ℃ for 1 and 2 h exhibited an improved corrosion resistance in 3% of NaCl solution with high pitting potential due to presence of a dense passive oxide film almost free from voids at the surface.

关键词： steel electrodeposition annealing corrosion resistance

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Tailoring of electrical properties of BiFeO_(3) by praseodymium

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Journal of Advanced Ceramics 2013年第3期2卷 235-241页

作者： Samita PATTANAYAK Ashwasa PRIYADARSHAN Ritesh SUBUDHI ranjan kumar NAYAK Rajib PADHEE Department of Physics Institute of Technical Education&ResearchSiksha‘O’Anusandhan UniversityBhubaneswar 751030India

The polycrystalline samples of Bi_(1-x)Pr_(x)FeO_(3)(x=0 and 0.1)were prepared by a solid-state reaction *** X-ray structural analysis has confirmed the formation of a single-phase *** of dielectric and impedance spectroscopy of the materials,carried out in wide frequency(1 kHz-1 MHz)and temperature(25-400℃)ranges,have provided many interesting results including significant decrement in tangent loss,structural stability,obeying Jonscher’s universal power law,etc.

关键词： ceramics impedance spectroscopy electrical conductivity

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Hybrid Metamodel—NSGA-III—EDAS Based Optimal Design of Thin Film Coatings

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Computers, Materials & Continua 2021年第2期66卷 1771-1784页

作者： Kamlendra Vikram Uvaraja Ragavendran Kanak Kalita ranjan kumar Ghadai Xiao-Zhi Gao Department of Mechanical Engineering Vel Tech Rangarajan Dr.Sagunthala R&D Institute of Science and TechnologyAvadi600062India Department of Electronics and Telecommunication Engineering MPSTME SVKM’S Narsee Monjee Institute of Management StudiesShirpur425405India Department of Mechanical Engineering Sikkim Manipal Institute of TechnologySikkim Manipal UniversityMajhitar737136India School of Computing University of Eastern FinlandKuopio70211Finland

In this work,diamond-like carbon(DLC)thin film coatings are deposited on silicon substrates by using plasma-enhanced chemical vapour deposition(PECVD)*** varying the hydrogen(H2)flow rate,CH4−Argon(Ar)flow rate and deposition temperature(Td)as per a Box-Behnken experimental design(BBD),15 DLC deposition experiments are carried *** Young’s modulus(E)and the coefficient of friction(COF)for the DLCs are *** using a second-order polynomial regression approach,two metamodels are built for E and COF,that establish them as functions of H2 flow rate,CH4-Ar flow rate and Td.A non-dominated sorting genetic algorithm(NSGA-III)is used to obtain a set of Pareto solutions for the multi-objective optimization of E maximization and COF *** to various practical scenarios,evaluation based on distance from average solution(EDAS)approach is used to identify the most feasible solutions out of the Pareto solution *** experiments are conducted which shows the efficacy of the polynomial regression—NSGA-III—EDAS hybrid *** surface morphology of the DLCs deposited as per the optimal predictions is also studied by using atomic force microscopy.

关键词： Multi-objective optimization regression analysis thin-film coating

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Noscapine shows antimalarial activity against Plasmodium falciparum 3D7,its clinical isolate Pf140/SS,and Plasmodium berghei ANKA

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Asian Pacific Journal of Tropical Biomedicine 2024年第8期14卷 350-358页

作者： Swaraj kumar Babu Sameer Maharana Satyaranjan Chhatria Dibya ranjan Sahoo Ashirbad Nanda Satish Kanhar Prativa Kbehera Sanjib Mohanty Pradeep kumar Naik Praveen Kishore Sahu Centre of Excellence in Natural Products and Therapeutics Department of Biotechnology and BioinformaticsSambalpur UniversityJyoti ViharSambalpur OdishaIndia Department of Molecular Biology and Infectious Diseases Community Welfare Society HospitalRourkelaOdishaIndia Molecular&Immunology Laboratory Infectious Disease Biology UnitIspat General HospitalRourkelaOdishaIndia Department of Pharmacy Centurion University of Technology and ManagementBhubaneswarOdishaIndia

Objective:To evaluate the antimalarial activity of noscapine against Plasmodium falciparum 3D7 strain(Pf3D7),its clinical isolate(Pf140/SS),and Plasmodium berghei ANKA(PbA).Methods:Using ring-stage survival assay,phenotypic assessments,and SYBR-green-based fluorescence assay,the antimalarial activities of noscapine were assessed compared with dihydroartemisinin(DHA)in in vivo and in vitro *** addition,hemolysis and cytotoxicity tests were carried out to evaluate its ***-PCR assay was also conducted to determine the effect of noscapine on papain-like cysteine protease Plasmodium falciparum falcipain-2(PfFP-2).Results:The antimalarial efficacy of noscapine against Pf3D7 and Pf140/SS was comparable to DHA,with IC50 values of(7.68±0.88)and(5.57±0.74)nM/mL,respectively,and>95%inhibition of PbA infected *** also showed a safe profile,as evidenced by low hemolysis and cytotoxicity even at high ***,PfFP-2 expression was significantly inhibited in both noscapine-treated Pf3D7 and Pf140/SS(P<0.01).Conclusions:Noscapine has antimalarial properties comparable to standard antimalarial DHA with better safety profiles,which may be further explored as a therapeutic candidate for the treatment of malaria.

关键词： Malaria Plasmodium falciparum Plasmodium berghei Noscapine Antimalarial Dihydroartemisinin Cytotoxicity Falcipain-2

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Root cause of sand production and methodologies for prediction

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Petroleum 2021年第3期7卷 263-271页

作者： Surej kumar Subbiah Arifin Samsuri Assef Mohamad-Hussein Mohd Zaidi Jaafar Ying Ru Chen Rajeev ranjan kumar Department of Petroleum Engineering Faculty of EngineeringUniversiti Teknologi MalaysiaMalaysia Schlumberger GatwickUnited Kingdom Schlumberger DohaQatar Schlumberger MumbaiIndia

The consequences of sandstone reservoir rock failure may lead to sand *** phenomenon can have negative impact on lifting cost and economic of any field *** erosion due to sanding can lead to loss of integrity and hydrocarbon *** decision on the type of completion can risk the viability of the *** facilitate best sand management over the life of a field and to maintain economical productivity,accurate prediction of sand production volume/rates is needed to increase both productivity and the ultimate recovery of the hydrocarbon while keeping the operating cost *** paper summarizes the sand production modeling for onset and volume of sand namely technology that required to improve understanding on sand production and *** main questions will be answered,why industry needs to worry about sand production,what are the available technologies to predict sanding volume/rates finally,how the current technologies can be improved to estimate sand production volume/rates.

关键词： Sand production Sanding rates Geomechanics Sand control Constitutive model Failure criteria

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Magnetic separation studies for a low grade siliceous iron ore sample

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International Journal of Mining Science and Technology 2013年第1期23卷 1-5页

作者： Dwari ranjan kumar Rao Danda Srinivas Reddy Palli Sita Ram CSIR-Institute of Minerals and Materials Technology Council of Scientific and Industrial Research Bhubaneswar 751 013 India

Investigations were carried out, on a low grade siliceous iron ore sample by magnetic separation, to establish its amenability for physical beneficiation. Mineralogical studies revealed that the sample consists of magnetite, hematite and goethite as major opaque oxide minerals where as silicates as well as carbonates form the gangue minerals in the sample. Processes involving combination of classification, dry magnetic separation and wet magnetic separation were carried out to upgrade the low grade siliceous iron ore sample to make it suitable as a marketable product. The sample was first ground and each closed size sieve fractions were subjected to dry magnetic separation and it was observed that limited upgradation is possible. The ground sample was subjected to different finer sizes and separated by wet low intensity magnetic separator. It was possible to obtain a magnetic concentrate of 67% Fe by recovering 90% of iron values at below 200 lm size.

关键词： Iron ore Magnetite Characterization Dry and wet magnetic separation

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All-optical active THz metasurfaces for ultrafast polarization switching and dynamic beam splitting

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Light(Science & Applications) 2018年第1期7卷 766-774页

作者： Longqing Cong Yogesh kumar Srivastava Huifang Zhang Xueqian Zhang Jiaguang Han ranjan Singh Division of Physics and Applied Physics School of Physical and Mathematical SciencesNanyang Technological University21 Nanyang LinkSingapore 637371Singapore Centre for Disruptive Photonic Technologies The Photonics InstituteNanyang Technological University50 Nanyang AvenueSingapore 639798Singapore Center for Terahertz Waves and College of Precision Instrument and Optoelectronics Engineering Key Laboratory of Optoelectronic Information TechnologyMinistry of EducationTianjin University300072 TianjinPeople’s Republic of China

Miniaturized ultrafast switchable optical components with an extremely compact size and a high-speed response will be the core of next-generation all-optical devices instead of traditional integrated circuits,which are approaching the bottleneck of Moore’s *** have emerged as fascinating subwavelength flat optical components and devices for light focusing and holography ***,these devices exhibit a severe limitation due to their natural passive *** we introduce an active hybrid metasurface integrated with patterned semiconductor inclusions for all-optical active control of terahertz *** modulation of polarization states and the beam splitting ratio are experimentally demonstrated on a time scale of 667 *** scheme of hybrid metasurfaces could also be extended to the design of various free-space all-optical active devices,such as varifocal planar lenses,switchable vector beam generators,and components for holography in ultrafast imaging,display,and high-fidelity terahertz wireless communication systems.

关键词： polarization optical beam

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Morbidity Profile and Causes of Mortality in Type 2 Diabetes Patients: Data from a Tertiary Teaching Hospital from Eastern India

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Journal of Diabetes Mellitus 2017年第3期7卷 195-211页

作者： Soumya ranjan behera Manoranjan behera Sidhartha Das Bhabani Prasad Panda Saroj kumar Tripathy Purna Chandra Dash Department of Medicine VSS Institute of Medical Sciences and Research Burla Sambalpur Odisha India PG Department of Medicine Faculty of Medicine Sriram Chandra Bhanja Medical College Cuttack Odisha India PG Department of Medicine Sriram Chandra Bhanja Medical College Cuttack Odisha India

Background: Data regarding the prevalence of morbidity and mortality in patients of Type 2 Diabetes Mellitus (T2DM) is scanty in India. Objectives: To determine the prevalence of micro and macro vascular complications, acute metabolic complications, infections, Non Alcoholic Fatty Liver Disease (NAFLD) and cause of mortality in T2DM patients admitted to a tertiary care teaching hospital in Eastern India. Material and Methods: This was a hospital-based prospective study evaluating 150 T2DM patients admitted to a tertiary care institution in Eastern India. Diagnosis of micro and macro vascular complications, infections and NAFLD was made using standard protocols. In case of death, the most probable cause was noted. Results: Out of 150 patients, 14.7% of patients were newly diagnosed T2DM and out of them 41% of patients had vascular complications and 54.5% had infections. Of the total patients, 56% had nephropathy, 20% neuropathy, 17.3% retinopathy, 31.3% CVD, 11.3% CAD, 4.6% acute metabolic complications, 44% infections and 16.6% had NAFLD respectively. Macrovascular events occured earlier than microvascular complications. Multiple logistic regression analysis showed strong association of age, duration of diabetes, serum cholesterol, triglyceride, LDL-C with retinopathy (Regression coefficient β: -0.1086807, 0.4127152, -0.0513393, 0.0146429, 0.0587475;p < 0.05, < 0.001, < 0.05, < 0.05, < 0.05 respectively), while only duration of diabetes was strongly associated with nephropathy and neuropathy (Regression coefficient β: 0.2538751, 0.2261636;p < 0.001 for each). Increasing age was associated with CAD (Regression coefficient β: 0.055392;p β: 0.0055014;p 18.6% patients died due to diabetes related complications. Cardiovascular (CV)-related deaths (CVD+CAD) were most common cause (51.5%: CVD 36.4%, CAD 15.1%) to be followed by infections (27.3%) and then chronic kidney disease (12.1%). Conclusions: This study highlights the high prevalence of vascular complications and in

关键词： Type 2 Diabetes Mellitus Vascular Complications Infections NAFLD Mortality

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Translational products of adipose tissue-derived mesenchymal stem cells:Bench to bedside applications

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World Journal of Stem Cells 2021年第10期13卷 1360-1381页

作者： Shilpa Sharma Sathish Muthu Madhan Jeyaraman Rajni ranjan Saurabh kumar Jha Department of Pediatric Surgery All India Institute of Medical SciencesNew Delhi 110029India Indian Stem Cell Study Group LucknowUttar Pradesh 226010India Department of Orthopaedics Government Medical College and HospitalDindigulTamil Nadu 624304India Research Scholar Department of BiotechnologySchool of Engineering and TechnologyGreater NoidaSharda UniversityUttar Pradesh 201306India Department of Orthopaedics School of Medical Sciences and ResearchSharda UniversityGreater NoidaUttar Pradesh 201306India Department of Biotechnology School of Engineering and TechnologySharda UniversityGreater NoidaUttar Pradesh 201306India

With developments in the field of tissue engineering and regenerative medicine,the use of biological products for the treatment of various disorders has come into the limelight among researchers and *** all the available biological tissues,research and exploration of adipose tissue have become more *** tissue engineering aims to develop by-products and their substitutes for their regenerative and immunomodulatory *** use of biodegradable scaffolds along with adipose tissue products has a major role in cellular growth,proliferation,and *** tissue,apart from being the powerhouse of energy storage,also functions as the largest endocrine organ,with the release of various *** progenitor cells among the heterogeneous population in the adipose tissue are of paramount importance as they determine the capacity of regeneration of these *** results of adipose-derived stemcell assisted fat grafting to provide numerous growth factors and adipokines that improve vasculogenesis,fat graft integration,and survival within the recipient tissue and promote the regeneration of tissue are *** tissue gives rise to various by-products upon *** article highlights the significance and the usage of various adipose tissue by-products,their individual characteristics,and their clinical applications.

关键词： Adipose tissue Stem cells Fat graft Clinical applications Mesenchymal stem cells

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