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Usefulness of Presepsin (Soluble CD14 Subtype) as a Diagnostic Marker of Sepsis in Egyptian Patients with Acute Myeloid Leukemia

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American Journal of Molecular Biology 2014年第4期4卷 169-176页

作者： Maged Maurice Dalia Nafea Mohamed El Sawy rania soelam Sylvia Youssef Department of Clinical Pathology Faculty of Medicine Alexandria Egypt Department of Internal Medicine Alexandria Egypt

Background: Systemic inflammatory response syndrome (SIRS) is a systemic inflammatory response to a variety of insults. Presepsin;the soluble CD14 subtype is a novel soluble CD14 molecule that is useful for diagnosing sepsis. It plays an important role in modulating the immune response to endotoxin in vitro and vivo. The aim: Of the study was to evaluate the usefulness of presepsin as a diagnostic marker of sepsis in acute leukemia. Methods: The current study was carried out on 40 adult patients with acute myeloid leukemia after receiving chemotherapy. 10 clinically normal individuals were included in the study to measure the level of presepsin. Results: This study was conducted on 50 individuals divided into 2 groups. Group I included 40 adult AML patients who fulfilled at least two of the diagnostic criteria for SIRS and Group II were 10 healthy adult persons as a control group. In Group I there were 11 patients (27.5%) having SIRS, 8 (20%) having sepsis, 9 (22.5%) having severe sepsis and 12 (30%) having septic shock. Data indicate that presepsin level was significantly higher in patients than control P = 0.017. Our results showed that the level of presepsin has a significantly positive correlation to the degree of severity of sepsis with P value 0.0001. Using the ROC curve, we found that presepsin was more specific than CRP in detection of sepsis. Conclusion: sCD14-ST (presepsin) is a new important marker for diagnosis and prognosis of sepsis. Its level increases in the first six hours after the onset of sepsis. Our data demonstrated that the concentration of presepsin is specifically increased during sepsis and is directly proportional to the degree of sepsis. Regarding sensitivity and specificity of presepsin in the discrimination of sepsis patients from healthy controls, a high specificity but low sensitivity was reported by most of the studies.

关键词： AML SIRS Presepsin CRP

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Effects of variable properties on MHD heat and mass transfer flow near a stagnation point towards a stretching sheet in a porous medium with thermal radiation

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Chinese Physics B 2012年第5期21卷 353-363页

作者： A.M.Salem rania Fathy Department of Basic Science Faculty of Computer&InformaticsSuez Canal University Department of Mathematics Faculty of ScienceZagazig University

The effect of variable viscosity and thermal conductivity on steady magnetohydrodynamic（MHD） heat and mass transfer flow of viscous and incompressible fluid near a stagnation point towards a permeable stretching sheet embedded in a porous medium are presented,taking into account thermal radiation and internal heat genberation/*** stretching velocity and the ambient fluid velocity are assumed to vary linearly with the distance from the stagnation *** Rosseland approximation is used to describe the radiative heat flux in the energy *** governing fundamental equations are first transformed into a system of ordinary differential equations using a scaling group of transformations and are solved numerically by using the fourth-order Rung-Kutta method with the shooting technique.A comparison with previously published work has been carried out and the results are found to be in good *** results are analyzed for the effect of different physical parameters,such as the variable viscosity and thermal conductivity,the ratio of free stream velocity to stretching velocity,the magnetic field,the porosity,the radiation and suction/injection on the flow,and the heat and mass transfer *** results indicate that the inclusion of variable viscosity and thermal conductivity into the fluids of light and medium molecular weight is able to change the boundary-layer behavior for all values of the velocity ratio parameter λ except for λ = *** addition,the imposition of fluid suction increases both the rate of heat and mass transfer,whereas fluid injection shows the opposite effect.

关键词： variable viscosity variable thermal conductivity stagnation point

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Hydromagnetic flow of a Cu water nanofluid past a moving wedge with viscous dissipation

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Chinese Physics B 2014年第4期23卷 365-372页

作者： A.M.Salem Galal Ismail rania Fathy Department of Mathematics Faculty of Science and Arts Qassim University Department of Basic Science Faculty of Computers and Informatics Suez Canal University Department of Mathematics Faculty of Science Zagazig University

A numerical study is performed to investigate the flow and heat transfer at the surface of a permeable wedge immersed in a copper （Cu）-water-based nanofluid in the presence of magnetic field and viscous dissipation using a nanofluid model proposed by Tiwari and Das （Tiwari I K and Das M K 2007 Int. J. HeatMass Transfer 50 2002）. A similarity solution for the transformed governing equation is obtained, and those equations are solved by employing a numerical shooting technique with a fourth-order Runge-Kutta integration scheme. A comparison with previously published work is carried out and shows that they are in good agreement with each other. The effects of velocity ratio parameter ~, solid volume fraction tp, magnetic field M, viscous dissipation Ec, and suction parameter Fw on the fluid flow and heat transfer characteristics are discussed. The unique and dual solutions for self-similar equations of the flow and heat transfer are analyzed numerically. Moreover, the range of the velocity ratio parameter for which the solution exists increases in the presence of magnetic field and suction parameter.

关键词： nanofluid dual solution magnetic field viscous dissipation

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Resistance to acid degradation,sorptivity,and setting time of geopolymer mortars

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Frontiers of Structural and Civil Engineering 2022年第6期16卷 781-791页

作者： Osama A MOHAMED rania AL-KHATTAB Waddah AL-HAWAT College of Engineering Abu Dhabi UniversityAbu DhabiUnited Arab Emirates

Experimental evaluations were conducted to determine the water sorptivity,setting time,and resistance to a highly acidic environment,of mortar with alkali-activated ground granulated blast furnace slag(GBS)binder and also of combinations of fly ash and GBS *** were activated using mixtures of NaOH and Na_(2)SiO_(3)*** molarity of NaOH in the mixtures ranged from 10 mol·L^(−1)to 16 mol·L^(−1),and the Na_(2)SiO_(3)/NaOH ratio was varied from 1.5 to *** samples were produced using three binder combinations:1)GBS as the only binder;2)blended binder with a slag-to-fly ash ratio of 3:1;and 3)mixed binder with 1:1 ratio of slag to fly *** samples were mixed and cured at(22±2)°C till the day of the *** impact of activator solution alkalinity,activator ratio Na_(2)SiO_(3)/NaOH,GBS content on the rate of water absorption were *** 7,28,and 90 d of immersion in a 10%sulfuric acid solution,the resistance of a geopolymer matrix to degradation was assessed by measuring the change in sample *** influence of solution alkalinity and relative fly ash content on setting times was ***-activated mortar with a slag-to-fly ash ratio of 3:1 had the least sorptivity compared to the two other binder combinations,at each curing age,and for mortars made with each of the NaOH alkaline activator *** sorptivity decreased with age and sodium hydroxide concentrations,suggesting the production of geopolymerization *** reduction in weight of sample occurred after immersion in the strong acid H_(2)SO_(4)solution for three months,regardless of binder *** was due to the synthesis of hydration and geopolymerization products in the presence of curing water,which outweighed the degradation of the geopolymer matrix caused by sulfuric acid.

关键词： alkali-activated materials fly ash sorptivity durability of concrete sodium hydroxide sodium silicates reduction in CO_(2)emissions sulfuric acid

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Polymeric nanocarriers for nose-to-brain drug delivery in neurodegenerative diseases and neurodevelopmental disorders

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Acta Pharmaceutica Sinica B 2023年第5期13卷 1866-1886页

作者： rania Awad Avi Avital Alejandro Sosnik Laboratory of Pharmaceutical Nanomaterials Science Department of Materials Science and EngineeringTechnion-Israel Institute of TechnologyHaifa 3200003Israel Behavioral Neurobiology Laboratory Department of Occupational TherapyFaculty of Social Welfare and Health SciencesUniversity of HaifaHaifa 3498838Israel

Neurodegenerative diseases are progressive conditions that affect the neurons of the central nervous system(CNS)and result in their damage and *** disorders include intellectual disability,autism spectrum disorder,and attention-deficit/hyperactivity disorder and stem from the disruption of essential neurodevelopmental *** treatment of neurodegenerative and neurodevelopmental conditions,together affecting~120 million people worldwide,is challenged by the blood—brain barrier(BBB)and the blood—cerebrospinal fluid barrier that prevent the crossing of drugs from the systemic circulation into the *** nose-to-brain pathway that bypasses the BBB and increases the brain bioavailability of intranasally administered drugs is promising to improve the treatment of CNS *** pathway is more efficient for nanoparticles than for solutions,hence,the research on intranasal nano-drug delivery systems has grown exponentially over the last *** nanoparticles have become key players in the field owing to the high design and synthetic *** review describes the challenges faced for the treatment of neurodegenerative and neurodevelopmental conditions,the molecular and cellular features of the nasal mucosa and the contribution of intranasal nano-drug delivery to overcome ***,a comprehensive overview of polymeric nanocarriers investigated to increase drug bioavailability in the brain is introduced.

关键词： Neurodegenerative diseases Neurodevelopmental disorders Central nervous system Blood—brain barrier Nano-drug delivery systems Nose-to-brain pathway Intranasal administration Polymeric nanoparticles Polymeric micelles Dendrimers

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Applying design science approach to architectural design development

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Frontiers of Architectural Research 2020年第1期9卷 216-235页

作者： rania Aburamadan Claudia Trillo School of Architecture University of PhiladelphiaAmmanJordan School of Built Environment University of SalfordLancashireUK

Unlike research methods for social and positivist sciences,those for architectural design lack a discipline-specific conceptual *** science aims at producing outcomes for future use and therefore needs a robust methodological approach that encompasses different techniques and methods supporting an evidence-based architectural design *** study suggests that design science can be successfully applied to architectural design development and provides architects and designers with a powerful tool bridging the gap between research and *** so doing,this study explores the application of design science to implement a user-centered design approach.A design challenge is reframed within the robust framework of design science by referring to a case study on refugee *** traditional method by which shelter optimization is pursued by designers is questioned by involving the final users through an ethnographic approach within the framework of design *** design outcome produced through this process is a list of specifications allowing designers to create different architectural solutions and matching the requirements expressed by future *** authors argue that a user-centered design outcome can be achieved and validated through design science.

关键词： Design science Architectural design research methodology User-centered design Refugee shelter

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Singing Punishment and Redemption in the Taiping Civil War： Yu Zhrs Plays

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Frontiers of History in China 2018年第2期13卷 211-226页

作者： rania Huntington Department of Asian Languages and Cultures University of Wisconsin-Madison Madison 1220WI 53706 USA

Among the dramatists who depicted the Taiping Civil War, attempting to find meaning in the carnage and chaos, Yu Zhi （1809-74） is unique. He wrote plays during and after the war, so he considers the chaos from two historical vantage points. As one of the earliest literati to write plays in the newly popular pihuang form, he addressed different actual and imagined audiences compared to his peers. Although virtually all extant plays take an absolute anti-Taiping stance, his plays differ from his contemporaries＇ in their focus on morality rather than sentiment, and on edification rather than commemoration. At the root of these differences is an understanding of the nature of evil, redemption, and belief.

关键词： Taiping Civil War Yu Zhi drama didacticism

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Study of the prevalence and association of ocular chlamydial conjunctivitis in women with genital infection by Chlamydia trachomatis, Mycoplasma genitalium and Candida albicans attending outpatient clinic

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International Journal of Ophthalmology(English edition) 2016年第8期9卷 1176-1186页

作者： rania Abdelmonem Khattab Maha Mohssen Abdelfattah Microbiology and Immunology Department Faculty of Pharmacy Cairo University Microbiology and Immunology Department Research Institute of Ophthalmology

AIMTo determine the association between chlamydial conjunctivitis and genital infection by Chlamydia trachomatis, Mycoplasma genitalium and Candida albicans, in addition to the possible relationship between cultured bacterial pathogens and oculogenital chlamydial *** study was performed on 100 (50 symptomatic and 50 asymptomatic) women attending the Gynecological and Obstetric outpatient clinic of Alzahra hospital, Alazhar University. Simultaneously a conjunctival swab was taken from these patients. Polymerase chain reaction (PCR) was done on DNA extracted from both vaginal and conjunctival swab samples. Culture for both vaginal and conjunctival swabs was also *** albicans was the predominant organism isolated by culture in 20% and 40% of conjunctival and vaginal swabs respectively. By the PCR method, ocular Chlamydia trachomatis was present in 60% of symptomatic women, while genital Chlamydia trachomatis infection was present in 30% of symptomatic women. The results of this method also indicated that 25/50 (50%) vaginal swabs were positive with PCR for Candida albicans versus 15/50 (30%) were PCR positive in conjunctival swab. Mycoplasma genitalium was present in only 10% of vaginal swabs. Concomitant oculogenital PCR positive results for Chlamydia trachomatis and Candida albicans were 30% and 28% *** Chlamydia trachomatis was associated with genital Chlamydia trachomatis in a high percentage of women followed by Candida albicans. Cultured bacterial organisms do not play a role in enhancement of Chlamydia trachomatis infection.

关键词： Chlamydia trachomatis Mycoplasma genitalium Candida albicans vaginal swabs polymerase chain reaction

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Application of an Artificial Neural Network Method for the Prediction of the Tube-Side Fouling Resistance in a Shell-And-Tube Heat Exchanger

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Fluid Dynamics & Materials Processing 2022年第5期18卷 1511-1519页

作者： rania Jradi Christophe Marvillet Mohamed-Razak Jeday Research Laboratory“Process EnergyEnvironment&Electrical Systems”National Engineering School of GabesGabes6029Tunisia CMGPCE Laboratory French Institute of Refrigeration(IFFI)National Conservatory of Arts and Crafts(CNAM)Paris75141France

The accumulation of undesirable deposits on the heat exchange surface represents a critical issue in industrial heat *** experimental measurements of the fouling is relatively difficult and,often,this method does not lead to precise *** overcome these problems,in the present study,a new approach based on an Artificial Neural Network(ANN)is used to predict the fouling resistance as a function of specific measurable variables in the phosphoric acid concentration *** include:the phosphoric acid inlet and outlet temperatures,the steam temperature,the phosphoric acid density,the phosphoric acid volume flow rate circulating in the *** statistical accuracy indices are employed simultaneously to justify the interrelation between these independent variables and the fouling resistance and to select the best training algorithm allowing the determination of the optimal number of hidden *** particular,the BFGS quasi-Newton back-propagation approach is found to be the most performing of the considered training ***,the best topology ANN for the shell and tube heat exchanger is obtained with a network consisting of one hidden layer with 13 neurons using a tangent sigmoid transfer function for the hidden and output *** model predicts the experimental values of the fouling resistance with AARD%=0.065,MSE=2.168×10^(−11),RMSE=4.656×10^(−6)and r^(2)=0.994.

关键词： Artificial neural network fouling resistance phosphoric acid concentration process shell-and-tube heat exchanger

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Human papillomavirus-related squamous cell carcinoma of the anal canal with papillary features

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World Journal of Gastroenterology 2015年第7期21卷 2210-2213页

作者： Marino E Leon rania Shamekh Domenico Coppola Department of Anatomic Pathology H. Lee Moffitt Cancer Center and Research Institute Department of Pathology and Cell Biology University of South Florida

Human papillomavirus(HPV)related squamous cell carcinoma(SCC)involving the anal canal is a well-known carcinoma associated with high-risk types of *** SCC with papillary morphology(papillary SCC)has been described in the *** describe,for the first time,a case of anal HPV-related squamous carcinoma with papillary *** tumor arose from the anal *** biopsies revealed a superficially invasive SCCwith prominent papillary features and associated in situ *** tumor cells were positive for p16 and were also positive for high-risk types of HPV using chromogenic in situ *** findings are consistent with a HPV-related SCC of the anal canal with papillary *** tumor shows histologic features similar to a papillary HPV-related SCC of the *** studies are needed to characterize these lesions.

关键词： Anus Squamous cell carcinoma Papillary Human papil

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