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The C161T Polymorphism in Peroxisome Proliferator-Activated Receptor ɣ2, but Not Pro12Ala, Is Associated with Diabetic Retinopathy in Type 2 Diabetes Mellitus in an Egyptian Population

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Journal of Diabetes Mellitus 2016年第1期6卷 1-9页

作者： Ragaa Abelkader Ramadan Moyassar Ahmad Zaki rania mohamed el sharkawy Lubna mohamed Desouky Marwa Ahmed Madkour Karim Mahmoud Nabil mohamed Kamel Chemical Pathology Department Medical Research Institute Alexandria University Alexandria Egypt Department of Human Genetics Medical Research Institute Alexandria University Alexandria Egypt Clinical and Experimental Internal Medicine Department Medical Research Institute Alexandria University Alexandria Egypt Department of Ophthalmology Faculty of Medicine Alexandria University Alexandria Egypt

Objectives: Diabetic retinopathy (DR) is one of the most common microvascular complications of type 2 diabetes mellitus (T2DM). It is multifactorial with the contribution of multiple genetic factors. We questioned the association of polymorphisms in the peroxisome proliferator-activated receptor ?2 (PPAR?2) gene (Pro12Ala and C161T) with DR in an Egyptian population. Methods: This case control study included one hundred healthy individuals and 252 T2DM among them 122 with DR and 130 without DR. Genotyping was done by polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP). Results: The Pro12Ala Ala allele was associated with decreased risk of DR with an odds ratio (OR) of 0.484, 95% confidence interval (CI) (0.254 - 0.920), and a p value = 0.024. The C161T T allele was associated with increased risk of DR with OR = 2.593, 95% CI (1.672 - 4.020), p 1c) in multivariate regression analysis only C161T was associated with increased risk of DR with OR = 3.479, 95% CI (1.907 - 6.346), p 1c was higher in Pro/Pro genotype when compared to those with Ala/Ala and Pro/Ala genotypes. Conclusion: We report that T allele of C161T increased risk of DR in the studied population. Further studies are warranted to investigate functional implications of polymorphisms of the PPAR-? gene in DR development.

关键词： Type 2 Diabetes Mellitus Diabetic Retinopathy Polymorphism PPAR០ Pro12Ala C161T

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The impact of foot reflexology on fatigue and sleep quality in school-aged children undergoing hemodialysis

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Journal of Integrative Nursing 2024年第2期6卷 76-82页

作者： Amal Hashem mohamed Mostafa SHABAN Huda Hamdy MOHAMMED Randa mohamed ABOBAKER Salman Hamdan ALSAQRI rania Abd-elnaby Mohammed ALLAM Faculty of Nursing Minia UniversityMinyaEgypt College of Nursing Jouf UniversitySakakaSaudi Arabia Faculty of Nursing Cairo UniversityGizaEgypt Northern College of Nursing ARARSaudi Arabia College of Nursing University of HailHailSaudi Arabia

Objective:This study aimed to evaluate the effects of foot reflexology on fatigue and sleep quality in school-aged children receiving ***:A quasi-experimental pretest-posttest design was *** children of ages 6-12 undergoing in-center hemodialysis were *** Pittsburgh Sleep Quality Index(PSQI)and Inventory of Fatigue Symptom(IFS)scales were administered at *** then received 30 min of foot reflexology massage before hemodialysis sessions 3 days per week for 12 *** administration of the sleep and fatigue scales occurred after the intervention ***:Reflexology massage led to significant improvements in sleep quality components,including duration(0%-30%normal sleepers),efficiency(0%-50%>85%),latency(50%-0%>60 min),disturbances,and daytime *** mean PSQI score decreased from 18.2 to 9.7(P<0.05).Fatigue severity substantially decreased,with the mean IFS score improving from 105.7 to 64.1(P<0.05).Conclusion:Foot reflexology is an effective nursing intervention for reducing fatigue and improving sleep quality in children on hemodialysis,warranting integration into routine care.

关键词： Fatigue hemodialysis massage pediatric reflexology sleep

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Remote Monitoring of electric Vehicle Charging Stations in Smart Campus Parking Lot

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Journal of Modern Power Systems and Clean Energy 2020年第1期8卷 124-132页

作者： mohamed A.Ahmed mohamed R.el-sharkawy Young-Chon Kim Department of electronic Engineering Universidad Técnica Federico Santa MaríaValparaíso 2390123Chile Department of Communications and electronics Higher Institute of Engineering&TechnologyKing MarriottAlexandria 23713Egypt Department of Automotive and Tractor Engineering Minia UniversityEl-Minia 61111Egypt Department of Computer Engineering Chonbuk National UniversityJeonju 561-756Korea

Smart parking lots are smart places capable of supporting both parking and charging services for electric vehicles(EVs).In order to manage EV charging,the parking lot local controller(PLLC)requires data exchange with EV charging stations(EVCSs)through communication ***,data losses and communication delays are unavoidable and may significantly degrade the system *** work aims to investigate the underlying communication networks for remote monitoring of EVCSs in a smart campus parking *** communication network consists of two subnetworks:parking area network(PAN)and campus area network(CAN).PAN covers communication among EVs,charging stations and PLLC,while CAN enables dedicated communication between PLLCs and a global controller of the *** one of the major obstacles in EV system is the lack of unified communication architecture to integrate EVCS in the power grid,we develop communication models for the in-vehicle system and EVCSs based on logical node concept of IEC 61850 ***,we implement network models for EVCSs using OPNET *** communication technologies and configurations are considered in modeling and simulations,and end-toend delay is evaluated and discussed.

关键词： Communication network electric vehicle(EV) electric vehicle charging station(EVCS) IEC 61850 OPNET smart parking lot

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Patterns of liver profile disturbance in patients with COVID-19

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World Journal of Clinical Cases 2022年第7期10卷 2063-2071页

作者： Hend Ibrahim Shousha Ahmed Ramadan rania Lithy mohamed el-Kassas Department of Endemic Medicine Faculty of MedicineCairo UniversityCairo 12556Egypt Department of Endemic Medicine Faculty of MedicineHelwan UniversityCairo 11795Egypt

Fever and cough are the most common clinical symptoms of coronavirus disease 2019(COVID-19),but complications(such as pneumonia,respiratory distress syndrome,and multiorgan failure)can occur in people with additional ***-19 may be a new cause of liver disease,as liver profile disturbance is one of the most common findings among *** molecular mechanism underlying this phenomenon,however,is still *** this paper,we review the most current research on the patterns of change in liver profile among patients with COVID-19,the possible explanation for these findings,and the relation to pre-existing liver disease in these patients.

关键词： Liver functions COVID-19 Liver profile Alanine transaminase aspartate transaminase Bilirubin

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Resistance to acid degradation,sorptivity,and setting time of geopolymer mortars

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Frontiers of Structural and Civil Engineering 2022年第6期16卷 781-791页

作者： Osama A mohamed rania AL-KHATTAB Waddah AL-HAWAT College of Engineering Abu Dhabi UniversityAbu DhabiUnited Arab Emirates

Experimental evaluations were conducted to determine the water sorptivity,setting time,and resistance to a highly acidic environment,of mortar with alkali-activated ground granulated blast furnace slag(GBS)binder and also of combinations of fly ash and GBS *** were activated using mixtures of NaOH and Na_(2)SiO_(3)*** molarity of NaOH in the mixtures ranged from 10 mol·L^(−1)to 16 mol·L^(−1),and the Na_(2)SiO_(3)/NaOH ratio was varied from 1.5 to *** samples were produced using three binder combinations:1)GBS as the only binder;2)blended binder with a slag-to-fly ash ratio of 3:1;and 3)mixed binder with 1:1 ratio of slag to fly *** samples were mixed and cured at(22±2)°C till the day of the *** impact of activator solution alkalinity,activator ratio Na_(2)SiO_(3)/NaOH,GBS content on the rate of water absorption were *** 7,28,and 90 d of immersion in a 10%sulfuric acid solution,the resistance of a geopolymer matrix to degradation was assessed by measuring the change in sample *** influence of solution alkalinity and relative fly ash content on setting times was ***-activated mortar with a slag-to-fly ash ratio of 3:1 had the least sorptivity compared to the two other binder combinations,at each curing age,and for mortars made with each of the NaOH alkaline activator *** sorptivity decreased with age and sodium hydroxide concentrations,suggesting the production of geopolymerization *** reduction in weight of sample occurred after immersion in the strong acid H_(2)SO_(4)solution for three months,regardless of binder *** was due to the synthesis of hydration and geopolymerization products in the presence of curing water,which outweighed the degradation of the geopolymer matrix caused by sulfuric acid.

关键词： alkali-activated materials fly ash sorptivity durability of concrete sodium hydroxide sodium silicates reduction in CO_(2)emissions sulfuric acid

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Introduction of longstanding complicated sulcus intraocular lens into the intact capsular bag

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International Journal of Ophthalmology(English edition) 2021年第11期14卷 1779-1783页

作者： Fathy Fawzy Morkos Nader Fathy Fawzy mohamed el Bahrawy rania Serag elkitkat Watany Research and Development Center Watany Eye HospitalCairo 11799Egypt Department of Ophthalmology Faculty of MedicineAin Shams UniversityCairo 11799Egypt

AIM:To propose a surgical technique that successfully reopened the empty and intact capsular bag after long periods of closure,with repositioning of the intraocular lens(IOL)from the ciliary sulcus into its preferred habitat inside the capsular ***:This is a case series,prospective,and interventional *** technique was first performed on an aphakic high myope with a closed posterior capsule for 18 ***,five patients with recurrently displaced sulcus IOLs for a range of 1 mo to 7 y were performed for the same *** surgery,identifying a"telltale white line"was an important landmark for detecting the site of major adhesions between the edge of the capsulorhexis and the posterior *** adhesions were freed using combined manual and viscoelastic dissection,followed by an easier freeing of adhesions along the whole capsular *** IOL was safely implanted,exchanged,or introduced from the sulcus into the fibrotic and closed capsular *** were followed up for a period ranging from 6 to 17 mo ***:All the patients experienced a remarkable improvement in their subjective *** lamp examination showed a postoperative centralized IOL in the *** follow up visits confirmed visual and IOL ***:This newly-introduced surgical technique facilitates the reopening of the empty yet intact capsular bag that has been closed by fibrotic proliferations,with secured implantation of the IOL inside the capsular *** with inadvertent implantation of IOLs into the ciliary sulcus,yet having an intact capsular bag,can benefit from this technique.

关键词： late in the bag technique displaced sulcus lOLs post cataract visual rehabilitation closed capsular lens bag

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Biological silicon nanoparticles improve Phaseolus vulgaris L. yield and minimize its contaminant contents on a heavy metals-contaminated saline soil

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Journal of Environmental Sciences 2021年第8期33卷 1-14页

作者： mohamed T.el-Saadony el-Sayed M.Desoky Ahmed M.Saad rania S.M.Eid Eman Selem Ahmed S.elrys Department of Agricultural Microbiology Faculty of AgricultureZagazig UniversityZagazig 44511Egypt Botany Department Faculty of AgricultureZagazig UniversityZagazig 44511Egypt Biochemistry Department Faculty of AgricultureZagazig UniversityZagazig 44511Egypt Agricultural Botany Department Faculty of AgricultureBenha University13736Egypt Botany and Microbiology Department Faculty of ScienceZagazig University44511Egypt Soil Science Department Faculty of AgricultureZagazig University44511ZagazigEgypt

The synthesis of biological silicon nano-particles(Bio-Si-NPs)is an eco-friendly and lowcost *** is no study focusing on the effect of Bio-Si-NPs on the plants grown on saline soil contaminated with heavy *** this study,an attempt was made to synthesis Bio-Si-NPs using potassium silica florid substrate,and the identified Aspergillus tubingensis AM11 isolate that separated from distribution systems of the potable water.A twoyear field trial was conducted to compare the protective effects of Bio-Si-NPs(2.5 and 5.0 mmol/L)and potassium silicate(10 mmol/L)as a foliar spray on the antioxidant defense system,physio-biochemical components,and the contaminants contents of Phaseolus vulgaris *** on saline soil contaminated with heavy *** findings showed that all treatments of Bio-Si-NPs and potassium silicate significantly improved plant growth and production,chlorophylls,carotenoids,transpiration rate,net photosynthetic rate,stomatal conductance,membrane stability index,relative water content,free proline,total soluble sugars,N,P,K,Ca2+,K+/Na+,and the activities of peroxidase,catalase,ascorbic peroxidase and superoxide oxide *** of Bio-Si-NPs and potassium silicate significantly decreased electrolyte leakage,malondialdehyde,H2 O2,O2·-,Na+,Pb,Cd,and Ni in leaves and pods of Phaseolus vulgaris *** to ***-Si-NPs were more effective compared to potassium *** of Bio-Si-NPs at the rate of 5 mmol/L was the recommended treatment to enhance the performance and reduce heavy metals content on plants grown on contaminated saline soils.

关键词： Bean Silicon Nano-silicon Aspergillus tubingensis AM11 Salinity Heavy metals

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Application of an Artificial Neural Network Method for the Prediction of the Tube-Side Fouling Resistance in a Shell-And-Tube Heat Exchanger

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Fluid Dynamics & Materials Processing 2022年第5期18卷 1511-1519页

作者： rania Jradi Christophe Marvillet mohamed-Razak Jeday Research Laboratory“Process EnergyEnvironment&Electrical Systems”National Engineering School of GabesGabes6029Tunisia CMGPCE Laboratory French Institute of Refrigeration(IFFI)National Conservatory of Arts and Crafts(CNAM)Paris75141France

The accumulation of undesirable deposits on the heat exchange surface represents a critical issue in industrial heat *** experimental measurements of the fouling is relatively difficult and,often,this method does not lead to precise *** overcome these problems,in the present study,a new approach based on an Artificial Neural Network(ANN)is used to predict the fouling resistance as a function of specific measurable variables in the phosphoric acid concentration *** include:the phosphoric acid inlet and outlet temperatures,the steam temperature,the phosphoric acid density,the phosphoric acid volume flow rate circulating in the *** statistical accuracy indices are employed simultaneously to justify the interrelation between these independent variables and the fouling resistance and to select the best training algorithm allowing the determination of the optimal number of hidden *** particular,the BFGS quasi-Newton back-propagation approach is found to be the most performing of the considered training ***,the best topology ANN for the shell and tube heat exchanger is obtained with a network consisting of one hidden layer with 13 neurons using a tangent sigmoid transfer function for the hidden and output *** model predicts the experimental values of the fouling resistance with AARD%=0.065,MSE=2.168×10^(−11),RMSE=4.656×10^(−6)and r^(2)=0.994.

关键词： Artificial neural network fouling resistance phosphoric acid concentration process shell-and-tube heat exchanger

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Towards hepatitis C virus elimination:Egyptian experience,achievements and limitations

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World Journal of Gastroenterology 2018年第38期24卷 4330-4340页

作者： Dalia Omran mohamed Alboraie rania A Zayed mohamed-Naguib Wifi Mervat Naguib mohamed eltabbakh mohamed Abdellah Ahmed Fouad Sherief Sahar Maklad Heba Hamdy eldemellawy Omar Khalid Saad Doaa mohamed Khamiss mohamed el Kassas Department of Endemic Medicine and Hepatology Faculty of MedicineCairo UniversityCairo 11651Egypt Department of Endemic Medicine Faculty of MedicineHelwan UniversityCairo 11599Egypt Department of Internal Medicine Al-Azhar UniversityCairo 11651Egypt Department of Clinical and Chemical Pathology Faculty of MedicineCairo UniversityCairo 11651Egypt Department of Internal Medicine Faculty of MedicineCairo UniversityCairo 11599Egypt Department of Tropical Medicine Faculty of MedicineAin Shams UniversityCairo 11566Egypt National Hepatology and Tropical Medicine Research Institute Cairo 11599Egypt Department of Internal Medicine Faculty of MedicineBeni-Suef UniversityBeni-Suef 62511Egypt Faculty of Medicine Ain Shams UniversityCairo 11566Egypt Department of Clinical and Chemical Pathology El-monera hospitalMinistry of HealthCairo 11562Egypt

Worldwide, more than one million people die each year from hepatitis C virus(HCV) related diseases, and over 300 million people are chronically infected with hepatitis B or C. Egypt used to be on the top of the countries with heavy HCV burden. Some countries are making advances in elimination of HCV, yet multiple factors preventing progress; remain for the majority. These factors include lack of global funding sources for treatment, late diagnosis, poor data, and inadequate screening. Treatment of HCV in Egypt has become one of the top national priorities since 2007. Egypt started a national treatment program intending to provide cure for Egyptian HCV-infected patients. Mass HCV treatment program had started using Pegylated interferon and ribavirin between 2007 and 2014. Yet, with the development of highly-effective direct acting antivirals(DAAs) for HCV, elimination of viral hepatitis has become a real possibility. The Egyptian National Committee for the Control of Viral Hepatitis did its best to provide Egyptian HCV patients with DAAs. Egypt adopted a strategy that represents a model of care that could help other countries with high HCV prevalence rate in their battle against HCV. This review covers the effects of HCV management in Egyptian real life settings and the outcome of different treatment protocols. Also, it deals with the current and future strategies for HCV prevention and screening as well as the challenges facing HCV elimination and the prospect of future eradication of HCV.

关键词： Hepatitis C virus Egypt Direct acting antivirals screening elimination Limitations

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Effect of Plant Growth Stimulants on Alfalfa Response to Salt Stress

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Agricultural Sciences 2017年第4期8卷 267-291页

作者： Mahmoud el-sharkawy Talaat el-Beshsbeshy rania Al-Shal Ali Missaoui Soil Science and Water Department Faculty of Agriculture Tanta University Tanta Egypt Department of Crop and Soil Sciences Institute of Plant Breeding Genetics and Genomics University of Georgia Athens USA

Salinity is a major impediment to crop production. This study was undertaken to compare the effect of seaweed extract, humic acid, and potassium sulfate nanoparticles in alleviating salt stress in Alfalfa (Medicago sativa L.). Seeds of ten alfalfa genotypes were germinated in a growth chamber at five salt concentrations (0%, 0.5%, 1.0%, 1.5%, and 2.00%). Salt concentrations above 1% reduced seed germination by more than 70% in most genotypes. One salt tolerant genotype (Mesa-Sirsa) and one salt sensitive (Bulldog 505) were selected and planted in greenhouse pots containing 2 kg of sand and subjected to two salt levels (10 and 15 dS· m-1). Four treatments consisting of 1) control (Hoagland solution, no-salt), 2) seaweed extract at 4 Kg·ha-1, 3) humic acid at 28 L· ha-1, and 4) potassium sulfate at 300 Kg· ha-1. Plant biomass was reduced under both salt concentrations in both genotypes, with a greater magnitude in the salt sensitive genotype. Application of seaweed extract resulted in higher relative water content and proline under both salt concentrations (10 and 15 dS·m-1) in the salt sensitive genotype, and lower electrolyte leakage in both salt tolerant and salt sensitive genotypes, under both salt concentrations. Seaweed extract also resulted in higher catalase and SOD activities in both genotypes under 10 dS·m-1. Catalase and SOD activities were associated with significantly (p electrolyte leakage and increased shoot dry weight. Overall, seaweed extract seemed to have a positive effect in alleviating salt stress in alfalfa.

关键词： Biological Growth Stimulants Humic Acid Salt Stress Seaweed Extract Potassium Nanoparticles

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