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maternal vitamin D level and vitamin D receptor gene polymorphism as a risk factor for congenital heart diseases in offspring;An Egyptian case-control study

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Genes & Diseases 2019年第2期6卷 193-200页

作者： Wesam A.mokhtar Amal Fawzy Reem m.Allam rania m.Amer mona S.Hamed Pediatric Department Faculty of MedicineZagazig UniversityEgypt medical Biochemistry Department Faculty of MedicineZagazig UniversityEgypt Clinical Pathology Department Faculty of MedicineZagazig UniversityEgypt medical microbiology and Immunology Department Faculty of MedicineZagazig UniversityEgypt Public Health and Community medicine Faculty of MedicineZagazig UniversityEgypt

Vitamin D&vitamin D receptor(VDR)signaling play a very crucial role in early embryonic heart *** construct this case-control study to investigate the association between maternal serum vitamin D level&VDR gene Fok1 polymorphism and risk of congenital heart defects(CHD)in *** mothers who had term neonates with CHD were considered as *** age-comparable healthy mothers who had neonates without CHD were contemplated as *** serum 25 hydroxyvitamin D[25(OH)D]level was tested using *** VDR gene Fok1 polymorphism was analyzed using PCR-based *** was a significant decrease in maternal vitamin D level(P=0.002)and a significant increase in vitamin D deficient status(P=0.007)among cases when compared to *** gene Fok1 genotypes distribution frequency were in accordance with Hardy Weinberg equilibrium(HW)among controls.A significant increase in VDR gene Fok1 F/f&f/f genotypes and f allele were observed in cases compared to controls with estimated odds ratio(95%confidence interval)&P-value of 3(1e8)&P=0.006,11(1e97)&P=0.01 and 3(2e6)&P=0.001 *** was a significant decrease in maternal vitamin D level in neonates with cyanotic CHD(P=0.000)compared to those with a cyanotic CHD while there was no significant difference in VDR Fok1 genotype(P=0.18)&allele(P=0.05)distribution between two *** concluded that maternal vitamin D deficiency and VDR gene Fok1 F/f,f/f genotype and f allele were associated with increased risk of CHD in offspring.

关键词： Congenital heart disease FoK1 polymorphism Vitamin D Vitamin D receptor gene maternal vitamin D

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Current and Future Treatment of Hepatocellular Carcinoma:An Updated Comprehensive Review

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Journal of Clinical and Translational Hepatology 2018年第1期6卷 69-78页

作者： Saleh Daher muhammad massarwa Ariel A. Benson tawfik Khoury Gastroenterology and Liver Units Department of MedicineHadassah-Hebrew University Medical CenterJerusalemIsrael

Hepatocellular carcinoma(HCC)is among the leading causes of cancer-related *** principal treatment is surgical resection or liver transplantation,depending on whether the patient is a suitable transplant ***,in most patients with HCC the diagnosis is often late,thereby excluding the patients from definitive surgical *** treatment includes sorafenib,which is the most commonly used systemic therapy;although,it has been shown to only minimally impact patient survival by several *** and radiotherapy are generally *** to the poor prognosis of patients with HCC,newer treatments are needed with several being in development,either in preclinical or clinical *** this review article,we provide an update on the current and future medical and surgical management of HCC.

关键词： HCC Treatments Sorafenib mortality

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Preserving Privacy of User Identity Based on Pseudonym Variable in 5G

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Computers, materials & Continua 2022年第3期70卷 5551-5568页

作者： mamoon m.Saeed mohammad Kamrul Hasan Rosilah Hassan rania mokhtar Rashid A.Saeed Elsadig Saeid manoj Gupta Electrical Engineering Department Faculty of EngineeringAlzaiem Alazahri UniversityKhartoumSudan Center for Cyber Security Faculty of Information Science and TechnologyUniversiti KebangsaanMalaysia(UKM)43600BangiMalaysia Department of Computer Engineering College of Computers and Information TechnologyTaif UniversityPO Box 11099Taif21944Saudi Arabia Department of Electronics Engineering College of EngineeringSudan University of Science and TechnologyKhartoumSudan Department of Electronics and Communication Engineering JECRC UniversityJaipurIndia

The fifth generation(5G)system is the forthcoming generation of the mobile communication *** has numerous additional features and offers an extensively high data rate,more capacity,and low ***,these features and applications have many problems and issues in terms of security,which has become a great challenge in the telecommunication *** paper aimed to propose a solution to preserve the user identity privacy in the 5G system that can identify permanent identity by using Variable mobile Subscriber Identity,which randomly changes and does not use the permanent identity between the user equipment and home *** this mechanism,the user identity privacy would be secured and ***,it improves the synchronization between mobile users and home ***,its compliance with the Authentication and Key Agreement(AKA)structure was adopted in the previous *** can be deployed efficiently in the preceding generations because the current architecture imposes minimal modifications on the network parties without changes in the authentication vector’s message ***,the addition of any hardware to the AKA carries minor adjustments on the network *** this paper,the ProVerif is used to verify the proposed scheme.

关键词： 5G privacy and security user identity ImSI authentication and key agreement(AKA)

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Safety and efficacy of ultrasound ciliary plasty as a primary intervention in glaucoma patients

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International Journal of Ophthalmology(English edition) 2019年第4期12卷 597-602页

作者： magda A.Torky Yousif A Al Zafiri Sherein m.Hagras Abeer m.Khattab rania m.Bassiouny Tharwat H.mokbel Department of Ophthalmology Faculty of Medicine Mansoura University Department of Ophthalmology Dar AlS hifa Hospital

AIm: To evaluate the safety and the efficacy of the ultrasound ciliary plasty(UCP) on the intraocular pressure(IOP) control in glaucomatous eyes without previous glaucoma ***: A retrospective study included patients with primary and secondary glaucoma who underwent UCP in Dar Al Shifa Hospital, Kuwait between January 2017 to June 2018. High-intensity focused ultrasound procedures were performed under peribulbar anesthesia using the 2^(nd) generation probe with 8 s duration of each of the 6 shots. Complete ophthalmologic examinations were scheduled pre-treatment, and at 1 d, 1 wk, 1, 3, 6 and 12 mo posttreatment. Primary outcomes were the IOP reduction and success rates at 12 mo, while the secondary outcomes were the occurrence of vision threatening complications and visual ***: The records of 62 eyes of 62 patients were analyzed with mean age of 63.8 y(67.7% males). There was statistically significant reduction in the mean IOP from 35.2±8.3 mm Hg before treatment to 20.6±8.7 mm Hg at 12^(th) month(Pmean percentage IOP reduction of 42.3% with significant reduction in the mean number of antiglaucomatous drugs from 3.2±0.4 before treatment to 2.1±1.02 at 12 mo(Pmo. No major intra-or posttreatment complications were ***: Second-generation UCP prove to be effective in reducing IOP in naive glaucoma patients with lower success rates in cases of neovascular and uveitic glaucomas.

关键词： ultrasound ciliary plasty glaucoma intraocular pressure

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Changing dietary n-6:n-3 ratio using different oil sources affects performance,behavior,cytokines mRNA expression and meat fatty acid profile of broiler chickens

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Animal Nutrition 2018年第1期4卷 -页

作者： Doaa Ibrahim rania El-Sayed Safaa I.Khater Enas N.Said Shefaa A.m.El-mandrawy Department of Nutrition and Clinical Nutrition Faculty of Veterinary MedicineZagazig University Department of Biochemistry Faculty of Veterinary MedicineZagazig University Department of Veterinary Public Health Faculty of Veterinary MedicineZagazig University Department of Clinical Pathology Faculty of Veterinary MedicineZagazig University

Typical formulated broiler diets are deficient in n-3 poly-unsaturated fatty acids(PUFA) due to widening n-6:n-3 PUFA ratio which could greatly affect performance,immune system of birds and,more importantly,meat *** study was conducted to evaluate the effect of modifying dietary n-6:n-3 PUFA ratio from plant and animal oil sources on performance,behavior,cytokine m RNA expression,antioxidative status and meat fatty acid profile of broiler ***(n=420) were fed 7 diets enriched with different dietary oil sources and ratios as follows: sunflower oil in control diet(C); fish oil(FO); 1:1 ratio of sunflower oil to FO(C1 FO1); 3:1 ratio of sunflower oil to fish oil(C3 FO1); linseed oil(LO); 1:1 ratio of sunflower oil to linseed oil(C1 LO1); 3:1 ratio of sunflower oil to linseed oil(C3 LO1),resulting in dietary n-6:n-3 ratios of approximately 40:1,1.5:1,4:1,8:1,1:1,2.5:1 and 5:1,*** best final body weight,feed conversion ratio as well as protein efficiency ratio of broilers were recorded in the C1 FO1 and C1 LO1 *** with the control group,the dressing percentage and breast and thigh yield were highest in the C1 FO1 and C1 LO1 *** the dietary n-6:n-3 ratio increased(P meat contents of eicosapentaenoic acid and docosahexaenoic acid increased(P m FO and LO clearly decreased(P m total cholesterol,triglycerides and very low-density lipoproteins and enhanced antioxidative *** feeding frequency was decreased(P mpared to plant oil,to broiler diets enhanced the relative m RNA expression of interferon gamma,interleukin-1 beta,interleukin-2 and

关键词： Broiler n-6:n-3 PUFA ratio Performance Antioxidant status meat Immunity

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Preparation of epoxy resin/rare earth doped aluminate nanocomposite toward photoluminescent and superhydrophobic transparent woods

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Journal of Rare Earths 2023年第3期41卷 397-405,I0003页

作者： mehrez E.El-Naggar Sami Ullah S.Wageh m.A.Abu-Saied tawfik A.Khattab Dalal Alhashmialameer manal Abou Taleb E.A.matter Institute of Textile Research and Technology National Research CenterDokkiCairo16221Egypt Research Center for Advanced materials Science(RCAmS) King Khalid UniversityP.O.Box 9004Abha61413Saudi Arabia Department of Chemistry College of ScienceKing Khalid UniversityP.O.Box 9004Abha61413Saudi Arabia Department of Physics Faculty of ScienceKing Abdulaziz UniversityJeddah21589Saudi Arabia K.A.CARE Energy Research and Innovation Center King Abdulaziz UniversityJeddah21589Saudi Arabia Polymeric materials Research Department Advanced Technology and New Materials Research InstituteCity of Scientific Research and Technological Applications(SRTACITY)New Borg El-Arab CityAlexandria21934Saudi Arabia Department of Chemistry College of ScienceTaif UniversityTaif21944Saudi Arabia Department of Chemistry College of Science and HumanitiesPrince Sattam Bin Abdulaziz UniversityAl-kharj11942Saudi Arabia Department of Polymer Chemistry National Center for Radiation Research and Technology(NCRRT)Egyptian Atomic Energy AuthorityNasr CityP.O.Box 7551Cairo11762Egypt Department of Chemistry Faculty of ScienceDamanhour University22111 DamanhourEgypt

A translucent wooden substrate with long-lasting phosphorescence,high photostability and durability,tough surface,ultraviolet protection,high optical transmittance,and superhydrophobicity was *** long-lasting phosphorescent wooden substrate is able to continue emitting light for extended time ***-modified wood(LmW)was immobilized with a solution of epoxy resin(ER)and rare-earth doped aluminate(REDA)phosphor nanoparticles(NPs).For an improved dispersion of pigment,REDA was synthesized in a nanoscale particle size,and characterized by transmission electron microscopy(TEm)to indicate a particle size of 8-14 *** crystal structure of REDA nanoparticles was also proved by X-ray diffraction(XRD).For an improved production of long-persistent phosphorescent colo rless woods,REDA must be well-dispersed in mAA without *** and emissio n,as well as decay and lifetime spectra were *** morphologies of the wooden substrates with different ratios of REDA were investigated by scanning electron microscopy(SEm),X-ray fluorescence(XRF)analysis,Fourier transform infrared spectra(FT-IR),elemental mapping,and energy-dispersion Xray(EDXA).The phosphorescent woods show changes in color from colorless to green under ultraviolet(UV)irradiation,and to yellowish-green in the dark,as proved by the colorimetric parameters of the CIE Lab *** afterglow wood samples display an absorbance band at 365 nm and two phosphorescent bands at 431 and 520 *** UV shielding,photostability,and hydrophobicity were *** increasing REDA ratio,both static contact and slide angles are found to improve in the ranges of147.6°-163.6°and 9°-14°,*** long-lasting photoluminescence is optimized at a REDA ratio of 8%.The present strategy shows a large-scale production approach of multiple functional woods for many potential applications,such as smart glow in the dark windows and safety signs.

关键词： Translucent wood Rare-earth doped aluminate Superhydrophobic Long-lasting light emission Ultraviolet protection

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Risk Assessment of mediterranean Sea Waters on Cooling System of Nuclear Power Plant

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Journal of Environmental Protection 2019年第6期10卷 738-744页

作者： m. S. tawfik F. S. tawfik Siting & Environmental Department NRRA Cairo Egypt

The study evaluated the impacts such as corrosion and scale formation which may result from, using the once-through pass cooling system of a suggested nuclear power at different selected coastal regions of Alexandria coast. (Abu-Qir, Sidi Kerrir, Estern Harbour, El max and Sidi Abd Elrhaman). The study had used The Langelier Saturation Index (LSI), which is a measure of a solution’s ability to dissolve or deposit calcium carbonate, which is often used as an indicator of the corrosivity of water. Like the Langelier saturation index, the Ryznar stability index (RSI) is also used to predicate the formation of scale and also the tendency for corrosion due to the concentration of calcium carbonate in the selected water system. Both of the two indexes ((LSI) and (RSI)) had been used to evaluate the internal environmental impact which may be occurred when used once-through pass system is as a cooling method of a coastal pressurized water reactor power plant. The study results showed that the calculated LSI and RSI values for selected regions indicated that, there was a low tendency for scale formation and possibility of corrosion at these selected study areas, so using nickel copper alloys in condenser is recommended to prevent any possibility of attack of corrosion besides the using of chemical treatment method of inlet cooling water system.

关键词： Cooling Water Corrosion Langelier Saturation Index

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Floc meal as potential substitute for soybean meal in tilapia diets under biofloc system conditions

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Journal of Oceanology and Limnology 2019年第1期37卷 313-320页

作者： rania S. mABROKE Osama m. EL-HUSSEINY Abd El-Naem F. A. ZIDAN Al-Azab TAHOUN Ashraf SULOmA Fish Nutrition Laboratory (FNL) Animal Production Department Faculty of Agriculture Cairo University Aquaculture Department Faculty of Fish ResourcesSuez University

This study was conducted to evaluate the ef fect of replacing soybean meal(SBm) by low protein ?oc meal(LPFm; 24% CP) in tilapia diets on growth performance, feed utilization and ?sh chemical composition. Three isonitrogenous and isocaloric diets were formulated; control diet(C; without LPFm),Fm 25(25% of SBm protein was substituted by LPFm) and Fm 50(50% of SBm protein was substituted by LPFm). Nine 55 l circular plastic tanks were stocked by 12 ?sh to form three experimental *** dif ferences in tilapia performance were observed between the control and the Fm 25 diet. Chemical composition of ?sh did not dif fer signi?cantly among treatments except for protein and selenium contents where the highest values were recorded in the control treatment. The highest mineral content was recorded in ?oc collected from the control tanks, while calcium content showed its highest value in ?oc collected from Fm 50 e ? uent. These data indicate that replacing soybean meal with LPFm up to 25%, had no negative ef fect on growth performance and potentially may improve the system sustainability. meanwhile, the adverse ef fect of more inclusion of LPFm in tilapia diet may be attributed to the higher content of ash. In other word,minerals seem to cause more energy utilization in ?sh fed ?oc meal since it is needed to maintain osmotic homeostasis.

关键词： microbial flocs alternative protein sources tilapia diet sustainability

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Staphylococcal Cassette Chromosome mec(SCCmec) Gene Typing in Detection of methicillin-Resistant Staphylococcus aureus: Toward Precise Detection in Health Care Facility

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Open Journal of medical microbiology 2019年第3期9卷 127-137页

作者： rania m.Kishk mohamed F.mandour rania m.Saleh microbiology and Immunology Department Faculty of MedicineSuez Canal UniversityIsmailiaEgypt Clinical Pathology Department Faculty of MedicineSuez Canal UniversityIsmailiaEgypt

Background: Blood stream infections (BSI) are considered key issues in critical care units. methicillin resistant Staphylococcus aureus, mRSA-related infections, are considered a major health problem. This is attributed to the emerging new society dangerous strains with continuous antibiotics pressure and fluctuations in resistance patterns. Aim: We aimed to study epidemiology of methicillin resistance S. aureus (mRSA) infections by using conventional phenotypic methods [cefoxitin disk diffusion (CDD) and oxacillin screening agar] and molecular typing of the mec-gene (SCCmec) using multiplex PCR in Suez Canal University Hospital. methods: 100 non-repetitive staphylococcus aureus were collected and identified morphologically and biochemically by standard laboratory procedures. The strains were considered mRSA if the mIC of oxacillin ≥ 4 μg/ml, and the inhibition zone of cefoxitin was ≤21 mm (CDD). Characterization of SCCmec elements in isolated mRSA strains was done via multiplex-PCR. Results: From total of 100 isolates, eighty were detected as mRSA by using CDD (sensitivity and specificity were 83.6% and 24.4% respectively) and only 65 by using oxacillin screening agar (sensitivity and specificity were 85.5% and 60% respectively). mecA gene was identified in 55 samples;the majority of isolates were SCCmec type IVa (63.7%). Both type I and III of SCCmec couldn’t be detected. Antimicrobial sensitivity rates among SCCmec-V isolates were expectedly higher than those among Type-II isolates. SCCmec type II was characterized by 100% resistant to ciprofloxacin, erythromycin, oxacillin and cefepime as well as greater resistance to clindamycin (70%) with the same pattern between all typing strains (7 strains). Conclusion: SCCmec types IVa and V are generally dominant in our community with no detection of SCCmec types I or III. PCR is the optimum method for mRSA detection.

关键词： mRSA Blood Stream Infections mecA

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Role of Platelet Rich Plasma in Treatment of Diabetic Foot Ulcers

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Surgical Science 2016年第6期7卷 272-277页

作者： Aymen Salem Ahmad m. tawfik Faculty of medicine Zagazig University Zagazig Egypt

Objectives: The aim of this study is to compare between the platelet rich plasma and balanced moist dressing as regards the healing rate in chronic non ischemic diabetic foot ulcers. Patients and method: From Feb. 2014 till may 2015, 73 patients from the attendees to Zagazig university hospitals were selected to our study. 2 groups were created, one for PRP (platelet rich plasma) and the other for balanced moist dressing. Frequent registration for the number of healed ulcers was done every week. Results: By the end of the 3rd week almost all the ulcers in the PRP group were healed. But the other group needed about 8th weeks for the same results. Conclusion: PRP seems to be an attractive choice in management of chronic diabetic ulcers provided that there is good blood supply and proper offloading was done.

关键词： Ulcer Platelet Plasma Offloading and moist Dressing

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