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Mixed epithelial endocrine neoplasms of the colon and rectum–An evolution over time:A systematic review

World Journal of Gastroenterology 2020年第34期26卷 5181-5206页

作者： rani kanthan Suresh Tharmaradinam Tehmina Asif Shahid Ahmed Selliah C kanthan Department of Pathology and Laboratory Medicine University of SaskatchewanSaskatoon S7N 0W8SKCanada Division of Oncology Saskatoon Cancer CentreSaskatoon S7N 0W8SKCanada Division of General Surgery University of SaskatchewanSaskatoon S7N 0W8SKCanada

BACKGROUND Mixed tumors of the colon and rectum,composed of a combination of epithelial and endocrine elements of benign and malignant potential are rare *** can occur anywhere in the gastrointestinal tract and are often diagnosed *** they have been a well-documented entity in the pancreas,where the exocrine-endocrine mixed tumors have been known for a while,recognition and accurate diagnosis of these tumors in the colon and rectum,to date,remains a *** is further compounded by the different terminologies that have been attributed to these lesions over the years adding to increased confusion and ***,dedicated literature reviews of these lesions in the colon and rectum are inconsistent and are predominantly limited to case reports and case series of limited case ***,most of these tumors are high grade and of advanced stage,intermediate and low grade lesions of these mixed tumors are also increasingly been *** are no established independent consensus based guidelines for the therapeutic patient management of these unique *** To provide a comprehensive targeted literature review of these complex mixed tumors in the colon and rectum that chronicles the evolution over time with summarization of historical perspectives of terminology and to further our understanding regarding their pathogenesis including genomic landscape,clinicoradiological features,pathology,treatment,prognosis,the current status of the management of the primary lesions,their recurrences and *** A comprehensive review of the published English literature was conducted using the search engines PubMed,MEDLINE and GOOGLE *** following search terms[“mixed tumors colon”OR mixed endocrine/neuroendocrine tumor/neoplasm/lesion colon OR adenocarcinoma and endocrine/neuroendocrine tumor colon OR mixed adenocarcinoma and endocrine/neuroendocrine carcinoma colon OR Amphicrine tumors OR Collision tumors

关键词： Mixed epithelial endocrine neoplasms Mixed adeno-neuroendocrine carcinoma Mixed adeno neuro endocrine tumors Mixed neuroendocrine-non neuroendocrine neoplasms Colorectal

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Emergency gastrectomy for gastric necrosis 5 years after laparoscopic adjustable gastric banding (LAGB)

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Open Journal of Gastroenterology 2011年第1期1卷 1-6页

作者： rani kanthan Jenna-Lynn Senger Selliah Chandra kanthan 不详

Laparoscopic adjustable gastric banding (LAGB) is currently one of the most common bariatric surgical procedures performed worldwide for the treatment of morbid obesity. Among bariatric surgeries, the percentage of LAGB has increased from 24.4% to 42.3%. In North America alone, the number of LAGB procedures has increased exponentially by 944.2% (from 9,270 to 96, 800 cases). Though early and late complications following LAGB are well-understood, data regarding long term complications remains indefinite due to the limited follow-up periods. We report a case of acute gastric necrosis associated with band slippage presenting as a surgical emergency five years after LAGB. Gastric necrosis represents a rare, but life threatening complication of gastric banding that has been reported in the early post-operative period. To the best of our knowledge, this case report is the longest time-interval reported between LAGB and the diagnosis of this very rare complication. Accurate diagnosis is often delayed due to its rarity and nonspecific clinical presentation. Increased awareness of this delayed complication should facilitate early recognition as it often requires urgent surgical intervention to prevent fatal outcomes.

关键词： LAGB Gastric Necrosis Band Slippage

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Recent Advances in the Management of Stage IV Colon Cancer

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Journal of Cancer Therapy 2012年第6期3卷 1104-1118页

作者： rani kanthan Jenna-Lynn Senger Shahid Ahmed Selliah kanthan Department of Pathology and Laboratory Medicine University of Saskatchewan Saskatoon Canada Department of Surgery University of Saskatchewan Saskatoon Canada. Medical Oncologist Saskatoon Cancer Centre Saskatoon Canada

Colon cancer is the second commonest cause of cancer-related death in Canadian men and women, with approximately one-third of patients dying from this disease. One quarter of patients present with metastases initially, and up to half of all colon cancer patients will develop stage IV disease over the course of their life. Despite ongoing advances in the evolution of newer cytotoxic drugs, targeted biological agents and improved metastasectomy techniques, the gain in overall survival in these patients is of low magnitude. This manuscript is a targeted review of the recent advances over the last decade in the management of advanced stage IV colon cancer as available in the published English literature. The two major arms of metastatic colon cancer management that include surgery and systemic chemotherapy and palliative measures as available are discussed. A multi-modality team-based approach involving medical oncologists, surgical oncologists, radiologists, and other health-care providers continues to be critical for ongoing success in the therapeutic management of these patients. Future studies of well-designed prospective, randomized-controlled clinical trials to develop and evaluate newer therapeutic strategies are recommended for continued and improved understanding for optimization of clinical management in advanced colon cancer.

关键词： Stage IV Colon Cancer Systemic Therapy Surgical Management

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Gastrointestinal Stromal Tumors in the 21<sup>st</sup>Century

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Journal of Cancer Therapy 2014年第8期5卷 769-796页

作者： rani kanthan Jenna-Lynn Senger Shahid Ahmed Selliah Chandra kanthan Department of Pathology & Laboratory Medicine University of Saskatchewan Saskatoon Canada Department of Surgery University of Saskatchewan Saskatoon Canada Divison of Medical Oncology Department of Medicine University of Saskatchewan Saskatoon Canada

Gastrointestinal stromal tumours (GISTs) are rare mesenchymal lesions accounting for only 0.2% of all gastrointestinal neoplasms. These tumors arise from the interstitial cells of Cajal, with mutations described in proto-oncogenes such as KIT, PDGFRA, DOG-1, and SDH. The majority of these lesions are asymptomatic, thus the true incidence remains unknown. While patients typically undergo initial endoscopy, CT scan and/or MRI, findings are often nonspecific and require a biopsy to identify the tumor. As such, immunohistochemical evaluation is the gold-standard for the accurate diagnosis of GIST. Though surgical excision remains the gold-standard for curative management, the discovery of imatinib, a tyrosine kinase inhibitor (TKI), has revolutionized the treatment of GIST in the 21st?century as a “prototype” of molecular targeted therapy for solid tumors. Risk assessment for recurrence divides these tumors into low and high-risk categories. In the latter, a role for adjuvant therapy with TKI confers a significantly better prognosis than previously observed. However, secondary mutations conferring drug resistance remain an ongoing challenge for management, as few alternative treatment options are available for patients intolerant/refractory to TKI therapy. In this review, we summarize the epidemiology, molecular pathogenesis, clinical presentation, diagnosis, pathology features, management options, and prognostic features of GISTs.

关键词： Gastrointestinal Stromal Tumor Targeted Therapy Drug Resistance Histopathology Surgery

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Pancreatic Neuroendocrine Tumors in the 21<sup>st</sup>Century—An Update

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Journal of Cancer Therapy 2017年第13期8卷 1194-1233页

作者： rani kanthan Jenna-Lynn Senger Shahid Ahmed Selliah Chandra kanthan Department of Pathology & Laboratory Medicine University of Saskatchewan Saskatoon Canada Department of Surgery University of Alberta Edmonton Canada Division of Medical Oncology University of Saskatchewan Saskatoon Canada Deparment of Surgery University of Saskatchewan Saskatoon Canada

Pancreatic neuroendocrine tumors (PNETs) are rare, reported to account for less than 1% - 2% of all pancreatic tumors. This, however, is likely an underestimation, as improved radiologic techniques and heightened awareness have resulted in an increase in the detection of incidentalomas, with estimations of true prevalence as high as 10%. The term “PNET” is an umbrella name that encompasses a heterogeneous group of neoplasms each with distinct clinical presentations, diagnostic radiographic features, management principles, and tumor/patient outcomes. In this context, accurate diagnosis is challenging, and management guidelines remain unclear. A high degree of clinical suspicion is required for best patient management. This manuscript provides an update on PNETs in the 21st century, in which we re-examine the terminology, epidemiology, classification, etiopathogenesis, radiographic and histopathologic diagnostic features, management for localized and metastatic disease, as well as a review of features defining functional and non-functional PNETS, and finally deliberates on the prognosis and predictive features of this unpredictable and largely unfathomable neoplasm.

关键词： Neuroendocrine Tumors Pancreatic Unfathomable Neoplasm

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FEA-based Geometrical Modification of Switched Reluctance Motor for Radial Force Reduction

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Chinese Journal of Electrical Engineering 2024年第1期10卷 124-135页

作者： rani S Jayapragash R School of Electrical Engineering Vellore Institute of TechnologyChennai 600127India

Switched reluctance motors(SRMs)are becoming increasingly popular in the automotive sector owing to their robust ***,SRMs are preferred particularly for EV applications owing to their fault tolerance,magnet-free structure,and high power/torque *** main concerns of SRM compared to other machines include torque ripple and *** primary cause of vibration is the radial force created by the SRM.A geometry-based modification of the SRM to reduce the radial force without significantly changing the average torque produced is *** primary goal is to design a 4-phase,8/6 SRM with a lower radial *** possible geometrical alterations are proposed:one with square windows and the other with circular holes on the rotor *** windows are sized and positioned to avoid flux *** criteria are developed for the optimal window size and *** element analysis(FEA)modelling of the SRM is used to validate its *** FEA results are compared with the performance parameters obtained using the analytical *** the multiphysics design tool ANSYS to obtain the natural frequencies and associated deformations through modal *** to the conventional geometry,the radial force is significantly reduced by providing windows.

关键词： 8/6 SRM radial force modal analysis FEA analysis natural frequencies SRM with windows

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Chaplygin gas inspired warm inflation and swampland conjectures through various scalar potentials

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Chinese Physics C 2024年第9期48卷 254-273页

作者： Abdul Jawad Nadeem Azhar Shama Sadiq Shamaila rani Institute for Theoretical Physics and Cosmology Zhejiang University of TechnologyHangzhou 310023China Department of Mathematics COMSATS University IslamabadLahore CampusLahore-54000Pakistan Department of Mathematics National University of Modern Languages(NUML)Lahore CampusLahore-54000Pakistan

In this paper,we analyze inflationary parameters and swampland conjectures in the presence of a scalar field and Chaplygin *** examine inflationary parameters,such as slow-roll parameters,scalar and tensor power spectra,spectral index,and tensor-to-scalar ratio,in the presence of a scalar field and Chaplygin gas *** also discuss recently proposed swampland *** assume that the inflationary expansion is driven by a standard scalar field with a decay ratioΓthat has a generic power-law dependence on the scalar field 0 and that the temperature of the thermal bath T is given byΓ(φ,T)=C_(φ)T^(a)/φ^(a-1),where C_(φ)is a dimensionless parameter and a is the inflation decay *** a scenario where our model operates within a robust dissipative environment(R>>1),we analyze both fundamental and perturbative dynamics to extract key inflationary *** include the scalar power spectrum P_(R),dissipative ratio R,scalar spectral index n_(s),tensor-to-scalar ratio r,running of the scalar spectral index dn_s/dlnk,and generalized ratio of the swampland de-Sitter conjecture T'V/V'T for three different potentials.

关键词： warm inflation swampland conjectures scalar potentials inflationary parameters

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Niche differentiation among facultative filter feeders: Insights from invasive Ponto-Caspian mysids

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Current Zoology 2024年第4期70卷 513-521页

作者： Péter Borza Varsha rani Csaba F.Vada Institute of Aquatic Ecology Centre for Ecological ResearchKarolina ut 29.1113 BudapestHungary Doctoral School of Biology Institute of BiologyEotvos Lorand UniversityPazmany Péter sétany 1/C1117 BudapestHungary

The degree of dietary specialization has a fundamental impact on the ecological function and interactions of suspension *** niche differentiation by food particle size is common among obligate suspension feeders,its role is not evident in facultative *** this study,we aimed at providing new insights on the matter by focusing on sympatric mysid *** mysids use different mechanisms for raptorial and filter-feeding,they represent a more adequate model system than for example,the more extensively studied *** made morpholog-ical measurements on the 4 coexisting invasive Ponto-Caspian mysid species to determine the areas and mesh sizes of their *** also quantified their clearance rates on the microalga Cryptomonas *** a laboratory experiment to reveal how morphological differences manifest in their overall filtering *** found relatively small but consistent differences in the primary filter area among the species,indicating that morphological constraints due to the enclosed position of the setae might limit the possibility for *** primary filter mesh sizes were small in all 4 species(0.69-2.73μm)with moderate but consistent intraspecific differences,suggesting that the benefit of being able to capture small particles might outweigh the pressure for *** observed clearance rates were in accordance with the morphological characteristics of the species,highlighting that auxiliary filters(present in one of the species,Limnomysis benedeni)are needed to increase filtering capacity *** study confirmed that food particle size can contribute to the niche differentiation of facultative filter feeders,but also indicated that they can tolerate a higher overlap than obligate *** observed differences were related to the habitat preferences and predatory potentials of the species,suggesting that complementarity among the different niche axes might further facilitate theircoexistence.

关键词： clearance rate coexistence filter area filtermesh size.

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Photometric Studies of EV Cnc and AH Cnc in the Open Cluster M67

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Research in Astronomy and Astrophysics 2024年第8期24卷 196-211页

作者： Mamatha rani G. K.Sriram Deblina Lahiri Vijaya,A. Department of Astronomy Osmania UniversityHyderabad 500007India

Contact binaries at various stages of evolution unveil various operating mechanisms that drive *** report the photometric and period variation analysis of two contact binaries EV Cnc and AH Cnc in open cluster *** observed the cluster from the JCBT 1.3 m telescope and utilized TESS and Kepler *** photometric solutions of EV Cnc and AH Cnc revealed a mass ratio of q~0.41 and~0.15 with an inclination of i=42°and87°*** solutions suggest that EV Cnc is probably a semi-detached and AH Cnc is a deep low-mass ratio contact *** study of O-C variation analysis indicates that for both systems,the period is increasing which suggests the mass transfer is occurring from secondary to *** the case of AH Cnc and based on simulations by randomly varying the time of minima to fit the LITE solution,we noted the third body orbital period to be around P_(3)=26.82±2.54 yr,which is different from earlier reported values and conclude that future observations are required to confirm this *** compare these two systems with other similar contact binaries to get an estimate of the final configuration of the respective systems.

关键词： (stars)binaries(including multiple) close-(stars)binaries eclipsing-stars activity

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Time and Space Efficient Multi-Model Convolution Vision Transformer for Tomato Disease Detection from Leaf Images with Varied Backgrounds

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Computers, Materials & Continua 2024年第4期79卷 117-142页

作者： Ankita Gangwar Vijaypal Singh Dhaka Geeta rani Shrey Khandelwal Ester Zumpano Eugenio Vocaturo Department of Computer and Communication Engineering Manipal University JaipurJaipurIndia Department of IoT and Intelligent Systems Manipal University JaipurJaipurIndia Department of Computer Engineering ModellingElectronics and Systems(DIMES)University of CalabriaRende(Cosenza)Italy National Research Council Institute of Nanotechnology(NANOTEC)Rende(Cosenza)Italy

A consumption of 46.9 million tons of processed tomatoes was reported in 2022 which is merely 20%of the total *** increase of 3.3%in consumption is predicted from 2024 to *** are also rich in iron,potassium,antioxidant lycopene,vitamins A,C and K which are important for preventing cancer,and maintaining blood pressure and glucose ***,tomatoes are globally important due to their widespread usage and nutritional *** face the high demand for tomatoes,it is mandatory to investigate the causes of crop loss and minimize *** are one of the major causes that adversely affect crop yield and degrade the quality of the tomato *** leads to financial losses and affects the livelihood of ***,automatic disease detection at any stage of the tomato plant is a critical *** learning models introduced in the literature show promising results,but the models are difficult to implement on handheld devices such as mobile phones due to high computational costs and a large number of ***,most of the models proposed so far work efficiently for images with plain backgrounds where a clear demarcation exists between the background and leaf ***,the existing techniques lack in recognizing multiple diseases on the same *** address these concerns,we introduce a customized deep learning-based convolution vision transformer *** achieves an accuracy of 93.51%for classifying tomato leaf images with plain as well as complex backgrounds into 13 *** requires a space storage of merely 5.8 MB which is 98.93%,98.33%,and 92.64%less than stateof-the-art visual geometry group,vision transformers,and convolution vision transformermodels,*** training time of 44 min is 51.12%,74.12%,and 57.7%lower than the above-mentioned ***,it can be deployed on(Internet of Things)IoT-enabled devices,drones,or mobile devices to assist farmers in the real-time monitoring of tomato *** p

关键词： Tomato disease transformer deep learning mobile devices

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