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Inflammatory bowel disease:Therapeutic limitations and prospective of the stem cell therapy

World Journal of Stem Cells 2020年第10期12卷 1050-1066页

作者： rangnath mishra Punita Dhawan Anand S Srivastava Amar B Singh Institute of Stem Cell Therapy and Research San DiegoCA 92122United States Department of Biochemistry and Molecular Biology University of Nebraska Medical CenterOmahaNE 68118United States Fred and Pamela Buffett Cancer Center OmahaNE 68118United States VA Nebraska-Western Iowa Health Care System OmahaNE 68118United States

Inflammatory bowel disease(IBD),consisting primarily of ulcerative colitis and Crohn’s disease,is a group of debilitating auto-immune disorders,which also increases the risk of colitis-associated ***,due to the chronic nature of the disease and inconsistent treatment outcomes of current anti-IBD drugs(e.g.,approximately 30%non-responders to anti-TNFαagents),and related serious side effects,about half of all IBD patients(in millions)turn to alternative treatment *** this regard,mucosal healing is gaining acceptance as a measure of disease activity in IBD patients as recent studies have correlated the success of mucosal healing with improved ***,despite the increasing clinical realization of the significance of the concept of mucosal healing,its regulation and means of therapeutic targeting remain largely ***,stemcell therapy,which uses hematopoietic stem cells or mesenchymal stem cells,remains a promising *** cells are the pluripotent cells with ability to differentiate into the epithelial and/or immune-modulatory *** overreaching concept is that the stem cells can migrate to the damaged areas of the intestine to provide curative help in the mucosal healing ***,by differentiating into the mature intestinal epithelial cells,the stem cells also help in restoring the barrier integrity of the intestinal lining and hence prevent the immunomodulatory induction,the root cause of the *** this article,we elaborate upon the current status of the clinical management of IBD and potential role of the stem cell therapy in improving IBD therapy and patient’s quality of life.

关键词： Crohn′s disease Ulcerative colitis Mesenchymal stem cells Hematopoietic stem cells Mucosal healing

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