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Diagnostic delay in inflammatory bowel diseases in a German population

World Journal of Gastroenterology 2024年第29期30卷 3465-3478页

作者： Elisabeth Blüthner Annalena Dehe Carsten Büning Britta Siegmund Matthias Prager Jochen Maul Alexander Krannich Jan Preiß Bertram Wiedenmann Florian Rieder raneem Khedraki Frank Tacke Andreas Sturm Anja Schirbel Department of Hepatology and Gastroenterology Campus Virchow-Klinikum and Campus CharitéMitteCharité-Universitätsmedizin BerlinBerlin 10117Germany Department of Gastroenterology Vivantes Klinikum im FriedrichshainBerlin 10249Germany Department of Internal Medicine Krankenhaus WaldfriedeBerlin 14163Germany Department of Gastroenterology Infectious Diseases and RheumatologyCharité-Universitätsmedizin BerlinBerlin 12203Germany Praxis für Gastroenterologie Berlin Zehlendorf Berlin 14195Germany Gastroenterologie am Bayrischen Platz Berlin 10825Germany Clinical Trial Office Charité-Universitätsmedizin BerlinBerlin 10117Germany Department of Gastroenterology Diabetology and HepatologyVivantes Klinikum NeuköllnBerlin 10117Germany Department of Gastroenterology Hepatology and NutritionDigestive Diseases and Surgery InstituteThe Cleveland Clinic FoundationClevelandOH 44195United States Department of Internal Medicine DRK Kliniken Berlin WestendBerlin 14050Germany Gastroenterologie im Havelland Straße der EinheitFalkensee 14612Germany

BACKGROUND Early diagnosis is key to prevent bowel damage in inflammatory bowel disease(IBD).Risk factor analyses linked with delayed diagnosis in European IBD patients are scarce and no data in German IBD patients *** To identify risk factors leading to prolonged diagnostic time in a German IBD *** Between 2012 and 2022,430 IBD patients from four Berlin hospitals were enrolled in a prospective study and asked to complete a 16-item questionnaire to determine features of the path leading to IBD *** diagnostic time was defined as the time from symptom onset to consulting a physician(patient waiting time)and from first consultation to IBD diagnosis(physician diagnostic time).Univariate and multivariate analyses were performed to identify risk factors for each time *** The total diagnostic time was significantly longer in Crohn’s disease(CD)compared to ulcerative colitis(UC)patients(12.0 vs 4.0 mo;P<0.001),mainly due to increased physician diagnostic time(5.5 vs 1.0 mo;P<0.001).In a multivariate analysis,the predominant symptoms diarrhea(P=0.012)and skin lesions(P=0.028)as well as performed gastroscopy(P=0.042)were associated with longer physician diagnostic time in CD *** UC,fever was correlated(P=0.020)with shorter physician diagnostic time,while fatigue(P=0.011)and positive family history(P=0.046)were correlated with longer physician diagnostic *** We demonstrated that CD patients compared to UC are at risk of long diagnostic *** efforts should focus on shortening the diagnostic delay for a better outcome in these patients.

关键词： Diagnostic time Diagnostic delay Crohn’s disease Ulcerative colitis Germany

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Correlation between Radiological Staging of Chronic Rhinosinusitis and Revision of Endoscopic Sinus Surgery

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International Journal of Otolaryngology and Head & Neck Surgery 2021年第2期10卷 119-130页

作者： Dhaidan Alshammari raneem alshaik. Manuel Bakheet Waleed Janahi Hiba Alreefy Ministry of Health Riyadh KSA King Hamad University Hospital Busaiteen Kingdom of Bahrain Ministry of Health Manama Kingdom of Bahrain Awali Hospital Awali Kingdom of Bahrain

Introduction: Chronic rhinosinusitis (CRS) is an inflammatory condition affecting the sinonasal mucosa with duration of more than 12 weeks. Multifactorial aetiology contributes to its refractoriness. Functional endoscopic sinus surgery (FESS) is the most common surgical technique preferred in CRS not responding to medical management, showing high success rates. However, some failure has been noted, requiring revision FESS. CT (Computed Tomography) is a diagnostic tool for CRS, and aids in improving surgical outcomes. Combined with the Lund-Mackay scoring system, CT can help stage the CRS, predicting the need for revision surgery. Methods: In our paper, we aimed to study the relationship between severity of CRS using radiological staging and revision of functional endoscopic sinus surgery, assessing outcome after at least 1 year of follow-up. There was a single centre retrospective study involving 150 patients selected by random sampling, to study the correlation between the severity of chronic rhinosinusitis and revision of functional endoscopic sinus surgery (FESS). The study was conducted in the ENT department of King Hamad University Hospital, Bahrain for a time period of 6 months. Records were scanned and scored using Lund-Mackay system. Lund Mackay score of 10 and above was considered severe. The relation between increased severity with Lund Mackay score on the CT scan and the need for revision sinus surgeries was then determined. Results and Conclusion: This study concludes that LMS score in CT scans can be used to predict the outcomes of primary FESS procedure and the need for revision surgery in the management of CRS.

关键词： FESS Lund-Mackay System ENT Revision Sinus Surgery Revision FESS Chronic Rhinosinusitis (CRS)

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Therapeutic Efficacy of Diode Laser Turbinoplasty on Nasal Obstruction Estimated with Rhinomanometry

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International Journal of Otolaryngology and Head & Neck Surgery 2021年第6期10卷 487-496页

作者： Ebrahim Almulla Dhaidan Alshammari raneem alshaik. Abdulrahman Almannai Noora Althawadi Waleed Janahi Andrew Riskalla Zied Zid ENT Department King Hamad University Hospital Muharraq Kingdom of Bahrain Ministry of Health Dammam Saudi Arabia Ministry of Health Manama Kingdom of Bahrain Head and Neck Surgery Department University College London Hospital London UK

Objective: Diode-assisted laser turbinoplasty is a popular surgical technique that improves airflow during nasal obstruction. In this study, we aimed to evaluate the efficacy of a diode laser for turbinate hypertrophy by using rhinomanometry. Methods: This cross-sectional study included 199 patients for 13 months. Preoperative, intraoperative, and 6-week postoperative rhinomanometry values were measured. Results: The most common intraoperative symptoms were olfactory annoyance (barbecue smell) (76.4%) and a painful burning or stinging sensation (64.3%). The inspiratory and expiratory mean nasal airflow values increased both intraoperatively and postoperatively, illustrating the effect of decongestants and inferior turbinate surgery. Intraoperatively, inspiration improved by 262.73 ± 196.09 (p Conclusions: The therapeutic efficacy of using diode lasers in inferior turbinate resection was established in this study on the basis of rhinomanometric data with a follow-up of 6 weeks. Postoperative nasal obstruction was effectively decreased and the other symptoms displayed a female preponderance.

关键词： Diode-Assisted Laser Turbinoplasty Nasal Obstruction Turbinate Hypertrophy Rhinomanometry

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Evaluation of the Knowledge and Perceptions of Patients towards Generic Medicines in UAE

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Pharmacology & Pharmacy 2016年第9期7卷 369-378页

作者： Suleiman I. Sharif raneem J. Chaar Zahraa Z. Albadrani Jameel S. Shahwan Mohamed N. Badreddin Mohamed A. K. Charbaji Department of Pharmacy Practice and Pharmacotherapeutics College of Pharmacy University of Sharjah Sharjah United Arab Emirates

Objectives: The objective of this study was to evaluate the knowledge and perceptions of patients towards generic medicines in some Emirates of the United Arab Emirates. Methods: A cross-sectional survey involving patients in three Emirates was undertaken. A 23-item questionnaire was designed, pre-validated and administered. Results: The questionnaire was fully answered by 96 patients out of 120 producing a response rate of 80%. The majority of patients were young Arab females with a university degree. Slightly less than 50% of patients were having a monthly income of less than ED 10,000. Results of the patient’s survey indicate that they have poor knowledge and perception of generic medicines. They did not know the meaning of generic or brand medicines and this negatively influenced their responses to consequent questions. Conclusion: Patients’ knowledge and perception of generic drugs were poor. Efforts are needed to increase public awareness of generic drugs and possible brand substitution. Both the prescribing physician and the dispensing pharmacists have an essential role to play in educating their patients of generic drugs.

关键词： Evaluation Patients Generic Medicines Brand Medicines Knowledge Perception

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Correlation between Radiological Staging of Chronic Rhinosinusitis and Revision of Endoscopic Sinus Surgery

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International Journal of Otolaryngology and Head & Neck Surgery（耳鼻喉） 2021年第2期

作者： Dhaidan Alshammari raneem alshaik. Manuel Bakheet Waleed Janahi Hiba Alreefy

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Therapeutic Efficacy of Diode Laser Turbinoplasty on Nasal Obstruction Estimated with Rhinomanometry

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International Journal of Otolaryngology and Head & Neck Surgery（耳鼻喉） 2021年第6期

作者： Ebrahim Almulla Dhaidan Alshammari raneem alshaik. Abdulrahman Almannai Noora Althawadi Waleed Janahi Andrew Riskalla Zied Zid

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