检索结果-南通市图书馆

中华急诊医学杂志 2003年第10期12卷 685-687页

作者：卢君强李春盛杨佳勇张舒 Jay Zhu W.c.shoemaker 深圳南山医院IcU 518052 首都医科大学朝阳医院急救中心美国南加州大学总医院

目的　评估高频振动通气 (high frequencypercussiveventilation ,HFPV)在成人ARDS治疗中的有效性和安全性 ,探索ARDS治疗的新途径。方法　临床观察 93例IcU条件下使用HFPV的ARDS病人 ,对常规通气 (conventionalventilation ,cV)和HFPV下的PaO2 /FiO2 、PacO2 、DO2 、VO2 、Qs/Qt、PEEP/cPAP、PAWP等氧代谢、血流动力学指标和呼吸参数的变化进行统计分析。结果　 93例病人中 ,存活 6 6例 ,死亡2 7例 ,死亡率为 2 9 0 % (除外 7例未死于IcU者 ,实际死亡率为 2 1 5 % )。使用HFPV前后PaO2 /FiO2 、Pac O2 、DO2 、VO2 、Qs/Qt的变化为 (77 6± 2 0 0 )和 (2 0 8 7± 70 8)、 (471 2± 114 7)和 (6 0 1 3± 14 0 9)、(10 7 6± 34 3)和 (14 6 4± 2 3 3)、 (35 7± 2 0 5 )和 (2 4 5± 6 5 ) (P <0 0 5 )。X ray胸片双肺阴影减轻或消失 ,同时可看到病人鼻腔口腔有不等量的混浊液体从呼吸道溢出。结论　HFPV在ARDS治疗中是有效和安全的。临床应用HFPV能明显改善氧代谢 ,提高PaO2 /FIO2 。

关键词：高频振动通气急性呼吸窘迫综合征治疗有效性安全性

经皮氧监测在ARDS病人氧复苏治疗中的作用

在线全文

学校读者我要写书评

暂无评论

经皮氧监测在ARDS病人氧复苏治疗中的作用

The JAK2<sup>V617F</sup>Mutation Seen in Myeloproliferative Neoplasms (MPNs) Occurs in Patients with Inflammatory Bowel Disease: Implications of a Pilot Study

中华医学会急诊医学分会第十次全国复苏中毒学术论文交流会

作者：芦君强李春盛 Jay Zhu charles Wo W．c.shoemaker 深圳市南山医院IcU 首都医科大学附属医院急诊科美国南加州大学总医院

ARDS是以氧代谢紊乱为主的缺氧综合症,主要死因是顽固性组织细胞缺氧(难以纠正的低氧血症)。传统的经肺动脉导管法监测计算氧代谢指标,虽能直接了解组织细胞氧代谢的情况,但属有创法,技术要求高操作复杂,无法常规推广使用。经皮氧监测...

ARDS是以氧代谢紊乱为主的缺氧综合症,主要死因是顽固性组织细胞缺氧(难以纠正的低氧血症)。传统的经肺动脉导管法监测计算氧代谢指标,虽能直接了解组织细胞氧代谢的情况,但属有创法,技术要求高操作复杂,无法常规推广使用。经皮氧监测方便、安全、易操作、数据呈动态,能较早的反映ARDS 病人自身的氧代谢情况,为及时发现ARDS氧代谢障碍、指导氧复苏治疗提供科学可靠的依据。 1．临床资料和方法: 本研究所涉及的临床资料均来源于美国南加州大学总医院SIcU。 1．1 病人选择: 93例(男67,女26),年龄15-80岁(44．35±18．23),体重45-173kg。所有病人均行气管插管常

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

International Journal of clinical Medicine 2013年第12期4卷 10-15页

作者： Emil Kuriakose Elena Lascu Y. Lynn Wang Stefani Gjoni Nicholas c. P. cross Ruth Baumann Kerilee Tam Ellen Scherl randy S. Longman Richard T. Silver Department of Pathology University of Chicago Chicago USA Division of Hematology and Medical Oncology Weill Cornell Medical College New York USA Jill Roberts center for Inflammatory Bowel Disease Division of Gastroenterology Weill Cornell Medical College New York USA Wessex Regional Genetics Laboratory Salisbury District Hospital University of Southampton Salisbury UK

Patients with IBD frequently have hematologic abnormalities suggestive of JAK2 mutated MPNs, but are traditionally classified as reactive processes. Haplotype 46/1 is a well-characterized genetic predisposition, common to both inflammatory bowel disease (IBD) and myeloproliferative neoplasms (MPN). In view of this shared genetic predisposition, we measured the frequency of the JAK2V617F mutation in IBD patients with thrombocytosis or erythrocytosis, in order to ascertain whether a higher than expected proportion of these patients may in fact have underlying MPNs. 1121 patients were identified with an active diagnosis of crohn’s disease or ulcerative colitis, of which 474 had either thrombocytosis or erythrocytosis. Patients with abnormal counts were tested for the JAK2V617F mutation during routine follow-up visits. Interim analysis of first 23 patients tested was performed to assess whether the JAK2V617F positivity rate was statistically significant compared with known expected frequencies in a comparable control population. Of 23 patients, 13 patients had thrombocytosis and 10 had erythrocytosis. Three patients with thrombocytosis (23%), and 1 patient with erythrocytosis (10%), tested positive for JAK2V617F, exceeding the expected thresholds for statistical significance. In patients with IBD and thrombocytosis or erythrocytosis, a meaningful proportion may harbor an undiagnosed MPN, as indicated by clonal abnormalities such as JAK2V617F. These findings imply the need for increased testing of these patients for clonal hematologic abnormalities, and importantly, if found, suggest the need for therapeutic strategies with drugs, such as JAK2 inhibitors, in patients with both MPN and IBD.

关键词： JAK2V617F Myeloproliferative Neoplasms Inflammatory Bowel Disease Thrombocythemia Polycythemia

cyclomatic complexity and Lines of code: Empirical Evidence of a Stable Linear Relationship

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Software Engineering and Applications 2009年第3期2卷 137-143页

作者： Graylin JAY Joanne E. HALE randy K. SMITH David HALE Nicholas A. KRAFT charles WARD 不详

Researchers have often commented on the high correlation between Mccabe’s cyclomatic complexity (cc) and lines of code (LOc). Many have believed this correlation high enough to justify adjusting cc by LOc or even substituting LOc for cc. However, from an empirical standpoint the relationship of cc to LOc is still an open one. We undertake the largest statistical study of this relationship to date. Employing modern regression techniques, we find the linearity of this relationship has been severely underestimated, so much so that cc can be said to have absolutely no explana-tory power of its own. This research presents evidence that LOc and cc have a stable practically perfect linear rela-tionship that holds across programmers, languages, code paradigms (procedural versus object-oriented), and software processes. Linear models are developed relating LOc and cc. These models are verified against over 1.2 million randomly selected source files from the SourceForge code repository. These files represent software projects from three target languages (c, c++, and Java) and a variety of programmer experience levels, software architectures, and de-velopment methodologies. The models developed are found to successfully predict roughly 90% of cc’s variance by LOc alone. This suggest not only that the linear relationship between LOc and cc is stable, but the aspects of code complexity that cc measures, such as the size of the test case space, grow linearly with source code size across lan-guages and programming paradigms.

关键词： Software complexity Software Metrics cyclomatic complexity

cD40 P227A突变是系统性红斑狼疮的易感因素之一

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

CD40 P227A突变是系统性红斑狼疮的易感因素之一

基于GIS栅格数据的城市河网水质综合评价模型构建

全国自身免疫性疾病专题研讨会暨第十一次全国风湿病学学术年会

作者：张文张烜 randy Fischer P．E．Lipsky A．c．Grammer 中国医学科学院中国协和医科大学北京协和医院风湿免疫科美国国立卫生研究院自身免疫病系

背景:cD40通过激活B淋巴细胞中NF-kB和AP-1信号传导而促进B细胞活化、分化和产生抗体,在系统性红斑狼疮发病中至关重要。而TRAF2则在cD40和其信号传导系统中起承上启下的作用。我们收集了一组cD40-P227A单核苷酸多态性突变的SLE家系,并...

背景:cD40通过激活B淋巴细胞中NF-kB和AP-1信号传导而促进B细胞活化、分化和产生抗体,在系统性红斑狼疮发病中至关重要。而TRAF2则在cD40和其信号传导系统中起承上启下的作用。我们收集了一组cD40-P227A单核苷酸多态性突变的SLE家系,并对此突变对患者外周血B淋巴细胞功能的影响进行了研究。

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

环境与健康杂志 2015年第1期32卷 54-58,F0003页

作者：朱慧敏陈强王振峰任坤何溶 randy A Dahlgren 张明华温州医科大学水环境应用技术研究所浙南水科学研究院浙江温州325035 美国加州大学戴维斯分校陆地大气与水资源系

目的建立基于GIS栅格数据的城市河网水质综合评价模型。方法该文章利用温瑞塘河流域32个水质监测点2008年至2010年水质监测数据,采用一种基于GIS栅格的指数模型对城市河网水质进行多因子综合评价,并根据GB3838—2002《地表水环境质量标... 详细信息

目的建立基于GIS栅格数据的城市河网水质综合评价模型。方法该文章利用温瑞塘河流域32个水质监测点2008年至2010年水质监测数据,采用一种基于GIS栅格的指数模型对城市河网水质进行多因子综合评价,并根据GB3838—2002《地表水环境质量标准》对评价结果进行水质等级分类。通过对比分类结果与实际情况来探讨该种水质评价方法的评价效果以及栅格指数模型在温瑞塘河的适用性。结果温瑞塘河流域温州市区河网部分水质较差,大部分区域属于劣Ⅴ类水质,水质综合整治仍需加强;氨氮、总磷为温瑞塘河的主要污染物;塘河水质综合污染状况呈现城市重于郊区农村、旧城区重于新城区、支流重于干流的空间分布特征;GIS指数模型在温瑞塘河流域水质评价的结果与实际水质状况高度吻合。结论该方法具有可行性,适用于城市河网水质评价。

关键词：水质评价 GIS指数模型温瑞塘河

基于GIS的平原河网走航在线水质监测方法研究

在线全文

学校读者我要写书评

暂无评论

浙江农业学报 2012年第3期24卷 503-508页

作者：马小雪纪晓亮李军胡昊梅琨 randy Dahlgren 商栩张明华温州医学院水域科学与环境生态研究所浙江温州325035 美国加州大学戴维斯分校土壤、大气与水资源系戴维斯CA95616 浙江省农业科学院数字农业研究所浙江杭州310021

针对常规定点水质监测方法无法完整再现水质指标的时空连续分布特征的问题,将船只搭载的水质实时监测设备与GPS同步形成基于GIS数据支撑的走航在线水质监测手段。通过与常规水质监测方法的对比,走航在线水质监测结果的可靠性得到了验证... 详细信息

针对常规定点水质监测方法无法完整再现水质指标的时空连续分布特征的问题,将船只搭载的水质实时监测设备与GPS同步形成基于GIS数据支撑的走航在线水质监测手段。通过与常规水质监测方法的对比,走航在线水质监测结果的可靠性得到了验证。在温瑞塘河河网选择部分河段进行的实地研究结果表明,走航在线水质监测能够较好地实现对较小尺度范围内水质指标空间分布细节的描绘及对分散点源污染的监测,是对常规定点水质监测的有益补充。

关键词：走航连续水质监测 GIS 分散点源污染

环境水体中沙门菌环介导等温扩增快速检测方法

在线全文

学校读者我要写书评

暂无评论

环境与健康杂志 2013年第2期30卷 146-149页

作者：尹红果马小雪商栩任湘鹏 randy A Dehlgren 张明华温州医学院水域科学与环境生态研究所浙江温州325035 南京大学地理与海洋科学学院美国加州大学戴维斯分校土壤大气与水资源系

目的建立环境水体中沙门菌的环介导等温扩增(loop-mediated isothermal amplification,LAMP)快速检测方法。方法以沙门菌的特异性基因(phoP)序列为靶序列,于63℃恒温条件下扩增1 h,80℃灭活10 min,扩增产物通过肉眼观察即可判断检测结... 详细信息

目的建立环境水体中沙门菌的环介导等温扩增(loop-mediated isothermal amplification,LAMP)快速检测方法。方法以沙门菌的特异性基因(phoP)序列为靶序列,于63℃恒温条件下扩增1 h,80℃灭活10 min,扩增产物通过肉眼观察即可判断检测结果。结果该方法对超纯水加标水样中沙门菌的检测限可达3.07 fg/μl,对环境加标水样的检出限为2.39×10 cfu/ml。结论该方法灵敏度高、耗时短、方法简便,适用于现场或者基层实验室进行环境水体中病原微生物的快速检测。

关键词：沙门菌环介导等温扩增环境水体

Potential of Some Granites from Foumban (West Region of cameroon) as Fluxing Materials for ceramics

在线全文

学校读者我要写书评

暂无评论

Journal of Minerals and Materials characterization and Engineering 2020年第5期8卷 353-363页

作者： Njimbouombouo Mouliom Soualiou Etone Macka Alexandre Dodo Ondoua Abondo Ebengue Yannick che randy Nangah Njoya André Mouncherou Oumar Farouk Ndigui Billong University of Yaounde I Yaounde Cameroon

This study focuses on the mineralogical, geochemical and petrographic characterization of three granite rock samples (LTP, LTS and LTMB) from Foumban, West Region of cameroon. Fusibility tests were carried out on the samples containing the highest amount of alkali to assess the potential of these materials as fluxing admixture for ceramics. The results show that the granite consists of alkaline feldspars, notably orthoclase and microcline of perthitic micro-texture, plagioclases (in particular albite) and also mafic minerals such as amphibole and pyroxene. The quantity of alkali in the samples is quite high (16.83% for LTS, 17.08% for LTMB and 18.87% for LTP) compared to standard data. Fusibility tests carried out on the samples having the highest alkali content (LTMB and LTP) showed that the vitreous phase appears between 1050°c and 1100°c in these samples when they were heated. The Fe2O3 and TiO2 content of LTMB (3.01% and 1.49% respectively) led to a brown colour of its fired product. Therefore, based on their composition, these materials can be used as feldspathic fluxes for the formulation of ceramic products.

关键词： Feldspars Granite characterization Fusibility ceramics Foumban cameroon