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中国危重病急救医学 2003年第12期15卷 730-734页

作者：卢君强李春盛杨佳勇 Jay Zhu charles Wo William c.shoemaker 深圳南山医院广东深圳518052 首都医科大学附属朝阳医院急救中心北京100020 美国南加洲总医院

目的 :探讨在急诊条件下早期应用无创血流动力学监护系统的必要性和可行性 ,评估其早期揭示循环功能不良和在早期高危急诊外科患者复苏治疗中的指导作用。方法 :用无创血流动力学监护系统监测 1 5 6例高危急诊外科患者 ,对其中 4 8例同... 详细信息

目的 :探讨在急诊条件下早期应用无创血流动力学监护系统的必要性和可行性 ,评估其早期揭示循环功能不良和在早期高危急诊外科患者复苏治疗中的指导作用。方法 :用无创血流动力学监护系统监测 1 5 6例高危急诊外科患者 ,对其中 4 8例同时进行了有创血流动力学监护系统 (Swan Ganz法 )的观察 ,并将两种方法所得结果进行比较。结果 :无创血流动力学监护系统所获得的心排血量 (cO)和心脏指数 (cI)值与有创血流动力学监护系统所获得的值非常接近 ,在急诊条件下 ,r=0 .6 9,r2 =0 .87,PcU条件下进一步比较两种方法所得结果 :r=0 .84 ,r2 =0 .93,PcI、低经皮氧张力 (Ptc O2 )、低血氧饱和度 (Sa O2 )和高经皮二氧化碳张力 (Ptc cO2 )的变化过程 ,并且为早期复苏治疗提供直观、可靠、连续性的依据 ,对预防由于长时间组织低血流量和低灌注所致的休克。

关键词：血流动力学监护系统无创性高危外科患者 Wwan—Ganz法早期复苏治疗

Low-cost,simple,and scalable self-assembly of DNA origami nanostructures

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Nano Research 2019年第5期12卷 1207-1215页

作者： Patrick D.Halley randy A.Patton Amjad chowdhury John c.Byrd carlos E.castro Department of chemical and Biomolecular Engineering The Ohio State UniversityColumbusOH 43210USA Department of Mechanical and Aerospace Engineering The Ohio State UniversityColumbusOH 43210USA Division of Hematology Department of Internal Medicineand OSU Comprehensive Cancer CenterThe Ohio State UniversityColumbusOH 43210USA Biophysics Graduate Program The Ohio State UniversityColumbusOH 43210USA

Despite demonstrating exciting potential for applications such as drug delivery and biosensing,the development of nanodevices for practical applications and broader use in research and education are still hindered by the time,effort,and cost associated with DNA origami *** and robust methods to perform and scale the DNA origami self-assembly process are critical to facilitate broader use and translation to industrial or clinical *** report a simple approach to fold DNA origami nanostructures that is fast,robust,and *** demonstrate fabrication at scales approximately 100-1,500-fold higher than typical *** further demonstrate an approach we termed low-cost efficient annealing (LEAN) self-assembly involving initial heating at 65 ℃ for 10 min,then annealing at 51 ℃ for 2 h,followed by brief quenching at 4 ℃ that leads to effective assembly of a range of DNA origami structures *** contrast to other methods for scaling DNA origami assembly,this approach can be carried out using cheap and widely available equipment (e.g.,hot plates,water baths,and laboratory burners) and uses standard recipes and materials so is readily applied to any existing or new DNA origami *** envision these methods can facilitate device development for commercial applications and facilitate broader use of DNA origami in research and education.

关键词： DNA origami DNA nanotechnology self assembly scalable nanofabrication low cost fabrication nanotechnology education

covariance estimation via fiducial inference

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Statistical Theory and Related Fields 2021年第4期5卷 316-331页

作者： W.Jenny Shi Jan Hannig randy c.S.Lai Thomas c.M.Lee Financial Planning&Analysis MassMutualBostonMAUSA Department of Statistics&Operations Research University of North CarolinaChapel HillNCUSA Department of Statistics University of CaliforniaDavisCAUSA

As a classical problem,covariance estimation has drawn much attention from the statistical com-munity for *** work has been done under the frequentist and Bayesian *** to quantify the uncertainty of the estimators without having to choose a prior,we have developed a fiducial approach to the estimation of covariance *** upon the Fiducial Berstein-von Mises Theorem,we show that the fiducial distribution of the covariate matrix is consistent under our ***,the samples generated from this fiducial distri-bution are good estimators to the true covariance matrix,which enable us to define a meaningful confidence region for the covariance ***,we also show that the fiducial approach can be a powerful tool for identifying clique structures in covariance matrices.

关键词： covariance estimation sparsity fiducial inference cliques

comparative analysis on dynamic behavior of two HMA railway substructures

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Journal of Modern Transportation 2011年第1期19卷 26-34页

作者： Mingjing FANG Yanjun QIU Jerry G. ROSE randy c. WEST changfa AI National center for Asphalt Technology （NcAT） College of Engineering Auburn University Auburn AL 36830-5577 USA School of civil Engineering Southwest Jiaotong University Chengdu 610031 China college of Engineering Civil Engineering Department University of Kentucky Lexington KY40506-0281 USA

A numerical analysis using a finite element program was performed on three structures： hot mix asphalt （HMA） reinforced trackbed （RAcS-1）, HMA directly supported trackbed （RAcS-2）, and traditional Portland cement concrete （Pcc） slab track （SlabTrack）. Although the comprehensive dynamic responses of RAcS-1 were similar with SlabTrack, HMA layer can positively affect the stress distributions. In particular, the horizontal stresses indicate that the resilience of RAcS-1 was improved relative to SlabTrack. In addition, HMA reinforced substructure has the capacity to recover the residual vertical deformation. The effective depth for weakening dynamic loadings is mainly from 0 to 2 m, this being especially true at 0.5 m. The results from the analysis show that HMA is a suitable material for the railway substructure to enhance resilient performance, improve the stress distribution, weaken dynamic loading, and lower the vibration, especially at the effective depth of 2 m. The HMA constructed at the top of the stone subbase layer allows the vertical modulus a smooth transition. In terms of the comprehensive dynamic behaviors, RAcS-1 is better than SlabTrack, while the results for RAcS-2 are inconclusive and require further research.

关键词： high-speed railway HMA railway substructure FEM analysis

Vasoactive intestinal polypeptide (VIP) corrects chronic inflammatory response syndrome (cIRS) acquired following exposure to water-damaged buildings

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Health 2013年第3期5卷 396-401页

作者： Ritchie c. shoemaker Dennis House James c. Ryan center for Research on Biotoxin Associated Illnesses Pocomoke City USA Proteogenomics LLC Vero Beach USA

Exposure in water-damaged buildings (WDB) to airborne bioaerosols including metabolic products of toxigenic fungi, bacteria and actinomycetes;and inflammagens, can lead to a persistent innate immune inflammatory illness. This illness, termed a chronic inflammatory response syndrome (cIRS-WDB), is systemic with symptoms acquired from multiple organ systems. Treatment of cIRS-WDB has progressed rapidly as a better understanding of the inflammatory pathophysiology has led to targeted, sequential therapies. The fundamental basis of uncontrolled innate immune responses, the humoral deficiency of regulatory neuropeptides melanocyte stimulating hormone (MSH) or vasoactive intestinal polypeptide (VIP), seen in over 98% of pa tients, has not consistently responded to any treatment modality. Use of replacement VIP has been attempted anecdotally;VIP replacement therapies show promise in short term studies but longer therapies have not been attempted. Here we report an open label trial of 20 patients with refractory cIRS-WDB illness who took replacement VIP in a nasal spray for at least 18 months with confirmation of durable efficacy and absence of significant side effects. These 20 patients were similar in symptoms and lab find- ings to three previously published cohorts in- volving 1829 patients and 169 controls. Dosage of VIP was titrated downwards from four to zero doses a day to determine minimum effective dose, and retitrated upwards for maximum improvement over time. The trial showed that VIP therapy safely 1) reduced refractory symptoms to equal controls;2) corrected inflammatory parameters c4a, TGF beta-1, VEGF, MMP9;3) corrected estradiol, testosterone and 25-OH Vitamin D;4) returned pulmonary artery systolic pressure (PASP) during exercise to normal;and 5) enhanced quality of life in 100% of trial patients. Subsequent identification of correction of T-regulatory cell levels supports the potential role of VIP in both innate and adaptive immune function.

关键词： Vasoactive Intestinal Polypeptide (VIP) chronic Inflammatory Response Syndrome (cIRS) TGF Beta-1 c4a MSH T Regulatory cells Water-Damaged Buildings

changes in profile distribution and chemical properties of natural nanoparticles in paddy soils as affected by long-term rice cultivation

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Pedosphere 2021年第5期31卷 659-669页

作者： Dan HUANG Xinyu ZHU Baile XU Yan HE Mingkui ZHANG Fei LIU Zhenghua LIAN randy ADAHLGREN Philip cBROOKES Jianming XU Institute of Soil and Water Resources and Environmental Science College of Environmental and Resource SciencesZhejiang UniversityHangzhou 310058(China) Zhejiang Provincial Key Laboratory of Agricultural Resources and Environment Hangzhou 310058(China) Department of Land Air and Water ResourcesUniversity of California-DavisDavis CA 95616(USA)

Systematic studies on the genesis,properties,and distribution of natural nanoparticles(NNPs)in soil remain *** study examined a soil chronosequence of continuous paddy field land use for periods ranging from 0 to 1000 years to determine how NNPs in soil changed at the early stages of soil genesis in eastern *** samples were collected from coastal reclaimed paddy fields that were cultivated for 0,50,100,300,700,and 1000 *** nanoparticles were isolated and characterized along with bulk soil samples(ction)for selected physical and chemical *** NNP content increased with increasing soil cultivation age at 60 g m^(-2) year-1,which was related to decreasing soil electrical conductivity(172-1297μS cm^(-1))and NNP zeta potentials(from -22 to -36 mV)with increasing soil cultivation *** in several NNP properties,such as pedogenic iron oxide and total organic carbon contents,were consistent with those of the bulk soils across the soil ***,changes in NNP iron oxide content were obvious and illustrated active chemical weathering,pedogenesis,and potential impacts on the microbial *** analysis demonstrated that the soil cultivation age was the most important factor affecting NNP properties,contributing 60.7% of the total *** and principal component analysis(PcA)revealed splitting of NNP samples into age groups of 50-300 and 700-1000 years,indicating rapid evolution of NNP properties,after an initial period of desalinization(approximately 50 years).Overall,this study provides new insights into NNP evolution in soil during pedogenesis and predicting their influences on agriculture and ecological risks over millennial-scale rice cultivation.

关键词： natural nanoparticle evolution soil chronosequence soil cultivation age soil genesis soil nanoparticles

Non-Linear Matrix completion

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Journal of Data Analysis and Information Processing 2024年第1期12卷 115-137页

作者： Fengrui Zhang randy c. Paffenroth David Worth Worcester Polytechnic Institute Worcester MA USA

current methods for predicting missing values in datasets often rely on simplistic approaches such as taking median value of attributes, limiting their applicability. Real-world observations can be diverse, taking stock price as example, ranging from prices post-IPO to values before a company’s collapse, or instances where certain data points are missing due to stock suspension. In this paper, we propose a novel approach using Nonlinear Matrix completion (NIMc) and Deep Matrix completion (DIMc) to predict associations, and conduct experiment on financial data between dates and stocks. Our method leverages various types of stock observations to capture latent factors explaining the observed date-stock associations. Notably, our approach is nonlinear, making it suitable for datasets with nonlinear structures, such as the Russell 3000. Unlike traditional methods that may suffer from information loss, NIMc and DIMc maintain nearly complete information, especially in high-dimensional parameters. We compared our approach with state-of-the-art linear methods, including Inductive Matrix completion, Nonlinear Inductive Matrix completion, and Deep Inductive Matrix completion. Our findings show that the nonlinear matrix completion method is particularly effective for handling nonlinear structured data, as exemplified by the Russell 3000. Additionally, we validate the information loss of the three methods across different dimensionalities.

关键词： Matrix completion Data Pipeline Machine Learning

Increased catabolism and decreased unsaturation of ganglioside in patients with inflammatory bowel disease

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World Journal of Gastroenterology 2015年第35期21卷 10080-10090页

作者： John J Miklavcic Glen K shoemaker Vera c Mazurak M Tom clandinin Tasha DL Hart Kareena L Schnabl Gordon M Lees Bodil MK Larsen Oliver F Bathe Alan BR Thomson M Tom clandinin Alberta Institute for Human Nutrition University of Alberta Edmonton AB T6G 2R1 Canada Department of Laboratory Medicine and Pathology University of Alberta Edmonton AB T6G 2B7 Canada Division of General Surgery University of Alberta Edmonton AB T6G 2B7 Canada Alberta Health Services Edmonton AB T6G 2B7 Canada Alberta Health Services Calgary AB T2N 4N2 Canada Division of Gastroenterology Western University London ON N6A 5A5 Canada Department of Medicine University of Alberta Edmonton AB T6G 2B7 Canada

AIM: To investigate whether accelerated catabolism of ganglioside and decreased ganglioside content contribute to the etiology of pro-inflammatory intestinal disease. METHODS: Intestinal mucosa from terminal ileum or colon was obtained from patients with ulcerative colitis or inflammatory crohn's disease(n = 11) undergoing bowel resection and compared to control samples of normal intestine from patients with benign colon polyps(n = 6) and colorectal cancer(n = 12) in this observational case-control study. Gangliosides and phospholipids of intestinal mucosa were characterized by class and ceramide or fatty acid composition using liquid chromatography triple-quad mass spectrometry. content and composition of ganglioside classes GM1, GM3, GD3, GD1 a, GT1 and GT3 were compared among subject groups. content and composition of phospholipid classes phosphatidylcholine(Pc) and phosphatidylethanolamine were compared among subject groups. Unsaturation index of individual ganglioside and phospholipid classes was computed and compared among subject groups. Ganglioside catabolism enzymes beta-hexosaminidase A(HEXA) and sialidase-3(NEU3) were measured in intestinal mucosa using western blot and compared among subject groups. RESULTS: Relative GM3 ganglioside content was 2-fold higher(P compared to control intestine. The quantity of GM3 and ratio of GM3/GD3 was also higher in IBD intestine than control tissue(P control intestine exhibited 3-fold higher(P content than IBD intestine. GD3 and GD1 a species of ganglioside containing three unsaturated bonds were present in control intestine, but were not detected in IBD intestine. The relative content of Pc containing more than two unsaturated bonds was 30% lower in IBD intestine than control intestine(P content of HEXA in IBD intestine was increased 1.7-fold(P creased 8.3-fold

关键词： Ganglioside Phospholipid Fatty acid Lipid Inflamma

Prevalence and factors associated with vitamin c deficiency in inflammatory bowel disease

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World Journal of Gastroenterology 2022年第33期28卷 4834-4845页

作者： Benjamin Langan Gordon Jonathan S Galati Stevie Yang randy S Longman Dana Lukin Ellen J Scherl Robert Battat Department of Medicine New York Presbyterian/Weill Cornell Medical CenterNew YorkNY 10065United States Department of Gastroenterology and Hepatology New York Presbyterian/Weill Cornell Medical CenterNew YorkNY 10021United States

BAcKGROUND Patients with inflammatory bowel disease(IBD) are prone to several nutritional deficiencies. However, data are lacking on vitamin c deficiency in crohn’s disease(cD) and ulcerative colitis(Uc) patients, as well as the impact of clinical, biomarker and endoscopic disease severity on the development of vitamin c *** To determine proportions and factors associated with vitamin c deficiency in cD and Uc *** In this retrospective study, we obtained clinical, laboratory and endoscopic data from cD and Uc patients presenting to the IBD clinic at a single tertiary care center from 2014 to 2019. All patients had an available plasma vitamin c level. Of 353 subjects who met initial search criteria using a cohort discovery tool, 301ultimately met criteria for inclusion in the study. The primary aim described vitamin c deficiency(≤ 11.4 μmol/L) rates in IBD. Secondary analyses compared proportions with deficiency between active and inactive IBD. Multivariate logistic regression analysis evaluated factors associated with *** Of 301 IBD patients, 21.6% had deficiency, including 24.4% of cD patients and 16.0% of Uc patients. Patients with elevated c-reactive protein(cRP)(39.1% vs 16.9%, P cal calprotectin(50.0% vs 20.0%, P = 0.009) had significantly higher proportions of deficiency compared to those without. Penetrating disease(P = 0.03),obesity(P = 0.02) and current biologic use(P = 0.006) were also associated with deficiency on univariate analysis. On multivariate analysis, the objective inflammatory marker utilized for analysis(elevated cRP) was the only factor associated with deficiency(odds ratio = 3.1, 95%confidence interval: 1.5-6.6, P = 0.003). There was no difference in the presence of clinical symptoms of scurvy in those with vitamin c deficiency and those *** Vitamin c deficiency was common in IBD. Patients with elevated inflammatory markers and penetrating disease had higher rates of vitamin

关键词： Inflammatory bowel disease crohn’s disease Ulcerative colitis Vitamin c deficiency Scurvy Malnutrition