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Hepatic intra-arterial infusion of yttrium-90 microspheres in the treatment of recurrent hepatocellular carcinoma after liver transplantation: A case report

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World Journal of Gastroenterology 2006年第35期12卷 5729-5732页

作者： louis Rivera Huan Giap William Miller Jonathan Fisher Donald J Hillebrand Christopher Marsh randolph l schaffer Naval Medical Center San Diego San Diego CA 92134 United States Department of Radiation Oncology Scripps Clinic/ Green Hospital La Jolla CA 92037 United States Department of Hematology/Oncology Scripps Clinic/Green Hospital La Jolla CA 92037 United States Scripps Center for Organ and Cell Transplantation Scripps Clinic/Green Hospital La Jolla CA 92037 United States

Hepatocellular carcinoma （HCC） recurs with a reported frequency of 12%-18% after liver transplantation. Recurrence is associated with a mortality rate exceeding 75%. Approximately one-third of recurrences develop in the transplanted liver and are therefore amenable to local therapy. A variety of treatment modalities have been reported including resection, transarterial chemoembolization （TACE）, radiofrequency ablation （RFA）, ethanol ablation, cryoablation, and external beam irradiation. Goals of treatment are tumor control and the minimization of toxic effect to functional parenchyma. Efficacy of treatment is mitigated by the need for ongoing immunosuppression. Yttrium-90 microspheres have been used as a treatment modality both for primary HCC and for pre-transplant management of HCC with promising results. Twenty-two months after liver transplantation for hepatitis C cirrhosis complicated by HCC, a 42-year old man developed recurrence of HCC in his transplant allograft. Treatment of multiple right lobe lesions with anatomic resection and adjuvant chemotherapy was unsuccessful. Multifocal recurrence in the remaining liver allograft was treated with hepatic intra-arterial infusion of yttrium-90 microspheres （SIR-Spheres, Sirtex Medical Inc., lake Forest, Il, USA）. Efficacy was demonstrated by tumor necrosis on imaging and a decrease in alpha-fetoprotein （AFP） level. There were no adverse consequences of initial treatment.

关键词： Recurrent hepatocellular carcinoma Yttrium-90 microspheres liver transplantation

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The fate of the herbicide propanil in plants of the littoral zone of the Three Gorges Reservoir(TGR),China

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Journal of Environmental Sciences 2016年第10期28卷 24-33页

作者： Zhongli Chen Andreas schaffer Institute for Environmental Research(Biology V) RWTH Aachen UniversityAachen 52074Germany. Nanjing University School of the Environment Nanjing 210023China Chongqing University College of Resource and Eavironmental ScienceChongqing 400030China

The anti-seasonal hydrology with 30 m water fluctuations in the Three Gorges Reservoir(TGR)of China attracts growing environmental and ecological *** investigated the biotransformation of the herbicide propanil in plants dominating in the littoral zone of the TGR by applying the 14C-ring-labeled herbicide into non-aseptic hydroponic plant systems(Cynodon dactylon,Nelumbo nucifera and Bidens pilosa),aseptic plants(lemna minor and lemna gibba)and cell suspension cultures(*** and ***).(1)Propanil absorbed in plants of the hydroponic systems was(12.46±1.63)%of applied radioactivity(AR)(***),(52.36±6.38)%(***)and(76.55±6.07)%(***),*** 14C-residues in the plant extractable fractions and the corresponding media were confirmed by radio-Thin layer Chromatography(TlC),radio-High Performance liquid Chromatography(HPlC)and Gas Chromatography-Electron Ionization Mass Spectrometry(GC-EIMS)as propanil,3,4-dichloroaniline(DCA)and N-(3,4-dichlorophenyl)-β-D-glucopyranosylamine(Glu-DCA).(2)About 8%of AR was taken up by both aseptic plants,from which 7.0%of AR was extracted and identified also as propanfl,DCA and Glu-DCA.(3)Concerning cell suspension cultures,(39.22±9.39)%of AR was absorbed by *** after 72 hr,whereas the accumulated 14C-propanil by *** cell suspension culture amounted to(65.04±1.72)%after 7 *** identified compounds in cell cultures are consistent with those in the tested *** of the pesticide residues in the intact plants were un-extractable,which are recognized as the end of the detoxificafion *** therefore consider these plants as suitable for the phytoremediation of the herbicide propanil in the TGR region.

关键词： Three Gorges Reservoir(TGR) Propanil Plant degradation Non-extractable residues(NER)

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Proton pump inhibitor-associated pneumonia:Not a breath of fresh air after all?

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2011年第3期2卷 17-26页

作者： Alexander l Fohl randolph E Regal University of Michigan Hospitals and College of Pharmacy Adult Internal Medicine University of Michigan Hospitals and College of Pharmacy

Over the past two decades,proton pump inhibitors (PPIs)have emerged as highly effective and relatively safe agents for the treatment of a variety of gastrointestinal ***,this desirable pharmacological profile has also contributed to superfluous and widespread use in both the inpatient and outpatient *** generally well-tolerated,research published over the last decade has associated these agents with increased risks of Clostridium difficile disease, fractures likely due to calcium malabsorption and both community-acquired(CAP)and hospital-acquired pneumonias(HAP).The mechanism behind PPI-associated pneumonia may be multifactorial,but is thought to stem from compromising the stomach's"acid mantle"against gastric colonization of acid-labile pathogenic bacteria which then may be aspirated.A secondary postulate is that PPIs,through their inhibition of extra-gastric H+/K+ATPase enzymes,may reduce the acidity of the upper aerodigestive tract,thus resulting in increased bacterial colonization of the larynx,esophagus and *** date,several retrospective case control studies have been published looking at the association between PPI use and *** studies found a temporal relationship between PPI exposure and the incidence of pneumonia,but only two could define a dose-response ***,other studies found an inverse correlation between duration of PPI use and risk of CAP. In terms of HAP,we reviewed two retrospective cohort studies and one prospective *** retrospective study in a medical ICU found no increased association of HAP in PPI-exposed patients compared to no acid-lowering therapy,while the other in cardiothoracic surgery patients showed a markedly increased risk compared to those receiving *** one prospective study in ICU patients showed an increased risk of HAP with PPIs, but not with *** conclusion,the current literature shows a slight trend toward an association between PPI use and pneumonia and

关键词： Proton pump inhibition Pneumonia Pharmacotherapy Gastroesophageal reflux disease Gastric acid

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A novel homozygous missense variant in ARSK causes MPS X,a new subtype of mucopolysaccharidosis

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Genes & Diseases 2024年第3期11卷 87-90页

作者： Miao Sun Cornelia K.Kaminsky Philip Deppe Mai-Brittllse Frederic M.Vaz Barbara Plecko Torben lubke linda M.randolph Division of Genomic Medicine Department of Pathology and Laboratory MedicineChildren's Hospital Los Angeles/Keck School of Medicine of USCLos AngelesCA 90027USA Department of Radiology Children's Hospital Los Angeles/Keck School of Medicine of USCLos AngelesCA 90027USA Department of Chemistry BiochemistryBielefeld UniversityBielefeld 33615Germany Amsterdam UMC location University of Amsterdam Department of Clinical Chemistry and PediatricsLaboratory Genetic Metabolic DiseasesEmma Children's HospitalMeibergdreef 9Amsterdam 1100 DEthe Netherlands Amsterdam Gastroenterology Endocrinology Metabolism Inborn Errors of MetabolismAmsterdam 1105 BKthe Netherlands Core Facility Metabolomics Amsterdam UMC Location University of AmsterdamAmsterdam 1100DDthe Netherlands Department of Pediatrics Division of General PediatricsMedical Universityof GrazGraz8036Austria Division of Medical Genetics Department of PediatricsChildren's Hospital Los Angeles/Keck School of Medicine of USCLos AngelesCA 90027USA

Mucopolysaccharidoses(MPS)are a group of rare inborn errors of metabolism caused by defective lysosomal enzymes which prevent cells from degrading and recycling certain carbohydrates and fats,resulting in the storage of glycosaminoglycans in cells throughout the *** leads to multisystem abnormalities involving bone,connective tissues,brain,blood,spinal cord,skin,and other tissues.

关键词： metabolism doses polys

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Developing targets for radiation transport experiments at the Omega laser facility

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High Power laser Science and Engineering 2017年第3期5卷 1-4页

作者： D.Capelli C.A.Charsley-Groffman R.B.randolph D.W.Schmidt T.Cardenas F.Fierro G.Rivera C.Hamilton J.D.Hager H.M.Johns N.E.lanier J.l.Kline los Alamos National laboratory

Targets have been developed to measure supersonic radiation transport in aerogel foams usinff absorption spectroscopy. The target consists of an aerogel foam uniformly doped with either titanium or scandium inserted into an undoped aerogel foam package. This creates a localized doped foam region to provide spatial resolution for the measurement. Development and characterization of the foams is a key challenge in addition to machining and assembling the two foams so they mate without gaps. The foam package is inserted into a beryllium sleeve and mounted on a gold hohlranm. The target is mounted to a holder created using additive manufacturing and mounted on a stalk. The manufacturing of the components, along with assembly and metrology of the target are described here.

关键词： absorption spectroscopy doped foams radiation transport

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Radiopaque FeMnN-Mo composite drawn filled tubing wires for braided absorbable neurovascular devices

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Bioactive Materials 2024年第10期40卷 74-87页

作者： Adam J.Griebel Petra Maier Henry Summers Benjamin Clausius Isabella Kanasty Weilue He Nicholas Peterson Carolyn Czerniak Alexander A.Oliver David F.Kallmes Ramanathan Kadirvel Jeremy E.schaffer Roger J.GuilloryⅡ Fort Wayne Metals Fort WayneINUSA School of Mechanical Engineering Stralsund University of Applied SciencesStralsundDEUSA Department of Materials Science and Engineering Michigan Technological UniversityUSA Department of Biomedical Engineering Michigan Technological UniversityUSA Department of Biological Sciences Michigan Technological UniversityUSA Joint Department of Biomedical Engineering Medical College of WisconsinMarquette UniversityUSA Department of Radiology Mayo ClinicRochesterMNUSA Department of Neurosurgery Mayo ClinicRochesterMNUSA

Flow diverter devices are small stents used to divert blood flow away from aneurysms in the brain,stagnating flow and inducing intra-aneurysmal thrombosis which in time will prevent aneurysm *** devices are formed from thin(~25μm)wires which will remain in place long after the aneurysm has been *** their continued presence could lead to secondary complications,an absorbable flow diverter which dissolves into the body after aneurysm occlusion is *** absorbable metals investigated to date struggle to achieve the necessary combination of strength,elasticity,corrosion rate,fragmentation resistance,radiopacity,and *** work proposes and investigates a new composite wire concept combining absorbable iron alloy(FeMnN)shells with one or more pure molybdenum(Mo)*** wire configurations are produced and drawn to 25–250μm *** testing revealed high and tunable mechanical properties on par with existing flow diverter *** vitro degradation testing of 100μm wire in DMEM to 7 days indicated progressive corrosion and cracking of the FeMnN shell but not of the Mo,confirming the cathodic protection of the Mo by the FeMnN and thus mitigation of premature fragmentation *** vivo implantation and subsequentμCT of the same wires in mouse aortas to 6 months showed meaningful corrosion had begun in the FeMnN shell but not yet in the Mo filament *** total,these results indicate that these composites may offer an ideal combination of properties for absorbable flow diverters.

关键词： corrosion composite filled

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Decline in stroke alerts and hospitalisations during the COVID-19 pandemic

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Stroke & Vascular Neurology 2020年第4期5卷 403-405页

作者： Malveeka Sharma Vasileios-Arsenios lioutas Tracy Madsen Judith Clark Jillian O'Sullivan Mitchell S.VElkind Joshua Z.Willey randolph S.Marshall Magdy H.Selim David Greer David l.Tirschwell Tina Burton Amelia Boehme Hugo J.Aparicio Department of Neurology University of Washington School of MedicineSeattleWashingtonUSA Department of Neurology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMassachusettsUSA Deparment of Emergency Medicine Brown UniversityProvidenceRhode IslandUSA Department of Neurology Boston University School of MedicineBostonMassachusettsUSA Department of Neurology Vagelos College of Physicians and SurgeonColumbia UniversityNew YorkNew YorkUSA Department of Epidemiology Mailman School of Public HealthColumbia UniversityNew YorkNew YorkUSA Department of Neurology Brown UniversityProvidenceRhode IslandUSA

Introduction Patients with stroke-like symptoms may be underutilising emergency medical services and avoiding hospitalisation during the COVID-19 *** investigated a decline in admissions for stroke and transient ischaemic attack(TIA)and emergency department(ED)stroke alert *** We retrospectively compiled total weekly hospital admissions for stroke and TIA between 31 December 2018 and 21 April 2019 versus 30 December 2019 and 19 April 2020 at five US tertiary academic comprehensive stroke centres in cities with early COVID-19 outbreaks in Boston,New York City,Providence and *** collected available data on ED stroke alerts,stroke severity using the National Institutes of Health Stroke Scale(NIHSS)and time from symptom onset to hospital *** Compared with 31 December 2018 to 21 April 2019,a decline in stroke/TIA admissions and ED stroke alerts occurred during 30 December 2019 to 19 April 2020(p trendlines coincided with state stay-at home recommendations in late *** greatest decline in hospital admissions was observed between 23 March and 19 April 2020,with a 31%decline compared with the corresponding weeks in *** of the five centres with 2019 and 2020 stroke alert data had a 46%decline in ED stroke alerts in late March and April 2020,compared with *** baseline NIHSS during these 4 weeks was 10 in 2020 and 7 in *** was no difference in time from symptom onset to hospital *** At these five large academic US hospitals,admissions for stroke and TIA declined during the COVID-19 *** was a trend for fewer ED stroke alerts at three of the five centres with available 2019 and 2020 *** stroke therapies are time-sensitive,so decreased healthcare access or utilisation may lead to more disabling or fatal strokes,or more severe non-neurological complications related to *** findings underscore the indirect effects of this *** health offici

关键词： alert centre hospital

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High-affinity mutant Interleukin-13 targeted CAR T cells enhance delivery of clickable biodegradable fluorescent nanoparticles to glioblastoma

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Bioactive Materials 2020年第3期5卷 624-635页

作者： Gloria B.Kim Virginia Aragon-Sanabria lauren randolph Hali Jiang Joshua A.Reynolds Becky S.Webb Achuthamangalam Madhankumar Xiaojun lian James R.Connor Jian Yang Cheng Dong Department of Biomedical Engineering The Pennsylvania State UniversityUniversity ParkPA16802United States Department of Neurosurgery M.S.Hershey Medical CenterThe Pennsylvania State UniversityHersheyPA17033United States

Glioblastoma(GBM),the deadliest form of brain cancer,presents long-standing problems due to its *** antigen receptor(CAR)T cell immunotherapy has emerged as a powerful strategy to treat ***-13-receptor-α2(Il13Rα2),present in over 75%of GBMs,has been recognized as an attractive candidate for antiglioblastoma ***,we propose a novel multidisciplinary approach to target brain tumors using a combination of fluorescent,therapeutic nanoparticles and CAR T cells modified with a targeted-quadruplemutant of Il13(TQM-13)shown to have high binding affinity to Il13Rα2-expressing glioblastoma cells with low off-target ***-alkyne cycloaddition conjugation of nanoparticles to the surface of T cells allowed a facile,selective,and high-yielding clicking of the *** clicked onto T cells were retained for at least 8 days showing that the linkage is stable and promising a suitable time window for in vivo delivery.T cells clicked with doxorubicin-loaded nanoparticles showed a higher cytotoxic effect in vitro compared to bare T *** vitro and in vivo T cells expressing TQM-13 served as delivery shuttles for nanoparticles and significantly increased the number of nanoparticles reaching brain tumors compared to nanoparticles *** work represents a new platform to allow the delivery of therapeutic nanoparticles and T cells to solid tumors.

关键词： Glioblastoma T cells Nanoparticles Targeted drug delivery Citrate polymers Fluorescence

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前期活检及家族史等皮肤监测相关因素对黑色素瘤Breslow厚度的影响

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世界核心医学期刊文摘（皮肤病学分册） 2005年第12期1卷 7-8页

作者： Fisher N.M. schaffer J.V. Berwick M. Bolognia J.l. 刘芯 Dr. Department of Dermatology Yale University School of Medicine 333 Cedar St New Haven CT 06520 United States

Background: Because the early detection of cutaneous melanoma can dramatically improve survival, identification and surveillance of persons at risk have received much attention. Objective: Our purpose was to examine the influences of personal or family history, patterns of detection, and prior skin biopsies (considered to be a measurement of surveillance by medical personnel) on the Breslow depth of cutaneous melanomas. Methods: A retrospective cohort analysis of 218 patients with a history of at least one invasive cutaneous melanoma who visited the Yale Pigmented lesion Clinic between January 1995 and January 1996 was performed. Data on patterns of detection, melanocytic nevi, and skin biopsies before and after the initial diagnosis of melanoma were collected, and patients with a family history of melanoma were compared with sporadic patients. Results: Initial melanomas discovered by dermatologists were more likely to be 0.75 mm or less in depth than those found by other physicians (P=.03). Although patients detected 45% of the initial primary melanomas (98/218), dermatologists discovered 80% of the second primary tumors (33/41; P=.001). A personal history of melanoma was predictive of a thinner Breslow depth (P=.01), but a family history of melanoma was not. Having a biopsy of any type or combination of types of skin lesion(s) performed in the 5 years, 2 years, or 1 year before the first diagnosis of melanoma did not predict a melanoma of thinner Breslow depth among either familial or sporadic patients. The mean number of skin biopsies performed per patient was 8 times higher in the 5- year period after (5.6) versus the 5- year period before (0.7) the initial diagnosis of melanoma, with a peak in the first year after the diagnosis (2.3 vs 0.25 in the prior year). In 27 patients, one or more skin biopsies were performed in the year before the initial diagnosis of melanoma; 41% of these biopsies (23/56)were of lesions in normally exposed sites (eg, the face, neck, a

关键词：黑色素瘤 Breslow 色素性皮肤病原发肿瘤初发性患者存活率回顾性队列研究早期检测研究中心侵袭性

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复合微量营养素补充剂对北京市成人血和尿营养素水平的影响

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中华临床营养杂志 2011年第4期19卷 227-231页

作者：李可基元香南杜芳伟 Yumei lIN Mei lI 黄晓明 randolph R. Keith 北京大学公共卫生学院营养与食品卫生系 100191 安利（中国）研发中心北京100191 美国纽崔莱健康研究所广州510730

目的探讨复合微量营养素补充剂对健康成人体内营养素水平的影响。方法选择北京市152名推荐食谱问卷得分低于12分的健康成年人作为研究对象，采用随机数字表法分为安慰剂组和补充剂组，每组76名。两组分别服用安慰剂和复合微量营养素补... 详细信息

目的探讨复合微量营养素补充剂对健康成人体内营养素水平的影响。方法选择北京市152名推荐食谱问卷得分低于12分的健康成年人作为研究对象，采用随机数字表法分为安慰剂组和补充剂组，每组76名。两组分别服用安慰剂和复合微量营养素补充剂。8周后检测受试者血浆及尿液中营养素浓度的变化情况。并于研究第56天同时给两组受试者服用复合微量营养素补充剂，观察服药前和服药后2 h血浆营养素水平变化。结果安慰剂组有3例失访，失访率为5.7%。服用复合微量营养素补充剂8周后，补充剂组的血浆α-生育酚［（18.23±0.82）比（14.55±0.73）μmol/l］、β-胡萝卜素［（4.28±0.29）比（2.38±0.24）μmol/l］、维生素C［（42.65±2.11）比（27.49±1.76）μmol/l］、B6［（323.51±15.88）比（69.43±10.47）nmol/l］和B12浓度［（1005.27±23.00）比（796.85±35.57）pmol/l］，尿维生素B1［（899.24±70.73）比（174.42±13.38）μg/g·Cr］和B2水平［（3227.68±330.04）比（259.10±33.33）μg/g·Cr］，及红细胞叶酸水平［（720.09±21.33）比（633.17±28.75）nmol/l］均明显高于安慰剂组（P均=0.0000），血浆γ-生育酚浓度明显低于安慰剂组［（2.18±0.13）比（2.87±0.26）μmol/l，P=0.0001］。服用复合微量营养素补充剂2 h后，补充剂组的血浆维生素C水平明显高于安慰剂组［（54.53±2.43）比（23.02±1.77）μmol/l，P=0.0000］。结论服用复合微量营养素补充剂可改变健康成人体内的营养素水平，但其意义有待进一步研究探讨。

关键词：复合微量营养素补充剂营养素中国成人

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