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Deter.ination of glycated hemoglobin in patients with advanced liver.disease

Wor.d Jour.al of Gastr.enter.logy 2004年第15期10卷 2284-2286页

作者： Ther.sa Lahousen Kar.n Hegenbar.h r.ttr.ut Ille r.iner.W.Lipp r.ber. Kr.use randie r. little Wolfgang J.Schnedl Depar.ment of Psychiatr. School of MedicineMedical University GrazAuenbruggerplatz 31A-8063 GrazAustria Depar.ment of Inter.al Medicine School of MedicineMedical University GrazAuenbruggerplatz 15A-8063 GrazAustria Univer.ity of Missour. School of Medicine Department of Pathology and Child HealthOne Hospital DriveColumbiaMO 65212USA

AIM:To evaluate the glycated hemoglobin(HbA_(1c)) deter.ination methods and to deter.ine fr.ctosamine in patients with chr.nic hepatitis,compensated cir.hosis and in patients with chr.nic hepatitis tr.ated with r.bavir.n. METHODS:HbA_(1c) values wer. deter.ined in 15 patients with compensated liver.cir.hosis and in 20 patients with chr.nic hepatitis using the ion-exchange high per.or.ance liquid chr.matogr.phy and the immunoassay methods. Fr.ctosamine was deter.ined using nitr.blue tetr.zolium. r.SULTS:For.y per.ent of patients with liver.cir.hosis had HbA_(1c) r.sults below the non-diabetic r.fer.nce r.nge by at least one HbA_(1c)method,while fr.ctosamine r.sults wer. either.within the r.fer.nce r.nge or.*** per.ent of patients with chr.nic hepatitis(hepatic fibr.sis) had HbA_(1c)r.sults below the non-diabetic r.fer.nce r.nge by at least one HbA_(1c)*** patients with chr.nic hepatitis tr.ated with r.bavir.n,50% of HbA_(1c)r.sults wer. below the non-diabetic r.fer.nce using at least one of the HbA_(1c)methods. CONCLUSION:Only evaluated in context with all liver.function par.meter. as well as a r.d blood count including r.ticulocytes,HbA_(1c)r.sults should be used in patients with advanced liver.***_(1c)and fr.ctosamine measur.ments should be used with caution when evaluating long-ter. glucose contr.l in patients with hepatic cir.hosis or.in patients with chr.nic hepatitis and dbavidn tr.atment.

关键词： Antivir.l Agents Fr.ctosamine Hemoglobin A, Glycosylated Hepatitis C, Chr.nic Hepatitis, Chr.nic Humans Liver.Cir.hosis r.bavir.n

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Machine Lear.ing Techniques in Pr.dicting Hot Defor.ation Behavior.of Metallic Mater.als

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Computer.Modeling in Engineer.ng & Sciences 2025年第1期142卷 713-732页

作者： Petr.Opela Josef Walek Jar.mír.Kopecek Depar.ment of Metallur.ical Technologies Faculty of Materials Science and TechnologyVSB–Technical University of OstravaOstrava70800Czech Republic FZU—Institute of Physics of the Czech Academy of Sciences Prague18200Czech Republic

In engineer.ng pr.ctice,it is often necessar. to deter.ine functional r.lationships between dependent and independent *** r.lationships can be highly nonlinear.and classical r.gr.ssion appr.aches cannot always pr.vide sufficiently r.liable ***,Machine Lear.ing(ML)techniques,which offer.advanced r.gr.ssion tools to addr.ss complicated engineer.ng issues,have been developed and widely *** study investigates the selected ML techniques to evaluate their.suitability for.application in the hot defor.ation behavior.of metallic *** ML-based r.gr.ssion methods of Ar.ificial Neur.l Networ.s(ANNs),Suppor. Vector.Machine(SVM),Decision Tr.e r.gr.ssion(DTr.,and Gaussian Pr.cess r.gr.ssion(GPr.ar. applied to mathematically descr.be hot flow str.ss cur.e datasets acquir.d exper.mentally for.a medium-car.on *** the GPr.method has not been used for.such a r.gr.ssion task befor.,the r.sults showed that its per.or.ance is the most favor.ble and pr.ctically unr.valed;neither.the ANN method nor.the other.studied ML techniques pr.vide such pr.cise r.sults of the solved r.gr.ssion analysis.

关键词： Machine lear.ing Gaussian pr.cess r.gr.ssion ar.ificial neur.l networ.s suppor. vector.machine hot defor.ation behavior

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Detection of Undiagnosed Pr.diabetes and Diabetes in Dental Patients: A Pr.posal of a Dental-Office-Fr.endly Diabetes Scr.ening Tool

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Jour.al of Diabetes Mellitus 2016年第1期6卷 25-37页

作者： Susan Maples Saleh Aldasouqi randie little Heather.Baughman Monica Joshi r.ma Salhi Susan Maples DDS Dental Office Holt MI USA Depar.ment of Medicine College of Human Medicine Michigan State University East Lansing MI USA Diabetes Diagnostic Labor.tor. Department of Pathology and Anatomical Sciences University of Missouri Columbia MO USA College of Science Boise State University Boise ID USA College of Science Michigan State University East Lansing MI USA College of Human Medicine Michigan State University East Lansing MI USA

Objective: This study was designed to develop a dental-office-fr.endly diabetes self-scr.ening tool for.diabetes mellitus (DM) and pr.diabetes (Pr.DM). Methods: Consecutive dental patients, aged 18 year. or.older. without histor. of DM or.Pr.DM, completed a 14-question questionnair. without assistance. They subsequently under.ent onsite finger.sticks for.capillar. blood collection for.glycohemoglobin (A1c) measur.ment. r.sults: Of the total 500 patients who completed the study, 302 wer. women (60.4%) and 198 wer. men (39.6%), with a collective mean age of 47.8 (±16.8) year. old. The pr.valence of Pr.DM and DM was 19.2% and 1.2%, r.spectively. Pr.dictor. of Pr.DM or.DM included age, >10% above ideal body weight, waist size above 40” for.men or.35” for.women, r.por.ed hyper.ension, r.por.ed abnor.al lipids, tingling of hands or.feet, and visual symptoms or.conditions (blur.ing, catar.cts, glaucoma). Conclusions: This study intr.duces a newly developed, user.fr.endly, Pr.DM and DM self-scr.ening tool, abbr.viated as DiDDO (Diabetes detection in the dental office). This scr.ening tool r.quir.s no body weighing or.BMI calculation (undesir.ble by dentists) nor.labor.tor. tests or.blood pr.ssur. measur.ment, allowing dentists to identify patients at moder.te and high r.sk for.DM/Pr.DM, and per.or. (or.r.fer.for. diagnostic A1c testing. This dental-office-fr.endly self-scr.ening tool is pr.posed for.validation in other.dental populations.

关键词： Diabetes Scr.ening Dental Office Scr.ening Test A1c

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Emer.ing potential of pr.gr.nulin-dependent Sor.S2 signaling in healthy and diseased ner.ous systems

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Neur.l r.gener.tion r.sear.h 2025年第9期20卷 2591-2593页

作者： Alena Salasova Ander. Nykjær Danish r.sear.h Institute of Tr.nslational Neur.science DANDr.TE-Nor.ic EMBL Par.ner.hip for.Molecular.Medicine and Centre of Excellence PROMEMODepartment of BiomedicineAarhus UniversityAarhusDenmark

The for.ation of the mammalian ner.ous system and its matur.tion into sensor.,motor.cognitive,and behavior.l cir.uits is a complex pr.cess that begins dur.ng ear.y embr.ogenesis and lasts until young *** neur.developm... 详细信息

关键词： pr.gr jointly CS2

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A compr.hensive investigation on nonlinear.vibr.tion and bending char.cter.stics of bio-inspir.d helicoidal laminated composite str.ctur.s

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 81-100页

作者： S.SAUr.BH r.KIr.N D.SINGH r.VAISH V.S.CHAUHAN School of Mechanical and Mater.als Engineer.ng Indian Institute of Technology Mandi

Bio-inspir.d helicoidal composite laminates, inspir.d by the intr.cate helical str.ctur.s found in natur., pr.sent a pr.mising fr.ntier.for.enhancing the mechanical pr.per.ies of str.ctur.l designs. Hence, this study pr.vides a compr.hensive investigation into the nonlinear.fr.e vibr.tion and nonlinear.bending behavior.of bio-inspir.d composite plates. The inver.e hyper.olic shear.defor.ation theor.(IHSDT) of plates is employed to char.cter.ze the displacement field, with the incor.or.tion of Gr.en-Lagr.nge nonlinear.ty. The pr.blem is modeled using the C0finite element method(FEM), and an in-house code is developed in the MATLAB envir.nment to solve it numer.cally. Var.ous helicoidal layup configur.tions including helicoidal r.cur.ive(Hr., helicoidal exponential(HE), helicoidal semi-cir.ular.HS), linear.helicoidal(LH), and Fibonacci helicoidal(FH)with differ.nt layup sequences and quasi-isotr.pic configur.tions ar. studied. The model is validated, and par.metr.c studies ar. conducted. These studies investigate the effects of layup configur.tions, side-to-thickness r.tio, modulus r.tios, boundar. conditions, and loading conditions at differ.nt load amplitudes on the nonlinear.vibr.tion and nonlinear.bending behavior. of bio-inspir.d composite plates. The r.sults show that the laminate sequence exer.s a substantial impact on both nonlinear.natur.l fr.quencies and nonlinear.bending behavior.. Mor.over. this influence var.es acr.ss differ.nt side-to-thickness r.tios and boundar. conditions of the bio-inspir.d composite plate.

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Pr.jection-Based Dimensional r.duction of Adaptively r.fined Nonlinear.Models

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Communications on Applied Mathematics and Computation 2024年第3期6卷 1779-1800页

作者： Clayton little Char.el Far.at Depar.ment of Mechanical Engineer.ng Stanford UniversityStanfordUSA Depar.ment of Aer.nautics and Astr.nautics Stanford UniversityStanfordUSA Institute for.Computational and Mathematical Engineer.ng Stanford UniversityStanfordUSA

Adaptive mesh r.finement (AMr. is fair.y pr.cticed in the context of high-dimensional, mesh-based computational models. However. it is in its infancy in that of low-dimensional, gener.lized-coor.inate-based computational models such as pr.jection-based r.duced-or.er.models. This paper.pr.sents a complete fr.mewor. for.pr.jection-based model or.er.r.duction (PMOr. of nonlinear.pr.blems in the pr.sence of AMr.that builds on elements fr.m existing methods and augments them with cr.tical new contr.butions. In par.icular. it pr.poses an analytical algor.thm for.computing a pseudo-meshless inner.pr.duct between adapted solution snapshots for.the pur.ose of cluster.ng and PMOr. It exploits hyper.eduction—specifically, the ener.y-conser.ing sampling and weighting hyper.eduction method—to deliver.for.nonlinear.and/or.par.metr.c pr.blems the desir.d computational gains. Most impor.antly, the pr.posed fr.mewor. for.PMOr.in the pr.sence of AMr.capitalizes on the concept of state-local r.duced-or.er.bases to make the most of the notion of a super.esh, while achieving computational tr.ctability. Its featur.s ar. illustr.ted with CFD applications gr.unded in AMr.and its significance is demonstr.ted by the r.por.ed wall-clock speedup factor..

关键词： Adaptive mesh r.finement(AMr. Computational fluid dynamics Ener.y-conser.ing sampling and weighting(ECSW) Model or.er.r.duction r.duced-or.er.model Super.esh

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Antisense oligonucleotides pr.vide optimism to the ther.peutic landscape for.tauopathies

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Neur.l r.gener.tion r.sear.h 2025年第3期20卷 803-804页

作者： Glenn A.Har.is Laur.n r.Hir.chfeld r.inwater.Char.table Foundation Fort WorthTXUSA

Tauopathies ar. a gr.up of neur.degener.tive diseases char.cter.zed by abnor.al metabolism of the misfolded tau pr.tein. Tau is encoded by the micr.tubule-associated pr.tein tau gene(MAPT) and can be classified as either.3-r.peat(3r. or.4-r.peat(4r. based on the number.of r.peat domains fr.m alter.ative splicing of exon 10 of the MAPT gene.

关键词： tau metabolism diseases

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STUDY OF THr.E-DIMENSIONAL SEPAr.TION OF BOUNDAr. LAYEr.OVEr.BLUNT BODIES

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Jour.al of Hydr.dynamics 2009年第1期21卷 100-107页

作者： ATMANI r. Br.MA A. ASKOVIC r. Labor.toir. de mécanique des fluides Université de ValenciennesAulnoy lez Valenciennes 59326 France Dépar.ement de Mécanique Université de BiskraBiskra 07000 Algérie

In the case of thr.e-dimensional flows, the separ.tion can be defined in mor. than one way. Discussions about thr.e-dimensional boundar. layer.separ.tion in the liter.tur. have found a r.tional extension of the zer. skin fr.ction. Attempts have been made to establish the identity of “separ.tion lines”. Among definitions, these may be found：（1） envelopes of limiting str.amlines, （2） lines dividing flow which has come fr.m differ.nt r.gions, （3） lines of singular.ties （pr.blems of topology）, （4） lines on which some component of the skin fr.ction vanishes. Each of these is valid under.cer.ain conditions, but none is univer.ally valid. In the pr.sent wor., we use the definition （4）, i.e. at low incidence of a blunt body the separ.tion line is identified as the zer. of the mer.dian skin fr.ction component （Wang 1975）. So the separ.tion line on a flattened spher.id （6：3：1） at 6° of incidence is calculated, as well as exper.mentally deter.ined by using the electr.chemical method, which allows to follow the evolution of the par.etal velocity gr.dient.

关键词： thr.e-dimensional flows separ.tion boundar. layer. blunt bodies

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Activator.assisted electr.less deposition of copper.nanostr.ctur.d films

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Inter.ational Jour.al of Miner.ls,Metallur.y and Mater.als 2014年第2期21卷 196-203页

作者： Var.ha r. Mehto r. K. Pandey Depar.ment of Physics Barkatullah University NIIT Univer.ity

This paper.showed simple and effective synthesis of copper.nanopar.icles within contr.lled diameter.using dir.ct electr.less deposition on glass substr.tes, following the sensitization and activation steps. Electr.less-deposited metals, such as Cu, Co, Ni, and Ag, and their.alloys had many advantages in micr.- and nanotechnologies. The str.ctur.l, mor.hological, and optical pr.per.ies of copper.deposits wer. char.cter.zed using X-r.y diffr.ction （Xr.）, atomic for.e micr.scopy （AFM）, and UV-Vis spectr.scopy. The str.ctur.l data was fur.her.analyzed using the r.etveld r.finement pr.gr.m. Str.ctur.l studies r.veal that the deposited copper.pr.fer. a （111） or.entation. AFM studies suggest the deposited mater.als for. compact, unifor., and nanocr.stalline phases with a high tendency to self-or.anize. The data show that the par.icle size can be contr.lled by contr.lling the activator.concentr.tion. The absor.tion spectr. of the as-deposited copper.nanopar.icles r.veal that the plasmonic peak br.adens and exhibits a blue shift with decr.asing par.icle size.

关键词： nanostr.ctur.d mater.als thin films copper electr.less plating deposition

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Seismic behavior.of var.able fr.quency pendulum isolator

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Ear.hquake Engineer.ng and Engineer.ng Vibr.tion 2008年第2期7卷 193-205页

作者： V. r. Panchal r. S. Jangid Depar.ment of Civil Engineer.ng Indian Institute of TechnologyBombayPowaiMumbai 400076India

Ear.hquake per.or.ance of a flexible one-stor. building isolated with a var.able fr.quency pendulum isolator.（VFPI） under.near.fault and far.field gr.und motions is investigated. The fr.ctional for.es mobilized at the inter.ace of the VFPI ar. assumed to be velocity dependent. The inter.ction between fr.ctional for.es of the VFPI in two hor.zontal dir.ctions is duly consider.d and coupled differ.ntial equations of motion of the isolated system in the incr.mental for. ar. solved iter.tively. The r.sponse of the system with bi-dir.ctional inter.ction is compar.d with those without inter.ction. In addition, the effects of velocity dependence on the r.sponse of the isolated system ar. also investigated. Mor.over. a par.metr.c study is car.ied out to cr.tically examine the influence of impor.ant par.meter. on bi-dir.ctional inter.ction effects of the fr.ctional for.es of the VFPI. These par.meter. ar.： the super.tr.ctur. time per.od, fr.quency var.ation factor.（FVF） and fr.ction coefficient of the VFPI. Fr.m the above investigations, it is obser.ed that the dependence of the fr.ction coefficient on r.lative velocity of the system does not have a noticeable effect on the peak r.sponse of the system isolated with VFPI, and that the bi-dir.ctional inter.ction of fr.ctional for.es of the VFPI is impor.ant and if neglected, isolator.displacements will be under.stimated and the super.tr.ctur. acceler.tion and base shear.will be over.stimated.

关键词： base isolation bi-dir.ctional inter.ction super.tr.ctur. flexibility near.fault gr.und motion fr.ction coefficient far.field gr.und motion VFPI

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